#FlyBase_ID DBNAME DBID DBURL FBgn0261996 Reactome Synthesis of dolichyl-phosphate-glucose R-DME-480985 FBgn0278608 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0278608 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0278608 Reactome Regulation of TLR by endogenous ligand R-DME-5686938 FBgn0278608 Reactome Neutrophil degranulation R-DME-6798695 FBgn0041191 Reactome TOR signaling pathway R-DME-110523 FBgn0041191 Reactome Macroautophagy R-DME-1632852 FBgn0041191 Reactome mTOR signalling R-DME-165159 FBgn0041191 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0041191 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0041191 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0041191 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0041342 Reactome Synthesis of PC R-DME-1483191 FBgn0042627 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0042627 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0042627 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0042711 Reactome Regulation of Glucokinase by Glucokinase Regulatory Protein R-DME-170822 FBgn0042711 Reactome Neutrophil degranulation R-DME-6798695 FBgn0042711 Reactome Glycolysis R-DME-70171 FBgn0042712 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0044030 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0044030 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0011774 Reactome Nonhomologous End-Joining (NHEJ) R-DME-5693571 FBgn0011774 Reactome Neutrophil degranulation R-DME-6798695 FBgn0045843 Reactome Rho GTPase cycle R-DME-194840 FBgn0045843 Reactome Kinesins R-DME-983189 FBgn0046687 Reactome G alpha (s) signalling events R-DME-418555 FBgn0046687 Reactome Neutrophil degranulation R-DME-6798695 FBgn0263757 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0263757 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0263757 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0263757 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0263757 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0263757 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0263757 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0263757 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0263757 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0263757 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0263757 Reactome mRNA Capping R-DME-72086 FBgn0263757 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0263757 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0263757 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0263757 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0263757 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0263757 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0263757 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0263757 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0263757 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0263757 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0265184 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0265174 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0266438 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0013679 Reactome Respiratory electron transport R-DME-611105 FBgn0013679 Reactome Complex I biogenesis R-DME-6799198 FBgn0050005 Reactome Glutathione conjugation R-DME-156590 FBgn0050008 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0050008 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0050008 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0050016 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0050016 Reactome Neutrophil degranulation R-DME-6798695 FBgn0050054 Reactome G alpha (q) signalling events R-DME-416476 FBgn0050054 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0050054 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0260475 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0260475 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0260475 Reactome Neutrophil degranulation R-DME-6798695 FBgn0265272 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0265272 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0050062 Reactome Neutrophil degranulation R-DME-6798695 FBgn0050062 Reactome Antimicrobial peptides R-DME-6803157 FBgn0050077 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0050104 Reactome Nicotinate metabolism R-DME-196807 FBgn0050104 Reactome Pyrimidine catabolism R-DME-73621 FBgn0050104 Reactome Purine catabolism R-DME-74259 FBgn0050108 Reactome TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-DME-6803204 FBgn0050109 Reactome TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-DME-6803204 FBgn0061198 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0061198 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0061198 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0050203 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0050274 Reactome Creatine metabolism R-DME-71288 FBgn0050281 Reactome Platelet degranulation R-DME-114608 FBgn0050281 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0050281 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0050281 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0050281 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0050281 Reactome Integrin cell surface interactions R-DME-216083 FBgn0050281 Reactome Syndecan interactions R-DME-3000170 FBgn0050281 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0050281 Reactome ECM proteoglycans R-DME-3000178 FBgn0050281 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0050281 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0050281 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0050281 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0050281 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0050281 Reactome Neutrophil degranulation R-DME-6798695 FBgn0050281 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0050290 Reactome Coenzyme A biosynthesis R-DME-196783 FBgn0028669 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028669 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028669 Reactome Insulin receptor recycling R-DME-77387 FBgn0028669 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028669 Reactome Ion channel transport R-DME-983712 FBgn0050339 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0050339 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0050339 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0050340 Reactome Class A/1 (Rhodopsin-like receptors) R-DME-373076 FBgn0050340 Reactome G alpha (i) signalling events R-DME-418594 FBgn0050354 Reactome Respiratory electron transport R-DME-611105 FBgn0050360 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0050382 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0050382 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0050382 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0050382 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0050382 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0050382 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0050382 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0050382 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0050382 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0050382 Reactome Downstream TCR signaling R-DME-202424 FBgn0050382 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0050382 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0050382 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0050382 Reactome Nuclear CI is degraded R-DME-216167 FBgn0050382 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0050382 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0050382 Reactome Degradation of TIM R-DME-432395 FBgn0050382 Reactome Degradation of PER R-DME-432524 FBgn0050382 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0050382 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0050382 Reactome Degradation of AXIN R-DME-4641257 FBgn0050382 Reactome Degradation of DVL R-DME-4641258 FBgn0050382 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0050382 Reactome Degradation of CLK R-DME-538848 FBgn0050382 Reactome Degradation of CRY R-DME-538864 FBgn0050382 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0050382 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0050382 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0050382 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0050382 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0050382 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0050382 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0050382 Reactome UCH proteinases R-DME-5689603 FBgn0050382 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0050382 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0050382 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0050382 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0050382 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0050382 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0050382 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0050382 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0050382 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0050382 Reactome Neddylation R-DME-8951664 FBgn0050382 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0050382 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0050392 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0050410 Reactome Pentose phosphate pathway R-DME-71336 FBgn0050441 Reactome Intraflagellar transport R-DME-5620924 FBgn0050463 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0050476 Reactome Phosphorylation of CI R-DME-209190 FBgn0050476 Reactome Phosphorylation of SMO R-DME-209214 FBgn0050476 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0044871 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0044871 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0046114 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0046704 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0045063 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0045063 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0045063 Reactome CS/DS degradation R-DME-2024101 FBgn0045063 Reactome Hyaluronan uptake and degradation R-DME-2160916 FBgn0045063 Reactome Neutrophil degranulation R-DME-6798695 FBgn0045064 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0053198 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0053198 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0053198 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0053198 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0047135 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0066114 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0010053 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0053193 Reactome Signaling by Hippo R-DME-2028269 FBgn0053193 Reactome Formation of the Hippo kinase cassette R-DME-390089 FBgn0053193 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0053193 Reactome Negative regulation of TH R-DME-390197 FBgn0026313 Reactome Dopamine Neurotransmitter Release Cycle R-DME-212676 FBgn0267429 Reactome Cellular hexose transport R-DME-189200 FBgn0267796 Reactome Neutrophil degranulation R-DME-6798695 FBgn0267828 Reactome Transport of fatty acids R-DME-804914 FBgn0283432 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0283432 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0283432 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0283433 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0283433 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0283433 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0283434 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0283434 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0283434 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0037702 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0037702 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051956 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0051683 Reactome Hydrolysis of LPC R-DME-1483115 FBgn0051683 Reactome HDL remodeling R-DME-8964058 FBgn0051155 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0051155 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0051155 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0051155 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0051155 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0051155 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0051155 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0051155 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0051155 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0051155 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0051155 Reactome mRNA Capping R-DME-72086 FBgn0051155 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0051155 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0051155 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0051155 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0051155 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0051155 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0051155 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0051155 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0051155 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0051155 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0038827 Reactome Fanconi Anemia Pathway R-DME-6783310 FBgn0267339 Reactome NOD1/2 Signaling Pathway R-DME-168638 FBgn0267339 Reactome p38MAPK events R-DME-171007 FBgn0267339 Reactome ERK/MAPK targets R-DME-198753 FBgn0267339 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0267339 Reactome CDO in myogenesis R-DME-375170 FBgn0267339 Reactome DSCAM interactions R-DME-376172 FBgn0267339 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0267339 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0267339 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0267339 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0267339 Reactome Neutrophil degranulation R-DME-6798695 FBgn0066101 Reactome Reelin signalling pathway R-DME-8866376 FBgn0066101 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0066101 Reactome LDL clearance R-DME-8964038 FBgn0259878 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0259878 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0030791 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0030791 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0030791 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0053497 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0053497 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0053497 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0053499 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0053499 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0053499 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0030992 Reactome Nephrin family interactions R-DME-373753 FBgn0030992 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259166 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0259166 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0259166 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0023520 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0032120 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0053281 Reactome Cellular hexose transport R-DME-189200 FBgn0053281 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0053281 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0053282 Reactome Cellular hexose transport R-DME-189200 FBgn0053282 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0053282 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0260439 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0260439 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0260439 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0260439 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0260439 Reactome ERK/MAPK targets R-DME-198753 FBgn0260439 Reactome ERKs are inactivated R-DME-202670 FBgn0260439 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0260439 Reactome Phosphorylation of CI R-DME-209190 FBgn0260439 Reactome Phosphorylation of SMO R-DME-209214 FBgn0260439 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0260439 Reactome Phosphorylation of ARM R-DME-209396 FBgn0260439 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0260439 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0260439 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0260439 Reactome CTLA4 inhibitory signaling R-DME-389513 FBgn0260439 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0260439 Reactome Dephosphorylation of PER R-DME-432620 FBgn0260439 Reactome Dephosphorylation of CLK R-DME-538909 FBgn0260439 Reactome RAF activation R-DME-5673000 FBgn0260439 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0260439 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0260439 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0260439 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0259935 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0259935 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0035802 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0035802 Reactome Rho GTPase cycle R-DME-194840 FBgn0035802 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0037188 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0270926 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0036465 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0036465 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0036465 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0036465 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0036465 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0036465 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0036465 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0036465 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0036465 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0036465 Reactome Downstream TCR signaling R-DME-202424 FBgn0036465 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0036465 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0036465 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0036465 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0036465 Reactome Degradation of AXIN R-DME-4641257 FBgn0036465 Reactome Degradation of DVL R-DME-4641258 FBgn0036465 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0036465 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0036465 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0036465 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0036465 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0036465 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0036465 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0036465 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0036465 Reactome UCH proteinases R-DME-5689603 FBgn0036465 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0036465 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0036465 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0036465 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0036465 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0036465 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0036465 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0036465 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0036465 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0036465 Reactome Neddylation R-DME-8951664 FBgn0036465 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0036465 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0052318 Reactome Unwinding of DNA R-DME-176974 FBgn0044048 Reactome Insulin signaling pathway R-DME-110478 FBgn0263219 Reactome DSCAM interactions R-DME-376172 FBgn0263219 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0000316 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0011822 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0011822 Reactome Surfactant metabolism R-DME-5683826 FBgn0023536 Reactome Mitochondrial ABC transporters R-DME-1369007 FBgn0023537 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0260400 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0260400 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0000108 Reactome Platelet degranulation R-DME-114608 FBgn0000108 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0000108 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0025640 Reactome Pentose phosphate pathway R-DME-71336 FBgn0002579 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0002579 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0002579 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0002579 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0002579 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0002579 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0020381 Reactome Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214397 FBgn0020381 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0020381 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0020381 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0003575 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0025638 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0025638 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0025638 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0025638 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0025638 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0025638 Reactome Degradation of DVL R-DME-4641258 FBgn0025638 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0025638 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0025638 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0025638 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0025638 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0025638 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0025638 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0025638 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0025638 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0025638 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0025638 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0025638 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0025638 Reactome Neddylation R-DME-8951664 FBgn0025638 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0025638 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0025639 Reactome PKMTs methylate histone lysines R-DME-3214841 FBgn0025637 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0025637 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0025637 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0025637 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0025637 Reactome Downstream TCR signaling R-DME-202424 FBgn0025637 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0025637 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0025637 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0025637 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0025637 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0025637 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0025637 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0025637 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0025637 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0025637 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0025637 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0025637 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0025637 Reactome Neddylation R-DME-8951664 FBgn0025637 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0025637 Reactome Iron uptake and transport R-DME-917937 FBgn0025637 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0040383 Reactome Lysine catabolism R-DME-71064 FBgn0015288 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0015288 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0015288 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0015288 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0015288 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0015288 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0086368 Reactome O-linked glycosylation R-DME-5173105 FBgn0015799 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0015799 Reactome G0 and Early G1 R-DME-1538133 FBgn0015799 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0015799 Reactome Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69200 FBgn0015799 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0015799 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0015799 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0260855 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260855 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0260855 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0040347 Reactome Resolution of D-loop Structures through Holliday Junction Intermediates R-DME-5693568 FBgn0026143 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0026143 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0040368 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0040368 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0040368 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0040368 Reactome Deadenylation of mRNA R-DME-429947 FBgn0040368 Reactome Translation initiation complex formation R-DME-72649 FBgn0040368 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0040368 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0040368 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261444 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0025641 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0025641 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0025641 Reactome PCP/CE pathway R-DME-4086400 FBgn0025641 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0027791 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0025382 Reactome Neutrophil degranulation R-DME-6798695 FBgn0025382 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0025382 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0003517 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0003517 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0003517 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0003517 Reactome Translation initiation complex formation R-DME-72649 FBgn0003517 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0003517 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0003517 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0003517 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003517 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0003517 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0053513 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0053513 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0053513 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0053513 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0026086 Reactome C6 deamination of adenosine R-DME-75102 FBgn0026086 Reactome Formation of editosomes by ADAR proteins R-DME-77042 FBgn0023516 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0023516 Reactome Peroxisomal protein import R-DME-9033241 FBgn0023514 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0023518 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0023518 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0023519 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0023519 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0000117 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0000117 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0000117 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0000117 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0000117 Reactome Phosphorylation of SMO R-DME-209214 FBgn0000117 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0000117 Reactome Phosphorylation of ARM R-DME-209396 FBgn0000117 Reactome Transport of ARM to the nucleus R-DME-209407 FBgn0000117 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0000117 Reactome Transcription activation by ARM R-DME-209421 FBgn0000117 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0000117 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0000117 Reactome LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-DME-3134973 FBgn0000117 Reactome Apoptotic cleavage of cell adhesion proteins R-DME-351906 FBgn0000117 Reactome CDO in myogenesis R-DME-375170 FBgn0000117 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0000117 Reactome Ca2+ pathway R-DME-4086398 FBgn0000117 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0023509 Reactome G0 and Early G1 R-DME-1538133 FBgn0023511 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0023512 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0023508 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0023508 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0023508 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0023508 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0023508 Reactome Rho GTPase cycle R-DME-194840 FBgn0023508 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0023508 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0023522 Reactome Histidine catabolism R-DME-70921 FBgn0264562 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0003964 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0003964 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0003964 Reactome Transcriptional regulation of white adipocyte differentiation R-DME-381340 FBgn0003964 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0003964 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0003964 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0000667 Reactome Platelet degranulation R-DME-114608 FBgn0000667 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0000667 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0000667 Reactome Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-DME-446388 FBgn0025631 Reactome G alpha (s) signalling events R-DME-418555 FBgn0025631 Reactome Neutrophil degranulation R-DME-6798695 FBgn0025632 Reactome G alpha (s) signalling events R-DME-418555 FBgn0025632 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004861 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0004861 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0004861 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0004861 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0004861 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0004861 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0004861 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0023507 Reactome Interconversion of 2-oxoglutarate and 2-hydroxyglutarate R-DME-880009 FBgn0004654 Reactome Pentose phosphate pathway R-DME-71336 FBgn0013432 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0004655 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0004655 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0004655 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0025839 Reactome Respiratory electron transport R-DME-611105 FBgn0025839 Reactome Complex I biogenesis R-DME-6799198 FBgn0004397 Reactome Platelet degranulation R-DME-114608 FBgn0004397 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0004397 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0004397 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001330 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0000377 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0023525 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0023525 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0023525 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0029608 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0029608 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0029608 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0023524 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0023527 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0023528 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0023528 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0044047 Reactome Insulin signaling pathway R-DME-110478 FBgn0003079 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0003079 Reactome Phosphorylation of CI R-DME-209190 FBgn0003079 Reactome Phosphorylation of SMO R-DME-209214 FBgn0003079 Reactome Rap1 signalling R-DME-392517 FBgn0003079 Reactome GP1b-IX-V activation signalling R-DME-430116 FBgn0003079 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0003079 Reactome CREB phosphorylation through the activation of Ras R-DME-442742 FBgn0003079 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0003079 Reactome RAF activation R-DME-5673000 FBgn0003079 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0003079 Reactome Negative feedback regulation of MAPK pathway R-DME-5674499 FBgn0003079 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0040389 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0040389 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0003714 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0003714 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0040388 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0040388 Reactome CDO in myogenesis R-DME-375170 FBgn0040388 Reactome Ligand-receptor interactions R-DME-5632681 FBgn0040377 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0040377 Reactome Neutrophil degranulation R-DME-6798695 FBgn0040377 Reactome Insulin receptor recycling R-DME-77387 FBgn0040377 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0040377 Reactome Ion channel transport R-DME-983712 FBgn0011606 Reactome Kinesins R-DME-983189 FBgn0029629 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0029629 Reactome Translation initiation complex formation R-DME-72649 FBgn0029629 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0029629 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0029629 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0029629 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0267350 Reactome Synthesis of PIPs at the ER membrane R-DME-1483248 FBgn0267350 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0003371 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0003371 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0003371 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0003371 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0003371 Reactome Phosphorylation of CI R-DME-209190 FBgn0003371 Reactome Phosphorylation of SMO R-DME-209214 FBgn0003371 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0003371 Reactome Phosphorylation of ARR R-DME-209387 FBgn0003371 Reactome Phosphorylation of ARM R-DME-209396 FBgn0003371 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0003371 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0003371 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0003371 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0003371 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0003371 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0003371 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0011276 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0003068 Reactome Degradation of TIM R-DME-432395 FBgn0003068 Reactome Nuclear import of PER and TIM R-DME-432490 FBgn0003068 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0003068 Reactome Degradation of PER R-DME-432524 FBgn0003068 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0003068 Reactome Dephosphorylation of PER R-DME-432620 FBgn0003068 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0024992 Reactome Processing of SMDT1 R-DME-8949664 FBgn0024994 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0024996 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0024998 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0040355 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003285 Reactome Nephrin family interactions R-DME-373753 FBgn0028369 Reactome Nephrin family interactions R-DME-373753 FBgn0004647 Reactome Pre-NOTCH Processing in Golgi R-DME-1912420 FBgn0004647 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0004647 Reactome NOTCH2 Activation and Transmission of Signal to the Nucleus R-DME-2979096 FBgn0004647 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0004647 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0004647 Reactome NOTCH4 Activation and Transmission of Signal to the Nucleus R-DME-9013700 FBgn0004647 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0004647 Reactome Negative regulation of NOTCH4 signaling R-DME-9604323 FBgn0000479 Reactome DARPP-32 events R-DME-180024 FBgn0000479 Reactome G alpha (s) signalling events R-DME-418555 FBgn0262656 Reactome TFAP2 (AP-2) family regulates transcription of cell cycle factors R-DME-8866911 FBgn0029663 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0029663 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0029664 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0029664 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0029664 Reactome Aryl hydrocarbon receptor signalling R-DME-8937144 FBgn0029672 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0044046 Reactome Insulin signaling pathway R-DME-110478 FBgn0023216 Reactome POLB-Dependent Long Patch Base Excision Repair R-DME-110362 FBgn0015286 Reactome Translocation of SLC2A4 (GLUT4) to the plasma membrane R-DME-1445148 FBgn0029676 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0265575 Reactome Proton/oligopeptide cotransporters R-DME-427975 FBgn0028491 Reactome Proton/oligopeptide cotransporters R-DME-427975 FBgn0285910 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0285910 Reactome Insulin receptor recycling R-DME-77387 FBgn0285910 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0285910 Reactome Ion channel transport R-DME-983712 FBgn0029687 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0029687 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029689 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0004832 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0004832 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0004832 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0004832 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0026080 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0026080 Reactome DNA Damage/Telomere Stress Induced Senescence R-DME-2559586 FBgn0026080 Reactome Sensing of DNA Double Strand Breaks R-DME-5693548 FBgn0026080 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0026080 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0026080 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0000635 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0000635 Reactome NCAM1 interactions R-DME-419037 FBgn0000635 Reactome Signal transduction by L1 R-DME-445144 FBgn0000635 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0002707 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0002707 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0002707 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0262738 Reactome PLC beta mediated events R-DME-112043 FBgn0262738 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0262738 Reactome G alpha (q) signalling events R-DME-416476 FBgn0029706 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0003210 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0029709 Reactome Pre-NOTCH Processing in Golgi R-DME-1912420 FBgn0029709 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0029709 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0029714 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0029715 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029718 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0029718 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0025615 Reactome Platelet degranulation R-DME-114608 FBgn0025615 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0011760 Reactome Macroautophagy R-DME-1632852 FBgn0011760 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0011760 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011760 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0011760 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0028325 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0028325 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0028325 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0028325 Reactome Pyruvate metabolism R-DME-70268 FBgn0029722 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0029722 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0029722 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0029722 Reactome Pyruvate metabolism R-DME-70268 FBgn0029737 Reactome HS-GAG degradation R-DME-2024096 FBgn0029737 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029745 Reactome UCH proteinases R-DME-5689603 FBgn0029745 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0263237 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0263237 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0263237 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0263237 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0263237 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0263237 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0263237 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0263237 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0263237 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0263237 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0263237 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0263237 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0263237 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0263237 Reactome mRNA Capping R-DME-72086 FBgn0263237 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0263237 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0263237 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0263237 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0263237 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0263237 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0263237 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0003449 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0029755 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0284442 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0284442 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0284442 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0284442 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0284442 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0029756 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0026751 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0026751 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0029761 Reactome Ca2+ activated K+ channels R-DME-1296052 FBgn0029763 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029763 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0263987 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0029765 Reactome Lactose synthesis R-DME-5653890 FBgn0029778 Reactome Rho GTPase cycle R-DME-194840 FBgn0004687 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0004687 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0004687 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0029783 Reactome Transcriptional activation of mitochondrial biogenesis R-DME-2151201 FBgn0029785 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0029785 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0029785 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0029785 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0029785 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0029785 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0029791 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0261383 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0029800 Reactome G0 and Early G1 R-DME-1538133 FBgn0029801 Reactome Sialic acid metabolism R-DME-4085001 FBgn0029804 Reactome Regulation of Complement cascade R-DME-977606 FBgn0259149 Reactome Regulation of Complement cascade R-DME-977606 FBgn0029807 Reactome Regulation of Complement cascade R-DME-977606 FBgn0029812 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0029812 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0029812 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0029812 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029812 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0029812 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029812 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029812 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0029812 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0029812 Reactome Downstream TCR signaling R-DME-202424 FBgn0029812 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0029812 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0029812 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0029812 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029812 Reactome Degradation of AXIN R-DME-4641257 FBgn0029812 Reactome Degradation of DVL R-DME-4641258 FBgn0029812 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0029812 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0029812 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0029812 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0029812 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0029812 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029812 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0029812 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0029812 Reactome UCH proteinases R-DME-5689603 FBgn0029812 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029812 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029812 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0029812 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029812 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0029812 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0029812 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0029812 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0029812 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029812 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029812 Reactome Neddylation R-DME-8951664 FBgn0029812 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0029812 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029816 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0029816 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0029816 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0029816 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029816 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0029816 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029816 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029816 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0029816 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0029816 Reactome Downstream TCR signaling R-DME-202424 FBgn0029816 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0029816 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0029816 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0029816 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029816 Reactome Degradation of AXIN R-DME-4641257 FBgn0029816 Reactome Degradation of DVL R-DME-4641258 FBgn0029816 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0029816 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0029816 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0029816 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0029816 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0029816 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029816 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0029816 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0029816 Reactome UCH proteinases R-DME-5689603 FBgn0029816 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029816 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0029816 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029816 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0029816 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0029816 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0029816 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0029816 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029816 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029816 Reactome Neddylation R-DME-8951664 FBgn0029816 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0029816 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0014340 Reactome HATs acetylate histones R-DME-3214847 FBgn0029819 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029820 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0029821 Reactome Wax biosynthesis R-DME-8848584 FBgn0029823 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0029823 Reactome Carnitine synthesis R-DME-71262 FBgn0029831 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0029831 Reactome Synthesis of PA R-DME-1483166 FBgn0029831 Reactome Digestion of dietary lipid R-DME-192456 FBgn0029831 Reactome Assembly of active LPL and LIPC lipase complexes R-DME-8963889 FBgn0029831 Reactome HDL remodeling R-DME-8964058 FBgn0029840 Reactome Macroautophagy R-DME-1632852 FBgn0029840 Reactome mTOR signalling R-DME-165159 FBgn0029840 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0029840 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0029840 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0029840 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0029840 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0026060 Reactome Synthesis of IPs in the ER lumen R-DME-1855231 FBgn0040069 Reactome Biotin transport and metabolism R-DME-196780 FBgn0040069 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0040069 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029848 Reactome Biotin transport and metabolism R-DME-196780 FBgn0029848 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0029848 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029849 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0003514 Reactome Myosin phosphatase dephosphoylates SQH R-DME-350384 FBgn0003514 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0003514 Reactome Ephrin signaling R-DME-3928664 FBgn0003514 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0003514 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0262730 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0262730 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0015818 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015818 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0029853 Reactome Josephin domain DUBs R-DME-5689877 FBgn0029854 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0029854 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0029856 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0029856 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0029856 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0029856 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0029856 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0029856 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0029856 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0029856 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0029856 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0029856 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0029856 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029856 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0029856 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029856 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029856 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0029856 Reactome EGFR downregulation R-DME-182971 FBgn0029856 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0029856 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0029856 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0029856 Reactome Downstream TCR signaling R-DME-202424 FBgn0029856 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0029856 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0029856 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0029856 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0029856 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0029856 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0029856 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0029856 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0029856 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0029856 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0029856 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0029856 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0029856 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029856 Reactome Degradation of AXIN R-DME-4641257 FBgn0029856 Reactome Degradation of DVL R-DME-4641258 FBgn0029856 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0029856 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0029856 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0029856 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0029856 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0029856 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0029856 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0029856 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029856 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0029856 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0029856 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0029856 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0029856 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0029856 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0029856 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0029856 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0029856 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0029856 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0029856 Reactome UCH proteinases R-DME-5689603 FBgn0029856 Reactome Josephin domain DUBs R-DME-5689877 FBgn0029856 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029856 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0029856 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0029856 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0029856 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0029856 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0029856 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0029856 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0029856 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0029856 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0029856 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029856 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0029856 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0029856 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0029856 Reactome PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-DME-8849469 FBgn0029856 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0029856 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0029856 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0029856 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0029856 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0029856 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029856 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0029856 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029856 Reactome Neddylation R-DME-8951664 FBgn0029856 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0029856 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0029856 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0029856 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0029856 Reactome Peroxisomal protein import R-DME-9033241 FBgn0029856 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0029856 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0029856 Reactome Iron uptake and transport R-DME-917937 FBgn0029856 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0029856 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0029856 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0029856 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0029856 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0029856 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028685 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028685 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028685 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028685 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028685 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028685 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028685 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028685 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028685 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028685 Reactome Downstream TCR signaling R-DME-202424 FBgn0028685 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028685 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028685 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028685 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028685 Reactome Degradation of AXIN R-DME-4641257 FBgn0028685 Reactome Degradation of DVL R-DME-4641258 FBgn0028685 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028685 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028685 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028685 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028685 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028685 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028685 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028685 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028685 Reactome UCH proteinases R-DME-5689603 FBgn0028685 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028685 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028685 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028685 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028685 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028685 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028685 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028685 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028685 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028685 Reactome Neddylation R-DME-8951664 FBgn0028685 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028685 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029863 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0029863 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0029863 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0029868 Reactome Respiratory electron transport R-DME-611105 FBgn0029868 Reactome Complex I biogenesis R-DME-6799198 FBgn0261955 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0029870 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0029870 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0014031 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0014031 Reactome Peroxisomal protein import R-DME-9033241 FBgn0014026 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0014026 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0014026 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0014026 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0014026 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0014026 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000524 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0000524 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029879 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0029879 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0029879 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029879 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029879 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029879 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0029879 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0029879 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0029879 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0029879 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0029879 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0029879 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029879 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028360 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0028360 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0062413 Reactome Metal ion SLC transporters R-DME-425410 FBgn0025815 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0025815 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0025815 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0025815 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0025815 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0029888 Reactome Mitochondrial protein import R-DME-1268020 FBgn0029888 Reactome Respiratory electron transport R-DME-611105 FBgn0029888 Reactome Complex I biogenesis R-DME-6799198 FBgn0286222 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0029890 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0029891 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0029897 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0029897 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0029897 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0029897 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0029897 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0029897 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0259228 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0259228 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0086693 Reactome TRP channels R-DME-3295583 FBgn0029906 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0263968 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0029911 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029912 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0029924 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0029924 Reactome Beta-oxidation of very long chain fatty acids R-DME-390247 FBgn0029924 Reactome Peroxisomal protein import R-DME-9033241 FBgn0029932 Reactome Cellular hexose transport R-DME-189200 FBgn0029932 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0029932 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0029943 Reactome Macroautophagy R-DME-1632852 FBgn0029944 Reactome Tie2 Signaling R-DME-210993 FBgn0029944 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029945 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0029950 Reactome Cellular hexose transport R-DME-189200 FBgn0029950 Reactome Inositol transporters R-DME-429593 FBgn0029950 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0027553 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0027553 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0027553 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0027553 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0027553 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0029958 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0029959 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0029959 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0029959 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0029969 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0029969 Reactome Utilization of Ketone Bodies R-DME-77108 FBgn0029969 Reactome Synthesis of Ketone Bodies R-DME-77111 FBgn0029970 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0040087 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0261592 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261592 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0261592 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261592 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261592 Reactome Translation initiation complex formation R-DME-72649 FBgn0261592 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261592 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0261592 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0261592 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261592 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261592 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0010292 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0029975 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0260858 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260858 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0260858 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0029979 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0029979 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0029979 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0029980 Reactome Synthesis of Dolichyl-phosphate R-DME-446199 FBgn0003656 Reactome Glycerophospholipid catabolism R-DME-6814848 FBgn0010329 Reactome Catecholamine biosynthesis R-DME-209905 FBgn0029992 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0029996 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0029996 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029997 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0029997 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0029999 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0030000 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0025800 Reactome Signaling by NODAL R-DME-1181150 FBgn0025800 Reactome Signaling by Activin R-DME-1502540 FBgn0025800 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0025800 Reactome TGF-beta receptor signaling activates SMADs R-DME-2173789 FBgn0025800 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0025800 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0025800 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0030011 Reactome G alpha (s) signalling events R-DME-418555 FBgn0030011 Reactome G alpha (i) signalling events R-DME-418594 FBgn0030011 Reactome G alpha (z) signalling events R-DME-418597 FBgn0030011 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0265464 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0265464 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0265464 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0265464 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0265464 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0265464 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0265464 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0265464 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0265464 Reactome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-DME-975138 FBgn0265464 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0265464 Reactome MyD88 dependent cascade initiated on endosome R-DME-975155 FBgn0265464 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0020653 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0017566 Reactome Respiratory electron transport R-DME-611105 FBgn0017566 Reactome Complex I biogenesis R-DME-6799198 FBgn0015519 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0015519 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0015519 Reactome Highly calcium permeable nicotinic acetylcholine receptors R-DME-629597 FBgn0015519 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030037 Reactome Synthesis of PA R-DME-1483166 FBgn0030038 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0014032 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0014032 Reactome eNOS activation R-DME-203615 FBgn0052000 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0030041 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0030041 Reactome eNOS activation R-DME-203615 FBgn0011642 Reactome Miscellaneous transport and binding events R-DME-5223345 FBgn0028667 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028667 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028667 Reactome Insulin receptor recycling R-DME-77387 FBgn0028667 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028667 Reactome Ion channel transport R-DME-983712 FBgn0052099 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0052110 Reactome SUMO is proteolytically processed R-DME-3065679 FBgn0052110 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0263232 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0263607 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003023 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0052191 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0052191 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0052191 Reactome CS/DS degradation R-DME-2024101 FBgn0052191 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052196 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0264975 Reactome Basigin interactions R-DME-210991 FBgn0264975 Reactome L1CAM interactions R-DME-373760 FBgn0264975 Reactome Recycling pathway of L1 R-DME-437239 FBgn0264975 Reactome Signal transduction by L1 R-DME-445144 FBgn0264975 Reactome Neurofascin interactions R-DME-447043 FBgn0264975 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052220 Reactome Sialic acid metabolism R-DME-4085001 FBgn0026679 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0052246 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0052246 Reactome snRNP Assembly R-DME-191859 FBgn0052246 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0052246 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0052246 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0052246 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0052246 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0035240 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0035240 Reactome Lysine catabolism R-DME-71064 FBgn0035240 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0025864 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0052373 Reactome Platelet degranulation R-DME-114608 FBgn0052373 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0052373 Reactome Gamma-carboxylation of protein precursors R-DME-159740 FBgn0052373 Reactome Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-DME-159763 FBgn0052373 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0052373 Reactome Release of Hh-Np from the secreting cell R-DME-5362798 FBgn0052373 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052373 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0052413 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052442 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0030057 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0052495 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0027864 Reactome Cleavage of the damaged pyrimidine R-DME-110329 FBgn0027864 Reactome Cleavage of the damaged purine R-DME-110331 FBgn0027864 Reactome Displacement of DNA glycosylase by APEX1 R-DME-110357 FBgn0083956 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0083956 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0041629 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0041629 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0041629 Reactome CS/DS degradation R-DME-2024101 FBgn0041629 Reactome Hyaluronan uptake and degradation R-DME-2160916 FBgn0041629 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052581 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0052581 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0030063 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0011661 Reactome Netrin-1 signaling R-DME-373752 FBgn0011661 Reactome Recycling pathway of L1 R-DME-437239 FBgn0030066 Reactome Heme biosynthesis R-DME-189451 FBgn0052751 Reactome Biotin transport and metabolism R-DME-196780 FBgn0052751 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0052751 Reactome Neutrophil degranulation R-DME-6798695 FBgn0260484 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0052808 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0052808 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052808 Reactome Antimicrobial peptides R-DME-6803157 FBgn0052823 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0052823 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0052823 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0052847 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0052847 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0261549 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0030081 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0030082 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0052707 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0052707 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0052707 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0052707 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0052707 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0052707 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0052707 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0052707 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0052707 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0052707 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0052707 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0052707 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0052707 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030086 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0030086 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030086 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0030087 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0004856 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0004856 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004856 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0030088 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0030089 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0030089 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0030093 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0004828 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0004828 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0004828 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0004828 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0004828 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0004828 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0004828 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0004828 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0004828 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0014868 Reactome Neutrophil degranulation R-DME-6798695 FBgn0046332 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0046332 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0046332 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0046332 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0046332 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0003482 Reactome Homologous DNA Pairing and Strand Exchange R-DME-5693579 FBgn0086450 Reactome Pyrimidine catabolism R-DME-73621 FBgn0051091 Reactome Digestion of dietary lipid R-DME-192456 FBgn0051091 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0051115 Reactome Methionine salvage pathway R-DME-1237112 FBgn0051141 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0051141 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0051141 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0051201 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0051201 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0051202 Reactome Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-DME-964827 FBgn0051229 Reactome Mitochondrial protein import R-DME-1268020 FBgn0051262 Reactome Cellular hexose transport R-DME-189200 FBgn0051262 Reactome Inositol transporters R-DME-429593 FBgn0051262 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0010269 Reactome MAPK3 (ERK1) activation R-DME-110056 FBgn0010269 Reactome MAPK1 (ERK2) activation R-DME-112411 FBgn0010269 Reactome Phosphorylation of CI R-DME-209190 FBgn0010269 Reactome Phosphorylation of SMO R-DME-209214 FBgn0010269 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0010269 Reactome Signal transduction by L1 R-DME-445144 FBgn0010269 Reactome RAF activation R-DME-5673000 FBgn0010269 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0010269 Reactome Negative feedback regulation of MAPK pathway R-DME-5674499 FBgn0051413 Reactome Platelet degranulation R-DME-114608 FBgn0051413 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0051413 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051413 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0051414 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0030114 Reactome Neddylation R-DME-8951664 FBgn0030114 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0051473 Reactome Vitamins B6 activation to pyridoxal phosphate R-DME-964975 FBgn0030122 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0030122 Reactome snRNP Assembly R-DME-191859 FBgn0030122 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0030122 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0030122 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0030122 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0030122 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053196 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0053196 Reactome Elastic fibre formation R-DME-1566948 FBgn0053196 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0053196 Reactome Integrin cell surface interactions R-DME-216083 FBgn0053196 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0053196 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0053002 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0053002 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0002576 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0002576 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0002576 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0002576 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0002576 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0002576 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0002576 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0002576 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0002576 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0002576 Reactome RUNX2 regulates osteoblast differentiation R-DME-8940973 FBgn0002576 Reactome RUNX2 regulates bone development R-DME-8941326 FBgn0002576 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0002576 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0002576 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0002576 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0002576 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0002576 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0261822 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0261822 Reactome Basigin interactions R-DME-210991 FBgn0261822 Reactome Integrin cell surface interactions R-DME-216083 FBgn0051613 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0051613 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0051613 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0051613 Reactome HATs acetylate histones R-DME-3214847 FBgn0051613 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0051613 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0051613 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0051613 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0051613 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0051613 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0051613 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0051613 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0051618 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0051618 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0051618 Reactome HATs acetylate histones R-DME-3214847 FBgn0051618 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0051618 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0051618 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0051618 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0051618 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0051618 Reactome UCH proteinases R-DME-5689603 FBgn0051618 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0051618 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0051618 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0051618 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0051618 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0051636 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0051636 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0051636 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0051687 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0051687 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0051687 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0051687 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0051687 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0051687 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0051687 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0051687 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0051687 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0051687 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0051687 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0051687 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0051687 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0053105 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0053105 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0053124 Reactome Cellular hexose transport R-DME-189200 FBgn0053124 Reactome Inositol transporters R-DME-429593 FBgn0053124 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0051702 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0051702 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0051702 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0051703 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0051703 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0051703 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0051713 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0051717 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0053178 Reactome Glutathione conjugation R-DME-156590 FBgn0053178 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0053178 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0053178 Reactome Neutrophil degranulation R-DME-6798695 FBgn0053181 Reactome Metal ion SLC transporters R-DME-425410 FBgn0053182 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053182 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0051742 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0051742 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0051742 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0051742 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0051742 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0051742 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0051742 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0051742 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0051742 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0051742 Reactome Downstream TCR signaling R-DME-202424 FBgn0051742 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0051742 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0051742 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0051742 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0051742 Reactome Degradation of AXIN R-DME-4641257 FBgn0051742 Reactome Degradation of DVL R-DME-4641258 FBgn0051742 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0051742 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0051742 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0051742 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0051742 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0051742 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0051742 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0051742 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0051742 Reactome UCH proteinases R-DME-5689603 FBgn0051742 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0051742 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0051742 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0051742 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0051742 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0051742 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0051742 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0051742 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0051742 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0051742 Reactome Neddylation R-DME-8951664 FBgn0051742 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0051742 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0051787 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0051802 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0051802 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0051802 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0030136 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0030136 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0030136 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0030136 Reactome Translation initiation complex formation R-DME-72649 FBgn0030136 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0030136 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0030136 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0030136 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0030136 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0030136 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0051832 Reactome Platelet degranulation R-DME-114608 FBgn0051832 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0051832 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0051832 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0051832 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0051832 Reactome Integrin cell surface interactions R-DME-216083 FBgn0051832 Reactome Syndecan interactions R-DME-3000170 FBgn0051832 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0051832 Reactome ECM proteoglycans R-DME-3000178 FBgn0051832 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0051832 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0051832 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0051832 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0051832 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0051832 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051832 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0051835 Reactome Neutrophil degranulation R-DME-6798695 FBgn0260407 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0260407 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0051849 Reactome Reactions specific to the hybrid N-glycan synthesis pathway R-DME-975574 FBgn0051855 Reactome Neddylation R-DME-8951664 FBgn0052699 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0052699 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0052699 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0052699 Reactome Acyl chain remodelling of PG R-DME-1482925 FBgn0052699 Reactome Synthesis of PA R-DME-1483166 FBgn0052699 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051864 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0051864 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0051874 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0051915 Reactome Collagen biosynthesis and modifying enzymes R-DME-1650814 FBgn0051922 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0264691 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0264691 Reactome Macroautophagy R-DME-1632852 FBgn0264691 Reactome mTOR signalling R-DME-165159 FBgn0264691 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0264691 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0264691 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0264691 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0264691 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0264691 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0264691 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0051924 Reactome Pyrimidine salvage R-DME-73614 FBgn0260648 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0260648 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0260648 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261931 Reactome Degradation of DVL R-DME-4641258 FBgn0261931 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030151 Reactome Platelet degranulation R-DME-114608 FBgn0030163 Reactome Platelet degranulation R-DME-114608 FBgn0030163 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0030163 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0030163 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0030163 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0030163 Reactome Integrin cell surface interactions R-DME-216083 FBgn0030163 Reactome Syndecan interactions R-DME-3000170 FBgn0030163 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0030163 Reactome ECM proteoglycans R-DME-3000178 FBgn0030163 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0030163 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0030163 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0030163 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0030163 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0030163 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030163 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0030164 Reactome Platelet degranulation R-DME-114608 FBgn0030164 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0030164 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0030164 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0030164 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0030164 Reactome Integrin cell surface interactions R-DME-216083 FBgn0030164 Reactome Syndecan interactions R-DME-3000170 FBgn0030164 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0030164 Reactome ECM proteoglycans R-DME-3000178 FBgn0030164 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0030164 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0030164 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0030164 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0030164 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0030164 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030164 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0030170 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0030177 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0030178 Reactome Nicotinamide salvaging R-DME-197264 FBgn0083940 Reactome Rho GTPase cycle R-DME-194840 FBgn0028342 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0028342 Reactome Cristae formation R-DME-8949613 FBgn0263220 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0263220 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259170 Reactome Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-DME-964827 FBgn0030196 Reactome Unwinding of DNA R-DME-176974 FBgn0052683 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0052683 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0052683 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0052683 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0052683 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0052683 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0052683 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0052683 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0052683 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0030207 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0030207 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0030207 Reactome Attenuation phase R-DME-3371568 FBgn0030207 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0085443 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0030218 Reactome Urea cycle R-DME-70635 FBgn0030222 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030223 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052677 Reactome Dopamine Neurotransmitter Release Cycle R-DME-212676 FBgn0052672 Reactome Macroautophagy R-DME-1632852 FBgn0052672 Reactome TBC/RABGAPs R-DME-8854214 FBgn0003360 Reactome Mitochondrial protein import R-DME-1268020 FBgn0003360 Reactome Regulation of insulin secretion R-DME-422356 FBgn0025111 Reactome Mitochondrial protein import R-DME-1268020 FBgn0025111 Reactome Regulation of insulin secretion R-DME-422356 FBgn0030239 Reactome Pentose phosphate pathway R-DME-71336 FBgn0030241 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0030242 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0003965 Reactome Tryptophan catabolism R-DME-71240 FBgn0259241 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0259101 Reactome Nicotinate metabolism R-DME-196807 FBgn0259101 Reactome Pyrimidine catabolism R-DME-73621 FBgn0259101 Reactome Purine catabolism R-DME-74259 FBgn0028686 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028686 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028686 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028686 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028686 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028686 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028686 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028686 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028686 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028686 Reactome Downstream TCR signaling R-DME-202424 FBgn0028686 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028686 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028686 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028686 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028686 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028686 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028686 Reactome Degradation of TIM R-DME-432395 FBgn0028686 Reactome Degradation of PER R-DME-432524 FBgn0028686 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028686 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028686 Reactome Degradation of AXIN R-DME-4641257 FBgn0028686 Reactome Degradation of DVL R-DME-4641258 FBgn0028686 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028686 Reactome Degradation of CLK R-DME-538848 FBgn0028686 Reactome Degradation of CRY R-DME-538864 FBgn0028686 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028686 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028686 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028686 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028686 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028686 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028686 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028686 Reactome UCH proteinases R-DME-5689603 FBgn0028686 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028686 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028686 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028686 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028686 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028686 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028686 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028686 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028686 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028686 Reactome Neddylation R-DME-8951664 FBgn0028686 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028686 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030268 Reactome Kinesins R-DME-983189 FBgn0030276 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0030276 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030276 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0030276 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0265595 Reactome Phase 1 - inactivation of fast Na+ channels R-DME-5576894 FBgn0001491 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0030286 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0030286 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0030289 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0000499 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0000499 Reactome Signaling by Hippo R-DME-2028269 FBgn0000499 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0000499 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0000499 Reactome Negative feedback loop regulates asymmetric localisation R-DME-350369 FBgn0000499 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0000499 Reactome Formation and asymmetric localisation of transmembrane complexes R-DME-350411 FBgn0000499 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0000499 Reactome PCP/CE pathway R-DME-4086400 FBgn0000499 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0000499 Reactome Degradation of DVL R-DME-4641258 FBgn0000499 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0000499 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0000499 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0004864 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0004864 Reactome Formation of the activated receptor complex R-DME-209209 FBgn0004864 Reactome Formation of the activated STAT92E dimer and transport to the nucleus R-DME-209228 FBgn0004864 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0004864 Reactome RAF activation R-DME-5673000 FBgn0004864 Reactome Interleukin-2 signaling R-DME-9020558 FBgn0004864 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0004864 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0004864 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0001145 Reactome Astrocytic Glutamate-Glutamine Uptake And Metabolism R-DME-210455 FBgn0001145 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0030300 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0030300 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0030300 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0262685 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0262685 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0030305 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030310 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030310 Reactome Antimicrobial peptides R-DME-6803157 FBgn0030321 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0030323 Reactome Neddylation R-DME-8951664 FBgn0011754 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0030327 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0030329 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0030329 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030330 Reactome Platelet degranulation R-DME-114608 FBgn0000259 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0000259 Reactome Phosphorylation of CI R-DME-209190 FBgn0000259 Reactome Phosphorylation of SMO R-DME-209214 FBgn0000259 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0000259 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0000259 Reactome Signal transduction by L1 R-DME-445144 FBgn0000259 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000259 Reactome Regulation of TP53 Activity through Phosphorylation R-DME-6804756 FBgn0000259 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0000259 Reactome Receptor Mediated Mitophagy R-DME-8934903 FBgn0000259 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0030336 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0030341 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0030341 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0030343 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0030345 Reactome Aryl hydrocarbon receptor signalling R-DME-8937144 FBgn0030349 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0030349 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030352 Reactome Complex I biogenesis R-DME-6799198 FBgn0030354 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0030354 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000808 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0001083 Reactome Platelet degranulation R-DME-114608 FBgn0001083 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0001083 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030365 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0030366 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0030366 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0030366 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0030366 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0030366 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0030366 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0030370 Reactome UCH proteinases R-DME-5689603 FBgn0030377 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0259680 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0259680 Reactome Calmodulin induced events R-DME-111933 FBgn0259680 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0259680 Reactome SHC1 events in ERBB2 signaling R-DME-1250196 FBgn0259680 Reactome DAG and IP3 signaling R-DME-1489509 FBgn0259680 Reactome Downstream TCR signaling R-DME-202424 FBgn0259680 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0259680 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0259680 Reactome Netrin-1 signaling R-DME-373752 FBgn0259680 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0259680 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0259680 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0259680 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030391 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0030395 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0264542 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0283712 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0283712 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0030403 Reactome Mitochondrial ABC transporters R-DME-1369007 FBgn0052654 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0030407 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0030411 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0015024 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0015024 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0015024 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0015024 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0015024 Reactome Phosphorylation of CI R-DME-209190 FBgn0015024 Reactome Phosphorylation of SMO R-DME-209214 FBgn0015024 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0015024 Reactome Phosphorylation of ARM R-DME-209396 FBgn0015024 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0015024 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0015024 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0015024 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0015024 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0015024 Reactome Activation of SMO R-DME-5635838 FBgn0011837 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0265523 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0265523 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0020513 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0030421 Reactome Synthesis of PA R-DME-1483166 FBgn0030421 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0030421 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259171 Reactome cGMP effects R-DME-418457 FBgn0030433 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030433 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0086675 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0086675 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0010303 Reactome Formation of the cytosolic BSK 'scaffolding complex' R-DME-209397 FBgn0010303 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0010303 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0010303 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0010303 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0010303 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0261524 Reactome NOD1/2 Signaling Pathway R-DME-168638 FBgn0261524 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0261524 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0261524 Reactome PI5P Regulates TP53 Acetylation R-DME-6811555 FBgn0263005 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0030449 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030449 Reactome Iron uptake and transport R-DME-917937 FBgn0025463 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0030457 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0030457 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0030457 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0030457 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0030457 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0030457 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0030457 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0030457 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0030457 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0030457 Reactome Downstream TCR signaling R-DME-202424 FBgn0030457 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0030457 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0030457 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0030457 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0030457 Reactome Degradation of AXIN R-DME-4641257 FBgn0030457 Reactome Degradation of DVL R-DME-4641258 FBgn0030457 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0030457 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0030457 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0030457 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0030457 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0030457 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0030457 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0030457 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0030457 Reactome UCH proteinases R-DME-5689603 FBgn0030457 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0030457 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0030457 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0030457 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0030457 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0030457 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0030457 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0030457 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0030457 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0030457 Reactome Neddylation R-DME-8951664 FBgn0030457 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0030457 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029133 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0029133 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0029133 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0029133 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029133 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0029133 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029133 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029133 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0029133 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0029133 Reactome Downstream TCR signaling R-DME-202424 FBgn0029133 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0029133 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0029133 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0029133 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029133 Reactome Degradation of AXIN R-DME-4641257 FBgn0029133 Reactome Degradation of DVL R-DME-4641258 FBgn0029133 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0029133 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0029133 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0029133 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0029133 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0029133 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029133 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0029133 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0029133 Reactome UCH proteinases R-DME-5689603 FBgn0029133 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029133 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0029133 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029133 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0029133 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0029133 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0029133 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0029133 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029133 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029133 Reactome Neddylation R-DME-8951664 FBgn0029133 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0029133 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0004456 Reactome Basigin interactions R-DME-210991 FBgn0004456 Reactome Integrin cell surface interactions R-DME-216083 FBgn0004456 Reactome Syndecan interactions R-DME-3000170 FBgn0004456 Reactome ECM proteoglycans R-DME-3000178 FBgn0041210 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0041210 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0041210 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0030465 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0030467 Reactome eNOS activation R-DME-203615 FBgn0283680 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0030478 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0030480 Reactome Mitochondrial protein import R-DME-1268020 FBgn0026749 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030482 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0030484 Reactome Glutathione conjugation R-DME-156590 FBgn0030505 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0030505 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0030505 Reactome Ca2+ pathway R-DME-4086398 FBgn0030505 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763 FBgn0030512 Reactome Nicotinate metabolism R-DME-196807 FBgn0030514 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0020909 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0003218 Reactome Synthesis of PI R-DME-1483226 FBgn0030521 Reactome Collagen degradation R-DME-1442490 FBgn0030521 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0030521 Reactome Assembly of collagen fibrils and other multimeric structures R-DME-2022090 FBgn0030521 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0030521 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261244 Reactome Arachidonate production from DAG R-DME-426048 FBgn0027537 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0027537 Reactome snRNP Assembly R-DME-191859 FBgn0027537 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0027537 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0027537 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0027537 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0027537 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0030530 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0052626 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052626 Reactome Purine salvage R-DME-74217 FBgn0000173 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0000173 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0000173 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0000173 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0000173 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0000173 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0000173 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0000173 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0026713 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0026713 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0026713 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0026713 Reactome mRNA 3'-end processing R-DME-72187 FBgn0030552 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030552 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0030555 Reactome Neddylation R-DME-8951664 FBgn0030555 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030556 Reactome mRNA Capping R-DME-72086 FBgn0030556 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0030558 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0030572 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030572 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0030574 Reactome Basigin interactions R-DME-210991 FBgn0030574 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0015773 Reactome Netrin-1 signaling R-DME-373752 FBgn0015773 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0030575 Reactome Carnitine synthesis R-DME-71262 FBgn0015774 Reactome Netrin-1 signaling R-DME-373752 FBgn0015774 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0030577 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0030577 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0030577 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030578 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0030578 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0030578 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003301 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0003301 Reactome PKA activation R-DME-163615 FBgn0003301 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0003301 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0003301 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0003301 Reactome G alpha (s) signalling events R-DME-418555 FBgn0003301 Reactome G alpha (z) signalling events R-DME-418597 FBgn0003301 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0003301 Reactome CREB phosphorylation through the activation of Adenylate Cyclase R-DME-442720 FBgn0003301 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0030582 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0030584 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0264078 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0000535 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0030605 Reactome Respiratory electron transport R-DME-611105 FBgn0030605 Reactome Complex I biogenesis R-DME-6799198 FBgn0264389 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0030607 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0030607 Reactome Triglyceride catabolism R-DME-163560 FBgn0030607 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0030607 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0053177 Reactome Glutathione conjugation R-DME-156590 FBgn0053177 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0053177 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0053177 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030612 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0030612 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0030613 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0030616 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0030616 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0030616 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0030616 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0030616 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0030616 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0030617 Reactome Platelet degranulation R-DME-114608 FBgn0030617 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0030617 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030631 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0040285 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014455 Reactome Methylation R-DME-156581 FBgn0014455 Reactome Sulfur amino acid metabolism R-DME-1614635 FBgn0030638 Reactome Transport of bile salts and organic acids, metal ions and amine compounds R-DME-425366 FBgn0004391 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0004391 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0004391 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0004391 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0004391 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0004391 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0004391 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0004391 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0004391 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0004391 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0004391 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0004391 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0004391 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030641 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0030645 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0267977 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0027287 Reactome Intraflagellar transport R-DME-5620924 FBgn0027287 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0022710 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0022710 Reactome PKA activation R-DME-163615 FBgn0022710 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0022710 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0022710 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0022710 Reactome G alpha (s) signalling events R-DME-418555 FBgn0022710 Reactome G alpha (z) signalling events R-DME-418597 FBgn0022710 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0022710 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0030653 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0030661 Reactome Synthesis of PA R-DME-1483166 FBgn0030661 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0030661 Reactome Digestion R-DME-8935690 FBgn0030662 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0003463 Reactome Signaling by BMP R-DME-201451 FBgn0003463 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0003463 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0030663 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0030663 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0030663 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0030663 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0030663 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0030663 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0030663 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0030670 Reactome Synthesis of PI R-DME-1483226 FBgn0030674 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030674 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0026666 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0027329 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0027329 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0030683 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0030683 Reactome Synthesis of Dolichyl-phosphate R-DME-446199 FBgn0030685 Reactome Rho GTPase cycle R-DME-194840 FBgn0030686 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030686 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0025809 Reactome Neutrophil degranulation R-DME-6798695 FBgn0025809 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0030692 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030692 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0026374 Reactome RHO GTPases Activate Rhotekin and Rhophilins R-DME-5666185 FBgn0030693 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0030693 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0030695 Reactome Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE R-DME-209171 FBgn0030695 Reactome Peptidoglycan bound PGRP-LC/LE oligomerises R-DME-209266 FBgn0030695 Reactome Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214397 FBgn0030695 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0030695 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0030695 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0030695 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030695 Reactome Antimicrobial peptides R-DME-6803157 FBgn0003345 Reactome YAP1- and WWTR1 (TAZ)-stimulated gene expression R-DME-2032785 FBgn0003345 Reactome Transcriptional activation by YKI R-DME-390193 FBgn0003345 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0000319 Reactome Gap junction degradation R-DME-190873 FBgn0000319 Reactome Formation of annular gap junctions R-DME-196025 FBgn0000319 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0000319 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0000319 Reactome Recycling pathway of L1 R-DME-437239 FBgn0000319 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0000319 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0000319 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0000319 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0000319 Reactome LDL clearance R-DME-8964038 FBgn0001105 Reactome Activation of G protein gated Potassium channels R-DME-1296041 FBgn0001105 Reactome G alpha (s) signalling events R-DME-418555 FBgn0001105 Reactome G alpha (i) signalling events R-DME-418594 FBgn0001105 Reactome G alpha (z) signalling events R-DME-418597 FBgn0001105 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0001105 Reactome Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-DME-997272 FBgn0030703 Reactome Neutrophil degranulation R-DME-6798695 FBgn0010315 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0010315 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0010315 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0010315 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0010315 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0010315 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0030707 Reactome GABA A receptor activation R-DME-977441 FBgn0010240 Reactome GABA A receptor activation R-DME-977441 FBgn0045073 Reactome Ion homeostasis R-DME-5578775 FBgn0045073 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0030718 Reactome Respiratory electron transport R-DME-611105 FBgn0030718 Reactome Complex I biogenesis R-DME-6799198 FBgn0030719 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0030719 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003969 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0003969 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0003969 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0003969 Reactome PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-8849471 FBgn0028397 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0004066 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0004066 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0004066 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0004066 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0004066 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0004066 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0004066 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0004066 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0004066 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0004066 Reactome Downstream TCR signaling R-DME-202424 FBgn0004066 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0004066 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0004066 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0004066 Reactome Nuclear CI is degraded R-DME-216167 FBgn0004066 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0004066 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0004066 Reactome Degradation of TIM R-DME-432395 FBgn0004066 Reactome Degradation of PER R-DME-432524 FBgn0004066 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0004066 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0004066 Reactome Degradation of AXIN R-DME-4641257 FBgn0004066 Reactome Degradation of DVL R-DME-4641258 FBgn0004066 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0004066 Reactome Degradation of CLK R-DME-538848 FBgn0004066 Reactome Degradation of CRY R-DME-538864 FBgn0004066 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0004066 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0004066 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0004066 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0004066 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0004066 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0004066 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0004066 Reactome UCH proteinases R-DME-5689603 FBgn0004066 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0004066 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0004066 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0004066 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0004066 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0004066 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0004066 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0004066 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0004066 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0004066 Reactome Neddylation R-DME-8951664 FBgn0004066 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0004066 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0000536 Reactome Synthesis of PE R-DME-1483213 FBgn0030733 Reactome Respiratory electron transport R-DME-611105 FBgn0285954 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0285954 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0285954 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0285954 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0285954 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0285954 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0030734 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030735 Reactome Macroautophagy R-DME-1632852 FBgn0030735 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0030735 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0030735 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0030735 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0286508 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0030738 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0030738 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0030738 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0260450 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0003416 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0003416 Reactome Generation of second messenger molecules R-DME-202433 FBgn0003416 Reactome DAP12 signaling R-DME-2424491 FBgn0003416 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0003416 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0003416 Reactome Phospholipase C-mediated cascade: FGFR1 R-DME-5654219 FBgn0003416 Reactome Phospholipase C-mediated cascade; FGFR2 R-DME-5654221 FBgn0003416 Reactome Phospholipase C-mediated cascade; FGFR3 R-DME-5654227 FBgn0003416 Reactome Phospholipase C-mediated cascade; FGFR4 R-DME-5654228 FBgn0005411 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0005411 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0005411 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0005411 Reactome mRNA 3'-end processing R-DME-72187 FBgn0030746 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030746 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0030747 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030747 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0042175 Reactome Hydrolysis of LPC R-DME-1483115 FBgn0042175 Reactome HDL remodeling R-DME-8964058 FBgn0030748 Reactome Regulation of TNFR1 signaling R-DME-5357905 FBgn0030748 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0030748 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0039705 Reactome Macroautophagy R-DME-1632852 FBgn0266579 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0259178 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0030749 Reactome Platelet degranulation R-DME-114608 FBgn0030749 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051431 Reactome FGFRL1 modulation of FGFR1 signaling R-DME-5658623 FBgn0051445 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051450 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0051450 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0051523 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0051523 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0051523 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0051642 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030752 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031681 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0031681 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0031390 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0031390 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0031390 Reactome mRNA 3'-end processing R-DME-72187 FBgn0032618 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0032618 Reactome Dermatan sulfate biosynthesis R-DME-2022923 FBgn0032618 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0051773 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0002939 Reactome Platelet degranulation R-DME-114608 FBgn0002939 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0002939 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002939 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0002939 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051793 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0051793 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0051793 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0051793 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051860 Reactome Insulin processing R-DME-264876 FBgn0051860 Reactome Zinc efflux and compartmentalization by the SLC30 family R-DME-435368 FBgn0260750 Reactome Glycerophospholipid biosynthesis R-DME-1483206 FBgn0261609 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261609 Reactome PERK regulates gene expression R-DME-381042 FBgn0261609 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0261609 Reactome Translation initiation complex formation R-DME-72649 FBgn0261609 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0261609 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0261609 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261609 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0051926 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0051926 Reactome Surfactant metabolism R-DME-5683826 FBgn0051928 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0051928 Reactome Surfactant metabolism R-DME-5683826 FBgn0052068 Reactome Methionine salvage pathway R-DME-1237112 FBgn0052075 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0264077 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0052251 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0052251 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0030756 Reactome Transport of bile salts and organic acids, metal ions and amine compounds R-DME-425366 FBgn0052379 Reactome Regulation of Complement cascade R-DME-977606 FBgn0052484 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0052484 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0052484 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0052669 Reactome Nicotinamide salvaging R-DME-197264 FBgn0052669 Reactome Thyroxine biosynthesis R-DME-209968 FBgn0052669 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0052669 Reactome Organic anion transporters R-DME-428643 FBgn0011742 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0011742 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0011742 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011742 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0052702 Reactome Crosslinking of collagen fibrils R-DME-2243919 FBgn0086558 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0086558 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0086558 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0086558 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0086558 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0086558 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0086558 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0086558 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0086558 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0086558 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0086558 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0086558 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0086558 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0086558 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0086558 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0086558 Reactome EGFR downregulation R-DME-182971 FBgn0086558 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0086558 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0086558 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0086558 Reactome Downstream TCR signaling R-DME-202424 FBgn0086558 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0086558 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0086558 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0086558 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0086558 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0086558 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0086558 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0086558 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0086558 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0086558 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0086558 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0086558 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0086558 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0086558 Reactome Degradation of AXIN R-DME-4641257 FBgn0086558 Reactome Degradation of DVL R-DME-4641258 FBgn0086558 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0086558 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0086558 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0086558 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0086558 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0086558 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0086558 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0086558 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0086558 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0086558 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0086558 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0086558 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0086558 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0086558 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0086558 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0086558 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0086558 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0086558 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0086558 Reactome UCH proteinases R-DME-5689603 FBgn0086558 Reactome Josephin domain DUBs R-DME-5689877 FBgn0086558 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0086558 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0086558 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0086558 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0086558 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0086558 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0086558 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0086558 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0086558 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0086558 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0086558 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0086558 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0086558 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0086558 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0086558 Reactome PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-DME-8849469 FBgn0086558 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0086558 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0086558 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0086558 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0086558 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0086558 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0086558 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0086558 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0086558 Reactome Neddylation R-DME-8951664 FBgn0086558 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0086558 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0086558 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0086558 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0086558 Reactome Peroxisomal protein import R-DME-9033241 FBgn0086558 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0086558 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0086558 Reactome Iron uptake and transport R-DME-917937 FBgn0086558 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0086558 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0086558 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0086558 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0086558 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0086558 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0052750 Reactome Biotin transport and metabolism R-DME-196780 FBgn0052750 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0052750 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011826 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0011826 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0011826 Reactome Ca2+ pathway R-DME-4086398 FBgn0011826 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763 FBgn0053092 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0053092 Reactome Proline catabolism R-DME-70688 FBgn0053098 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0053100 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0053116 Reactome Synthesis of PE R-DME-1483213 FBgn0053128 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0053128 Reactome Surfactant metabolism R-DME-5683826 FBgn0053138 Reactome Glycogen synthesis R-DME-3322077 FBgn0015615 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0015615 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0015615 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0030761 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0030761 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0030761 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0061200 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0061200 Reactome snRNP Assembly R-DME-191859 FBgn0061200 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0061200 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0061200 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0061200 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0061200 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0010412 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010412 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010412 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0010412 Reactome Translation initiation complex formation R-DME-72649 FBgn0010412 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010412 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0010412 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0010412 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010412 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010412 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0261791 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261791 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0003189 Reactome Pyrimidine biosynthesis R-DME-500753 FBgn0000152 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0001250 Reactome Platelet degranulation R-DME-114608 FBgn0001250 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0001250 Reactome Elastic fibre formation R-DME-1566948 FBgn0001250 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0001250 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0001250 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0001250 Reactome Integrin cell surface interactions R-DME-216083 FBgn0001250 Reactome Syndecan interactions R-DME-3000170 FBgn0001250 Reactome ECM proteoglycans R-DME-3000178 FBgn0001250 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0001250 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0001250 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0001250 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0001250 Reactome Signal transduction by L1 R-DME-445144 FBgn0001250 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0001250 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030786 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0030786 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0030787 Reactome RNA Polymerase III Transcription Initiation From Type 1 Promoter R-DME-76061 FBgn0030789 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0030789 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0030789 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0024941 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0030799 Reactome Lysine catabolism R-DME-71064 FBgn0030809 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0030815 Reactome Regulation of Complement cascade R-DME-977606 FBgn0030816 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0030816 Reactome Proton-coupled neutral amino acid transporters R-DME-428559 FBgn0030816 Reactome Tryptophan catabolism R-DME-71240 FBgn0030817 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0030817 Reactome Proton-coupled neutral amino acid transporters R-DME-428559 FBgn0030817 Reactome Tryptophan catabolism R-DME-71240 FBgn0065032 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0065032 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0065032 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0002590 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0002590 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0002590 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0002590 Reactome Translation initiation complex formation R-DME-72649 FBgn0002590 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0002590 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0002590 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0002590 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0002590 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0002590 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000163 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0030839 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0263706 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0263706 Reactome Rho GTPase cycle R-DME-194840 FBgn0263706 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0028343 Reactome Initiation of Nuclear Envelope Reformation R-DME-2995383 FBgn0030853 Reactome Respiratory electron transport R-DME-611105 FBgn0030853 Reactome Complex I biogenesis R-DME-6799198 FBgn0026375 Reactome Rho GTPase cycle R-DME-194840 FBgn0026375 Reactome RHO1 GTPase cycle R-DME-350407 FBgn0026375 Reactome PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-8849471 FBgn0030858 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0250788 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0250788 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0250788 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0030863 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0030863 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0026192 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0026192 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0261570 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0000617 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0000617 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0000617 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0000617 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0000617 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0000617 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0000617 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0030871 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0030871 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0030871 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0030871 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0030871 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0030871 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0030871 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0030871 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0030871 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0030871 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0030871 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0030871 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0030871 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0030871 Reactome Polymerase switching R-DME-69091 FBgn0030872 Reactome The fatty acid cycling model R-DME-167826 FBgn0030872 Reactome The proton buffering model R-DME-167827 FBgn0030877 Reactome UCH proteinases R-DME-5689603 FBgn0030877 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0259168 Reactome G0 and Early G1 R-DME-1538133 FBgn0030880 Reactome Platelet degranulation R-DME-114608 FBgn0030880 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0030880 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0030880 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0030880 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0030880 Reactome Integrin cell surface interactions R-DME-216083 FBgn0030880 Reactome Syndecan interactions R-DME-3000170 FBgn0030880 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0030880 Reactome ECM proteoglycans R-DME-3000178 FBgn0030880 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0030880 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0030880 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0030880 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0030880 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0030880 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030880 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0030882 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0283469 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0030884 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0030884 Reactome Synthesis of PA R-DME-1483166 FBgn0030884 Reactome Digestion of dietary lipid R-DME-192456 FBgn0030884 Reactome Assembly of active LPL and LIPC lipase complexes R-DME-8963889 FBgn0030884 Reactome HDL remodeling R-DME-8964058 FBgn0003380 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0030891 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0021765 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0030894 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0022724 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0017418 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0030904 Reactome Formation of the activated receptor complex R-DME-209209 FBgn0030904 Reactome Formation of the activated STAT92E dimer and transport to the nucleus R-DME-209228 FBgn0030904 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0265784 Reactome AKT phosphorylates targets in the nucleus R-DME-198693 FBgn0265784 Reactome CREB phosphorylation R-DME-199920 FBgn0265784 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0265784 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0265784 Reactome CREB phosphorylation through the activation of Ras R-DME-442742 FBgn0265784 Reactome Gastrin-CREB signalling pathway via PKC and MAPK R-DME-881907 FBgn0030915 Reactome NOSIP mediated eNOS trafficking R-DME-203754 FBgn0008635 Reactome Neutrophil degranulation R-DME-6798695 FBgn0008635 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0008635 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0052549 Reactome Abacavir metabolism R-DME-2161541 FBgn0052549 Reactome Purine catabolism R-DME-74259 FBgn0030930 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0010194 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0010194 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0030932 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0030932 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0030932 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0265598 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0030943 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0030943 Reactome snRNP Assembly R-DME-191859 FBgn0030943 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0030943 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0030943 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0030943 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0030943 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0001079 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0001079 Reactome Phosphorylation of CI R-DME-209190 FBgn0001079 Reactome Phosphorylation of SMO R-DME-209214 FBgn0001079 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0001079 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0001079 Reactome Activation of CI R-DME-216119 FBgn0001079 Reactome Activation of SMO R-DME-216217 FBgn0010383 Reactome Vitamin D (calciferol) metabolism R-DME-196791 FBgn0010383 Reactome Vitamins R-DME-211916 FBgn0010383 Reactome Fatty acids R-DME-211935 FBgn0010383 Reactome Miscellaneous substrates R-DME-211958 FBgn0010383 Reactome Xenobiotics R-DME-211981 FBgn0010383 Reactome Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-DME-2142670 FBgn0010383 Reactome Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-DME-2142816 FBgn0010383 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0030955 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030956 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0030956 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0030956 Reactome mRNA 3'-end processing R-DME-72187 FBgn0030959 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0030959 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0030959 Reactome mRNA 3'-end processing R-DME-72187 FBgn0030960 Reactome Macroautophagy R-DME-1632852 FBgn0259927 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0030966 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0030968 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0030969 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0030975 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0030976 Reactome ERKs are inactivated R-DME-202670 FBgn0030993 Reactome Nephrin family interactions R-DME-373753 FBgn0030993 Reactome Neutrophil degranulation R-DME-6798695 FBgn0027603 Reactome SUMO is proteolytically processed R-DME-3065679 FBgn0027603 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031003 Reactome Protein methylation R-DME-8876725 FBgn0031005 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0031006 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0031006 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0031006 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0040068 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0040068 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0040068 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0040068 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0040068 Reactome Rho GTPase cycle R-DME-194840 FBgn0040068 Reactome DAP12 signaling R-DME-2424491 FBgn0040068 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0040068 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0040068 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0040068 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0040068 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0040068 Reactome Signal transduction by L1 R-DME-445144 FBgn0040068 Reactome Interleukin-3, Interleukin-5 and GM-CSF signaling R-DME-512988 FBgn0040068 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0040068 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0040068 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0040068 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0040068 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0086778 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0031016 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0020261 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0031021 Reactome Respiratory electron transport R-DME-611105 FBgn0027621 Reactome Glycolysis R-DME-70171 FBgn0027291 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0261573 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0285947 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0285947 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0285947 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0285947 Reactome Translation initiation complex formation R-DME-72649 FBgn0285947 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0285947 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0285947 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0285947 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0285947 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0285947 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0031036 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0031045 Reactome Synthesis of PC R-DME-1483191 FBgn0031045 Reactome Synthesis of PE R-DME-1483213 FBgn0031047 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0031048 Reactome Synthesis of PC R-DME-1483191 FBgn0031048 Reactome Synthesis of PE R-DME-1483213 FBgn0031050 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0031050 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031050 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0031050 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0031054 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0004057 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0004057 Reactome Pentose phosphate pathway R-DME-71336 FBgn0043903 Reactome Formation of the activated receptor complex R-DME-209209 FBgn0043903 Reactome Formation of the activated STAT92E dimer and transport to the nucleus R-DME-209228 FBgn0043903 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0031057 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0086384 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0086384 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0010341 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0010341 Reactome Rho GTPase cycle R-DME-194840 FBgn0010341 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0010341 Reactome CDO in myogenesis R-DME-375170 FBgn0010341 Reactome CD28 dependent Vav1 pathway R-DME-389359 FBgn0010341 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0010341 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0010341 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0010341 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0010341 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0010341 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0010341 Reactome MAPK6/MAPK4 signaling R-DME-5687128 FBgn0010341 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0010380 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0010380 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0052528 Reactome Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-DME-446388 FBgn0031069 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0026174 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0026174 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0026174 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0026174 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026174 Reactome Downstream TCR signaling R-DME-202424 FBgn0026174 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0026174 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0026174 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0026174 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0026174 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0026174 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0026174 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0026174 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0026174 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0026174 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0026174 Reactome Neddylation R-DME-8951664 FBgn0026174 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0026174 Reactome Iron uptake and transport R-DME-917937 FBgn0026174 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0026175 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0026175 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0026175 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0026175 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026175 Reactome Downstream TCR signaling R-DME-202424 FBgn0026175 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0026175 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0026175 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0026175 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0026175 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0026175 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0026175 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0026175 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0026175 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0026175 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0026175 Reactome Neddylation R-DME-8951664 FBgn0026175 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0026175 Reactome Iron uptake and transport R-DME-917937 FBgn0026175 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031074 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0031074 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0031074 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0031074 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0031074 Reactome Downstream TCR signaling R-DME-202424 FBgn0031074 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0031074 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0031074 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0031074 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0031074 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0031074 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0031074 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0031074 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0031074 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0031074 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0031074 Reactome Neddylation R-DME-8951664 FBgn0031074 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0031074 Reactome Iron uptake and transport R-DME-917937 FBgn0031074 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031078 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0031078 Reactome snRNP Assembly R-DME-191859 FBgn0031078 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0031078 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0031078 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0031078 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0031078 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0261811 Reactome Tie2 Signaling R-DME-210993 FBgn0261811 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0261811 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0261811 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0261811 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0053517 Reactome Dopamine receptors R-DME-390651 FBgn0053517 Reactome G alpha (i) signalling events R-DME-418594 FBgn0031090 Reactome TBC/RABGAPs R-DME-8854214 FBgn0031090 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0031090 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0031092 Reactome Peroxisomal protein import R-DME-9033241 FBgn0000084 Reactome Platelet degranulation R-DME-114608 FBgn0000084 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015789 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015789 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0015789 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0031099 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0027334 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031106 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0031106 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0031107 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0031107 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0002641 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0031117 Reactome Glutathione conjugation R-DME-156590 FBgn0031118 Reactome Rho GTPase cycle R-DME-194840 FBgn0259162 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0259162 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0259162 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0259162 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0259162 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0259162 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0259162 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0259162 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0259162 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0259162 Reactome RUNX2 regulates osteoblast differentiation R-DME-8940973 FBgn0259162 Reactome RUNX2 regulates bone development R-DME-8941326 FBgn0259162 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0259162 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0259162 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0259162 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0259162 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0259162 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0031126 Reactome Miscellaneous substrates R-DME-211958 FBgn0031126 Reactome Eicosanoids R-DME-211979 FBgn0031126 Reactome Xenobiotics R-DME-211981 FBgn0031126 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0031126 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0031126 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0003300 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0003300 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0003300 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0003300 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0003300 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0003300 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0003300 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0003300 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0003300 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0003300 Reactome RUNX2 regulates osteoblast differentiation R-DME-8940973 FBgn0003300 Reactome RUNX2 regulates bone development R-DME-8941326 FBgn0003300 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0003300 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0003300 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0003300 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0003300 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0003300 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0031132 Reactome Synthesis of PA R-DME-1483166 FBgn0261675 Reactome LDL clearance R-DME-8964038 FBgn0031148 Reactome Cysteine formation from homocysteine R-DME-1614603 FBgn0031161 Reactome Neddylation R-DME-8951664 FBgn0031164 Reactome Mitochondrial protein import R-DME-1268020 FBgn0031170 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0031170 Reactome Surfactant metabolism R-DME-5683826 FBgn0020369 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0020369 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0020369 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0020369 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0020369 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0020369 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0020369 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0020369 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0020369 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0020369 Reactome Downstream TCR signaling R-DME-202424 FBgn0020369 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0020369 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0020369 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0020369 Reactome Nuclear CI is degraded R-DME-216167 FBgn0020369 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0020369 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0020369 Reactome Degradation of TIM R-DME-432395 FBgn0020369 Reactome Degradation of PER R-DME-432524 FBgn0020369 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0020369 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0020369 Reactome Degradation of AXIN R-DME-4641257 FBgn0020369 Reactome Degradation of DVL R-DME-4641258 FBgn0020369 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0020369 Reactome Degradation of CLK R-DME-538848 FBgn0020369 Reactome Degradation of CRY R-DME-538864 FBgn0020369 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0020369 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0020369 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0020369 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0020369 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0020369 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0020369 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0020369 Reactome UCH proteinases R-DME-5689603 FBgn0020369 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0020369 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0020369 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0020369 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0020369 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0020369 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0020369 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0020369 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0020369 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0020369 Reactome Neddylation R-DME-8951664 FBgn0020369 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0020369 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029067 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0015558 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0015379 Reactome PI5P Regulates TP53 Acetylation R-DME-6811555 FBgn0003423 Reactome Proline catabolism R-DME-70688 FBgn0031182 Reactome Miscellaneous substrates R-DME-211958 FBgn0031182 Reactome Eicosanoids R-DME-211979 FBgn0031182 Reactome Xenobiotics R-DME-211981 FBgn0031182 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0031182 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0031182 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0266848 Reactome Neddylation R-DME-8951664 FBgn0031187 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0027279 Reactome Synthesis of pyrophosphates in the cytosol R-DME-1855167 FBgn0262866 Reactome ERK/MAPK targets R-DME-198753 FBgn0262866 Reactome CREB phosphorylation R-DME-199920 FBgn0262866 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0262866 Reactome CREB phosphorylation through the activation of Ras R-DME-442742 FBgn0262866 Reactome RSK activation R-DME-444257 FBgn0262866 Reactome Gastrin-CREB signalling pathway via PKC and MAPK R-DME-881907 FBgn0031208 Reactome SUMO is proteolytically processed R-DME-3065679 FBgn0031208 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031216 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0026787 Reactome Sodium/Proton exchangers R-DME-425986 FBgn0001142 Reactome Astrocytic Glutamate-Glutamine Uptake And Metabolism R-DME-210455 FBgn0001142 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0031229 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031229 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0031231 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0031231 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0031233 Reactome TBC/RABGAPs R-DME-8854214 FBgn0266557 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0003444 Reactome Phosphorylation of SMO R-DME-209214 FBgn0003444 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0003444 Reactome Activation of CI R-DME-216119 FBgn0003444 Reactome Activation of SMO R-DME-216217 FBgn0003444 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0003444 Reactome Activation of SMO R-DME-5635838 FBgn0017457 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0017457 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0017457 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0017457 Reactome mRNA 3'-end processing R-DME-72187 FBgn0020622 Reactome PI3K Cascade R-DME-109704 FBgn0020622 Reactome IRS-mediated signalling R-DME-112399 FBgn0020622 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0020622 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0020622 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0020622 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0020622 Reactome Rho GTPase cycle R-DME-194840 FBgn0020622 Reactome PI3K/AKT activation R-DME-198203 FBgn0020622 Reactome Tie2 Signaling R-DME-210993 FBgn0020622 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0020622 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0020622 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0020622 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0020622 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0020622 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0020622 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0020622 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0020622 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0020622 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0004611 Reactome PLC beta mediated events R-DME-112043 FBgn0004611 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0004611 Reactome G alpha (q) signalling events R-DME-416476 FBgn0031250 Reactome Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-DME-83936 FBgn0003278 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0264855 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0264855 Reactome Recycling pathway of L1 R-DME-437239 FBgn0264855 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0264855 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0264855 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0264855 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0264855 Reactome LDL clearance R-DME-8964038 FBgn0263933 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0002593 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0002593 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0002593 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0002593 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0002593 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0002593 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0004583 Reactome Phosphorylation-independent inhibition of YKI R-DME-451806 FBgn0015924 Reactome Platelet degranulation R-DME-114608 FBgn0015924 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0015924 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015924 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0015924 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0027592 Reactome Generic Transcription Pathway R-DME-212436 FBgn0010602 Reactome Vitamin D (calciferol) metabolism R-DME-196791 FBgn0010602 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0010602 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0010602 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0010602 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0010602 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0010602 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0010602 Reactome SUMOylation of immune response proteins R-DME-4755510 FBgn0010602 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0031261 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0031263 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0031266 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031266 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0031267 Reactome Synthesis of IPs in the nucleus R-DME-1855191 FBgn0284247 Reactome Homo-/heterophilic binding of transmembrane components R-DME-350379 FBgn0284247 Reactome Subcellular localisation of D R-DME-390023 FBgn0284247 Reactome Positive regulation of FT and DS R-DME-451850 FBgn0026438 Reactome Astrocytic Glutamate-Glutamine Uptake And Metabolism R-DME-210455 FBgn0026438 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0026438 Reactome Transport of inorganic cations/anions and amino acids/oligopeptides R-DME-425393 FBgn0031279 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0031282 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0031282 Reactome Peroxisomal protein import R-DME-9033241 FBgn0015621 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0015621 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015621 Reactome mRNA 3'-end processing R-DME-72187 FBgn0015621 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0010583 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0010583 Reactome Nephrin family interactions R-DME-373753 FBgn0010583 Reactome Ephrin signaling R-DME-3928664 FBgn0010583 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0010583 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0010583 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0020304 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0020304 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031287 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0020305 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0046113 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0046113 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0031294 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031298 Reactome Macroautophagy R-DME-1632852 FBgn0031309 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0031309 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0031309 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0031309 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0031309 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0031309 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0031309 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0031309 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0031309 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0031309 Reactome mRNA Capping R-DME-72086 FBgn0031309 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0031309 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0031309 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0031309 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0031309 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0031309 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0031312 Reactome Synthesis of Dolichyl-phosphate R-DME-446199 FBgn0031314 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0031318 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031319 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031322 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0031322 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0031322 Reactome Attenuation phase R-DME-3371568 FBgn0031322 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0041097 Reactome Signaling by ROBO receptors R-DME-376176 FBgn0041097 Reactome Regulation of commissural axon pathfinding by SLIT and ROBO R-DME-428542 FBgn0041097 Reactome Role of ABL in ROBO-SLIT signaling R-DME-428890 FBgn0041097 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0026141 Reactome Macroautophagy R-DME-1632852 FBgn0026141 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0026141 Reactome Neutrophil degranulation R-DME-6798695 FBgn0026141 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0026141 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0051661 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0051661 Reactome Surfactant metabolism R-DME-5683826 FBgn0051935 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0051935 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0011570 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0011570 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0011570 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0011570 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0031357 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0031357 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0000579 Reactome Glycolysis R-DME-70171 FBgn0000579 Reactome Gluconeogenesis R-DME-70263 FBgn0267972 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0267972 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0001125 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0001125 Reactome Gluconeogenesis R-DME-70263 FBgn0001125 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0031381 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031381 Reactome LDL clearance R-DME-8964038 FBgn0031384 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003557 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0003557 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0003557 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0003557 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0003557 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0003557 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0003557 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0004507 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004507 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0051668 Reactome Cellular hexose transport R-DME-189200 FBgn0051668 Reactome Inositol transporters R-DME-429593 FBgn0051668 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0010288 Reactome UCH proteinases R-DME-5689603 FBgn0010288 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0010288 Reactome Neddylation R-DME-8951664 FBgn0262126 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0262126 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0262126 Reactome Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-DME-983170 FBgn0014010 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0014010 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0014010 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014010 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0014010 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0014010 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0014010 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0264672 Reactome O-linked glycosylation R-DME-5173105 FBgn0031422 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0031424 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0031424 Reactome Organic anion transporters R-DME-428643 FBgn0031428 Reactome Fructose catabolism R-DME-70350 FBgn0000490 Reactome Signaling by BMP R-DME-201451 FBgn0000490 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0000490 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0000490 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0264978 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0026778 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0031436 Reactome Respiratory electron transport R-DME-611105 FBgn0031437 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0031437 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0031437 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031437 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0026479 Reactome Apoptotic execution phase R-DME-75153 FBgn0031442 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0031442 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0031442 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0031442 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0031442 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0031442 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0031442 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0031442 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0031442 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0031442 Reactome Downstream TCR signaling R-DME-202424 FBgn0031442 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0031442 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0031442 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0031442 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0031442 Reactome Degradation of AXIN R-DME-4641257 FBgn0031442 Reactome Degradation of DVL R-DME-4641258 FBgn0031442 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0031442 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0031442 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0031442 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0031442 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0031442 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0031442 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0031442 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0031442 Reactome UCH proteinases R-DME-5689603 FBgn0031442 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0031442 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0031442 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0031442 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0031442 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0031442 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0031442 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0031442 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0031442 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0031442 Reactome Neddylation R-DME-8951664 FBgn0031442 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0031442 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031443 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0031443 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0031443 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0031443 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0031443 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0031443 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0031443 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0031443 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0031443 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0031443 Reactome Downstream TCR signaling R-DME-202424 FBgn0031443 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0031443 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0031443 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0031443 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0031443 Reactome Degradation of AXIN R-DME-4641257 FBgn0031443 Reactome Degradation of DVL R-DME-4641258 FBgn0031443 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0031443 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0031443 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0031443 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0031443 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0031443 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0031443 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0031443 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0031443 Reactome UCH proteinases R-DME-5689603 FBgn0031443 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0031443 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0031443 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0031443 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0031443 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0031443 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0031443 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0031443 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0031443 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0031443 Reactome Neddylation R-DME-8951664 FBgn0031443 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0031443 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031450 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0031450 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0031450 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031450 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031450 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0031451 Reactome Glycolysis R-DME-70171 FBgn0031451 Reactome Gluconeogenesis R-DME-70263 FBgn0031452 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0250906 Reactome Glycolysis R-DME-70171 FBgn0250906 Reactome Gluconeogenesis R-DME-70263 FBgn0053542 Reactome Formation of the activated receptor complex R-DME-209209 FBgn0053542 Reactome Formation of the activated STAT92E dimer and transport to the nucleus R-DME-209228 FBgn0053542 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0266756 Reactome Platelet degranulation R-DME-114608 FBgn0266756 Reactome TBC/RABGAPs R-DME-8854214 FBgn0053505 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0053544 Reactome Metabolism of vitamin K R-DME-6806664 FBgn0261872 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0053514 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0053514 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0053514 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0031458 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0031458 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0031458 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0031458 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0028398 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028398 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0028398 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0028398 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0028398 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0028398 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0019830 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0004242 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0004242 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0004242 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0004242 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031461 Reactome Platelet degranulation R-DME-114608 FBgn0031461 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0031461 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0031461 Reactome TGF-beta receptor signaling activates SMADs R-DME-2173789 FBgn0031461 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0031461 Reactome Syndecan interactions R-DME-3000170 FBgn0031461 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0031461 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0031461 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0031462 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031462 Reactome Glycolysis R-DME-70171 FBgn0031463 Reactome Gluconeogenesis R-DME-70263 FBgn0283531 Reactome Thyroxine biosynthesis R-DME-209968 FBgn0015521 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0015521 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0015521 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0015521 Reactome Translation initiation complex formation R-DME-72649 FBgn0015521 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0015521 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0015521 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0015521 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0015521 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0015521 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0031478 Reactome Peroxisomal lipid metabolism R-DME-390918 FBgn0031479 Reactome Neutrophil degranulation R-DME-6798695 FBgn0024947 Reactome Phosphate bond hydrolysis by NTPDase proteins R-DME-8850843 FBgn0041111 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0041111 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0041111 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0010263 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0010263 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0024920 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0004584 Reactome Displacement of DNA glycosylase by APEX1 R-DME-110357 FBgn0004584 Reactome Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-DME-110373 FBgn0004584 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0004584 Reactome Resolution of Abasic Sites (AP sites) R-DME-73933 FBgn0031485 Reactome Protein methylation R-DME-8876725 FBgn0031489 Reactome Pyrimidine salvage R-DME-73614 FBgn0031489 Reactome Pyrimidine catabolism R-DME-73621 FBgn0031491 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0031493 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031493 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0283427 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0283427 Reactome Vitamin B5 (pantothenate) metabolism R-DME-199220 FBgn0283427 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0260817 Reactome Nonhomologous End-Joining (NHEJ) R-DME-5693571 FBgn0085422 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0031517 Reactome Cellular hexose transport R-DME-189200 FBgn0031517 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031517 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031520 Reactome Cellular hexose transport R-DME-189200 FBgn0031520 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031520 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031522 Reactome Cellular hexose transport R-DME-189200 FBgn0031522 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031522 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031523 Reactome Cellular hexose transport R-DME-189200 FBgn0031523 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031523 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0003256 Reactome MAPK3 (ERK1) activation R-DME-110056 FBgn0003256 Reactome RAF-independent MAPK1/3 activation R-DME-112409 FBgn0003256 Reactome MAPK1 (ERK2) activation R-DME-112411 FBgn0003256 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0003256 Reactome ERK/MAPK targets R-DME-198753 FBgn0003256 Reactome ERKs are inactivated R-DME-202670 FBgn0003256 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0003256 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0003256 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0003256 Reactome Oncogene Induced Senescence R-DME-2559585 FBgn0003256 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0003256 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0003256 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0003256 Reactome Recycling pathway of L1 R-DME-437239 FBgn0003256 Reactome CREB phosphorylation through the activation of Ras R-DME-442742 FBgn0003256 Reactome RSK activation R-DME-444257 FBgn0003256 Reactome Signal transduction by L1 R-DME-445144 FBgn0003256 Reactome Activation of the AP-1 family of transcription factors R-DME-450341 FBgn0003256 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0003256 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0003256 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0003256 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0003256 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0003256 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0003256 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0003256 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0003256 Reactome Negative feedback regulation of MAPK pathway R-DME-5674499 FBgn0003256 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0003256 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003256 Reactome Signal attenuation R-DME-74749 FBgn0003256 Reactome Gastrin-CREB signalling pathway via PKC and MAPK R-DME-881907 FBgn0260987 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0260987 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0260987 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0028697 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0028697 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0028697 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0028697 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0028697 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0028697 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0027341 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0267861 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0040031 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0039941 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0265767 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0003559 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0003559 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003559 Reactome mRNA 3'-end processing R-DME-72187 FBgn0003559 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0262117 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0260798 Reactome Calmodulin induced events R-DME-111933 FBgn0260798 Reactome G alpha (q) signalling events R-DME-416476 FBgn0260798 Reactome Activation of SMO R-DME-5635838 FBgn0020660 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0020660 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0020660 Reactome Deadenylation of mRNA R-DME-429947 FBgn0020660 Reactome Translation initiation complex formation R-DME-72649 FBgn0020660 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0020660 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0020660 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039993 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0039993 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0058045 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0058045 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0011288 Reactome Other interleukin signaling R-DME-449836 FBgn0011288 Reactome Neutrophil degranulation R-DME-6798695 FBgn0044510 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0044510 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0267976 Reactome Mitochondrial protein import R-DME-1268020 FBgn0263977 Reactome Mitochondrial protein import R-DME-1268020 FBgn0010247 Reactome POLB-Dependent Long Patch Base Excision Repair R-DME-110362 FBgn0010247 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0010247 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0010247 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0010247 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0010247 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0010247 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0086683 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0058006 Reactome Platelet degranulation R-DME-114608 FBgn0058006 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0058006 Reactome Neutrophil degranulation R-DME-6798695 FBgn0058006 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0058006 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0064225 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0064225 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0064225 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0064225 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0064225 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0064225 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0040010 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0040010 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0040010 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0000384 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0000384 Reactome Rho GTPase cycle R-DME-194840 FBgn0000384 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0026401 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0260799 Reactome Apoptotic cleavage of cell adhesion proteins R-DME-351906 FBgn0260799 Reactome Neutrophil degranulation R-DME-6798695 FBgn0040007 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0040007 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0040007 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0040007 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0040007 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0040007 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0250830 Reactome Platelet degranulation R-DME-114608 FBgn0058002 Reactome Respiratory electron transport R-DME-611105 FBgn0058002 Reactome Complex I biogenesis R-DME-6799198 FBgn0039966 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0039966 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0069938 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0031530 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0031530 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0031533 Reactome Digestion of dietary lipid R-DME-192456 FBgn0031533 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0031534 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0031536 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0031536 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0266670 Reactome Insulin processing R-DME-264876 FBgn0266670 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0005616 Reactome HATs acetylate histones R-DME-3214847 FBgn0051776 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0261560 Reactome TOR signaling pathway R-DME-110523 FBgn0261560 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0261560 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0014396 Reactome Degradation of TIM R-DME-432395 FBgn0014396 Reactome Nuclear import of PER and TIM R-DME-432490 FBgn0014396 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0014396 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0014396 Reactome Dephosphorylation of PER R-DME-432620 FBgn0014396 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0031550 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0003386 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0003386 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0031589 Reactome Nicotinamide salvaging R-DME-197264 FBgn0031589 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001075 Reactome Homo-/heterophilic binding of transmembrane components R-DME-350379 FBgn0001075 Reactome Subcellular localisation of D R-DME-390023 FBgn0001075 Reactome Positive regulation of FT and DS R-DME-451850 FBgn0003941 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0003941 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0003941 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0003941 Reactome Degradation of TIM R-DME-432395 FBgn0003941 Reactome Degradation of PER R-DME-432524 FBgn0003941 Reactome Degradation of CRY R-DME-538864 FBgn0020762 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0020762 Reactome HDL remodeling R-DME-8964058 FBgn0031598 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0261976 Reactome Unwinding of DNA R-DME-176974 FBgn0031600 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0031601 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031601 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0019982 Reactome Pyrimidine salvage R-DME-73614 FBgn0285948 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0285948 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0285948 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0285948 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0285948 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0285948 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0031613 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0031622 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0031628 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0031633 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0031639 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0031639 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0031640 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0031643 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031651 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0031651 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0031652 Reactome Neddylation R-DME-8951664 FBgn0031652 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0015834 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0015834 Reactome Translation initiation complex formation R-DME-72649 FBgn0015834 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0015834 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0015834 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0015834 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0031657 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0031660 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0031660 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0031661 Reactome GDP-fucose biosynthesis R-DME-6787639 FBgn0031662 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0031663 Reactome Purine catabolism R-DME-74259 FBgn0053113 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0053113 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0031675 Reactome Neddylation R-DME-8951664 FBgn0031675 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0014857 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0014857 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0014857 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0014857 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0014857 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0014857 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0014857 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0014857 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0014857 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0028694 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028694 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028694 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028694 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028694 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028694 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028694 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028694 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028694 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028694 Reactome Downstream TCR signaling R-DME-202424 FBgn0028694 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028694 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028694 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028694 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028694 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028694 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028694 Reactome Degradation of TIM R-DME-432395 FBgn0028694 Reactome Degradation of PER R-DME-432524 FBgn0028694 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028694 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028694 Reactome Degradation of AXIN R-DME-4641257 FBgn0028694 Reactome Degradation of DVL R-DME-4641258 FBgn0028694 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028694 Reactome Degradation of CLK R-DME-538848 FBgn0028694 Reactome Degradation of CRY R-DME-538864 FBgn0028694 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028694 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028694 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028694 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028694 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028694 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028694 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028694 Reactome UCH proteinases R-DME-5689603 FBgn0028694 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028694 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0028694 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028694 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028694 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028694 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028694 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028694 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028694 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028694 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028694 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028694 Reactome Neddylation R-DME-8951664 FBgn0028694 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028694 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031684 Reactome Respiratory electron transport R-DME-611105 FBgn0003716 Reactome Signaling by BMP R-DME-201451 FBgn0016076 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0016076 Reactome Transcription activation by CLK:CYC and repression by VRI R-DME-432560 FBgn0031697 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0031703 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0031710 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0031716 Reactome N-glycan trimming and elongation in the cis-Golgi R-DME-964739 FBgn0014189 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0014189 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0014189 Reactome mRNA 3'-end processing R-DME-72187 FBgn0002525 Reactome Breakdown of the nuclear lamina R-DME-352238 FBgn0002525 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0031717 Reactome Glycolysis R-DME-70171 FBgn0004620 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0004620 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0020429 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0020429 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0031735 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0031735 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0001128 Reactome Synthesis of PA R-DME-1483166 FBgn0001942 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0001942 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0001942 Reactome Deadenylation of mRNA R-DME-429947 FBgn0001942 Reactome Translation initiation complex formation R-DME-72649 FBgn0001942 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0001942 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0001942 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0001941 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0001941 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031759 Reactome TFAP2 (AP-2) family regulates transcription of cell cycle factors R-DME-8866911 FBgn0031760 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001089 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0001089 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0001089 Reactome HS-GAG degradation R-DME-2024096 FBgn0001089 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031764 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031765 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0025742 Reactome Synthesis of PIPs at the ER membrane R-DME-1483248 FBgn0025742 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0025742 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0025742 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0000052 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0031771 Reactome Respiratory electron transport R-DME-611105 FBgn0031771 Reactome Complex I biogenesis R-DME-6799198 FBgn0031773 Reactome Neddylation R-DME-8951664 FBgn0031773 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031777 Reactome Protein methylation R-DME-8876725 FBgn0031779 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0031779 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0284255 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0284255 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0284255 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0265778 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0015623 Reactome Cytochrome P450 - arranged by substrate type R-DME-211897 FBgn0031804 Reactome Platelet degranulation R-DME-114608 FBgn0031804 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0031804 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0031804 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0031804 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0031804 Reactome Integrin cell surface interactions R-DME-216083 FBgn0031804 Reactome Syndecan interactions R-DME-3000170 FBgn0031804 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0031804 Reactome ECM proteoglycans R-DME-3000178 FBgn0031804 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0031804 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0031804 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0031804 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0031804 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0031804 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031804 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0031813 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0031813 Reactome Peroxisomal protein import R-DME-9033241 FBgn0031815 Reactome Acyl chain remodelling of PI R-DME-1482922 FBgn0031816 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0031816 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0259749 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0031818 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0086357 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0027496 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0027496 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0031822 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0031824 Reactome Lysine catabolism R-DME-71064 FBgn0031826 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0031826 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0051637 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0051637 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0000320 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0031829 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0263916 Reactome Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-DME-83936 FBgn0051634 Reactome Transport of organic anions R-DME-879518 FBgn0031842 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0031842 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0031842 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0028467 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0031844 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0263200 Reactome Galactose catabolism R-DME-70370 FBgn0028703 Reactome Sodium/Proton exchangers R-DME-425986 FBgn0031850 Reactome Platelet degranulation R-DME-114608 FBgn0031850 Reactome Integrin cell surface interactions R-DME-216083 FBgn0031850 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0025777 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0015776 Reactome Basigin interactions R-DME-210991 FBgn0015776 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0015777 Reactome Basigin interactions R-DME-210991 FBgn0015777 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0031860 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0031860 Reactome Peroxisomal protein import R-DME-9033241 FBgn0086451 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0031865 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0031866 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0042092 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0011737 Reactome Polo-like kinase mediated events R-DME-156711 FBgn0011737 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0011737 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0011737 Reactome G2/M DNA replication checkpoint R-DME-69478 FBgn0011737 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0011737 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0026196 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0026196 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0028554 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0028554 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0028554 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0028554 Reactome mRNA 3'-end processing R-DME-72187 FBgn0031872 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0031872 Reactome CDO in myogenesis R-DME-375170 FBgn0031872 Reactome Ligand-receptor interactions R-DME-5632681 FBgn0031873 Reactome Activation of the TFAP2 (AP-2) family of transcription factors R-DME-8866907 FBgn0020616 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0020616 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0020616 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0031877 Reactome Synthesis of Ketone Bodies R-DME-77111 FBgn0031877 Reactome Peroxisomal protein import R-DME-9033241 FBgn0264922 Reactome Vitamin D (calciferol) metabolism R-DME-196791 FBgn0264922 Reactome SUMO is proteolytically processed R-DME-3065679 FBgn0264922 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0264922 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0264922 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0264922 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0264922 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0264922 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0264922 Reactome SUMOylation of immune response proteins R-DME-4755510 FBgn0264922 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0016978 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0000053 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0031881 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0031882 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0031882 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0031885 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0031885 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0031885 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0031885 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0031893 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0031893 Reactome Processing of SMDT1 R-DME-8949664 FBgn0263133 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0259111 Reactome Bicarbonate transporters R-DME-425381 FBgn0284084 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0284084 Reactome Phosphorylation of ARR R-DME-209387 FBgn0284084 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0284084 Reactome Assembly of receptor complex R-DME-209472 FBgn0284084 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0284084 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0031902 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0031903 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0031909 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0283658 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0283658 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0283658 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0283658 Reactome Pyruvate metabolism R-DME-70268 FBgn0031913 Reactome Vitamin E R-DME-8877627 FBgn0031914 Reactome Vitamin E R-DME-8877627 FBgn0025697 Reactome Platelet degranulation R-DME-114608 FBgn0025697 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0025697 Reactome Neutrophil degranulation R-DME-6798695 FBgn0025697 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0025697 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0260486 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0264895 Reactome Rap1 signalling R-DME-392517 FBgn0031929 Reactome Regulation of Complement cascade R-DME-977606 FBgn0031930 Reactome Regulation of Complement cascade R-DME-977606 FBgn0041182 Reactome Platelet degranulation R-DME-114608 FBgn0041181 Reactome Platelet degranulation R-DME-114608 FBgn0031941 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0031941 Reactome Cristae formation R-DME-8949613 FBgn0031948 Reactome Synthesis of PE R-DME-1483213 FBgn0286198 Reactome Lysine catabolism R-DME-71064 FBgn0031952 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0261800 Reactome Laminin interactions R-DME-3000157 FBgn0261800 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0261800 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0027515 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0261790 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261790 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0031969 Reactome Platelet degranulation R-DME-114608 FBgn0031969 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0031969 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031969 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031969 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031970 Reactome Platelet degranulation R-DME-114608 FBgn0031970 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0031970 Reactome Neutrophil degranulation R-DME-6798695 FBgn0031970 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0031970 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0031972 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0031972 Reactome Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-DME-8866904 FBgn0031972 Reactome Activation of the TFAP2 (AP-2) family of transcription factors R-DME-8866907 FBgn0031973 Reactome Platelet degranulation R-DME-114608 FBgn0031973 Reactome Intrinsic Pathway of Fibrin Clot Formation R-DME-140837 FBgn0031975 Reactome Platelet degranulation R-DME-114608 FBgn0031975 Reactome Common Pathway of Fibrin Clot Formation R-DME-140875 FBgn0044323 Reactome Formation of the cytosolic BSK 'scaffolding complex' R-DME-209397 FBgn0044323 Reactome Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209409 FBgn0044323 Reactome Transcriptional activtion by AP-1 transcription factor R-DME-209425 FBgn0031980 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0031980 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0031980 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0031980 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0031980 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0031980 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0031990 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0261064 Reactome Toll Like Receptor 9 (TLR9) Cascade R-DME-168138 FBgn0261064 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0031992 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0031995 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0031996 Reactome Platelet degranulation R-DME-114608 FBgn0031998 Reactome Cellular hexose transport R-DME-189200 FBgn0031998 Reactome Inositol transporters R-DME-429593 FBgn0031998 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0003607 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0032001 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032001 Reactome Pyrimidine salvage R-DME-73614 FBgn0032002 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032002 Reactome Pyrimidine salvage R-DME-73614 FBgn0032003 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032003 Reactome Pyrimidine salvage R-DME-73614 FBgn0032005 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0032006 Reactome PI3K Cascade R-DME-109704 FBgn0032006 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0032006 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0032006 Reactome Integrin cell surface interactions R-DME-216083 FBgn0032006 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0032006 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0003502 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0003502 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0003502 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0003502 Reactome DAP12 signaling R-DME-2424491 FBgn0003502 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0003502 Reactome Interleukin-3, Interleukin-5 and GM-CSF signaling R-DME-512988 FBgn0003502 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0261020 Reactome Synthesis of dolichyl-phosphate-glucose R-DME-480985 FBgn0032014 Reactome Androgen biosynthesis R-DME-193048 FBgn0032014 Reactome Synthesis of Dolichyl-phosphate R-DME-446199 FBgn0032015 Reactome Miscellaneous transport and binding events R-DME-5223345 FBgn0032015 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032016 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0032018 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0032026 Reactome Platelet degranulation R-DME-114608 FBgn0032026 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0010265 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010265 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010265 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0010265 Reactome Translation initiation complex formation R-DME-72649 FBgn0010265 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010265 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0010265 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0010265 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010265 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010265 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0032036 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0032036 Reactome Proton-coupled neutral amino acid transporters R-DME-428559 FBgn0032036 Reactome Tryptophan catabolism R-DME-71240 FBgn0001084 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0020497 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0020497 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0032042 Reactome PI3K Cascade R-DME-109704 FBgn0032042 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0032042 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0032042 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0032042 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0032042 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0032042 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0032042 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0032042 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0032042 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0032042 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0032042 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0032042 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0032042 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0032042 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0032042 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0032049 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0032049 Reactome Surfactant metabolism R-DME-5683826 FBgn0032051 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0032053 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0032053 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0032054 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0032055 Reactome Wax biosynthesis R-DME-8848584 FBgn0032059 Reactome ARL13B-mediated ciliary trafficking of INPP5E R-DME-5624958 FBgn0260861 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260861 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0032061 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0032061 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032061 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032066 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032066 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0032067 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032067 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0032068 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032068 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0032069 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032069 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0032074 Reactome Platelet degranulation R-DME-114608 FBgn0032074 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032075 Reactome Platelet degranulation R-DME-114608 FBgn0032075 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032078 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0013746 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0013746 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0013746 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0013746 Reactome Neddylation R-DME-8951664 FBgn0032089 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0032090 Reactome Lysine catabolism R-DME-71064 FBgn0010314 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0010314 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0026439 Reactome Astrocytic Glutamate-Glutamine Uptake And Metabolism R-DME-210455 FBgn0026439 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0026439 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0026439 Reactome Transport of inorganic cations/anions and amino acids/oligopeptides R-DME-425393 FBgn0012036 Reactome Ethanol oxidation R-DME-71384 FBgn0032115 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000640 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0000640 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0000640 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0004868 Reactome Rho GTPase cycle R-DME-194840 FBgn0004868 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004868 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0028479 Reactome Acyl chain remodeling of CL R-DME-1482798 FBgn0028479 Reactome Beta oxidation of myristoyl-CoA to lauroyl-CoA R-DME-77285 FBgn0028479 Reactome Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-DME-77305 FBgn0028479 Reactome Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-DME-77310 FBgn0028479 Reactome Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-DME-77346 FBgn0028479 Reactome Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-DME-77348 FBgn0028479 Reactome Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-DME-77350 FBgn0032135 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0000273 Reactome PKA activation R-DME-163615 FBgn0000273 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0000273 Reactome DARPP-32 events R-DME-180024 FBgn0000273 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0000273 Reactome Phosphorylation of CI R-DME-209190 FBgn0000273 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0000273 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0000273 Reactome Rap1 signalling R-DME-392517 FBgn0000273 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0000273 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0000273 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0000273 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0000273 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0000273 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0032138 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0011291 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0011291 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0011291 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0011291 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0011291 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0011291 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0283478 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0032143 Reactome Regulation of Complement cascade R-DME-977606 FBgn0032144 Reactome Regulation of Complement cascade R-DME-977606 FBgn0032151 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0004867 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0004867 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0004867 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0004867 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0004867 Reactome Translation initiation complex formation R-DME-72649 FBgn0004867 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0004867 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0004867 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0004867 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0004867 Reactome Protein methylation R-DME-8876725 FBgn0004867 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0004867 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0024285 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0024285 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0024285 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0024285 Reactome mRNA 3'-end processing R-DME-72187 FBgn0040064 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0032160 Reactome mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-DME-77288 FBgn0032161 Reactome mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-DME-77288 FBgn0032162 Reactome mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-DME-77288 FBgn0011272 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0011272 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0011272 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0011272 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0011272 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0011272 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0011584 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0032188 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0032188 Reactome snRNP Assembly R-DME-191859 FBgn0032188 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0032188 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0032188 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0032188 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0032188 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0032192 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0032192 Reactome Neutrophil degranulation R-DME-6798695 FBgn0024320 Reactome LDL clearance R-DME-8964038 FBgn0250843 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0250843 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0250843 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0250843 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0250843 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0250843 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0250843 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0250843 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0250843 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0250843 Reactome Downstream TCR signaling R-DME-202424 FBgn0250843 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0250843 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0250843 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0250843 Reactome Nuclear CI is degraded R-DME-216167 FBgn0250843 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0250843 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0250843 Reactome Degradation of TIM R-DME-432395 FBgn0250843 Reactome Degradation of PER R-DME-432524 FBgn0250843 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0250843 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0250843 Reactome Degradation of AXIN R-DME-4641257 FBgn0250843 Reactome Degradation of DVL R-DME-4641258 FBgn0250843 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0250843 Reactome Degradation of CLK R-DME-538848 FBgn0250843 Reactome Degradation of CRY R-DME-538864 FBgn0250843 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0250843 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0250843 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0250843 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0250843 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0250843 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0250843 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0250843 Reactome UCH proteinases R-DME-5689603 FBgn0250843 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0250843 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0250843 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0250843 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0250843 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0250843 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0250843 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0250843 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0250843 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0250843 Reactome Neddylation R-DME-8951664 FBgn0250843 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0250843 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0004419 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0011305 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0011305 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0011305 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0011305 Reactome mRNA 3'-end processing R-DME-72187 FBgn0032204 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0032208 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032210 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032214 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032214 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0032216 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0032216 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0032216 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0032216 Reactome Nuclear CI is degraded R-DME-216167 FBgn0032216 Reactome Degradation of TIM R-DME-432395 FBgn0032216 Reactome Degradation of PER R-DME-432524 FBgn0032216 Reactome Degradation of CLK R-DME-538848 FBgn0032216 Reactome Degradation of CRY R-DME-538864 FBgn0032216 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032219 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0032222 Reactome Heme biosynthesis R-DME-189451 FBgn0019932 Reactome Metabolism of polyamines R-DME-351202 FBgn0027568 Reactome Neutrophil degranulation R-DME-6798695 FBgn0027568 Reactome Neddylation R-DME-8951664 FBgn0027568 Reactome Iron uptake and transport R-DME-917937 FBgn0032230 Reactome Positive regulation of FT and DS R-DME-451850 FBgn0032234 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0004106 Reactome MAPK3 (ERK1) activation R-DME-110056 FBgn0004106 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0004106 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0004106 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0004106 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0004106 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0004106 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0004106 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0004106 Reactome TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-DME-6804114 FBgn0004106 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0004106 Reactome G2/M DNA replication checkpoint R-DME-69478 FBgn0004106 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0004106 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0032236 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0032236 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0267821 Reactome CDO in myogenesis R-DME-375170 FBgn0267821 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0262782 Reactome Gluconeogenesis R-DME-70263 FBgn0051716 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0003942 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0003942 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0003942 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0003942 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0003942 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0003942 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0003942 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0003942 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0003942 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0003942 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0003942 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0003942 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0003942 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0003942 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0003942 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0003942 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0003942 Reactome EGFR downregulation R-DME-182971 FBgn0003942 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0003942 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0003942 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0003942 Reactome Downstream TCR signaling R-DME-202424 FBgn0003942 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0003942 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0003942 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0003942 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0003942 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0003942 Reactome Nuclear CI is degraded R-DME-216167 FBgn0003942 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0003942 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0003942 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0003942 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0003942 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0003942 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0003942 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0003942 Reactome Degradation of TIM R-DME-432395 FBgn0003942 Reactome Degradation of PER R-DME-432524 FBgn0003942 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0003942 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0003942 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0003942 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0003942 Reactome Degradation of AXIN R-DME-4641257 FBgn0003942 Reactome Degradation of DVL R-DME-4641258 FBgn0003942 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0003942 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0003942 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0003942 Reactome Degradation of CRY R-DME-538864 FBgn0003942 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0003942 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0003942 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0003942 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0003942 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0003942 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0003942 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0003942 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0003942 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0003942 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0003942 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0003942 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0003942 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0003942 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0003942 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0003942 Reactome UCH proteinases R-DME-5689603 FBgn0003942 Reactome Josephin domain DUBs R-DME-5689877 FBgn0003942 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0003942 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0003942 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0003942 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0003942 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0003942 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0003942 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0003942 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0003942 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0003942 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0003942 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0003942 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0003942 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0003942 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0003942 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0003942 Reactome Translation initiation complex formation R-DME-72649 FBgn0003942 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0003942 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0003942 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0003942 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003942 Reactome PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-DME-8849469 FBgn0003942 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0003942 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0003942 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0003942 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0003942 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0003942 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0003942 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0003942 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0003942 Reactome Neddylation R-DME-8951664 FBgn0003942 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0003942 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0003942 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0003942 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0003942 Reactome Peroxisomal protein import R-DME-9033241 FBgn0003942 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0003942 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0003942 Reactome Iron uptake and transport R-DME-917937 FBgn0003942 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0003942 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0003942 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0003942 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0003942 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0003942 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0003942 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0003942 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032244 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0032244 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0032244 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0032244 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0032244 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0032244 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0032244 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0032244 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0032244 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0032244 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0032244 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0032244 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0032244 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0032244 Reactome Polymerase switching R-DME-69091 FBgn0262601 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0262601 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0267330 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0267330 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0004915 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0004915 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0004915 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0004915 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0004915 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0004915 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0032249 Reactome TBC/RABGAPs R-DME-8854214 FBgn0032250 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0027052 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0027052 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0027052 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0027052 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0027052 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032252 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0032253 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032253 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0027611 Reactome Neutrophil degranulation R-DME-6798695 FBgn0027611 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0032258 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0032258 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0032261 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0032261 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0010398 Reactome Neddylation R-DME-8951664 FBgn0010398 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032264 Reactome Digestion of dietary lipid R-DME-192456 FBgn0032264 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0032265 Reactome Digestion of dietary lipid R-DME-192456 FBgn0032265 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0032266 Reactome Digestion of dietary lipid R-DME-192456 FBgn0032266 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0051721 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0051721 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032271 Reactome Digestion of dietary lipid R-DME-192456 FBgn0032271 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0051872 Reactome Digestion of dietary lipid R-DME-192456 FBgn0051872 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0043825 Reactome Digestion of dietary lipid R-DME-192456 FBgn0043825 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0265264 Reactome Digestion of dietary lipid R-DME-192456 FBgn0265264 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0051871 Reactome Digestion of dietary lipid R-DME-192456 FBgn0051871 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0032293 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0027868 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0027868 Reactome snRNP Assembly R-DME-191859 FBgn0027868 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0027868 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0027868 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0027868 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0027868 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0032294 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0032294 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032294 Reactome Insulin receptor recycling R-DME-77387 FBgn0032294 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0032294 Reactome Ion channel transport R-DME-983712 FBgn0032296 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0015320 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0015320 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0015320 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0015320 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0015320 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0015320 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0015320 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0015320 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0015320 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0015320 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0015320 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0015320 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0015320 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0015320 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032298 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0032303 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0032303 Reactome Surfactant metabolism R-DME-5683826 FBgn0032304 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0032304 Reactome Surfactant metabolism R-DME-5683826 FBgn0011676 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0011676 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0011676 Reactome eNOS activation R-DME-203615 FBgn0011676 Reactome NOSTRIN mediated eNOS trafficking R-DME-203641 FBgn0011676 Reactome NOSIP mediated eNOS trafficking R-DME-203754 FBgn0011676 Reactome Nitric oxide stimulates guanylate cyclase R-DME-392154 FBgn0011676 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0011676 Reactome Peroxisomal protein import R-DME-9033241 FBgn0069354 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0069354 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0069354 Reactome Pyruvate metabolism R-DME-70268 FBgn0004363 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0004363 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0004363 Reactome Pyruvate metabolism R-DME-70268 FBgn0027363 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0027363 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0027363 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027363 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0027363 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0032314 Reactome Sodium-coupled sulphate, di- and tri-carboxylate transporters R-DME-433137 FBgn0041781 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0041781 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0041781 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0015756 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0015756 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0015756 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0015756 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0015756 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0015756 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0021761 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0021761 Reactome snRNP Assembly R-DME-191859 FBgn0021761 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0021761 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0021761 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0021761 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0021761 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0250837 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0283682 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0032343 Reactome HS-GAG degradation R-DME-2024096 FBgn0032343 Reactome CS/DS degradation R-DME-2024101 FBgn0027582 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0032346 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0032346 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0032346 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0262647 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0262647 Reactome snRNP Assembly R-DME-191859 FBgn0262647 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0262647 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0262647 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0262647 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0262647 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0028700 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0028700 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0028700 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0028700 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0028700 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0028700 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0028700 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0028700 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0028700 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0028700 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0028700 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0028700 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0028700 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0028700 Reactome Polymerase switching R-DME-69091 FBgn0032348 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0040211 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0032350 Reactome Serine biosynthesis R-DME-977347 FBgn0032358 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0020270 Reactome Cytosolic sensors of pathogen-associated DNA R-DME-1834949 FBgn0020270 Reactome DNA Damage/Telomere Stress Induced Senescence R-DME-2559586 FBgn0020270 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0020270 Reactome Sensing of DNA Double Strand Breaks R-DME-5693548 FBgn0020270 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0020270 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0000287 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0261648 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0032361 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0032361 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0015400 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0264815 Reactome Cam-PDE 1 activation R-DME-111957 FBgn0264815 Reactome cGMP effects R-DME-418457 FBgn0264815 Reactome G alpha (s) signalling events R-DME-418555 FBgn0000588 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0000588 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0000588 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0000588 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0032381 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0032382 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0032388 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261266 Reactome Synthesis of PA R-DME-1483166 FBgn0032391 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0032391 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0032391 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0032391 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0032394 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0014019 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0014019 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0014019 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0014019 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0014019 Reactome G alpha (i) signalling events R-DME-418594 FBgn0014019 Reactome Opsins R-DME-419771 FBgn0014019 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0032397 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032398 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0032398 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0032404 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0032404 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0032404 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0032404 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0032404 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0032404 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0027505 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0027505 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0032407 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0015797 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015797 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0015797 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0015797 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0015797 Reactome TBC/RABGAPs R-DME-8854214 FBgn0015797 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0015797 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0032424 Reactome Pentose phosphate pathway R-DME-71336 FBgn0041195 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0032429 Reactome Attenuation phase R-DME-3371568 FBgn0032429 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0020443 Reactome Eukaryotic Translation Termination R-DME-72764 FBgn0020443 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0020443 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0085424 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0032444 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0032444 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0032447 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0032449 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0032449 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0032451 Reactome Miscellaneous transport and binding events R-DME-5223345 FBgn0032453 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0032453 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0032456 Reactome Cobalamin (Cbl, vitamin B12) transport and metabolism R-DME-196741 FBgn0032456 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0032456 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0015399 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0032474 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0024291 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0024291 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0032477 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0032480 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0032482 Reactome Synthesis of PE R-DME-1483213 FBgn0032484 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0032486 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0032487 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0032487 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0032487 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0032492 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0032492 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0032492 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0032492 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0032492 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0032492 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0032492 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0032492 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0032492 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0032492 Reactome Downstream TCR signaling R-DME-202424 FBgn0032492 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0032492 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0032492 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0032492 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0032492 Reactome Degradation of AXIN R-DME-4641257 FBgn0032492 Reactome Degradation of DVL R-DME-4641258 FBgn0032492 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0032492 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0032492 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0032492 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0032492 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0032492 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0032492 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0032492 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0032492 Reactome UCH proteinases R-DME-5689603 FBgn0032492 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032492 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0032492 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0032492 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0032492 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0032492 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0032492 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0032492 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0032492 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0032492 Reactome Neddylation R-DME-8951664 FBgn0032492 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0032492 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028406 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0032499 Reactome Macroautophagy R-DME-1632852 FBgn0051729 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0032511 Reactome Respiratory electron transport R-DME-611105 FBgn0032511 Reactome Complex I biogenesis R-DME-6799198 FBgn0032513 Reactome Synthesis of PC R-DME-1483191 FBgn0032513 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0032515 Reactome MicroRNA (miRNA) biogenesis R-DME-203927 FBgn0032515 Reactome Small interfering RNA (siRNA) biogenesis R-DME-426486 FBgn0032516 Reactome Regulation of TP53 Activity through Acetylation R-DME-6804758 FBgn0032518 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0032518 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0032518 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0032518 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0032518 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0032518 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0032522 Reactome Vitamin B2 (riboflavin) metabolism R-DME-196843 FBgn0032524 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0259984 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0259984 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259984 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0259984 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0028546 Reactome Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-DME-446388 FBgn0024846 Reactome NOD1/2 Signaling Pathway R-DME-168638 FBgn0024846 Reactome p38MAPK events R-DME-171007 FBgn0024846 Reactome ERK/MAPK targets R-DME-198753 FBgn0024846 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0024846 Reactome CDO in myogenesis R-DME-375170 FBgn0024846 Reactome DSCAM interactions R-DME-376172 FBgn0024846 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0024846 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0024846 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0024846 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0024846 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028539 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0028539 Reactome Surfactant metabolism R-DME-5683826 FBgn0027844 Reactome Erythrocytes take up carbon dioxide and release oxygen R-DME-1237044 FBgn0027844 Reactome Erythrocytes take up oxygen and release carbon dioxide R-DME-1247673 FBgn0027844 Reactome Reversible hydration of carbon dioxide R-DME-1475029 FBgn0001965 Reactome SOS-mediated signalling R-DME-112412 FBgn0001965 Reactome SHC1 events in ERBB4 signaling R-DME-1250347 FBgn0001965 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0001965 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0001965 Reactome Signalling to RAS R-DME-167044 FBgn0001965 Reactome GRB2 events in EGFR signaling R-DME-179812 FBgn0001965 Reactome SHC1 events in EGFR signaling R-DME-180336 FBgn0001965 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0001965 Reactome Rho GTPase cycle R-DME-194840 FBgn0001965 Reactome GRB2 events in ERBB2 signaling R-DME-1963640 FBgn0001965 Reactome Tie2 Signaling R-DME-210993 FBgn0001965 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0001965 Reactome DAP12 signaling R-DME-2424491 FBgn0001965 Reactome SHC-related events triggered by IGF1R R-DME-2428933 FBgn0001965 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0001965 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0001965 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0001965 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0001965 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0001965 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0001965 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0001965 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0001965 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0001965 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0001965 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0001965 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0001965 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0001965 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0001965 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0001965 Reactome Signal attenuation R-DME-74749 FBgn0001965 Reactome Insulin receptor signalling cascade R-DME-74751 FBgn0000153 Reactome Degradation of cysteine and homocysteine R-DME-1614558 FBgn0000153 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0001961 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0001961 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0001961 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0015271 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0015271 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0015271 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0015271 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0015271 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0015271 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015271 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0026373 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0026373 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0026373 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0026373 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0026373 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0026373 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0026373 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0026373 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0026373 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0026373 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0026373 Reactome mRNA Capping R-DME-72086 FBgn0026373 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0026373 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0026373 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0026373 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0026373 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0026373 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0026373 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0026373 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0026373 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0026373 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0286723 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0028875 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0028531 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028916 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0015791 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0015791 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015791 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0015791 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0015546 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0028913 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0028913 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0028913 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028913 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0028913 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0028913 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0028913 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0040228 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0040228 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0040228 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0286027 Reactome mRNA Capping R-DME-72086 FBgn0286027 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0260446 Reactome Activation of G protein gated Potassium channels R-DME-1296041 FBgn0260446 Reactome G alpha (i) signalling events R-DME-418594 FBgn0260446 Reactome Class C/3 (Metabotropic glutamate/pheromone receptors) R-DME-420499 FBgn0260446 Reactome GABA B receptor activation R-DME-977444 FBgn0260446 Reactome Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-DME-997272 FBgn0004837 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0000317 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0010422 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0010422 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010422 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0010422 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0010422 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0010422 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0010422 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0024183 Reactome Platelet degranulation R-DME-114608 FBgn0028879 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0028879 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0028879 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0028516 Reactome Insulin processing R-DME-264876 FBgn0028516 Reactome Zinc efflux and compartmentalization by the SLC30 family R-DME-435368 FBgn0261268 Reactome Nuclear CI is degraded R-DME-216167 FBgn0261268 Reactome Degradation of DVL R-DME-4641258 FBgn0261268 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0261268 Reactome Neddylation R-DME-8951664 FBgn0261268 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0086691 Reactome Threonine catabolism R-DME-8849175 FBgn0028852 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0028370 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0010382 Reactome G0 and Early G1 R-DME-1538133 FBgn0010382 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0010382 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0010382 Reactome Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69200 FBgn0010382 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0028507 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0041627 Reactome Nonhomologous End-Joining (NHEJ) R-DME-5693571 FBgn0041627 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028935 Reactome Neutrophil degranulation R-DME-6798695 FBgn0041183 Reactome Platelet degranulation R-DME-114608 FBgn0024734 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0002673 Reactome Polo-like kinase mediated events R-DME-156711 FBgn0002673 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0002673 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0002673 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0002673 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0002673 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0002673 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0002673 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0002673 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0028897 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0040079 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0028375 Reactome Metabolism of vitamin K R-DME-6806664 FBgn0028894 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011708 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0011708 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0011708 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0011708 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0000339 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0000339 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0001086 Reactome Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-DME-141405 FBgn0001086 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0001086 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0001086 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0001086 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0001086 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0001086 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0001086 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0001086 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0001086 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0000250 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0000250 Reactome Downstream TCR signaling R-DME-202424 FBgn0000250 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0000250 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0000250 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0000250 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0000250 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0000250 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0000250 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0000250 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0025678 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0025678 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0032586 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0032593 Reactome TRP channels R-DME-3295583 FBgn0032593 Reactome Ion homeostasis R-DME-5578775 FBgn0032593 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0261278 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0261278 Reactome Presynaptic phase of homologous DNA pairing and strand exchange R-DME-5693616 FBgn0261278 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0261278 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0086907 Reactome Release of apoptotic factors from the mitochondria R-DME-111457 FBgn0086907 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0086907 Reactome Respiratory electron transport R-DME-611105 FBgn0284248 Reactome Release of apoptotic factors from the mitochondria R-DME-111457 FBgn0284248 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0284248 Reactome Respiratory electron transport R-DME-611105 FBgn0027779 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0027779 Reactome Insulin receptor recycling R-DME-77387 FBgn0027779 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0027779 Reactome Ion channel transport R-DME-983712 FBgn0032596 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0032596 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0032596 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0032596 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0032596 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0032596 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0032596 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0032596 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0032596 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0032596 Reactome Downstream TCR signaling R-DME-202424 FBgn0032596 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0032596 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0032596 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0032596 Reactome Nuclear CI is degraded R-DME-216167 FBgn0032596 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0032596 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0032596 Reactome Degradation of TIM R-DME-432395 FBgn0032596 Reactome Degradation of PER R-DME-432524 FBgn0032596 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0032596 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0032596 Reactome Degradation of AXIN R-DME-4641257 FBgn0032596 Reactome Degradation of DVL R-DME-4641258 FBgn0032596 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0032596 Reactome Degradation of CLK R-DME-538848 FBgn0032596 Reactome Degradation of CRY R-DME-538864 FBgn0032596 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0032596 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0032596 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0032596 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0032596 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0032596 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0032596 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0032596 Reactome UCH proteinases R-DME-5689603 FBgn0032596 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0032596 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0032596 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0032596 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0032596 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0032596 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0032596 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0032596 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0032596 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0032596 Reactome Neddylation R-DME-8951664 FBgn0032596 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0032596 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0015391 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0261068 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0261068 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0032634 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0032634 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0032634 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0032634 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0032634 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0032634 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0032634 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0032634 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0032634 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0032634 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0032634 Reactome mRNA Capping R-DME-72086 FBgn0032634 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0032634 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0032634 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0032634 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0032634 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0032634 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0032634 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0032634 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0032634 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0032634 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0011274 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0011274 Reactome RIP-mediated NFkB activation via ZBP1 R-DME-1810476 FBgn0011274 Reactome Downstream TCR signaling R-DME-202424 FBgn0011274 Reactome Transcriptional activtion by phosphorylated DL/DIF dimer R-DME-209400 FBgn0011274 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0011274 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0011274 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0011274 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0011274 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0011274 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0011274 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0011274 Reactome TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-DME-445989 FBgn0011274 Reactome SUMOylation of immune response proteins R-DME-4755510 FBgn0011274 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0011274 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0011274 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0011274 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0011274 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0011274 Reactome TRAF6 mediated NF-kB activation R-DME-933542 FBgn0260632 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0260632 Reactome RIP-mediated NFkB activation via ZBP1 R-DME-1810476 FBgn0260632 Reactome Downstream TCR signaling R-DME-202424 FBgn0260632 Reactome Transcriptional activtion by phosphorylated DL/DIF dimer R-DME-209400 FBgn0260632 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0260632 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0260632 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0260632 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0260632 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0260632 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0260632 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0260632 Reactome TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-DME-445989 FBgn0260632 Reactome SUMOylation of immune response proteins R-DME-4755510 FBgn0260632 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0260632 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0260632 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0260632 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0260632 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0260632 Reactome TRAF6 mediated NF-kB activation R-DME-933542 FBgn0000183 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0024689 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0024689 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0032642 Reactome Macroautophagy R-DME-1632852 FBgn0032642 Reactome mTOR signalling R-DME-165159 FBgn0032642 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0032642 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0032642 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0032642 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0032642 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032642 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0000120 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0000120 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0000120 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0000120 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0000120 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0000120 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0000120 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0000120 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0000120 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051741 Reactome Platelet degranulation R-DME-114608 FBgn0051741 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0051741 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051741 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0051741 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0001301 Reactome Neddylation R-DME-8951664 FBgn0001301 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0041184 Reactome Neddylation R-DME-8951664 FBgn0261804 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0261804 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0032677 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0032677 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0261597 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261597 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261597 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261597 Reactome Translation initiation complex formation R-DME-72649 FBgn0261597 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261597 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0261597 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0261597 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261597 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261597 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0086707 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0032683 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0032683 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0032683 Reactome Dermatan sulfate biosynthesis R-DME-2022923 FBgn0032683 Reactome CS/DS degradation R-DME-2024101 FBgn0085370 Reactome cGMP effects R-DME-418457 FBgn0032688 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0032690 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0032690 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0086909 Reactome Lysine catabolism R-DME-71064 FBgn0015553 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0032704 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0025608 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032715 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0032715 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0032715 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0032715 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032720 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0032720 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0032721 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0032721 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032721 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0032721 Reactome Biosynthesis of protectins R-DME-9018681 FBgn0032721 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0032721 Reactome Biosynthesis of aspirin-triggered D-series resolvins R-DME-9020265 FBgn0032721 Reactome Biosynthesis of E-series 18(R)-resolvins R-DME-9023661 FBgn0032725 Reactome UCH proteinases R-DME-5689603 FBgn0032725 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0032725 Reactome Neddylation R-DME-8951664 FBgn0032725 Reactome Iron uptake and transport R-DME-917937 FBgn0015772 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0015772 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0032729 Reactome Interconversion of 2-oxoglutarate and 2-hydroxyglutarate R-DME-880009 FBgn0051792 Reactome Platelet degranulation R-DME-114608 FBgn0051792 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0086442 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263198 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0261396 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0261396 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0261396 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0261396 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0261396 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0261396 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0261396 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0261396 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0261396 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0261396 Reactome Downstream TCR signaling R-DME-202424 FBgn0261396 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0261396 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0261396 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0261396 Reactome Nuclear CI is degraded R-DME-216167 FBgn0261396 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0261396 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0261396 Reactome Degradation of TIM R-DME-432395 FBgn0261396 Reactome Degradation of PER R-DME-432524 FBgn0261396 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0261396 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0261396 Reactome Degradation of AXIN R-DME-4641257 FBgn0261396 Reactome Degradation of DVL R-DME-4641258 FBgn0261396 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0261396 Reactome Degradation of CLK R-DME-538848 FBgn0261396 Reactome Degradation of CRY R-DME-538864 FBgn0261396 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0261396 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0261396 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0261396 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0261396 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0261396 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0261396 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0261396 Reactome UCH proteinases R-DME-5689603 FBgn0261396 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0261396 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261396 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0261396 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0261396 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0261396 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0261396 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0261396 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0261396 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0261396 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0261396 Reactome Neddylation R-DME-8951664 FBgn0261396 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0261396 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032749 Reactome Negative regulation of the PI3K/AKT network R-DME-199418 FBgn0000422 Reactome Catecholamine biosynthesis R-DME-209905 FBgn0000422 Reactome Serotonin and melatonin biosynthesis R-DME-209931 FBgn0086444 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0086446 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0086446 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0086446 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0032775 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0032775 Reactome Peroxisomal protein import R-DME-9033241 FBgn0041789 Reactome GAB1 signalosome R-DME-180292 FBgn0041789 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0032779 Reactome Synthesis of PA R-DME-1483166 FBgn0032779 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0032779 Reactome Digestion R-DME-8935690 FBgn0032782 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032782 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0032782 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0032783 Reactome Vitamin E R-DME-8877627 FBgn0284220 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0032785 Reactome Vitamin E R-DME-8877627 FBgn0032787 Reactome Peroxisomal lipid metabolism R-DME-390918 FBgn0032787 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032790 Reactome Peroxisomal lipid metabolism R-DME-390918 FBgn0032790 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032791 Reactome Peroxisomal lipid metabolism R-DME-390918 FBgn0032791 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032796 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0032796 Reactome Rho GTPase cycle R-DME-194840 FBgn0032796 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0032796 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0032796 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0032797 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032797 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0032797 Reactome Regulation of Complement cascade R-DME-977606 FBgn0041180 Reactome Platelet degranulation R-DME-114608 FBgn0032811 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0032812 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032813 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0032813 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0032813 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0032813 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0032813 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0032813 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0032813 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0032813 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0032813 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0032813 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0032813 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0032813 Reactome Polymerase switching R-DME-69091 FBgn0032813 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0032813 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0000464 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0000464 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0032820 Reactome Gluconeogenesis R-DME-70263 FBgn0032821 Reactome Rho GTPase cycle R-DME-194840 FBgn0014127 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0019686 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0019686 Reactome G2/M DNA damage checkpoint R-DME-69473 FBgn0019686 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0019686 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0003141 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0004374 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0032847 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0032847 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0032847 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0032847 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0032847 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0032847 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0032849 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0032849 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0015803 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0015803 Reactome Rho GTPase cycle R-DME-194840 FBgn0015803 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0015803 Reactome Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-DME-446388 FBgn0032857 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0032857 Reactome Protein methylation R-DME-8876725 FBgn0032859 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0032859 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0032859 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0032863 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0032863 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0032863 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0032863 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0032863 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0032863 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0032863 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0032863 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0032863 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0032863 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0032863 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0032863 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0032863 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0032864 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261787 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0261787 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0086657 Reactome Interleukin-37 signaling R-DME-9008059 FBgn0014859 Reactome AKT phosphorylates targets in the nucleus R-DME-198693 FBgn0014859 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0032879 Reactome Neurotransmitter clearance R-DME-112311 FBgn0032879 Reactome Norepinephrine Neurotransmitter Release Cycle R-DME-181430 FBgn0032879 Reactome Abacavir transmembrane transport R-DME-2161517 FBgn0032879 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0032879 Reactome Organic cation transport R-DME-549127 FBgn0262743 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0262743 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0262743 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032881 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0032881 Reactome Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-DME-193775 FBgn0032881 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0032881 Reactome Peroxisomal protein import R-DME-9033241 FBgn0032883 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0011202 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0011202 Reactome ERBB2 Regulates Cell Motility R-DME-6785631 FBgn0011202 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032901 Reactome TBC/RABGAPs R-DME-8854214 FBgn0032906 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0032906 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0032906 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0032906 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0032906 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0032906 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0032906 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0032906 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0032906 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0032906 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0032906 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0032906 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0032906 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0032906 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0032906 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0032907 Reactome Cleavage of the damaged pyrimidine R-DME-110329 FBgn0032907 Reactome Displacement of DNA glycosylase by APEX1 R-DME-110357 FBgn0032908 Reactome Platelet degranulation R-DME-114608 FBgn0032908 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0010395 Reactome Syndecan interactions R-DME-3000170 FBgn0032910 Reactome Estrogen biosynthesis R-DME-193144 FBgn0032910 Reactome Lipid particle organization R-DME-8964572 FBgn0284251 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0032916 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0032916 Reactome Neutrophil degranulation R-DME-6798695 FBgn0040297 Reactome Sodium/Proton exchangers R-DME-425986 FBgn0023388 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0023388 Reactome Rho GTPase cycle R-DME-194840 FBgn0023388 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0023388 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0023388 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0023388 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0032919 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0024371 Reactome G0 and Early G1 R-DME-1538133 FBgn0024371 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0024371 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0032921 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0032922 Reactome Ubiquinol biosynthesis R-DME-2142789 FBgn0032923 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0032923 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0263050 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0263050 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0032929 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0032929 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0026255 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0026255 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0032940 Reactome PKA-mediated phosphorylation of key metabolic factors R-DME-163358 FBgn0032940 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0032943 Reactome Platelet degranulation R-DME-114608 FBgn0032943 Reactome Neutrophil degranulation R-DME-6798695 FBgn0032945 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0032946 Reactome Basigin interactions R-DME-210991 FBgn0032946 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0032949 Reactome Platelet degranulation R-DME-114608 FBgn0032949 Reactome Neutrophil degranulation R-DME-6798695 FBgn0016919 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0032955 Reactome Synthesis of PC R-DME-1483191 FBgn0032955 Reactome Synthesis of PE R-DME-1483213 FBgn0023416 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0023416 Reactome PKA activation R-DME-163615 FBgn0023416 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0023416 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0023416 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0023416 Reactome G alpha (s) signalling events R-DME-418555 FBgn0023416 Reactome G alpha (z) signalling events R-DME-418597 FBgn0023416 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0023416 Reactome CREB phosphorylation through the activation of Adenylate Cyclase R-DME-442720 FBgn0023416 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0032956 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0032956 Reactome Neddylation R-DME-8951664 FBgn0032956 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0000559 Reactome Peptide chain elongation R-DME-156902 FBgn0000559 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0000559 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000559 Reactome Protein methylation R-DME-8876725 FBgn0051619 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0086779 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0003866 Reactome Transcriptional activation by YKI R-DME-390193 FBgn0032981 Reactome Digestion of dietary lipid R-DME-192456 FBgn0032981 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0032986 Reactome Complex I biogenesis R-DME-6799198 FBgn0032987 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0032987 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0032987 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0032987 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0032987 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0032987 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0032988 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0033005 Reactome Mitochondrial protein import R-DME-1268020 FBgn0026238 Reactome Neddylation R-DME-8951664 FBgn0026238 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033010 Reactome ATF6 (ATF6-alpha) activates chaperones R-DME-381033 FBgn0053554 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0053554 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0261403 Reactome HATs acetylate histones R-DME-3214847 FBgn0261403 Reactome UCH proteinases R-DME-5689603 FBgn0033019 Reactome UCH proteinases R-DME-5689603 FBgn0033019 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0050440 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0050440 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0050440 Reactome Rho GTPase cycle R-DME-194840 FBgn0050440 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0033029 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0259979 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0266580 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0266580 Reactome snRNP Assembly R-DME-191859 FBgn0266580 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0266580 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0266580 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0266580 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0266580 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0263855 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0263855 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0263855 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0263855 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0002774 Reactome RIP-mediated NFkB activation via ZBP1 R-DME-1810476 FBgn0002774 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0002774 Reactome TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-DME-445989 FBgn0002774 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0002774 Reactome TRAF6 mediated NF-kB activation R-DME-933542 FBgn0264959 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0264959 Reactome Neutrophil degranulation R-DME-6798695 FBgn0264959 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0033050 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0033052 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0033058 Reactome Peptide ligand-binding receptors R-DME-375276 FBgn0033058 Reactome G alpha (i) signalling events R-DME-418594 FBgn0033062 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0033062 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0000546 Reactome Recycling of bile acids and salts R-DME-159418 FBgn0000546 Reactome Vitamin D (calciferol) metabolism R-DME-196791 FBgn0000546 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0000546 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0000546 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0000546 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0033065 Reactome Miscellaneous substrates R-DME-211958 FBgn0033065 Reactome Eicosanoids R-DME-211979 FBgn0033065 Reactome Xenobiotics R-DME-211981 FBgn0033065 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033065 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033065 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033069 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0033069 Reactome Translation initiation complex formation R-DME-72649 FBgn0033069 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0033069 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0033069 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0033069 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0286511 Reactome Synthesis of PA R-DME-1483166 FBgn0286511 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0286511 Reactome Neutrophil degranulation R-DME-6798695 FBgn0086655 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0042085 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0033079 Reactome FMO oxidises nucleophiles R-DME-217271 FBgn0033086 Reactome Respiratory electron transport R-DME-611105 FBgn0033089 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033092 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0014009 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0033096 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0033097 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0000473 Reactome Miscellaneous substrates R-DME-211958 FBgn0000473 Reactome Eicosanoids R-DME-211979 FBgn0000473 Reactome Xenobiotics R-DME-211981 FBgn0000473 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0000473 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0000473 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0085421 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0085421 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0085421 Reactome Rap1 signalling R-DME-392517 FBgn0014028 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0027558 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0027558 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0015038 Reactome Miscellaneous substrates R-DME-211958 FBgn0015038 Reactome Eicosanoids R-DME-211979 FBgn0015038 Reactome Xenobiotics R-DME-211981 FBgn0015038 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0015038 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0015038 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0015039 Reactome Miscellaneous substrates R-DME-211958 FBgn0015039 Reactome Eicosanoids R-DME-211979 FBgn0015039 Reactome Xenobiotics R-DME-211981 FBgn0015039 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0015039 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0015039 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033155 Reactome Regulation of TP53 Activity through Acetylation R-DME-6804758 FBgn0000352 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0000352 Reactome Phosphorylation of CI R-DME-209190 FBgn0000352 Reactome Phosphorylation of SMO R-DME-209214 FBgn0000352 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0000352 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0000352 Reactome Activation of CI R-DME-216119 FBgn0000352 Reactome Activation of SMO R-DME-216217 FBgn0033160 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0283450 Reactome Pyruvate metabolism R-DME-70268 FBgn0033166 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0033166 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0033166 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0050502 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0025885 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0015929 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0015929 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0015929 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015929 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0015929 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0022772 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0022772 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0022772 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0022772 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0022772 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0022772 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0022772 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0264294 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0264294 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0033191 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0033192 Reactome Intrinsic Pathway of Fibrin Clot Formation R-DME-140837 FBgn0033192 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0033192 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0050499 Reactome Pentose phosphate pathway R-DME-71336 FBgn0033196 Reactome Iron uptake and transport R-DME-917937 FBgn0028687 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028687 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028687 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028687 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028687 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028687 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028687 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028687 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028687 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028687 Reactome Downstream TCR signaling R-DME-202424 FBgn0028687 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028687 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028687 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028687 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028687 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028687 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028687 Reactome Degradation of TIM R-DME-432395 FBgn0028687 Reactome Degradation of PER R-DME-432524 FBgn0028687 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028687 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028687 Reactome Degradation of AXIN R-DME-4641257 FBgn0028687 Reactome Degradation of DVL R-DME-4641258 FBgn0028687 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028687 Reactome Degradation of CLK R-DME-538848 FBgn0028687 Reactome Degradation of CRY R-DME-538864 FBgn0028687 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028687 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028687 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028687 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028687 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028687 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028687 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028687 Reactome UCH proteinases R-DME-5689603 FBgn0028687 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028687 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028687 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028687 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028687 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028687 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028687 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028687 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028687 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028687 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028687 Reactome Neddylation R-DME-8951664 FBgn0028687 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028687 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033206 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0033206 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0033206 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0033208 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0033208 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0033210 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033212 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0033214 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0033214 Reactome Arachidonic acid metabolism R-DME-2142753 FBgn0033214 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0033214 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0033214 Reactome Wax biosynthesis R-DME-8848584 FBgn0033215 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0033215 Reactome Arachidonic acid metabolism R-DME-2142753 FBgn0033215 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0033215 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0033215 Reactome Wax biosynthesis R-DME-8848584 FBgn0033216 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0033216 Reactome Arachidonic acid metabolism R-DME-2142753 FBgn0033216 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0033216 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0033216 Reactome Wax biosynthesis R-DME-8848584 FBgn0000337 Reactome Tryptophan catabolism R-DME-71240 FBgn0033226 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0085390 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0015509 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0015509 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0015509 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0015509 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0015509 Reactome Downstream TCR signaling R-DME-202424 FBgn0015509 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0015509 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0015509 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0015509 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0015509 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0015509 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0015509 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0015509 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0015509 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015509 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0015509 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0015509 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0015509 Reactome Neddylation R-DME-8951664 FBgn0015509 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0015509 Reactome Iron uptake and transport R-DME-917937 FBgn0015509 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033233 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0033233 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0033235 Reactome Processing of SMDT1 R-DME-8949664 FBgn0033241 Reactome Regulation of Complement cascade R-DME-977606 FBgn0027054 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0027054 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0027054 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027054 Reactome Neddylation R-DME-8951664 FBgn0033246 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0033246 Reactome Biotin transport and metabolism R-DME-196780 FBgn0033246 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0033246 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0033247 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0033247 Reactome snRNP Assembly R-DME-191859 FBgn0033247 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0033247 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0033247 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0033247 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0033247 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033248 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0033248 Reactome Organic anion transporters R-DME-428643 FBgn0033248 Reactome Gluconeogenesis R-DME-70263 FBgn0013307 Reactome Agmatine biosynthesis R-DME-351143 FBgn0013307 Reactome Metabolism of polyamines R-DME-351202 FBgn0013308 Reactome Agmatine biosynthesis R-DME-351143 FBgn0013308 Reactome Metabolism of polyamines R-DME-351202 FBgn0033250 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0033250 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0033250 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0025469 Reactome Cellular hexose transport R-DME-189200 FBgn0028563 Reactome Cellular hexose transport R-DME-189200 FBgn0028563 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028563 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0033257 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0033257 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0033259 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033260 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0033260 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0033260 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0033260 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0033260 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0033260 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0033260 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0033260 Reactome Neddylation R-DME-8951664 FBgn0050372 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0033264 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0033264 Reactome snRNP Assembly R-DME-191859 FBgn0033264 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0033264 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0033264 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0033264 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0033264 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033266 Reactome Neddylation R-DME-8951664 FBgn0260398 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0005648 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0005648 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0005648 Reactome mRNA 3'-end processing R-DME-72187 FBgn0005648 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0263593 Reactome Synthesis of PC R-DME-1483191 FBgn0263593 Reactome Synthesis of PE R-DME-1483213 FBgn0263593 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0263593 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0033271 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0033272 Reactome Macroautophagy R-DME-1632852 FBgn0033272 Reactome mTOR signalling R-DME-165159 FBgn0033272 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0033272 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0033272 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0033272 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0011659 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0028836 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0028836 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0028836 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0028836 Reactome Neddylation R-DME-8951664 FBgn0002570 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0002569 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0002571 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0033294 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0050359 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0033296 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0033297 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0033304 Reactome Miscellaneous substrates R-DME-211958 FBgn0033304 Reactome Eicosanoids R-DME-211979 FBgn0033304 Reactome Xenobiotics R-DME-211981 FBgn0033304 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033304 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033304 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0022027 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0033315 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0033315 Reactome O-linked glycosylation R-DME-5173105 FBgn0033316 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0003892 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0003892 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0003892 Reactome Ligand-receptor interactions R-DME-5632681 FBgn0003892 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0033323 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0033323 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0033324 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0033324 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0043576 Reactome Neutrophil degranulation R-DME-6798695 FBgn0043576 Reactome Antimicrobial peptides R-DME-6803157 FBgn0033326 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0033326 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0033327 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033327 Reactome Antimicrobial peptides R-DME-6803157 FBgn0043575 Reactome Neutrophil degranulation R-DME-6798695 FBgn0043575 Reactome Antimicrobial peptides R-DME-6803157 FBgn0033339 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0284436 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0284436 Reactome Neutrophil degranulation R-DME-6798695 FBgn0284436 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0050349 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0003074 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0003074 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003074 Reactome Glycolysis R-DME-70171 FBgn0003074 Reactome Gluconeogenesis R-DME-70263 FBgn0033352 Reactome Deadenylation of mRNA R-DME-429947 FBgn0033354 Reactome Fanconi Anemia Pathway R-DME-6783310 FBgn0011300 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0011300 Reactome TGF-beta receptor signaling activates SMADs R-DME-2173789 FBgn0011300 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0025709 Reactome Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-DME-83936 FBgn0033371 Reactome Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-DME-83936 FBgn0010220 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0033373 Reactome Nicotinate metabolism R-DME-196807 FBgn0033376 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0033377 Reactome Glycogen synthesis R-DME-3322077 FBgn0033377 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033377 Reactome Glycolysis R-DME-70171 FBgn0033377 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0033377 Reactome Galactose catabolism R-DME-70370 FBgn0033377 Reactome Pentose phosphate pathway R-DME-71336 FBgn0033378 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0033378 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0033378 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033378 Reactome mRNA 3'-end processing R-DME-72187 FBgn0033378 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0033380 Reactome snRNP Assembly R-DME-191859 FBgn0033380 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0003612 Reactome Vitamin D (calciferol) metabolism R-DME-196791 FBgn0003612 Reactome Transcriptional repression by nuclear factors R-DME-210671 FBgn0003612 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0003612 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0003612 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0003612 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0003612 Reactome SUMOylation of immune response proteins R-DME-4755510 FBgn0003612 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0003612 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0027561 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0033382 Reactome Synthesis of PC R-DME-1483191 FBgn0260972 Reactome Macroautophagy R-DME-1632852 FBgn0260972 Reactome AMPK inhibits chREBP transcriptional activation activity R-DME-163680 FBgn0260972 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0260972 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0260972 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0086656 Reactome Macroautophagy R-DME-1632852 FBgn0086656 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0050342 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015477 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002567 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0002567 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0033391 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0262515 Reactome Insulin receptor recycling R-DME-77387 FBgn0262515 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0262515 Reactome Ion channel transport R-DME-983712 FBgn0020621 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0020621 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0033401 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0033401 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0033402 Reactome RIP-mediated NFkB activation via ZBP1 R-DME-1810476 FBgn0033402 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0033402 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0033402 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0033402 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0033402 Reactome Adaptor protein complex binds to TL receptor at the plasma membrane R-DME-214863 FBgn0033402 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0033402 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0033402 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0033402 Reactome TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-DME-445989 FBgn0033402 Reactome TRAF6 mediated NF-kB activation R-DME-933542 FBgn0033402 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0033402 Reactome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-DME-975138 FBgn0033402 Reactome MyD88 dependent cascade initiated on endosome R-DME-975155 FBgn0016078 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0033413 Reactome TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-DME-6803204 FBgn0017558 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0017558 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0004360 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0033423 Reactome Synthesis of PA R-DME-1483166 FBgn0033423 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0033423 Reactome Digestion R-DME-8935690 FBgn0033428 Reactome Heme biosynthesis R-DME-189451 FBgn0285949 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0285949 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0285949 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0285949 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0285949 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0285949 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0033431 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033434 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0033434 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0033434 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0050000 Reactome Glutathione conjugation R-DME-156590 FBgn0033437 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0033437 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0033437 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0033438 Reactome Collagen degradation R-DME-1442490 FBgn0033438 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0033438 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0033438 Reactome Assembly of collagen fibrils and other multimeric structures R-DME-2022090 FBgn0033438 Reactome Basigin interactions R-DME-210991 FBgn0033438 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0033438 Reactome Neutrophil degranulation R-DME-6798695 FBgn0023143 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0023143 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0023143 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033440 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0259678 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0259678 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0005614 Reactome TRP channels R-DME-3295583 FBgn0005614 Reactome Ion homeostasis R-DME-5578775 FBgn0005614 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0027589 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0027589 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0033451 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0266186 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0266186 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0266186 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0266186 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0023180 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0023180 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0023180 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0023180 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0023180 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0023180 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0023180 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0023175 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0023175 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0023175 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0023175 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0023175 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0023175 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0023175 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0023175 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0023175 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0023175 Reactome Downstream TCR signaling R-DME-202424 FBgn0023175 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0023175 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0023175 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0023175 Reactome Nuclear CI is degraded R-DME-216167 FBgn0023175 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0023175 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0023175 Reactome Degradation of TIM R-DME-432395 FBgn0023175 Reactome Degradation of PER R-DME-432524 FBgn0023175 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0023175 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0023175 Reactome Degradation of AXIN R-DME-4641257 FBgn0023175 Reactome Degradation of DVL R-DME-4641258 FBgn0023175 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0023175 Reactome Degradation of CLK R-DME-538848 FBgn0023175 Reactome Degradation of CRY R-DME-538864 FBgn0023175 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0023175 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0023175 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0023175 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0023175 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0023175 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0023175 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0023175 Reactome UCH proteinases R-DME-5689603 FBgn0023175 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0023175 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0023175 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0023175 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0023175 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0023175 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0023175 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0023175 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0023175 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0023175 Reactome Neddylation R-DME-8951664 FBgn0023175 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0023175 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033454 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0027580 Reactome Biotin transport and metabolism R-DME-196780 FBgn0027580 Reactome Gluconeogenesis R-DME-70263 FBgn0033460 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0033460 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0033460 Reactome Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-DME-983170 FBgn0033463 Reactome Synthesis of bile acids and bile salts R-DME-192105 FBgn0033464 Reactome Wax biosynthesis R-DME-8848584 FBgn0033465 Reactome Respiratory electron transport R-DME-611105 FBgn0011656 Reactome CDO in myogenesis R-DME-375170 FBgn0027619 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0027619 Reactome Translation initiation complex formation R-DME-72649 FBgn0027619 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0027619 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0027619 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0027619 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261014 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0261014 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0261014 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0261014 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0261014 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0261014 Reactome Neutrophil degranulation R-DME-6798695 FBgn0022382 Reactome PKA activation R-DME-163615 FBgn0022382 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0022382 Reactome DARPP-32 events R-DME-180024 FBgn0022382 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0022382 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0022382 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0033476 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0033476 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0033476 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0033479 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0028560 Reactome Cellular hexose transport R-DME-189200 FBgn0028560 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0028560 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0001291 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0001291 Reactome Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209409 FBgn0001291 Reactome Transcriptional activtion by AP-1 transcription factor R-DME-209425 FBgn0001291 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0001291 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0001291 Reactome Activation of the AP-1 family of transcription factors R-DME-450341 FBgn0004907 Reactome Translocation of SLC2A4 (GLUT4) to the plasma membrane R-DME-1445148 FBgn0004907 Reactome mTOR signalling R-DME-165159 FBgn0004907 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0004907 Reactome Signaling by Hippo R-DME-2028269 FBgn0004907 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0004907 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0004907 Reactome Rap1 signalling R-DME-392517 FBgn0004907 Reactome GP1b-IX-V activation signalling R-DME-430116 FBgn0004907 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0004907 Reactome KSRP (KHSRP) binds and destabilizes mRNA R-DME-450604 FBgn0004907 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0004907 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0004907 Reactome RAF activation R-DME-5673000 FBgn0004907 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0004907 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0004907 Reactome TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-DME-6804114 FBgn0004907 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0004907 Reactome NOTCH4 Activation and Transmission of Signal to the Nucleus R-DME-9013700 FBgn0003071 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003071 Reactome Glycolysis R-DME-70171 FBgn0033494 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0000448 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0000448 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0005619 Reactome Histidine catabolism R-DME-70921 FBgn0033500 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0003660 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0003660 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0003660 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0003660 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0003660 Reactome Other interleukin signaling R-DME-449836 FBgn0003660 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0003660 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0003660 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0033504 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0262114 Reactome L1CAM interactions R-DME-373760 FBgn0001122 Reactome PLC beta mediated events R-DME-112043 FBgn0001122 Reactome G-protein activation R-DME-202040 FBgn0033527 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261862 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0261862 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0033528 Reactome Small interfering RNA (siRNA) biogenesis R-DME-426486 FBgn0033529 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0033529 Reactome Reduction of cytosolic Ca++ levels R-DME-418359 FBgn0033529 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0033529 Reactome Ion homeostasis R-DME-5578775 FBgn0033529 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033529 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0033539 Reactome Ephrin signaling R-DME-3928664 FBgn0024836 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0024836 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0024836 Reactome Homo-/heterophilic binding of transmembrane components R-DME-350379 FBgn0024836 Reactome Formation and asymmetric localisation of transmembrane complexes R-DME-350411 FBgn0024836 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0005586 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0033543 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0033543 Reactome Peroxisomal protein import R-DME-9033241 FBgn0033544 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0033544 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0024956 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0024956 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0024956 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0024956 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0024956 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0024956 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0024956 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0024956 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0024956 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0024956 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0024956 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0024956 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0024956 Reactome mRNA Capping R-DME-72086 FBgn0024956 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0024956 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0024956 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0024956 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0024956 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0024956 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0024956 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0053144 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0027499 Reactome PKMTs methylate histone lysines R-DME-3214841 FBgn0033549 Reactome Resolution of D-loop Structures through Holliday Junction Intermediates R-DME-5693568 FBgn0086898 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0086898 Reactome Negative feedback loop regulates asymmetric localisation R-DME-350369 FBgn0086898 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0086898 Reactome Formation and asymmetric localisation of transmembrane complexes R-DME-350411 FBgn0086898 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0033556 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033557 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0027525 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0033566 Reactome UCH proteinases R-DME-5689603 FBgn0033566 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0033570 Reactome Respiratory electron transport R-DME-611105 FBgn0033570 Reactome Complex I biogenesis R-DME-6799198 FBgn0033571 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0033571 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0033571 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033571 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0033571 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0033571 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0033571 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0033571 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0033571 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0033571 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0033571 Reactome mRNA Capping R-DME-72086 FBgn0033571 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033571 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0033571 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0033571 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0033571 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0033571 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0033571 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0033571 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0033571 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0033571 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0033571 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0033599 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0033599 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0033605 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0033605 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0033607 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0033607 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0015582 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0015582 Reactome Endogenous sterols R-DME-211976 FBgn0015582 Reactome Electron transport from NADPH to Ferredoxin R-DME-2395516 FBgn0025373 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0033629 Reactome Platelet degranulation R-DME-114608 FBgn0033629 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033631 Reactome Platelet degranulation R-DME-114608 FBgn0033631 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0050022 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0000581 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0033639 Reactome Neddylation R-DME-8951664 FBgn0033639 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0044020 Reactome Neddylation R-DME-8951664 FBgn0044020 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0050035 Reactome Cellular hexose transport R-DME-189200 FBgn0050035 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0050035 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0033644 Reactome Cellular hexose transport R-DME-189200 FBgn0033644 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0033644 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0010516 Reactome Respiratory electron transport R-DME-611105 FBgn0033656 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0033656 Reactome ATF6 (ATF6-alpha) activates chaperones R-DME-381033 FBgn0013756 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0013756 Reactome snRNP Assembly R-DME-191859 FBgn0013756 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0013756 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0013756 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0013756 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0013756 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033663 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0284245 Reactome HSF1 activation R-DME-3371511 FBgn0284245 Reactome Neutrophil degranulation R-DME-6798695 FBgn0284245 Reactome Protein methylation R-DME-8876725 FBgn0033669 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0033669 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0033669 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0033669 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0033669 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0033669 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0033669 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0033669 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0033669 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0033669 Reactome Downstream TCR signaling R-DME-202424 FBgn0033669 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0033669 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0033669 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0033669 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0033669 Reactome Degradation of AXIN R-DME-4641257 FBgn0033669 Reactome Degradation of DVL R-DME-4641258 FBgn0033669 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0033669 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0033669 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0033669 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0033669 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0033669 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0033669 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0033669 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0033669 Reactome UCH proteinases R-DME-5689603 FBgn0033669 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0033669 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0033669 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0033669 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0033669 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0033669 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0033669 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0033669 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0033669 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0033669 Reactome Neddylation R-DME-8951664 FBgn0033669 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0033669 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033672 Reactome Processing of SMDT1 R-DME-8949664 FBgn0033673 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0260012 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0260012 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0260012 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0033679 Reactome Utilization of Ketone Bodies R-DME-77108 FBgn0033679 Reactome Synthesis of Ketone Bodies R-DME-77111 FBgn0026176 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0026176 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0026176 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0026176 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026176 Reactome Downstream TCR signaling R-DME-202424 FBgn0026176 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0026176 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0026176 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0026176 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0026176 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0026176 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0026176 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0026176 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0026176 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0026176 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0026176 Reactome Neddylation R-DME-8951664 FBgn0026176 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0026176 Reactome Iron uptake and transport R-DME-917937 FBgn0026176 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0027504 Reactome ERKs are inactivated R-DME-202670 FBgn0033688 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033688 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0023167 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0023167 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0010621 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0010621 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0000426 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0000426 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0025454 Reactome Miscellaneous substrates R-DME-211958 FBgn0025454 Reactome Eicosanoids R-DME-211979 FBgn0025454 Reactome Xenobiotics R-DME-211981 FBgn0025454 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0025454 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0025454 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033696 Reactome Miscellaneous substrates R-DME-211958 FBgn0033696 Reactome Eicosanoids R-DME-211979 FBgn0033696 Reactome Xenobiotics R-DME-211981 FBgn0033696 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033696 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033696 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033699 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0033699 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0033699 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0033699 Reactome Translation initiation complex formation R-DME-72649 FBgn0033699 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0033699 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0033699 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0033699 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0033699 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0033699 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0033706 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0033706 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033706 Reactome Insulin receptor recycling R-DME-77387 FBgn0033706 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0033706 Reactome Ion channel transport R-DME-983712 FBgn0033710 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0050046 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0264560 Reactome Clathrin derived vesicle budding R-DME-421837 FBgn0264560 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0033716 Reactome UCH proteinases R-DME-5689603 FBgn0033716 Reactome Neddylation R-DME-8951664 FBgn0033717 Reactome Arachidonic acid metabolism R-DME-2142753 FBgn0033735 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033735 Reactome Pentose phosphate pathway R-DME-71336 FBgn0033737 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0033737 Reactome snRNP Assembly R-DME-191859 FBgn0033737 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0033737 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0033737 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0033737 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0033737 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033748 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0033749 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0011592 Reactome Netrin-1 signaling R-DME-373752 FBgn0011592 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0011592 Reactome Caspase activation via Dependence Receptors in the absence of ligand R-DME-418889 FBgn0033754 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0033755 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0022764 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0022764 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0027356 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0004435 Reactome G alpha (q) signalling events R-DME-416476 FBgn0004435 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0004435 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0033756 Reactome G alpha (q) signalling events R-DME-416476 FBgn0033756 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0033756 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0028683 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0028683 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0028683 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0028683 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0028683 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0033761 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0033763 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0033763 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0033763 Reactome CS/DS degradation R-DME-2024101 FBgn0033763 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261673 Reactome Iron uptake and transport R-DME-917937 FBgn0261625 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0261625 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0261625 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0033766 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0033766 Reactome snRNP Assembly R-DME-191859 FBgn0033766 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0033766 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0033766 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0033766 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0033766 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0026619 Reactome Mitochondrial protein import R-DME-1268020 FBgn0026619 Reactome Acyl chain remodeling of CL R-DME-1482798 FBgn0026741 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0026741 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0020930 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0033774 Reactome Regulation of Complement cascade R-DME-977606 FBgn0003326 Reactome Platelet degranulation R-DME-114608 FBgn0003326 Reactome Common Pathway of Fibrin Clot Formation R-DME-140875 FBgn0003326 Reactome Integrin cell surface interactions R-DME-216083 FBgn0003326 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0003326 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0003326 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0003326 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0003326 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0003326 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0033775 Reactome Miscellaneous substrates R-DME-211958 FBgn0033775 Reactome Eicosanoids R-DME-211979 FBgn0033775 Reactome Xenobiotics R-DME-211981 FBgn0033775 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033775 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033775 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033778 Reactome Neurotransmitter clearance R-DME-112311 FBgn0033778 Reactome Norepinephrine Neurotransmitter Release Cycle R-DME-181430 FBgn0033778 Reactome Abacavir transmembrane transport R-DME-2161517 FBgn0033778 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0033778 Reactome Organic cation transport R-DME-549127 FBgn0033783 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033784 Reactome Neddylation R-DME-8951664 FBgn0004512 Reactome Recycling of bile acids and salts R-DME-159418 FBgn0004512 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0004512 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0005624 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0005624 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0005624 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0005624 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0005624 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0005624 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0005624 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0259876 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0020370 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0005654 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0005654 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0005654 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0005654 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0005654 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0005654 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0005654 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0033809 Reactome Organic cation transport R-DME-549127 FBgn0011763 Reactome G0 and Early G1 R-DME-1538133 FBgn0011763 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0011763 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0011763 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0033812 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0033812 Reactome Peroxisomal protein import R-DME-9033241 FBgn0033814 Reactome Platelet degranulation R-DME-114608 FBgn0033814 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0033814 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033814 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0033816 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0033816 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0033830 Reactome Carnitine synthesis R-DME-71262 FBgn0033836 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0033836 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0033836 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259221 Reactome Neutrophil degranulation R-DME-6798695 FBgn0259221 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0086757 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0033842 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0033842 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0033842 Reactome mRNA 3'-end processing R-DME-72187 FBgn0033842 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0033844 Reactome Synthesis of PC R-DME-1483191 FBgn0033844 Reactome Synthesis of PE R-DME-1483213 FBgn0004638 Reactome PI3K Cascade R-DME-109704 FBgn0004638 Reactome SOS-mediated signalling R-DME-112412 FBgn0004638 Reactome SHC1 events in ERBB4 signaling R-DME-1250347 FBgn0004638 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0004638 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0004638 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0004638 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0004638 Reactome Signalling to RAS R-DME-167044 FBgn0004638 Reactome GRB2 events in EGFR signaling R-DME-179812 FBgn0004638 Reactome GAB1 signalosome R-DME-180292 FBgn0004638 Reactome SHC1 events in EGFR signaling R-DME-180336 FBgn0004638 Reactome EGFR downregulation R-DME-182971 FBgn0004638 Reactome GRB2 events in ERBB2 signaling R-DME-1963640 FBgn0004638 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0004638 Reactome Tie2 Signaling R-DME-210993 FBgn0004638 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0004638 Reactome DAP12 signaling R-DME-2424491 FBgn0004638 Reactome SHC-related events triggered by IGF1R R-DME-2428933 FBgn0004638 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0004638 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0004638 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0004638 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0004638 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0004638 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0004638 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0004638 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0004638 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0004638 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0004638 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0004638 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0004638 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0004638 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0004638 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0004638 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0004638 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0004638 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0004638 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0004638 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0004638 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0004638 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0004638 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0004638 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0004638 Reactome Signal attenuation R-DME-74749 FBgn0004638 Reactome Insulin receptor signalling cascade R-DME-74751 FBgn0004638 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0004638 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0004638 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0004638 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0004638 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0033846 Reactome G0 and Early G1 R-DME-1538133 FBgn0033853 Reactome Nicotinate metabolism R-DME-196807 FBgn0053156 Reactome Nicotinate metabolism R-DME-196807 FBgn0033856 Reactome Pyruvate metabolism R-DME-70268 FBgn0027581 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0027581 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0033859 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0033859 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0033859 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0033859 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0000662 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0033876 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033879 Reactome Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-DME-77310 FBgn0033879 Reactome Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-DME-77346 FBgn0033879 Reactome Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-DME-77348 FBgn0033879 Reactome Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-DME-77350 FBgn0033879 Reactome Beta oxidation of butanoyl-CoA to acetyl-CoA R-DME-77352 FBgn0086356 Reactome Rho GTPase cycle R-DME-194840 FBgn0086356 Reactome Kinesins R-DME-983189 FBgn0263697 Reactome Neddylation R-DME-8951664 FBgn0263697 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0033883 Reactome Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-DME-77346 FBgn0033884 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0262739 Reactome MicroRNA (miRNA) biogenesis R-DME-203927 FBgn0262739 Reactome Small interfering RNA (siRNA) biogenesis R-DME-426486 FBgn0262739 Reactome Post-transcriptional silencing by small RNAs R-DME-426496 FBgn0262739 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0033886 Reactome UCH proteinases R-DME-5689603 FBgn0033886 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0013770 Reactome Collagen degradation R-DME-1442490 FBgn0013770 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0013770 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0013770 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0013770 Reactome Assembly of collagen fibrils and other multimeric structures R-DME-2022090 FBgn0013770 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0013770 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033887 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0033891 Reactome Complex I biogenesis R-DME-6799198 FBgn0020620 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0033897 Reactome HATs acetylate histones R-DME-3214847 FBgn0033902 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0033902 Reactome Translation initiation complex formation R-DME-72649 FBgn0033902 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0033902 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0033902 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0033902 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0033907 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0033907 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0033911 Reactome Transport of inorganic cations/anions and amino acids/oligopeptides R-DME-425393 FBgn0033911 Reactome GABA synthesis, release, reuptake and degradation R-DME-888590 FBgn0005613 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0033912 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0033912 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0033912 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0033912 Reactome Translation initiation complex formation R-DME-72649 FBgn0033912 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0033912 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0033912 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0033912 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0033912 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0033912 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0033916 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0033916 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0010241 Reactome Recycling of bile acids and salts R-DME-159418 FBgn0010241 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0010241 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0001220 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0261270 Reactome Selenocysteine synthesis R-DME-2408557 FBgn0263397 Reactome HCN channels R-DME-1296061 FBgn0033929 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0033929 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0033929 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0033929 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0033929 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0033929 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0033929 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0033929 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0033929 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0033929 Reactome mRNA Capping R-DME-72086 FBgn0033929 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0033929 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0033929 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0033929 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0033929 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0033929 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0033933 Reactome Collagen degradation R-DME-1442490 FBgn0033933 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0033933 Reactome Surfactant metabolism R-DME-5683826 FBgn0033933 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033935 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0033935 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0033935 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0261823 Reactome UCH proteinases R-DME-5689603 FBgn0265974 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0010397 Reactome Breakdown of the nuclear lamina R-DME-352238 FBgn0010397 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0019938 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0003742 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003742 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0033949 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0033952 Reactome Surfactant metabolism R-DME-5683826 FBgn0033952 Reactome Neutrophil degranulation R-DME-6798695 FBgn0020269 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0028689 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028689 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028689 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028689 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028689 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028689 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028689 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028689 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028689 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028689 Reactome Downstream TCR signaling R-DME-202424 FBgn0028689 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028689 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028689 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028689 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028689 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028689 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028689 Reactome Degradation of TIM R-DME-432395 FBgn0028689 Reactome Degradation of PER R-DME-432524 FBgn0028689 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028689 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028689 Reactome Degradation of AXIN R-DME-4641257 FBgn0028689 Reactome Degradation of DVL R-DME-4641258 FBgn0028689 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028689 Reactome Degradation of CLK R-DME-538848 FBgn0028689 Reactome Degradation of CRY R-DME-538864 FBgn0028689 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028689 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028689 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028689 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028689 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028689 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028689 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028689 Reactome UCH proteinases R-DME-5689603 FBgn0028689 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028689 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028689 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028689 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028689 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028689 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028689 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028689 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028689 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028689 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028689 Reactome Neddylation R-DME-8951664 FBgn0028689 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028689 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0266723 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0266723 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0020767 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0020767 Reactome FGFRL1 modulation of FGFR1 signaling R-DME-5658623 FBgn0033969 Reactome Glycogen synthesis R-DME-3322077 FBgn0033969 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033969 Reactome Glycolysis R-DME-70171 FBgn0033969 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0033969 Reactome Galactose catabolism R-DME-70370 FBgn0033969 Reactome Pentose phosphate pathway R-DME-71336 FBgn0027783 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0028434 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0028434 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0028434 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0033973 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0264962 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0264962 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0264962 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0264962 Reactome mRNA 3'-end processing R-DME-72187 FBgn0264962 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0033978 Reactome Miscellaneous substrates R-DME-211958 FBgn0033978 Reactome Eicosanoids R-DME-211979 FBgn0033978 Reactome Xenobiotics R-DME-211981 FBgn0033978 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033978 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033978 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033979 Reactome Miscellaneous substrates R-DME-211958 FBgn0033979 Reactome Eicosanoids R-DME-211979 FBgn0033979 Reactome Xenobiotics R-DME-211981 FBgn0033979 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033979 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033979 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0013771 Reactome Miscellaneous substrates R-DME-211958 FBgn0013771 Reactome Eicosanoids R-DME-211979 FBgn0013771 Reactome Xenobiotics R-DME-211981 FBgn0013771 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0013771 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0013771 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033981 Reactome Miscellaneous substrates R-DME-211958 FBgn0033981 Reactome Eicosanoids R-DME-211979 FBgn0033981 Reactome Xenobiotics R-DME-211981 FBgn0033981 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0033981 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0033981 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0013772 Reactome Miscellaneous substrates R-DME-211958 FBgn0013772 Reactome Eicosanoids R-DME-211979 FBgn0013772 Reactome Xenobiotics R-DME-211981 FBgn0013772 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0013772 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0013772 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0033983 Reactome Plasmalogen biosynthesis R-DME-75896 FBgn0033983 Reactome Peroxisomal protein import R-DME-9033241 FBgn0033984 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0033984 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0033984 Reactome Neutrophil degranulation R-DME-6798695 FBgn0033984 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0033999 Reactome Digestion of dietary lipid R-DME-192456 FBgn0033999 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0034001 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034001 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0003328 Reactome Integrin cell surface interactions R-DME-216083 FBgn0003328 Reactome Syndecan interactions R-DME-3000170 FBgn0003328 Reactome ECM proteoglycans R-DME-3000178 FBgn0003328 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0003328 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034005 Reactome Integrin cell surface interactions R-DME-216083 FBgn0034005 Reactome Syndecan interactions R-DME-3000170 FBgn0034005 Reactome ECM proteoglycans R-DME-3000178 FBgn0034005 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0034005 Reactome Neutrophil degranulation R-DME-6798695 FBgn0265194 Reactome TRP channels R-DME-3295583 FBgn0265194 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034007 Reactome Respiratory electron transport R-DME-611105 FBgn0034007 Reactome Complex I biogenesis R-DME-6799198 FBgn0004698 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0004698 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0034009 Reactome TBC/RABGAPs R-DME-8854214 FBgn0013750 Reactome TBC/RABGAPs R-DME-8854214 FBgn0034012 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0011660 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0034029 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0024754 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0034045 Reactome Cellular hexose transport R-DME-189200 FBgn0034045 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0034045 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0264089 Reactome Signaling by ROBO receptors R-DME-376176 FBgn0264089 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0264089 Reactome Role of ABL in ROBO-SLIT signaling R-DME-428890 FBgn0264089 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0015247 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0015247 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0015247 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0015247 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0015247 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0015247 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0265045 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0265045 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0020236 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0020236 Reactome Neutrophil degranulation R-DME-6798695 FBgn0020236 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0034065 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0034065 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0034065 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034072 Reactome ECM proteoglycans R-DME-3000178 FBgn0034072 Reactome O-linked glycosylation R-DME-5173105 FBgn0034072 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0034073 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0014020 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0014020 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0014020 Reactome Rho GTPase cycle R-DME-194840 FBgn0014020 Reactome PI3K/AKT activation R-DME-198203 FBgn0014020 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0014020 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0014020 Reactome RHO1 GTPase cycle R-DME-350407 FBgn0014020 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0014020 Reactome G beta:gamma signalling through PI3Kgamma R-DME-392451 FBgn0014020 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0014020 Reactome EPHA-mediated growth cone collapse R-DME-3928663 FBgn0014020 Reactome PCP/CE pathway R-DME-4086400 FBgn0014020 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0014020 Reactome Sema4D induced cell migration and growth-cone collapse R-DME-416572 FBgn0014020 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0014020 Reactome Inhibition of actin polymerisation R-DME-450728 FBgn0014020 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0014020 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0014020 Reactome RHO GTPases Activate ROCKs R-DME-5627117 FBgn0014020 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0014020 Reactome RHO GTPases Activate Rhotekin and Rhophilins R-DME-5666185 FBgn0014020 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0014020 Reactome ERBB2 Regulates Cell Motility R-DME-6785631 FBgn0014020 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014020 Reactome PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-8849471 FBgn0001124 Reactome Gluconeogenesis R-DME-70263 FBgn0001124 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0015754 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0262166 Reactome UCH proteinases R-DME-5689603 FBgn0265178 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0034091 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0034092 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034092 Reactome Antimicrobial peptides R-DME-6803157 FBgn0261612 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0261612 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0261612 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0015925 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0001308 Reactome Kinesins R-DME-983189 FBgn0034105 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0034109 Reactome Basigin interactions R-DME-210991 FBgn0034110 Reactome Macroautophagy R-DME-1632852 FBgn0262511 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0262511 Reactome Insulin receptor recycling R-DME-77387 FBgn0262511 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0262511 Reactome Ion channel transport R-DME-983712 FBgn0034117 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0034117 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034118 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034118 Reactome snRNP Assembly R-DME-191859 FBgn0034118 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0034118 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0034118 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0034118 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0034118 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0262560 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034127 Reactome Pyruvate metabolism R-DME-70268 FBgn0034127 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0034138 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034138 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0034138 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034138 Reactome Translation initiation complex formation R-DME-72649 FBgn0034138 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034138 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0034138 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0034138 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034138 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0034138 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0016131 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0016131 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0016131 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0016131 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0016131 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0003274 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0003274 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0003274 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0003274 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003274 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0003274 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034141 Reactome Synthesis of Dolichyl-phosphate R-DME-446199 FBgn0034142 Reactome Wax biosynthesis R-DME-8848584 FBgn0034143 Reactome Wax biosynthesis R-DME-8848584 FBgn0034145 Reactome Wax biosynthesis R-DME-8848584 FBgn0020506 Reactome Digestion of dietary carbohydrate R-DME-189085 FBgn0034156 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0034156 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0010213 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0034160 Reactome Platelet degranulation R-DME-114608 FBgn0034160 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0034160 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0034160 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0034160 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0034160 Reactome Integrin cell surface interactions R-DME-216083 FBgn0034160 Reactome Syndecan interactions R-DME-3000170 FBgn0034160 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0034160 Reactome ECM proteoglycans R-DME-3000178 FBgn0034160 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0034160 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0034160 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0034160 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0034160 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0034160 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034160 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0025830 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0014870 Reactome KSRP (KHSRP) binds and destabilizes mRNA R-DME-450604 FBgn0004784 Reactome Calmodulin induced events R-DME-111933 FBgn0004784 Reactome Disinhibition of SNARE formation R-DME-114516 FBgn0004784 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0004784 Reactome SHC1 events in ERBB2 signaling R-DME-1250196 FBgn0004784 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0004784 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0004784 Reactome Syndecan interactions R-DME-3000170 FBgn0004784 Reactome Acetylcholine regulates insulin secretion R-DME-399997 FBgn0004784 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0004784 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0004784 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0004784 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0004784 Reactome Response to elevated platelet cytosolic Ca2+ R-DME-76005 FBgn0262513 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0262513 Reactome Neutrophil degranulation R-DME-6798695 FBgn0262513 Reactome Insulin receptor recycling R-DME-77387 FBgn0262513 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0262513 Reactome Ion channel transport R-DME-983712 FBgn0034179 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0034179 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0034179 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0034181 Reactome Deadenylation of mRNA R-DME-429947 FBgn0023172 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0023172 Reactome Rho GTPase cycle R-DME-194840 FBgn0023172 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0026721 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0010226 Reactome Glutathione conjugation R-DME-156590 FBgn0010226 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0000078 Reactome Digestion of dietary carbohydrate R-DME-189085 FBgn0016697 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0016697 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0016697 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0016697 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0016697 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0016697 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0016697 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0016697 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0016697 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0016697 Reactome Downstream TCR signaling R-DME-202424 FBgn0016697 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0016697 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0016697 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0016697 Reactome Nuclear CI is degraded R-DME-216167 FBgn0016697 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0016697 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0016697 Reactome Degradation of TIM R-DME-432395 FBgn0016697 Reactome Degradation of PER R-DME-432524 FBgn0016697 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0016697 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0016697 Reactome Degradation of AXIN R-DME-4641257 FBgn0016697 Reactome Degradation of DVL R-DME-4641258 FBgn0016697 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0016697 Reactome Degradation of CLK R-DME-538848 FBgn0016697 Reactome Degradation of CRY R-DME-538864 FBgn0016697 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0016697 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0016697 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0016697 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0016697 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0016697 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0016697 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0016697 Reactome UCH proteinases R-DME-5689603 FBgn0016697 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0016697 Reactome Neutrophil degranulation R-DME-6798695 FBgn0016697 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0016697 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0016697 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0016697 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0016697 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0016697 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0016697 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0016697 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0016697 Reactome Neddylation R-DME-8951664 FBgn0016697 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0016697 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0286070 Reactome Phosphorylation of CI R-DME-209190 FBgn0286070 Reactome Phosphorylation of SMO R-DME-209214 FBgn0286070 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0286070 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0022029 Reactome Pyrimidine salvage R-DME-73614 FBgn0034215 Reactome Methionine salvage pathway R-DME-1237112 FBgn0025716 Reactome UCH proteinases R-DME-5689603 FBgn0025716 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0025716 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0027506 Reactome Macroautophagy R-DME-1632852 FBgn0027506 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0034223 Reactome Surfactant metabolism R-DME-5683826 FBgn0034225 Reactome Nicotinate metabolism R-DME-196807 FBgn0034225 Reactome Pyrimidine catabolism R-DME-73621 FBgn0034225 Reactome Purine catabolism R-DME-74259 FBgn0050103 Reactome Nicotinate metabolism R-DME-196807 FBgn0050103 Reactome Pyrimidine catabolism R-DME-73621 FBgn0050103 Reactome Purine catabolism R-DME-74259 FBgn0034230 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0034231 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0034231 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0034231 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0034231 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0034231 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0034231 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0034231 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0034231 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0034231 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0034231 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0034231 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0034231 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0034231 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034232 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034237 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034237 Reactome Translation initiation complex formation R-DME-72649 FBgn0034237 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034237 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0034237 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0034237 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0028382 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0028382 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0028382 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0028382 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028382 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0010409 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010409 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010409 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010409 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010409 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010409 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0016701 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0016701 Reactome Neutrophil degranulation R-DME-6798695 FBgn0016701 Reactome TBC/RABGAPs R-DME-8854214 FBgn0016701 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0034247 Reactome Cellular hexose transport R-DME-189200 FBgn0034247 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0034247 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0034249 Reactome Rho GTPase cycle R-DME-194840 FBgn0034251 Reactome Respiratory electron transport R-DME-611105 FBgn0034251 Reactome Complex I biogenesis R-DME-6799198 FBgn0029006 Reactome Signaling by BMP R-DME-201451 FBgn0029006 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0029006 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0029006 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0029006 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029006 Reactome Degradation of AXIN R-DME-4641257 FBgn0029006 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029006 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029006 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0050106 Reactome Peptide ligand-binding receptors R-DME-375276 FBgn0050106 Reactome G alpha (i) signalling events R-DME-418594 FBgn0034258 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034258 Reactome Translation initiation complex formation R-DME-72649 FBgn0034258 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034258 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0034258 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0034258 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034261 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0028494 Reactome Rho GTPase cycle R-DME-194840 FBgn0034275 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0034276 Reactome Choline catabolism R-DME-6798163 FBgn0027572 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0027572 Reactome Beta-oxidation of very long chain fatty acids R-DME-390247 FBgn0027572 Reactome Peroxisomal protein import R-DME-9033241 FBgn0026316 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0026316 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028744 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0028743 Reactome G alpha (q) signalling events R-DME-416476 FBgn0011589 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0034299 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0284221 Reactome Other semaphorin interactions R-DME-416700 FBgn0284221 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0003044 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0062440 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0062440 Reactome Processing of SMDT1 R-DME-8949664 FBgn0000057 Reactome Neddylation R-DME-8951664 FBgn0034310 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034310 Reactome snRNP Assembly R-DME-191859 FBgn0034310 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0034310 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0034310 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0034310 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0034310 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0034314 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034345 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0034350 Reactome Macroautophagy R-DME-1632852 FBgn0034350 Reactome mTOR signalling R-DME-165159 FBgn0034350 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0034350 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0034350 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0034350 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0034350 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034350 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0261119 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0261119 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0261119 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0261119 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0262476 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0262476 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0034356 Reactome Gluconeogenesis R-DME-70263 FBgn0003067 Reactome Gluconeogenesis R-DME-70263 FBgn0050115 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0050115 Reactome Rho GTPase cycle R-DME-194840 FBgn0050115 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0034361 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034361 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0034364 Reactome Degradation of cysteine and homocysteine R-DME-1614558 FBgn0034366 Reactome Macroautophagy R-DME-1632852 FBgn0034366 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034366 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0266671 Reactome Insulin processing R-DME-264876 FBgn0266671 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0000566 Reactome Degradation of cysteine and homocysteine R-DME-1614558 FBgn0000566 Reactome Cysteine formation from homocysteine R-DME-1614603 FBgn0034368 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0050122 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0050122 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0034380 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0034382 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0034382 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0034382 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0034383 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0034383 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0034383 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0053147 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0034390 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0034405 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0034406 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0263116 Reactome Serotonin receptors R-DME-390666 FBgn0263116 Reactome G alpha (i) signalling events R-DME-418594 FBgn0034415 Reactome Synthesis of 12-eicosatetraenoic acid derivatives R-DME-2142712 FBgn0034415 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0034415 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0034415 Reactome Biosynthesis of aspirin-triggered D-series resolvins R-DME-9020265 FBgn0034415 Reactome Biosynthesis of E-series 18(R)-resolvins R-DME-9023661 FBgn0004168 Reactome Serotonin receptors R-DME-390666 FBgn0004168 Reactome G alpha (i) signalling events R-DME-418594 FBgn0034417 Reactome HS-GAG degradation R-DME-2024096 FBgn0034417 Reactome Hyaluronan uptake and degradation R-DME-2160916 FBgn0034417 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034419 Reactome Arachidonate production from DAG R-DME-426048 FBgn0034422 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0010434 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0034427 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034430 Reactome G0 and Early G1 R-DME-1538133 FBgn0034432 Reactome Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-DME-77305 FBgn0261439 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0263391 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0263391 Reactome Miscellaneous transport and binding events R-DME-5223345 FBgn0012051 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0012051 Reactome Neutrophil degranulation R-DME-6798695 FBgn0020440 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0020440 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0020440 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0020440 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0020440 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0020440 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0020440 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0020440 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0020440 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0020440 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0020440 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0020440 Reactome Interleukin-2 signaling R-DME-9020558 FBgn0013325 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0013325 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0013325 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0013325 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0013325 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0013325 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0266711 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0266711 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0266711 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0266711 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0266711 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0266711 Reactome Neddylation R-DME-8951664 FBgn0266711 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0284243 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0284243 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0284243 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0026378 Reactome TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-DME-6803205 FBgn0026378 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0026378 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0261456 Reactome Signaling by Hippo R-DME-2028269 FBgn0261456 Reactome Formation of the Hippo kinase cassette R-DME-390089 FBgn0261456 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0261456 Reactome Negative regulation of HPO R-DME-390115 FBgn0261456 Reactome Negative regulation of TH R-DME-390197 FBgn0261456 Reactome Phosphorylation-independent inhibition of YKI R-DME-451806 FBgn0003435 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003435 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0028372 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034472 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0034479 Reactome Nicotinamide salvaging R-DME-197264 FBgn0034479 Reactome Organic anion transport R-DME-561048 FBgn0034488 Reactome Alpha-oxidation of phytanate R-DME-389599 FBgn0034488 Reactome Peroxisomal protein import R-DME-9033241 FBgn0005655 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0005655 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0005655 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0005655 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0005655 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0005655 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0005655 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0005655 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0005655 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0005655 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0005655 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0005655 Reactome Polymerase switching R-DME-69091 FBgn0005655 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0005655 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0010411 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010411 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010411 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0010411 Reactome Translation initiation complex formation R-DME-72649 FBgn0010411 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010411 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0010411 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0010411 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010411 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010411 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034493 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0034493 Reactome Surfactant metabolism R-DME-5683826 FBgn0034494 Reactome Nicotinamide salvaging R-DME-197264 FBgn0034494 Reactome Thyroxine biosynthesis R-DME-209968 FBgn0034494 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0034494 Reactome Organic anion transporters R-DME-428643 FBgn0034503 Reactome Generic Transcription Pathway R-DME-212436 FBgn0034513 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034521 Reactome N-glycan trimming and elongation in the cis-Golgi R-DME-964739 FBgn0034527 Reactome Neddylation R-DME-8951664 FBgn0034534 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0034538 Reactome Lactose synthesis R-DME-5653890 FBgn0034539 Reactome Lactose synthesis R-DME-5653890 FBgn0034542 Reactome Neddylation R-DME-8951664 FBgn0016984 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0016984 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0016984 Reactome SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-DME-399955 FBgn0016984 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0016984 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0050295 Reactome Synthesis of pyrophosphates in the cytosol R-DME-1855167 FBgn0050295 Reactome Synthesis of IPs in the nucleus R-DME-1855191 FBgn0034564 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0034564 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261394 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0261394 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0261394 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0261394 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0261394 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0261394 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0261394 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0261394 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0261394 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0261394 Reactome Downstream TCR signaling R-DME-202424 FBgn0261394 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0261394 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0261394 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0261394 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0261394 Reactome Degradation of AXIN R-DME-4641257 FBgn0261394 Reactome Degradation of DVL R-DME-4641258 FBgn0261394 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0261394 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0261394 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0261394 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0261394 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0261394 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0261394 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0261394 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0261394 Reactome UCH proteinases R-DME-5689603 FBgn0261394 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0261394 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0261394 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0261394 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0261394 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0261394 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0261394 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0261394 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0261394 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0261394 Reactome Neddylation R-DME-8951664 FBgn0261394 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0261394 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034572 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0034576 Reactome Respiratory electron transport R-DME-611105 FBgn0034576 Reactome Complex I biogenesis R-DME-6799198 FBgn0034577 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0034577 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0034577 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0034577 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0034579 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034579 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0085425 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0085425 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0002736 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0002736 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0002736 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0002736 Reactome mRNA 3'-end processing R-DME-72187 FBgn0002736 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0026582 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0261067 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0261850 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0261850 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0261850 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0261850 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0261850 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0261850 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0261850 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0261850 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0261850 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0261850 Reactome mRNA Capping R-DME-72086 FBgn0261850 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0261850 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0261850 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0261850 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0261850 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0261850 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0003162 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0265191 Reactome Glycogen synthesis R-DME-3322077 FBgn0265191 Reactome Neutrophil degranulation R-DME-6798695 FBgn0265191 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0034611 Reactome Gluconeogenesis R-DME-70263 FBgn0034612 Reactome Platelet degranulation R-DME-114608 FBgn0034612 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0016726 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0016726 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0016726 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0016726 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0016726 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0016726 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034618 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034618 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0034628 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0034628 Reactome Beta-oxidation of very long chain fatty acids R-DME-390247 FBgn0034628 Reactome Peroxisomal protein import R-DME-9033241 FBgn0034629 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0034629 Reactome Beta-oxidation of very long chain fatty acids R-DME-390247 FBgn0034629 Reactome Peroxisomal protein import R-DME-9033241 FBgn0010415 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0010415 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0010415 Reactome HS-GAG degradation R-DME-2024096 FBgn0010415 Reactome Syndecan interactions R-DME-3000170 FBgn0010415 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0010415 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0010415 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0003731 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0003731 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0003731 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0003731 Reactome GRB2 events in EGFR signaling R-DME-179812 FBgn0003731 Reactome GAB1 signalosome R-DME-180292 FBgn0003731 Reactome SHC1 events in EGFR signaling R-DME-180336 FBgn0003731 Reactome EGFR downregulation R-DME-182971 FBgn0003731 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0003731 Reactome Signal transduction by L1 R-DME-445144 FBgn0003731 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0003731 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0003731 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0003731 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0034636 Reactome Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-DME-8866904 FBgn0034641 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034644 Reactome Synthesis of pyrophosphates in the cytosol R-DME-1855167 FBgn0034644 Reactome Synthesis of IPs in the nucleus R-DME-1855191 FBgn0034645 Reactome Respiratory electron transport R-DME-611105 FBgn0034645 Reactome Complex I biogenesis R-DME-6799198 FBgn0034646 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034646 Reactome snRNP Assembly R-DME-191859 FBgn0034646 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0034646 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0034646 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0034646 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0034646 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0034654 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034654 Reactome Translation initiation complex formation R-DME-72649 FBgn0034654 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034654 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0034654 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0034654 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003687 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0003687 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0003687 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0003687 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0003687 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0003687 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0003687 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0027360 Reactome Mitochondrial protein import R-DME-1268020 FBgn0266346 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0266346 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0266346 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0034657 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0034660 Reactome Crosslinking of collagen fibrils R-DME-2243919 FBgn0034665 Reactome Neutrophil degranulation R-DME-6798695 FBgn0067102 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0034691 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0034691 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0034691 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0034691 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0050280 Reactome Platelet degranulation R-DME-114608 FBgn0050280 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0050280 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0050280 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0050280 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0050280 Reactome Integrin cell surface interactions R-DME-216083 FBgn0050280 Reactome Syndecan interactions R-DME-3000170 FBgn0050280 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0050280 Reactome ECM proteoglycans R-DME-3000178 FBgn0050280 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0050280 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0050280 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0050280 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0050280 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0050280 Reactome Neutrophil degranulation R-DME-6798695 FBgn0050280 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0034707 Reactome Generic Transcription Pathway R-DME-212436 FBgn0034710 Reactome Synthesis of PA R-DME-1483166 FBgn0034710 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0034710 Reactome Digestion R-DME-8935690 FBgn0283480 Reactome Synthesis of PA R-DME-1483166 FBgn0283480 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0283480 Reactome Digestion R-DME-8935690 FBgn0034712 Reactome Synthesis of PA R-DME-1483166 FBgn0034712 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0034712 Reactome Digestion R-DME-8935690 FBgn0025186 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0017482 Reactome Interconversion of 2-oxoglutarate and 2-hydroxyglutarate R-DME-880009 FBgn0034722 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0034722 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0034722 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0034726 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0034726 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0034726 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0034726 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0034726 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0034726 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0034726 Reactome DNA replication initiation R-DME-68952 FBgn0034726 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0034727 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034727 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0034728 Reactome DNA Damage/Telomere Stress Induced Senescence R-DME-2559586 FBgn0034728 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0034728 Reactome Sensing of DNA Double Strand Breaks R-DME-5693548 FBgn0034728 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0034728 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0034733 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0034734 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0260866 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0260866 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034743 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034743 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0034743 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034743 Reactome Translation initiation complex formation R-DME-72649 FBgn0034743 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034743 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0034743 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0034743 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034743 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0034743 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034744 Reactome Macroautophagy R-DME-1632852 FBgn0034744 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0019949 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0019949 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0019949 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0019949 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0019949 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0019949 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0019949 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0026261 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0026261 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0261596 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261596 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261596 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261596 Reactome Translation initiation complex formation R-DME-72649 FBgn0261596 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261596 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0261596 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0261596 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261596 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261596 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034756 Reactome Miscellaneous substrates R-DME-211958 FBgn0034756 Reactome Eicosanoids R-DME-211979 FBgn0034756 Reactome Xenobiotics R-DME-211981 FBgn0034756 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0034756 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0034756 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0034763 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0020257 Reactome Neddylation R-DME-8951664 FBgn0020257 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0005631 Reactome Signaling by ROBO receptors R-DME-376176 FBgn0005631 Reactome Regulation of commissural axon pathfinding by SLIT and ROBO R-DME-428542 FBgn0005631 Reactome Role of ABL in ROBO-SLIT signaling R-DME-428890 FBgn0005631 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0011211 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0011211 Reactome Cristae formation R-DME-8949613 FBgn0000405 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0000405 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0000405 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0000405 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0000405 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0000405 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0000405 Reactome TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-DME-6804114 FBgn0000405 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0000405 Reactome G2/M DNA replication checkpoint R-DME-69478 FBgn0000405 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0000405 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0086408 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0010078 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010078 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010078 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010078 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010078 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010078 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034789 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0034789 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0034789 Reactome SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-DME-399955 FBgn0034789 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0034789 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0034792 Reactome Processing of SMDT1 R-DME-8949664 FBgn0267823 Reactome GDP-fucose biosynthesis R-DME-6787639 FBgn0034795 Reactome Generic Transcription Pathway R-DME-212436 FBgn0034800 Reactome Pyrimidine salvage R-DME-73614 FBgn0034800 Reactome Pyrimidine catabolism R-DME-73621 FBgn0265187 Reactome Transport of fatty acids R-DME-804914 FBgn0003062 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034822 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034822 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0034822 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034822 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034822 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0034822 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034824 Reactome Kinesins R-DME-983189 FBgn0034825 Reactome Synthesis of PA R-DME-1483166 FBgn0034827 Reactome Kinesins R-DME-983189 FBgn0034834 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0034834 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034834 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0034834 Reactome mRNA 3'-end processing R-DME-72187 FBgn0034837 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034837 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0034837 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034837 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034837 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0034837 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0034842 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0034842 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0034842 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0034842 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0034842 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0034842 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0034842 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0034842 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0034842 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0034842 Reactome Downstream TCR signaling R-DME-202424 FBgn0034842 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0034842 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0034842 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0034842 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0034842 Reactome Degradation of AXIN R-DME-4641257 FBgn0034842 Reactome Degradation of DVL R-DME-4641258 FBgn0034842 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0034842 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0034842 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0034842 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0034842 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0034842 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0034842 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0034842 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0034842 Reactome UCH proteinases R-DME-5689603 FBgn0034842 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0034842 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0034842 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0034842 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0034842 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0034842 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0034842 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0034842 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0034842 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0034842 Reactome Neddylation R-DME-8951664 FBgn0034842 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0034842 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0046253 Reactome Neutrophil degranulation R-DME-6798695 FBgn0085453 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0034854 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0034858 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0028497 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0028497 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0034863 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0034863 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0034863 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0034863 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0034863 Reactome Downstream TCR signaling R-DME-202424 FBgn0034863 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0034863 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0034863 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0034863 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0034863 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0034863 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0034863 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0034863 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0034863 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0034863 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0034863 Reactome Neddylation R-DME-8951664 FBgn0034863 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0034863 Reactome Iron uptake and transport R-DME-917937 FBgn0034863 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0053836 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053836 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053836 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053836 Reactome HATs acetylate histones R-DME-3214847 FBgn0053836 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053836 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053836 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053836 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053836 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053836 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053836 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053836 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0064116 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0053842 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053842 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053842 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053842 Reactome HATs acetylate histones R-DME-3214847 FBgn0053842 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053842 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053842 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053842 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053842 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053842 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053842 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053842 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0032076 Reactome Urea cycle R-DME-70635 FBgn0038033 Reactome Wax biosynthesis R-DME-8848584 FBgn0053815 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053815 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053815 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053815 Reactome HATs acetylate histones R-DME-3214847 FBgn0053815 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053815 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053815 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053815 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053815 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053815 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053815 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053815 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053847 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053847 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053847 Reactome HATs acetylate histones R-DME-3214847 FBgn0053847 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053847 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053847 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053847 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053847 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053847 Reactome UCH proteinases R-DME-5689603 FBgn0053847 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053847 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053847 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053847 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053847 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0061356 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0061356 Reactome Peroxisomal lipid metabolism R-DME-390918 FBgn0061356 Reactome Peroxisomal protein import R-DME-9033241 FBgn0053823 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053823 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053823 Reactome HATs acetylate histones R-DME-3214847 FBgn0053823 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053823 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053823 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053823 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053823 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053823 Reactome UCH proteinases R-DME-5689603 FBgn0053823 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053823 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053823 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053823 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053823 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053826 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053826 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053826 Reactome HATs acetylate histones R-DME-3214847 FBgn0053826 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053826 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053826 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053826 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053826 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053826 Reactome UCH proteinases R-DME-5689603 FBgn0053826 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053826 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053826 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053826 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053826 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053830 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053830 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053830 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053830 Reactome HATs acetylate histones R-DME-3214847 FBgn0053830 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053830 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053830 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053830 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053830 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053830 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053830 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053830 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0001228 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0000055 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0000055 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0000055 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0038570 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0053806 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053806 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053806 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053806 Reactome HATs acetylate histones R-DME-3214847 FBgn0053806 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053806 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053806 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053806 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053806 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053806 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053806 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053806 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0032077 Reactome Serotonin and melatonin biosynthesis R-DME-209931 FBgn0031454 Reactome Methylation R-DME-156581 FBgn0031454 Reactome Eukaryotic Translation Termination R-DME-72764 FBgn0032240 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0032240 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0053839 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053839 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053839 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053839 Reactome HATs acetylate histones R-DME-3214847 FBgn0053839 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053839 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053839 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053839 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053839 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053839 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053839 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053839 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0002887 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0002887 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0002887 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0001297 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0001297 Reactome Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209409 FBgn0001297 Reactome Transcriptional activtion by AP-1 transcription factor R-DME-209425 FBgn0001297 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0001297 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0001297 Reactome Activation of the AP-1 family of transcription factors R-DME-450341 FBgn0029175 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0265140 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0265140 Reactome Neutrophil degranulation R-DME-6798695 FBgn0053859 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053859 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053859 Reactome HATs acetylate histones R-DME-3214847 FBgn0053859 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053859 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053859 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053859 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053859 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053859 Reactome UCH proteinases R-DME-5689603 FBgn0053859 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053859 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053859 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053859 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053859 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053850 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053850 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053850 Reactome HATs acetylate histones R-DME-3214847 FBgn0053850 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053850 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053850 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053850 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053850 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053850 Reactome UCH proteinases R-DME-5689603 FBgn0053850 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053850 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053850 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053850 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053850 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053803 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053803 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053803 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053803 Reactome HATs acetylate histones R-DME-3214847 FBgn0053803 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053803 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053803 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053803 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053803 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053803 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053803 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053803 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0064119 Reactome Sodium-coupled sulphate, di- and tri-carboxylate transporters R-DME-433137 FBgn0053809 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053809 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053809 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053809 Reactome HATs acetylate histones R-DME-3214847 FBgn0053809 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053809 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053809 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053809 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053809 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053809 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053809 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053809 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053863 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053863 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053863 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053863 Reactome HATs acetylate histones R-DME-3214847 FBgn0053863 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053863 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053863 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053863 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053863 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053863 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053863 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053863 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0038032 Reactome Wax biosynthesis R-DME-8848584 FBgn0053866 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053866 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053866 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053866 Reactome HATs acetylate histones R-DME-3214847 FBgn0053866 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053866 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053866 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053866 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053866 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053866 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053866 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053866 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053854 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053854 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053854 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053854 Reactome HATs acetylate histones R-DME-3214847 FBgn0053854 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053854 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053854 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053854 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053854 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053854 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053854 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053854 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053818 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053818 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053818 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053818 Reactome HATs acetylate histones R-DME-3214847 FBgn0053818 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053818 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053818 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053818 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053818 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053818 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053818 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053818 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0027358 Reactome Mitochondrial protein import R-DME-1268020 FBgn0037912 Reactome Gluconeogenesis R-DME-70263 FBgn0037912 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0053857 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053857 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053857 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053857 Reactome HATs acetylate histones R-DME-3214847 FBgn0053857 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053857 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053857 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053857 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053857 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053857 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053857 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053857 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0037913 Reactome Triglyceride catabolism R-DME-163560 FBgn0037913 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0037913 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0037913 Reactome RA biosynthesis pathway R-DME-5365859 FBgn0037913 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037913 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0061359 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0053862 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053862 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053862 Reactome HATs acetylate histones R-DME-3214847 FBgn0053862 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053862 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053862 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053862 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053862 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053862 Reactome UCH proteinases R-DME-5689603 FBgn0053862 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053862 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053862 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053862 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053862 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053808 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053808 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053808 Reactome HATs acetylate histones R-DME-3214847 FBgn0053808 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053808 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053808 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053808 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053808 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053808 Reactome UCH proteinases R-DME-5689603 FBgn0053808 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053808 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053808 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053808 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053808 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0034081 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0034081 Reactome Cristae formation R-DME-8949613 FBgn0043002 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0043002 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0043002 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0043002 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0043002 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0043002 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0043002 Reactome DNA replication initiation R-DME-68952 FBgn0043002 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0053814 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053814 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053814 Reactome HATs acetylate histones R-DME-3214847 FBgn0053814 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053814 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053814 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053814 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053814 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053814 Reactome UCH proteinases R-DME-5689603 FBgn0053814 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053814 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053814 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053814 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053814 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053853 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053853 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053853 Reactome HATs acetylate histones R-DME-3214847 FBgn0053853 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053853 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053853 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053853 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053853 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053853 Reactome UCH proteinases R-DME-5689603 FBgn0053853 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053853 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053853 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053853 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053853 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053817 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053817 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053817 Reactome HATs acetylate histones R-DME-3214847 FBgn0053817 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053817 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053817 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053817 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053817 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053817 Reactome UCH proteinases R-DME-5689603 FBgn0053817 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053817 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053817 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053817 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053817 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053841 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053841 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053841 Reactome HATs acetylate histones R-DME-3214847 FBgn0053841 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053841 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053841 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053841 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053841 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053841 Reactome UCH proteinases R-DME-5689603 FBgn0053841 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053841 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053841 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053841 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053841 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053821 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053821 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053821 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053821 Reactome HATs acetylate histones R-DME-3214847 FBgn0053821 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053821 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053821 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053821 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053821 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053821 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053821 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053821 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053824 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053824 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053824 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053824 Reactome HATs acetylate histones R-DME-3214847 FBgn0053824 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053824 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053824 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053824 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053824 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053824 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053824 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053824 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053845 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053845 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053845 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053845 Reactome HATs acetylate histones R-DME-3214847 FBgn0053845 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053845 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053845 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053845 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053845 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053845 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053845 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053845 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0000056 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0000056 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0000056 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0053829 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053829 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053829 Reactome HATs acetylate histones R-DME-3214847 FBgn0053829 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053829 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053829 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053829 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053829 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053829 Reactome UCH proteinases R-DME-5689603 FBgn0053829 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053829 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053829 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053829 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053829 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053835 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053835 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053835 Reactome HATs acetylate histones R-DME-3214847 FBgn0053835 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053835 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053835 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053835 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053835 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053835 Reactome UCH proteinases R-DME-5689603 FBgn0053835 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053835 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053835 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053835 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053835 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0260466 Reactome Sodium-coupled sulphate, di- and tri-carboxylate transporters R-DME-433137 FBgn0053812 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053812 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053812 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053812 Reactome HATs acetylate histones R-DME-3214847 FBgn0053812 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053812 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053812 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053812 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053812 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053812 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053812 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053812 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053865 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053865 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053865 Reactome HATs acetylate histones R-DME-3214847 FBgn0053865 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053865 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053865 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053865 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053865 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053865 Reactome UCH proteinases R-DME-5689603 FBgn0053865 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053865 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053865 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053865 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053865 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053860 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053860 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053860 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053860 Reactome HATs acetylate histones R-DME-3214847 FBgn0053860 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053860 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053860 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053860 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053860 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053860 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053860 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053860 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053851 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053851 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053851 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053851 Reactome HATs acetylate histones R-DME-3214847 FBgn0053851 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053851 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053851 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053851 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053851 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053851 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053851 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053851 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053820 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053820 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053820 Reactome HATs acetylate histones R-DME-3214847 FBgn0053820 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053820 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053820 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053820 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053820 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053820 Reactome UCH proteinases R-DME-5689603 FBgn0053820 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053820 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053820 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053820 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053820 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0029154 Reactome Pyruvate metabolism R-DME-70268 FBgn0029154 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0053833 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053833 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053833 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053833 Reactome HATs acetylate histones R-DME-3214847 FBgn0053833 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053833 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053833 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053833 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053833 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053833 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053833 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053833 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053856 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053856 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053856 Reactome HATs acetylate histones R-DME-3214847 FBgn0053856 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053856 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053856 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053856 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053856 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053856 Reactome UCH proteinases R-DME-5689603 FBgn0053856 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053856 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053856 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053856 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053856 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053844 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053844 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053844 Reactome HATs acetylate histones R-DME-3214847 FBgn0053844 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053844 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053844 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053844 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053844 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053844 Reactome UCH proteinases R-DME-5689603 FBgn0053844 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053844 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053844 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053844 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053844 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0285958 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0285958 Reactome Neutrophil degranulation R-DME-6798695 FBgn0285958 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0285958 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0053827 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053827 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053827 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053827 Reactome HATs acetylate histones R-DME-3214847 FBgn0053827 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053827 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053827 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053827 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053827 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053827 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053827 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053827 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053838 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053838 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053838 Reactome HATs acetylate histones R-DME-3214847 FBgn0053838 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053838 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053838 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053838 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053838 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053838 Reactome UCH proteinases R-DME-5689603 FBgn0053838 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053838 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053838 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053838 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053838 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053848 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0053848 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053848 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053848 Reactome HATs acetylate histones R-DME-3214847 FBgn0053848 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0053848 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053848 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053848 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053848 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053848 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053848 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0053848 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0053832 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0053832 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0053832 Reactome HATs acetylate histones R-DME-3214847 FBgn0053832 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0053832 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0053832 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0053832 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0053832 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0053832 Reactome UCH proteinases R-DME-5689603 FBgn0053832 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0053832 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0053832 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0053832 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0053832 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0031455 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0029153 Reactome Pyruvate metabolism R-DME-70268 FBgn0029153 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0034876 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0010501 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0010501 Reactome Signaling by Hippo R-DME-2028269 FBgn0010501 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0010501 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0010501 Reactome Apoptotic cleavage of cell adhesion proteins R-DME-351906 FBgn0010501 Reactome Breakdown of the nuclear lamina R-DME-352238 FBgn0010501 Reactome Caspase activation via Dependence Receptors in the absence of ligand R-DME-418889 FBgn0010501 Reactome Other interleukin signaling R-DME-449836 FBgn0034879 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0034879 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0034879 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0034880 Reactome Integrin cell surface interactions R-DME-216083 FBgn0034880 Reactome Syndecan interactions R-DME-3000170 FBgn0034880 Reactome ECM proteoglycans R-DME-3000178 FBgn0034880 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0034880 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015277 Reactome PI3K Cascade R-DME-109704 FBgn0015277 Reactome Macroautophagy R-DME-1632852 FBgn0015277 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0015277 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0015277 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0015277 Reactome Toll Like Receptor 9 (TLR9) Cascade R-DME-168138 FBgn0015277 Reactome RHO GTPases Activate NADPH Oxidases R-DME-5668599 FBgn0034882 Reactome Passive transport by Aquaporins R-DME-432047 FBgn0034883 Reactome Passive transport by Aquaporins R-DME-432047 FBgn0034884 Reactome Passive transport by Aquaporins R-DME-432047 FBgn0034885 Reactome Passive transport by Aquaporins R-DME-432047 FBgn0266377 Reactome G alpha (s) signalling events R-DME-418555 FBgn0034887 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0265052 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0011296 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0011296 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0034893 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034893 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0034894 Reactome PI Metabolism R-DME-1483255 FBgn0011297 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0034897 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0034898 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034898 Reactome Purine salvage R-DME-74217 FBgn0034898 Reactome Purine catabolism R-DME-74259 FBgn0028411 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034909 Reactome Cellular hexose transport R-DME-189200 FBgn0034909 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0034909 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0034911 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0034911 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0034913 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034913 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0024234 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0034919 Reactome Complex I biogenesis R-DME-6799198 FBgn0025352 Reactome Acyl chain remodeling of CL R-DME-1482798 FBgn0025352 Reactome Beta oxidation of myristoyl-CoA to lauroyl-CoA R-DME-77285 FBgn0025352 Reactome Beta oxidation of palmitoyl-CoA to myristoyl-CoA R-DME-77305 FBgn0025352 Reactome Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA R-DME-77310 FBgn0025352 Reactome Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-DME-77346 FBgn0025352 Reactome Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-DME-77348 FBgn0025352 Reactome Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-DME-77350 FBgn0011236 Reactome Transcriptional repression by nuclear factors R-DME-210671 FBgn0034921 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0034921 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0262619 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0262619 Reactome Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) R-DME-5358606 FBgn0262619 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0262619 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0262619 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0034923 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0034923 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034923 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0034923 Reactome mRNA 3'-end processing R-DME-72187 FBgn0034923 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0261794 Reactome Cation-coupled Chloride cotransporters R-DME-426117 FBgn0034933 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0023477 Reactome Insulin effects increased synthesis of Xylulose-5-Phosphate R-DME-163754 FBgn0023477 Reactome Pentose phosphate pathway R-DME-71336 FBgn0001123 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0001123 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0001123 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0001123 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0001123 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0001123 Reactome G alpha (s) signalling events R-DME-418555 FBgn0001123 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0001123 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0034936 Reactome Processing of SMDT1 R-DME-8949664 FBgn0034938 Reactome Heme biosynthesis R-DME-189451 FBgn0034939 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0034939 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0034939 Reactome mRNA 3'-end processing R-DME-72187 FBgn0034943 Reactome FMO oxidises nucleophiles R-DME-217271 FBgn0020764 Reactome Heme biosynthesis R-DME-189451 FBgn0005612 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0034951 Reactome Synthesis of bile acids and bile salts R-DME-192105 FBgn0283494 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0013764 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0034963 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0034964 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0028552 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0028552 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0028552 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0028552 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0028552 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0003353 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0285952 Reactome Hypusine synthesis from eIF5A-lysine R-DME-204626 FBgn0023170 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0023170 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0023170 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0023170 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0023170 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0023170 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0283666 Reactome Neutrophil degranulation R-DME-6798695 FBgn0034970 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0034970 Reactome Signaling by Hippo R-DME-2028269 FBgn0034970 Reactome YAP1- and WWTR1 (TAZ)-stimulated gene expression R-DME-2032785 FBgn0034970 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0034970 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0034970 Reactome Transcriptional activation by YKI R-DME-390193 FBgn0034970 Reactome Phosphorylation-independent inhibition of YKI R-DME-451806 FBgn0034970 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0034970 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0034971 Reactome Synthesis of PA R-DME-1483166 FBgn0086129 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034975 Reactome Regulation of TP53 Activity through Acetylation R-DME-6804758 FBgn0034986 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0034986 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0034988 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0034988 Reactome Pyrimidine catabolism R-DME-73621 FBgn0034989 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0034990 Reactome Digestion of dietary lipid R-DME-192456 FBgn0034990 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0034997 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0034999 Reactome Transport of fatty acids R-DME-804914 FBgn0004101 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0000037 Reactome Muscarinic acetylcholine receptors R-DME-390648 FBgn0000037 Reactome G alpha (i) signalling events R-DME-418594 FBgn0000037 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0000037 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035001 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002787 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0002787 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0002787 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0002787 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0002787 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0002787 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0002787 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0002787 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0002787 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0002787 Reactome Downstream TCR signaling R-DME-202424 FBgn0002787 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0002787 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0002787 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0002787 Reactome Nuclear CI is degraded R-DME-216167 FBgn0002787 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0002787 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0002787 Reactome Degradation of TIM R-DME-432395 FBgn0002787 Reactome Degradation of PER R-DME-432524 FBgn0002787 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0002787 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0002787 Reactome Degradation of AXIN R-DME-4641257 FBgn0002787 Reactome Degradation of DVL R-DME-4641258 FBgn0002787 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0002787 Reactome Degradation of CLK R-DME-538848 FBgn0002787 Reactome Degradation of CRY R-DME-538864 FBgn0002787 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0002787 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0002787 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0002787 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0002787 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0002787 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0002787 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0002787 Reactome UCH proteinases R-DME-5689603 FBgn0002787 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0002787 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002787 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0002787 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0002787 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0002787 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0002787 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0002787 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0002787 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0002787 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0002787 Reactome Neddylation R-DME-8951664 FBgn0002787 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0002787 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0010414 Reactome Serotonin clearance from the synaptic cleft R-DME-380615 FBgn0035005 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0017556 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0017556 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0017556 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0017556 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0017556 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0017556 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0017556 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0017556 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0017556 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0017556 Reactome Downstream TCR signaling R-DME-202424 FBgn0017556 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0017556 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0017556 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0017556 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0017556 Reactome Degradation of AXIN R-DME-4641257 FBgn0017556 Reactome Degradation of DVL R-DME-4641258 FBgn0017556 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0017556 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0017556 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0017556 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0017556 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0017556 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0017556 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0017556 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0017556 Reactome UCH proteinases R-DME-5689603 FBgn0017556 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0017556 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0017556 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0017556 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0017556 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0017556 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0017556 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0017556 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0017556 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0017556 Reactome Neddylation R-DME-8951664 FBgn0017556 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0017556 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035026 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0035026 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0035026 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0035026 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0035026 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0035027 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035028 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0035032 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0035032 Reactome Cristae formation R-DME-8949613 FBgn0015040 Reactome Miscellaneous substrates R-DME-211958 FBgn0015040 Reactome Eicosanoids R-DME-211979 FBgn0015040 Reactome Xenobiotics R-DME-211981 FBgn0015040 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0015040 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0015040 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0035046 Reactome Respiratory electron transport R-DME-611105 FBgn0035046 Reactome Complex I biogenesis R-DME-6799198 FBgn0035050 Reactome Sialic acid metabolism R-DME-4085001 FBgn0035050 Reactome N-Glycan antennae elongation R-DME-975577 FBgn0035050 Reactome Termination of O-glycan biosynthesis R-DME-977068 FBgn0050421 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0035059 Reactome Neddylation R-DME-8951664 FBgn0086908 Reactome PKMTs methylate histone lysines R-DME-3214841 FBgn0035065 Reactome Peroxisomal protein import R-DME-9033241 FBgn0035065 Reactome TYSND1 cleaves peroxisomal proteins R-DME-9033500 FBgn0041205 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0041205 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0023181 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0023181 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0023181 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0023181 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0023181 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0023181 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0023181 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0035078 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0043792 Reactome Wax biosynthesis R-DME-8848584 FBgn0035085 Reactome Platelet degranulation R-DME-114608 FBgn0285950 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0285950 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0285950 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0285950 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0285950 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0285950 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0035088 Reactome Processing of SMDT1 R-DME-8949664 FBgn0035090 Reactome Platelet degranulation R-DME-114608 FBgn0035090 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0035090 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035090 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0035090 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0010435 Reactome Platelet degranulation R-DME-114608 FBgn0010435 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0010435 Reactome Neutrophil degranulation R-DME-6798695 FBgn0010435 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0010435 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035091 Reactome Platelet degranulation R-DME-114608 FBgn0035091 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0035091 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035091 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0035091 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0265434 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0265434 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0265434 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0004919 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0004919 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0004919 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0020386 Reactome Insulin signaling pathway R-DME-110478 FBgn0020386 Reactome TOR signaling pathway R-DME-110523 FBgn0035101 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0035102 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0035102 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0035110 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0035110 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0035110 Reactome mRNA 3'-end processing R-DME-72187 FBgn0035122 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0035122 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0052343 Reactome Transcriptional activation of mitochondrial biogenesis R-DME-2151201 FBgn0265574 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035141 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035145 Reactome Generic Transcription Pathway R-DME-212436 FBgn0035147 Reactome Galactose catabolism R-DME-70370 FBgn0035149 Reactome Generic Transcription Pathway R-DME-212436 FBgn0260862 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0260862 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0000575 Reactome Oncogene Induced Senescence R-DME-2559585 FBgn0035162 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035162 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0035165 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0035165 Reactome Apoptotic execution phase R-DME-75153 FBgn0052479 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0052479 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0264574 Reactome Cellular hexose transport R-DME-189200 FBgn0264574 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0264574 Reactome Regulation of insulin secretion R-DME-422356 FBgn0264574 Reactome Lactose synthesis R-DME-5653890 FBgn0264574 Reactome Neutrophil degranulation R-DME-6798695 FBgn0264574 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0035187 Reactome Serotonin and melatonin biosynthesis R-DME-209931 FBgn0004431 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004431 Reactome Antimicrobial peptides R-DME-6803157 FBgn0004425 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004425 Reactome Antimicrobial peptides R-DME-6803157 FBgn0004427 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004427 Reactome Antimicrobial peptides R-DME-6803157 FBgn0004428 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004428 Reactome Antimicrobial peptides R-DME-6803157 FBgn0004429 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004429 Reactome Antimicrobial peptides R-DME-6803157 FBgn0004430 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004430 Reactome Antimicrobial peptides R-DME-6803157 FBgn0264272 Reactome Inhibition of actin polymerisation R-DME-450728 FBgn0035192 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0035192 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0035194 Reactome Unwinding of DNA R-DME-176974 FBgn0283500 Reactome Synthesis of PIPs at the ER membrane R-DME-1483248 FBgn0283500 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0262937 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0025682 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0025682 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0010333 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0010333 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0010333 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0010333 Reactome Rho GTPase cycle R-DME-194840 FBgn0010333 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0010333 Reactome DAP12 signaling R-DME-2424491 FBgn0010333 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0010333 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0010333 Reactome DSCAM interactions R-DME-376172 FBgn0010333 Reactome CD28 dependent Vav1 pathway R-DME-389359 FBgn0010333 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0010333 Reactome Ephrin signaling R-DME-3928664 FBgn0010333 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0010333 Reactome PCP/CE pathway R-DME-4086400 FBgn0010333 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0010333 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0010333 Reactome Signal transduction by L1 R-DME-445144 FBgn0010333 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0010333 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0010333 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0010333 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0010333 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0010333 Reactome MAPK6/MAPK4 signaling R-DME-5687128 FBgn0010333 Reactome Neutrophil degranulation R-DME-6798695 FBgn0010333 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0035203 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0035205 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0035205 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0035205 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0035207 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0011361 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0011361 Reactome Respiratory electron transport R-DME-611105 FBgn0011361 Reactome Complex I biogenesis R-DME-6799198 FBgn0011361 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0267487 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0267487 Reactome STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol R-DME-210693 FBgn0267487 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0267487 Reactome Regulation of IFNG signaling R-DME-877312 FBgn0043865 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0043865 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0043865 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0028577 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261243 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035229 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0035231 Reactome Synthesis of PC R-DME-1483191 FBgn0035233 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0035233 Reactome Peroxisomal protein import R-DME-9033241 FBgn0035243 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0035244 Reactome Mitochondrial ABC transporters R-DME-1369007 FBgn0035245 Reactome Gamma-carboxylation of protein precursors R-DME-159740 FBgn0013342 Reactome Glutamate Neurotransmitter Release Cycle R-DME-210500 FBgn0013342 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0013342 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0013342 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0013342 Reactome Other interleukin signaling R-DME-449836 FBgn0013342 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0013342 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0013342 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0013753 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0013753 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0013753 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0013753 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0013753 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0013753 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0013753 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0013753 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0013753 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0013753 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0035249 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0013755 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0013755 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0013755 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0013755 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0013755 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0013755 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0013755 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0013755 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0013755 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0013755 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0035251 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0035253 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0026372 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0026372 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0026372 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0026372 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0026372 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0026372 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0035255 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0035255 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0035265 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0035266 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0035268 Reactome Neddylation R-DME-8951664 FBgn0027903 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0027903 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0035271 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035272 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0035272 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0250789 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0250789 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0250789 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0250789 Reactome Neutrophil degranulation R-DME-6798695 FBgn0250789 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0011573 Reactome Platelet degranulation R-DME-114608 FBgn0011573 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0004636 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0004636 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0004636 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0004636 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0004636 Reactome Rap1 signalling R-DME-392517 FBgn0004636 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0004636 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002183 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0002183 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0002183 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0002183 Reactome Regulation of TP53 Activity through Phosphorylation R-DME-6804756 FBgn0002183 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0035287 Reactome Chondroitin sulfate biosynthesis R-DME-2022870 FBgn0035290 Reactome Platelet degranulation R-DME-114608 FBgn0035290 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0035290 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035290 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0035290 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035293 Reactome Cellular hexose transport R-DME-189200 FBgn0035293 Reactome Inositol transporters R-DME-429593 FBgn0035293 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0035298 Reactome Utilization of Ketone Bodies R-DME-77108 FBgn0035317 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0035318 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0035321 Reactome Iron uptake and transport R-DME-917937 FBgn0015360 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0035333 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0035334 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0035335 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0035335 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0035348 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035348 Reactome Purine salvage R-DME-74217 FBgn0035348 Reactome Purine catabolism R-DME-74259 FBgn0016794 Reactome PI3K Cascade R-DME-109704 FBgn0016794 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0016794 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0016794 Reactome GAB1 signalosome R-DME-180292 FBgn0016794 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0016794 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0016794 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0016794 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0016794 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0016794 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0016794 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0035355 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0035356 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0052296 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0035371 Reactome Bicarbonate transporters R-DME-425381 FBgn0035371 Reactome Ion homeostasis R-DME-5578775 FBgn0035374 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0035374 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0035375 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0262593 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0262593 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0035383 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0035397 Reactome Deadenylation of mRNA R-DME-429947 FBgn0035398 Reactome Digestion of dietary carbohydrate R-DME-189085 FBgn0035398 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035401 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0035402 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0035402 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0035402 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0266582 Reactome Respiratory electron transport R-DME-611105 FBgn0266582 Reactome Complex I biogenesis R-DME-6799198 FBgn0286567 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0035421 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0035422 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0035422 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0035422 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0035422 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0035422 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0035422 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0035432 Reactome Zinc efflux and compartmentalization by the SLC30 family R-DME-435368 FBgn0035436 Reactome Nicotinate metabolism R-DME-196807 FBgn0035438 Reactome Synthesis of 12-eicosatetraenoic acid derivatives R-DME-2142712 FBgn0035438 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0035438 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0035438 Reactome Biosynthesis of aspirin-triggered D-series resolvins R-DME-9020265 FBgn0035438 Reactome Biosynthesis of E-series 18(R)-resolvins R-DME-9023661 FBgn0035440 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0004167 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0004167 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0004167 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0035444 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035445 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0035445 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0035445 Reactome HS-GAG degradation R-DME-2024096 FBgn0035445 Reactome CS/DS degradation R-DME-2024101 FBgn0014388 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0014388 Reactome EGFR downregulation R-DME-182971 FBgn0035452 Reactome Platelet degranulation R-DME-114608 FBgn0035452 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0035452 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0035452 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0035452 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0035452 Reactome Integrin cell surface interactions R-DME-216083 FBgn0035452 Reactome Syndecan interactions R-DME-3000170 FBgn0035452 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0035452 Reactome ECM proteoglycans R-DME-3000178 FBgn0035452 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0035452 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0035452 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0035452 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0035452 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0035452 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035452 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0052264 Reactome Platelet degranulation R-DME-114608 FBgn0035462 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0035464 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0004888 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0035469 Reactome Macroautophagy R-DME-1632852 FBgn0035469 Reactome mTOR signalling R-DME-165159 FBgn0035469 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0035469 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0035469 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0035469 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0035470 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0003943 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0003943 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0003943 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0003943 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0003943 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0003943 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0003943 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0003943 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0003943 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0003943 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0003943 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0003943 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0003943 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0003943 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0003943 Reactome EGFR downregulation R-DME-182971 FBgn0003943 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0003943 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0003943 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0003943 Reactome Downstream TCR signaling R-DME-202424 FBgn0003943 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0003943 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0003943 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0003943 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0003943 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0003943 Reactome Nuclear CI is degraded R-DME-216167 FBgn0003943 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0003943 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0003943 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0003943 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0003943 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0003943 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0003943 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0003943 Reactome Degradation of TIM R-DME-432395 FBgn0003943 Reactome Degradation of PER R-DME-432524 FBgn0003943 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0003943 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0003943 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0003943 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0003943 Reactome Degradation of AXIN R-DME-4641257 FBgn0003943 Reactome Degradation of DVL R-DME-4641258 FBgn0003943 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0003943 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0003943 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0003943 Reactome Degradation of CRY R-DME-538864 FBgn0003943 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0003943 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0003943 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0003943 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0003943 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0003943 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0003943 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0003943 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0003943 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0003943 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0003943 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0003943 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0003943 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0003943 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0003943 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0003943 Reactome UCH proteinases R-DME-5689603 FBgn0003943 Reactome Josephin domain DUBs R-DME-5689877 FBgn0003943 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0003943 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0003943 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0003943 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0003943 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0003943 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0003943 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0003943 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0003943 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0003943 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0003943 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0003943 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0003943 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0003943 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0003943 Reactome PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-DME-8849469 FBgn0003943 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0003943 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0003943 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0003943 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0003943 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0003943 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0003943 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0003943 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0003943 Reactome Neddylation R-DME-8951664 FBgn0003943 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0003943 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0003943 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0003943 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0003943 Reactome Peroxisomal protein import R-DME-9033241 FBgn0003943 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0003943 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0003943 Reactome Iron uptake and transport R-DME-917937 FBgn0003943 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0003943 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0003943 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0003943 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0003943 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0003943 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035471 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0035483 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0035488 Reactome CDO in myogenesis R-DME-375170 FBgn0263832 Reactome HATs acetylate histones R-DME-3214847 FBgn0263832 Reactome UCH proteinases R-DME-5689603 FBgn0263832 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0035491 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0004516 Reactome GABA synthesis R-DME-888568 FBgn0035498 Reactome Platelet degranulation R-DME-114608 FBgn0260985 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0260985 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0260985 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0260985 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0260985 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0260985 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0260985 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0260985 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0260985 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0260985 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0260985 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0260985 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0260985 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0260985 Reactome Polymerase switching R-DME-69091 FBgn0004574 Reactome Disinhibition of SNARE formation R-DME-114516 FBgn0004574 Reactome Platelet degranulation R-DME-114608 FBgn0004574 Reactome Other interleukin signaling R-DME-449836 FBgn0263110 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035515 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0011692 Reactome Mitotic Telophase/Cytokinesis R-DME-68884 FBgn0011692 Reactome Kinesins R-DME-983189 FBgn0041171 Reactome Neddylation R-DME-8951664 FBgn0041171 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035521 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0035521 Reactome Insulin receptor recycling R-DME-77387 FBgn0035521 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0035521 Reactome Ion channel transport R-DME-983712 FBgn0035523 Reactome Synthesis of PC R-DME-1483191 FBgn0035523 Reactome Transport of bile salts and organic acids, metal ions and amine compounds R-DME-425366 FBgn0035523 Reactome Choline catabolism R-DME-6798163 FBgn0015829 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0015829 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0015829 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0015829 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0015829 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0015829 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0041630 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0041630 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0041630 Reactome CS/DS degradation R-DME-2024101 FBgn0041630 Reactome Hyaluronan uptake and degradation R-DME-2160916 FBgn0041630 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035529 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0035529 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0035529 Reactome Endogenous sterols R-DME-211976 FBgn0035529 Reactome Electron transport from NADPH to Ferredoxin R-DME-2395516 FBgn0052250 Reactome Alpha-oxidation of phytanate R-DME-389599 FBgn0035533 Reactome Rho GTPase cycle R-DME-194840 FBgn0035533 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035534 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0035534 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0035540 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0000038 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0014073 Reactome Tie2 Signaling R-DME-210993 FBgn0014073 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0260657 Reactome Nephrin family interactions R-DME-373753 FBgn0260657 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015805 Reactome G0 and Early G1 R-DME-1538133 FBgn0015805 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0015805 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0015805 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0015805 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0015805 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0015805 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0015805 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0015805 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0035567 Reactome Gluconeogenesis R-DME-70263 FBgn0035568 Reactome Gluconeogenesis R-DME-70263 FBgn0035574 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0035574 Reactome Rho GTPase cycle R-DME-194840 FBgn0035574 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0261797 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0261797 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261797 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0261797 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0028699 Reactome Erythrocytes take up carbon dioxide and release oxygen R-DME-1237044 FBgn0028699 Reactome Erythrocytes take up oxygen and release carbon dioxide R-DME-1247673 FBgn0028699 Reactome Rhesus glycoproteins mediate ammonium transport. R-DME-444411 FBgn0035585 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0035585 Reactome Cristae formation R-DME-8949613 FBgn0010747 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0035586 Reactome Lipid particle organization R-DME-8964572 FBgn0035588 Reactome RA biosynthesis pathway R-DME-5365859 FBgn0035588 Reactome Peroxisomal protein import R-DME-9033241 FBgn0035589 Reactome Macroautophagy R-DME-1632852 FBgn0035589 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0035593 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0016031 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0016031 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0016031 Reactome Acyl chain remodelling of PI R-DME-1482922 FBgn0016031 Reactome Hydrolysis of LPC R-DME-1483115 FBgn0004380 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0004380 Reactome Kinesins R-DME-983189 FBgn0035600 Reactome Respiratory electron transport R-DME-611105 FBgn0035601 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0035601 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0035601 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0035601 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0035601 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0035601 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0035601 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0035601 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0260856 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260856 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0260856 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0260856 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0003486 Reactome Methylation R-DME-156581 FBgn0003486 Reactome Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-DME-211957 FBgn0003486 Reactome Endogenous sterols R-DME-211976 FBgn0003486 Reactome Xenobiotics R-DME-211981 FBgn0003486 Reactome Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-DME-2142670 FBgn0003486 Reactome Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-DME-2142816 FBgn0003486 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0003486 Reactome Biosynthesis of protectins R-DME-9018681 FBgn0003486 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0035619 Reactome Synthesis of PA R-DME-1483166 FBgn0035619 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0035619 Reactome Digestion R-DME-8935690 FBgn0035620 Reactome Synthesis of PA R-DME-1483166 FBgn0035620 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0035620 Reactome Digestion R-DME-8935690 FBgn0035624 Reactome Regulation of TP53 Activity through Acetylation R-DME-6804758 FBgn0035627 Reactome Separation of Sister Chromatids R-DME-2467813 FBgn0263106 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0263106 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0263106 Reactome Attenuation phase R-DME-3371568 FBgn0263106 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0035630 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035632 Reactome Coenzyme A biosynthesis R-DME-196783 FBgn0260936 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0040298 Reactome Polo-like kinase mediated events R-DME-156711 FBgn0040298 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0040298 Reactome G2/M DNA replication checkpoint R-DME-69478 FBgn0035636 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0035636 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0035636 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0283472 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0283472 Reactome AKT phosphorylates targets in the nucleus R-DME-198693 FBgn0035640 Reactome Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-DME-141405 FBgn0035640 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0035640 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0035640 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0035640 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0035644 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0035644 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0035644 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0035644 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0035644 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0035644 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0035644 Reactome DNA replication initiation R-DME-68952 FBgn0035644 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0052412 Reactome Neutrophil degranulation R-DME-6798695 FBgn0052407 Reactome Neutrophil degranulation R-DME-6798695 FBgn0053523 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035675 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0035675 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035677 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0035678 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0035692 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035692 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0024921 Reactome Intraflagellar transport R-DME-5620924 FBgn0035693 Reactome Intraflagellar transport R-DME-5620924 FBgn0035695 Reactome Recycling of bile acids and salts R-DME-159418 FBgn0035695 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0035695 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0004513 Reactome Recycling of bile acids and salts R-DME-159418 FBgn0004513 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0004513 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0035696 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0020251 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0004619 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0004619 Reactome Activation of AMPA receptors R-DME-399710 FBgn0004619 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0004619 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0004619 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0004619 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0035709 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0035709 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0035709 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0035709 Reactome Deadenylation of mRNA R-DME-429947 FBgn0035709 Reactome Translation initiation complex formation R-DME-72649 FBgn0035709 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0035709 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0035709 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0005626 Reactome Catecholamine biosynthesis R-DME-209905 FBgn0035715 Reactome Neutrophil degranulation R-DME-6798695 FBgn0041194 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0035718 Reactome Regulation of Complement cascade R-DME-977606 FBgn0035720 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0035720 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035720 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0261445 Reactome Formation of the active cofactor, UDP-glucuronate R-DME-173599 FBgn0001104 Reactome PLC beta mediated events R-DME-112043 FBgn0001104 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0001104 Reactome G-protein activation R-DME-202040 FBgn0001104 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0001104 Reactome G alpha (i) signalling events R-DME-418594 FBgn0001104 Reactome G alpha (z) signalling events R-DME-418597 FBgn0260660 Reactome Collagen degradation R-DME-1442490 FBgn0260660 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0260660 Reactome Assembly of collagen fibrils and other multimeric structures R-DME-2022090 FBgn0260660 Reactome Integrin cell surface interactions R-DME-216083 FBgn0260660 Reactome Collagen chain trimerization R-DME-8948216 FBgn0002775 Reactome HATs acetylate histones R-DME-3214847 FBgn0035753 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0035753 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0035753 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0035753 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0035753 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0035753 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0012058 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0012058 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0012058 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0012058 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0012058 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0012058 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0012058 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0012058 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0012058 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0012058 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0012058 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0012058 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0012058 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035754 Reactome Generic Transcription Pathway R-DME-212436 FBgn0035756 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035762 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0035766 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0015298 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0019662 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0035771 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0052380 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0035776 Reactome Regulation of Complement cascade R-DME-977606 FBgn0035777 Reactome Regulation of Complement cascade R-DME-977606 FBgn0035779 Reactome Regulation of Complement cascade R-DME-977606 FBgn0035780 Reactome Regulation of Complement cascade R-DME-977606 FBgn0035781 Reactome Regulation of Complement cascade R-DME-977606 FBgn0014011 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0014011 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0014011 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0014011 Reactome Rho GTPase cycle R-DME-194840 FBgn0014011 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0014011 Reactome DAP12 signaling R-DME-2424491 FBgn0014011 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0014011 Reactome DSCAM interactions R-DME-376172 FBgn0014011 Reactome CD28 dependent Vav1 pathway R-DME-389359 FBgn0014011 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0014011 Reactome Ephrin signaling R-DME-3928664 FBgn0014011 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0014011 Reactome PCP/CE pathway R-DME-4086400 FBgn0014011 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0014011 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0014011 Reactome Signal transduction by L1 R-DME-445144 FBgn0014011 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0014011 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0014011 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0014011 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0014011 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0014011 Reactome MAPK6/MAPK4 signaling R-DME-5687128 FBgn0014011 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014011 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0035791 Reactome Regulation of Complement cascade R-DME-977606 FBgn0028582 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0028582 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0039924 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0039924 Reactome PI5P Regulates TP53 Acetylation R-DME-6811555 FBgn0039924 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0039924 Reactome Synthesis of PIPs in the nucleus R-DME-8847453 FBgn0027101 Reactome Regulation of TP53 Activity through Phosphorylation R-DME-6804756 FBgn0250910 Reactome Serotonin receptors R-DME-390666 FBgn0250910 Reactome G alpha (s) signalling events R-DME-418555 FBgn0260453 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0260453 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0260453 Reactome Pyruvate metabolism R-DME-70268 FBgn0053966 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0053966 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0053966 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0054039 Reactome Neddylation R-DME-8951664 FBgn0250851 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0053965 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0053965 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0053965 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0035806 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035806 Reactome Antimicrobial peptides R-DME-6803157 FBgn0035811 Reactome mitochondrial fatty acid beta-oxidation of unsaturated fatty acids R-DME-77288 FBgn0035811 Reactome Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA R-DME-77346 FBgn0035811 Reactome Beta oxidation of octanoyl-CoA to hexanoyl-CoA R-DME-77348 FBgn0035813 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035813 Reactome Antimicrobial peptides R-DME-6803157 FBgn0035815 Reactome Platelet degranulation R-DME-114608 FBgn0035815 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0035815 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035815 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0035815 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035817 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001208 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0023076 Reactome Degradation of TIM R-DME-432395 FBgn0023076 Reactome Transcription regulation of cwo gene R-DME-432408 FBgn0023076 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0023076 Reactome Degradation of PER R-DME-432524 FBgn0023076 Reactome Transcription activation by CLK:CYC and repression by VRI R-DME-432560 FBgn0023076 Reactome Dephosphorylation of PER R-DME-432620 FBgn0023076 Reactome Degradation of CLK R-DME-538848 FBgn0023076 Reactome Dephosphorylation of CLK R-DME-538909 FBgn0052369 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035823 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0035823 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0035823 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0035823 Reactome Deadenylation of mRNA R-DME-429947 FBgn0035823 Reactome Translation initiation complex formation R-DME-72649 FBgn0035823 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0035823 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0035823 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003041 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0003041 Reactome Rho GTPase cycle R-DME-194840 FBgn0003041 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0035827 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010406 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035830 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0011817 Reactome Ca2+ pathway R-DME-4086398 FBgn0035833 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0035833 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0262716 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0262716 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0262716 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035839 Reactome Degradation of cysteine and homocysteine R-DME-1614558 FBgn0020392 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0035849 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0035849 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0035849 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0035849 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0035849 Reactome RUNX2 regulates osteoblast differentiation R-DME-8940973 FBgn0035850 Reactome Macroautophagy R-DME-1632852 FBgn0035851 Reactome Generic Transcription Pathway R-DME-212436 FBgn0035853 Reactome Neddylation R-DME-8951664 FBgn0035853 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035854 Reactome Hypusine synthesis from eIF5A-lysine R-DME-204626 FBgn0265089 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0265089 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0265089 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0265089 Reactome Deadenylation of mRNA R-DME-429947 FBgn0265089 Reactome Translation initiation complex formation R-DME-72649 FBgn0265089 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0265089 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0265089 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0027569 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0015793 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0015793 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0035872 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0035872 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035872 Reactome mRNA 3'-end processing R-DME-72187 FBgn0035872 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0035876 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0035876 Reactome Peroxisomal protein import R-DME-9033241 FBgn0011762 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0011762 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0011762 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0011762 Reactome DNA replication initiation R-DME-68952 FBgn0011762 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0011762 Reactome Polymerase switching R-DME-69091 FBgn0011762 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0011762 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0035878 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0035879 Reactome TBC/RABGAPs R-DME-8854214 FBgn0265102 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0266667 Reactome Insulin processing R-DME-264876 FBgn0266667 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0020224 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0020224 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0020224 Reactome EGFR downregulation R-DME-182971 FBgn0020224 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0020224 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0020224 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0020224 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0020224 Reactome PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-DME-8849469 FBgn0020224 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0020224 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0020224 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0020224 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035904 Reactome Methylation R-DME-156581 FBgn0035904 Reactome Glutathione conjugation R-DME-156590 FBgn0035904 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0086348 Reactome Methylation R-DME-156581 FBgn0086348 Reactome Glutathione conjugation R-DME-156590 FBgn0086348 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0035906 Reactome Methylation R-DME-156581 FBgn0035906 Reactome Glutathione conjugation R-DME-156590 FBgn0035906 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0035907 Reactome Methylation R-DME-156581 FBgn0035907 Reactome Glutathione conjugation R-DME-156590 FBgn0035907 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0024236 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0035911 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0017430 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0017430 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0017430 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0017430 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0017430 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0017579 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0017579 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0017579 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0017579 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0017579 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0017579 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0035916 Reactome TBC/RABGAPs R-DME-8854214 FBgn0035918 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0035918 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0035918 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0035918 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0035918 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0035918 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0035918 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0000121 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0000121 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0000121 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0000121 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0000121 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0000121 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0000121 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0000121 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0000121 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0035922 Reactome Peroxisomal protein import R-DME-9033241 FBgn0035924 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0263930 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0263930 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0263930 Reactome HS-GAG degradation R-DME-2024096 FBgn0263930 Reactome Formation and transport of the N-HH ligand R-DME-209471 FBgn0263930 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0263930 Reactome Release of Hh-Np from the secreting cell R-DME-5362798 FBgn0263930 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0020633 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0020633 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0020633 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0020633 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0020633 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0035934 Reactome TRP channels R-DME-3295583 FBgn0035945 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0035947 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0035951 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0035953 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0035957 Reactome Creatine metabolism R-DME-71288 FBgn0000116 Reactome Creatine metabolism R-DME-71288 FBgn0035964 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0035965 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0035968 Reactome Cellular hexose transport R-DME-189200 FBgn0035975 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035975 Reactome Antimicrobial peptides R-DME-6803157 FBgn0035976 Reactome Peptidoglycans (PGN) bind to a peptidoglycan recognition protein receptor, PGRP-LC/LE R-DME-209171 FBgn0035976 Reactome Peptidoglycan bound PGRP-LC/LE oligomerises R-DME-209266 FBgn0035976 Reactome Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214397 FBgn0035976 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0035976 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0035976 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0035976 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035976 Reactome Antimicrobial peptides R-DME-6803157 FBgn0035977 Reactome Neutrophil degranulation R-DME-6798695 FBgn0035977 Reactome Antimicrobial peptides R-DME-6803157 FBgn0035978 Reactome Formation of the active cofactor, UDP-glucuronate R-DME-173599 FBgn0035978 Reactome Glycogen synthesis R-DME-3322077 FBgn0085484 Reactome Neutrophil degranulation R-DME-6798695 FBgn0085484 Reactome Vitamins B6 activation to pyridoxal phosphate R-DME-964975 FBgn0035980 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0011769 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0011769 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0011769 Reactome Endogenous sterols R-DME-211976 FBgn0011769 Reactome Electron transport from NADPH to Ferredoxin R-DME-2395516 FBgn0001229 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001225 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001227 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001224 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001226 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0035987 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0035987 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0035987 Reactome mRNA 3'-end processing R-DME-72187 FBgn0035987 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0023129 Reactome Serine biosynthesis R-DME-977347 FBgn0260859 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260859 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0035995 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011327 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0011327 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0011327 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0011327 Reactome Nuclear CI is degraded R-DME-216167 FBgn0011327 Reactome Degradation of TIM R-DME-432395 FBgn0011327 Reactome Degradation of PER R-DME-432524 FBgn0011327 Reactome Degradation of CLK R-DME-538848 FBgn0011327 Reactome Degradation of CRY R-DME-538864 FBgn0011327 Reactome UCH proteinases R-DME-5689603 FBgn0036004 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0010408 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0010408 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0010408 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0010408 Reactome Translation initiation complex formation R-DME-72649 FBgn0010408 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0010408 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0010408 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0010408 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010408 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0010408 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0267348 Reactome Laminin interactions R-DME-3000157 FBgn0036030 Reactome 5-Phosphoribose 1-diphosphate biosynthesis R-DME-73843 FBgn0015321 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0015321 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0040475 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0040475 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0036038 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0019644 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0019644 Reactome Cristae formation R-DME-8949613 FBgn0036043 Reactome Erythrocytes take up carbon dioxide and release oxygen R-DME-1237044 FBgn0036043 Reactome Erythrocytes take up oxygen and release carbon dioxide R-DME-1247673 FBgn0036043 Reactome Bicarbonate transporters R-DME-425381 FBgn0044051 Reactome Insulin signaling pathway R-DME-110478 FBgn0036046 Reactome Insulin signaling pathway R-DME-110478 FBgn0044050 Reactome Insulin signaling pathway R-DME-110478 FBgn0044049 Reactome Insulin signaling pathway R-DME-110478 FBgn0015618 Reactome Generic Transcription Pathway R-DME-212436 FBgn0015618 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0004390 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0036053 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0036053 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0036053 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0036053 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0011836 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0011836 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0011836 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0011836 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0011836 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0025866 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0025866 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036058 Reactome PI5P Regulates TP53 Acetylation R-DME-6811555 FBgn0036058 Reactome Synthesis of PIPs in the nucleus R-DME-8847453 FBgn0026404 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0026404 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0026404 Reactome Regulation of TNFR1 signaling R-DME-5357905 FBgn0026404 Reactome Apoptotic execution phase R-DME-75153 FBgn0036082 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0001179 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0001179 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0001179 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0001179 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0001179 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0001179 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0001179 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0001179 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0001179 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0001179 Reactome mRNA Capping R-DME-72086 FBgn0001179 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0001179 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0001179 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0001179 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0001179 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0001179 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0000629 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0000629 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0000629 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0000629 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0036090 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0052066 Reactome Platelet degranulation R-DME-114608 FBgn0010762 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0036099 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0036099 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0036099 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0036099 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0047038 Reactome Respiratory electron transport R-DME-611105 FBgn0047038 Reactome Complex I biogenesis R-DME-6799198 FBgn0036104 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036104 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0027615 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0027615 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0036111 Reactome Synthesis of pyrophosphates in the cytosol R-DME-1855167 FBgn0263241 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0020412 Reactome ERK/MAPK targets R-DME-198753 FBgn0020412 Reactome CREB phosphorylation R-DME-199920 FBgn0020412 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0020412 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0036125 Reactome Thyroxine biosynthesis R-DME-209968 FBgn0261112 Reactome Neddylation R-DME-8951664 FBgn0036134 Reactome UCH proteinases R-DME-5689603 FBgn0036135 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036135 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0036136 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0036136 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0260795 Reactome Sodium-coupled phosphate cotransporters R-DME-427652 FBgn0052082 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0052082 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0052082 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0036141 Reactome WNT ligand biogenesis and trafficking R-DME-3238698 FBgn0036144 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0036147 Reactome Collagen biosynthesis and modifying enzymes R-DME-1650814 FBgn0061469 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0041094 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0036157 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0036160 Reactome Fructose catabolism R-DME-70350 FBgn0036161 Reactome Fructose catabolism R-DME-70350 FBgn0036162 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0028668 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028668 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028668 Reactome Insulin receptor recycling R-DME-77387 FBgn0028668 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028668 Reactome Ion channel transport R-DME-983712 FBgn0036165 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0003292 Reactome O-linked glycosylation R-DME-5173105 FBgn0086254 Reactome Glutathione conjugation R-DME-156590 FBgn0086254 Reactome Estrogen biosynthesis R-DME-193144 FBgn0086254 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0086254 Reactome Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-DME-193775 FBgn0086254 Reactome Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-DME-193807 FBgn0086254 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0086254 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0086254 Reactome RA biosynthesis pathway R-DME-5365859 FBgn0086254 Reactome Fructose biosynthesis R-DME-5652227 FBgn0086254 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0086254 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0036183 Reactome Glutathione conjugation R-DME-156590 FBgn0036183 Reactome Estrogen biosynthesis R-DME-193144 FBgn0036183 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0036183 Reactome Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-DME-193775 FBgn0036183 Reactome Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-DME-193807 FBgn0036183 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0036183 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0036183 Reactome RA biosynthesis pathway R-DME-5365859 FBgn0036183 Reactome Fructose biosynthesis R-DME-5652227 FBgn0036183 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0036183 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0036186 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036187 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0052085 Reactome Neddylation R-DME-8951664 FBgn0052085 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0015828 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0015828 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0015828 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0015828 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0015828 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0015828 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0036194 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0036196 Reactome Neddylation R-DME-8951664 FBgn0036196 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0036199 Reactome The fatty acid cycling model R-DME-167826 FBgn0036199 Reactome The proton buffering model R-DME-167827 FBgn0015278 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0015278 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0015278 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0015278 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0015278 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0015278 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0036207 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004381 Reactome Kinesins R-DME-983189 FBgn0036211 Reactome Platelet degranulation R-DME-114608 FBgn0036211 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0036211 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0036211 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036213 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0036213 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0036213 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0036213 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0036213 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0036213 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000404 Reactome G0 and Early G1 R-DME-1538133 FBgn0000404 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0000404 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0000404 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0000404 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0000404 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0000404 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0000404 Reactome G2 Phase R-DME-68911 FBgn0000404 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0000404 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0000404 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0000404 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0036224 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0036224 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0036224 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0036224 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0036224 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0036224 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0036224 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0036224 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0036224 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0036224 Reactome Downstream TCR signaling R-DME-202424 FBgn0036224 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0036224 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0036224 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0036224 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0036224 Reactome Degradation of AXIN R-DME-4641257 FBgn0036224 Reactome Degradation of DVL R-DME-4641258 FBgn0036224 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0036224 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0036224 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0036224 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0036224 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0036224 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0036224 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0036224 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0036224 Reactome UCH proteinases R-DME-5689603 FBgn0036224 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0036224 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0036224 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0036224 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0036224 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0036224 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0036224 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0036224 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0036224 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0036224 Reactome Neddylation R-DME-8951664 FBgn0036224 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0036224 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0036235 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0036235 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036239 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0036240 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0022959 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0022959 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0022959 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0036255 Reactome Macroautophagy R-DME-1632852 FBgn0036257 Reactome Rho GTPase cycle R-DME-194840 FBgn0036258 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0036258 Reactome Translation initiation complex formation R-DME-72649 FBgn0036258 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0036258 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0036258 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0036258 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0036260 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0036260 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0036260 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0036260 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0036260 Reactome G alpha (i) signalling events R-DME-418594 FBgn0036260 Reactome Opsins R-DME-419771 FBgn0036260 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0036262 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0036263 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0036263 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0036263 Reactome mRNA 3'-end processing R-DME-72187 FBgn0022709 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0036271 Reactome Heme biosynthesis R-DME-189451 FBgn0036271 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036272 Reactome Metabolism of polyamines R-DME-351202 FBgn0036273 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0036273 Reactome ARL13B-mediated ciliary trafficking of INPP5E R-DME-5624958 FBgn0036277 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0036277 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036277 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0036279 Reactome Cation-coupled Chloride cotransporters R-DME-426117 FBgn0020655 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0036289 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0036289 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0036289 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0002466 Reactome RHO GTPases activate CIT R-DME-5625900 FBgn0004926 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0004926 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0004926 Reactome Translation initiation complex formation R-DME-72649 FBgn0004926 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0004926 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0004926 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0004926 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0036298 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0036299 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0036299 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0036300 Reactome Synthesis of GDP-mannose R-DME-446205 FBgn0010235 Reactome Kinesins R-DME-983189 FBgn0036309 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0036309 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0260945 Reactome Macroautophagy R-DME-1632852 FBgn0260945 Reactome Receptor Mediated Mitophagy R-DME-8934903 FBgn0036314 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036316 Reactome Cellular hexose transport R-DME-189200 FBgn0036316 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0036316 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0036319 Reactome Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-DME-83936 FBgn0036327 Reactome Gluconeogenesis R-DME-70263 FBgn0036327 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0036328 Reactome Gluconeogenesis R-DME-70263 FBgn0036328 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0036335 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036335 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0036336 Reactome Gamma carboxylation, hypusine formation and arylsulfatase activation R-DME-163841 FBgn0036337 Reactome Purine salvage R-DME-74217 FBgn0286213 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0286213 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0286213 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0286213 Reactome Translation initiation complex formation R-DME-72649 FBgn0286213 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0286213 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0286213 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0286213 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0286213 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0286213 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0036340 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0036340 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0036340 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036340 Reactome mRNA 3'-end processing R-DME-72187 FBgn0011284 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0011284 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0011284 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0011284 Reactome Translation initiation complex formation R-DME-72649 FBgn0011284 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0011284 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0011284 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0011284 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0011284 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0011284 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0010452 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0010452 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0010452 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0023095 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0023095 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0023095 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0260049 Reactome Platelet degranulation R-DME-114608 FBgn0086708 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0036372 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0036372 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0036372 Reactome Neutrophil degranulation R-DME-6798695 FBgn0086785 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0036376 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0029167 Reactome Platelet degranulation R-DME-114608 FBgn0029167 Reactome Integrin cell surface interactions R-DME-216083 FBgn0029167 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0029167 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0029167 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0029167 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0029167 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0029167 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0029167 Reactome Termination of O-glycan biosynthesis R-DME-977068 FBgn0036381 Reactome Collagen degradation R-DME-1442490 FBgn0036381 Reactome Synthesis of PE R-DME-1483213 FBgn0036381 Reactome Lysine catabolism R-DME-71064 FBgn0001216 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0001216 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0001216 Reactome Attenuation phase R-DME-3371568 FBgn0001216 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0001216 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0001216 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001216 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0001216 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0036398 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0052133 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0052133 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0061515 Reactome MASTL Facilitates Mitotic Progression R-DME-2465910 FBgn0036402 Reactome Glycolysis R-DME-70171 FBgn0026418 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0267795 Reactome RHO GTPases Activate Formins R-DME-5663220 FBgn0285896 Reactome PI3K Cascade R-DME-109704 FBgn0285896 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0285896 Reactome FGFR4 ligand binding and activation R-DME-190322 FBgn0285896 Reactome FGFR1b ligand binding and activation R-DME-190370 FBgn0285896 Reactome FGFR3b ligand binding and activation R-DME-190371 FBgn0285896 Reactome FGFR3c ligand binding and activation R-DME-190372 FBgn0285896 Reactome FGFR1c ligand binding and activation R-DME-190373 FBgn0285896 Reactome FGFR2c ligand binding and activation R-DME-190375 FBgn0285896 Reactome FGFR2b ligand binding and activation R-DME-190377 FBgn0285896 Reactome Signal transduction by L1 R-DME-445144 FBgn0285896 Reactome Phospholipase C-mediated cascade: FGFR1 R-DME-5654219 FBgn0285896 Reactome Phospholipase C-mediated cascade; FGFR2 R-DME-5654221 FBgn0285896 Reactome Phospholipase C-mediated cascade; FGFR3 R-DME-5654227 FBgn0285896 Reactome Phospholipase C-mediated cascade; FGFR4 R-DME-5654228 FBgn0285896 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0285896 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0285896 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0285896 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0285896 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0285896 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0285896 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0285896 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0285896 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0285896 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0285896 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0285896 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0285896 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0285896 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0285896 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0285896 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0285896 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0285896 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0036414 Reactome TRP channels R-DME-3295583 FBgn0013718 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0036428 Reactome Glycogen synthesis R-DME-3322077 FBgn0041604 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0041604 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0041604 Reactome HS-GAG degradation R-DME-2024096 FBgn0041604 Reactome Signaling by ROBO receptors R-DME-376176 FBgn0036446 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0036446 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0036446 Reactome N-Glycan antennae elongation R-DME-975577 FBgn0036447 Reactome N-Glycan antennae elongation R-DME-975577 FBgn0036449 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0036449 Reactome Triglyceride catabolism R-DME-163560 FBgn0036449 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0036449 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0002778 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0002778 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0002778 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0002778 Reactome Basigin interactions R-DME-210991 FBgn0002778 Reactome Nuclear CI is degraded R-DME-216167 FBgn0002778 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0002778 Reactome Degradation of TIM R-DME-432395 FBgn0002778 Reactome Degradation of PER R-DME-432524 FBgn0002778 Reactome Degradation of CLK R-DME-538848 FBgn0002778 Reactome Degradation of CRY R-DME-538864 FBgn0036461 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0036462 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036462 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0023174 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0023174 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0023174 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0023174 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0023174 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0023174 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0023174 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0023174 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0023174 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0023174 Reactome Downstream TCR signaling R-DME-202424 FBgn0023174 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0023174 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0023174 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0023174 Reactome Nuclear CI is degraded R-DME-216167 FBgn0023174 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0023174 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0023174 Reactome Degradation of TIM R-DME-432395 FBgn0023174 Reactome Degradation of PER R-DME-432524 FBgn0023174 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0023174 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0023174 Reactome Degradation of AXIN R-DME-4641257 FBgn0023174 Reactome Degradation of DVL R-DME-4641258 FBgn0023174 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0023174 Reactome Degradation of CLK R-DME-538848 FBgn0023174 Reactome Degradation of CRY R-DME-538864 FBgn0023174 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0023174 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0023174 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0023174 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0023174 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0023174 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0023174 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0023174 Reactome UCH proteinases R-DME-5689603 FBgn0023174 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0023174 Reactome Neutrophil degranulation R-DME-6798695 FBgn0023174 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0023174 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0023174 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0023174 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0023174 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0023174 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0023174 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0023174 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0023174 Reactome Neddylation R-DME-8951664 FBgn0023174 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0023174 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0266452 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0014002 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0014002 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0014002 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0036484 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0036485 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0036486 Reactome Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) R-DME-5358565 FBgn0036487 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036490 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0026323 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0026323 Reactome Ca2+ pathway R-DME-4086398 FBgn0026323 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0026323 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0036491 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0036492 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0036493 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0036500 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0036500 Reactome Neddylation R-DME-8951664 FBgn0036505 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0036510 Reactome Neddylation R-DME-8951664 FBgn0261109 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0261109 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0261109 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0261109 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0261109 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0261109 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0261109 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0261109 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0261109 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0261109 Reactome mRNA Capping R-DME-72086 FBgn0261109 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0261109 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0261109 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0261109 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0261109 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0261109 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0036514 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0036516 Reactome Downstream TCR signaling R-DME-202424 FBgn0036516 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0036516 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0036516 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0036516 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0036518 Reactome Rho GTPase cycle R-DME-194840 FBgn0036519 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0036527 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0036528 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0036529 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0036534 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0036534 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0036545 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0036545 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0036545 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0036545 Reactome Acyl chain remodelling of PI R-DME-1482922 FBgn0036545 Reactome Acyl chain remodelling of PG R-DME-1482925 FBgn0036545 Reactome Synthesis of PA R-DME-1483166 FBgn0283649 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0283649 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263599 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0263599 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0036549 Reactome Neddylation R-DME-8951664 FBgn0000212 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0000212 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0000212 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0000115 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0263600 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0263600 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0036557 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036557 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0044028 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0044028 Reactome Release of Hh-Np from the secreting cell R-DME-5362798 FBgn0044028 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0260635 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0260635 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0260635 Reactome Negative regulation of TH R-DME-390197 FBgn0260635 Reactome Regulation of necroptotic cell death R-DME-5675482 FBgn0260635 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0260635 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0036566 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0036570 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0010280 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010280 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010280 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010280 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010280 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0266724 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0266724 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0263605 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0036579 Reactome Platelet degranulation R-DME-114608 FBgn0036581 Reactome Generic Transcription Pathway R-DME-212436 FBgn0263608 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011693 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0011693 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0011693 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0036620 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0036620 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0036620 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0036622 Reactome Synthesis of PA R-DME-1483166 FBgn0036622 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0036623 Reactome Synthesis of PA R-DME-1483166 FBgn0036623 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0028399 Reactome Serine biosynthesis R-DME-977347 FBgn0263131 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0263131 Reactome PKA activation R-DME-163615 FBgn0263131 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0263131 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0263131 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0263131 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0263131 Reactome G alpha (s) signalling events R-DME-418555 FBgn0263131 Reactome G alpha (z) signalling events R-DME-418597 FBgn0263131 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0263131 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0026061 Reactome Synthesis of IPs in the ER lumen R-DME-1855231 FBgn0036640 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0028693 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028693 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028693 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028693 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028693 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028693 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028693 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028693 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028693 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028693 Reactome Downstream TCR signaling R-DME-202424 FBgn0028693 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028693 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028693 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028693 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028693 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028693 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028693 Reactome Degradation of TIM R-DME-432395 FBgn0028693 Reactome Degradation of PER R-DME-432524 FBgn0028693 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028693 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028693 Reactome Degradation of AXIN R-DME-4641257 FBgn0028693 Reactome Degradation of DVL R-DME-4641258 FBgn0028693 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028693 Reactome Degradation of CLK R-DME-538848 FBgn0028693 Reactome Degradation of CRY R-DME-538864 FBgn0028693 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028693 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028693 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028693 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028693 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028693 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028693 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028693 Reactome UCH proteinases R-DME-5689603 FBgn0028693 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028693 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028693 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028693 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028693 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028693 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028693 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028693 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028693 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028693 Reactome Neddylation R-DME-8951664 FBgn0028693 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028693 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0250814 Reactome Respiratory electron transport R-DME-611105 FBgn0036648 Reactome Phosphate bond hydrolysis by NUDT proteins R-DME-2393930 FBgn0002284 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0002284 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0002284 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0002284 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0002284 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0002284 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0002284 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0002284 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0002284 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0002284 Reactome Downstream TCR signaling R-DME-202424 FBgn0002284 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0002284 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0002284 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0002284 Reactome Nuclear CI is degraded R-DME-216167 FBgn0002284 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0002284 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0002284 Reactome Degradation of TIM R-DME-432395 FBgn0002284 Reactome Degradation of PER R-DME-432524 FBgn0002284 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0002284 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0002284 Reactome Degradation of AXIN R-DME-4641257 FBgn0002284 Reactome Degradation of DVL R-DME-4641258 FBgn0002284 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0002284 Reactome Degradation of CLK R-DME-538848 FBgn0002284 Reactome Degradation of CRY R-DME-538864 FBgn0002284 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0002284 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0002284 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0002284 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0002284 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0002284 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0002284 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0002284 Reactome UCH proteinases R-DME-5689603 FBgn0002284 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0002284 Reactome Neutrophil degranulation R-DME-6798695 FBgn0002284 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0002284 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0002284 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0002284 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0002284 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0002284 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0002284 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0002284 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0002284 Reactome Neddylation R-DME-8951664 FBgn0002284 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0002284 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0004465 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0004465 Reactome Neutrophil degranulation R-DME-6798695 FBgn0017572 Reactome Neutrophil degranulation R-DME-6798695 FBgn0260960 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0260960 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0260960 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0040512 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0040512 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0000414 Reactome Gap junction degradation R-DME-190873 FBgn0000414 Reactome Formation of annular gap junctions R-DME-196025 FBgn0000414 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0000414 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0000414 Reactome Reelin signalling pathway R-DME-8866376 FBgn0043577 Reactome Neutrophil degranulation R-DME-6798695 FBgn0043577 Reactome Antimicrobial peptides R-DME-6803157 FBgn0043578 Reactome Neutrophil degranulation R-DME-6798695 FBgn0043578 Reactome Antimicrobial peptides R-DME-6803157 FBgn0036662 Reactome Transport of vitamins, nucleosides, and related molecules R-DME-425397 FBgn0025582 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0025582 Reactome Translation initiation complex formation R-DME-72649 FBgn0025582 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0025582 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0025582 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0025582 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0021768 Reactome Mitotic Telophase/Cytokinesis R-DME-68884 FBgn0036666 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0003410 Reactome Netrin-1 signaling R-DME-373752 FBgn0003410 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0003410 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0259794 Reactome Netrin-1 signaling R-DME-373752 FBgn0259794 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003250 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0003250 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0003250 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0003250 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0003250 Reactome G alpha (i) signalling events R-DME-418594 FBgn0003250 Reactome Opsins R-DME-419771 FBgn0003250 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0036671 Reactome Neddylation R-DME-8951664 FBgn0010352 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0010352 Reactome Lysine catabolism R-DME-71064 FBgn0010352 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0261547 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0261547 Reactome Rho GTPase cycle R-DME-194840 FBgn0261547 Reactome EPHA-mediated growth cone collapse R-DME-3928663 FBgn0261547 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0036686 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0036688 Reactome Platelet degranulation R-DME-114608 FBgn0036691 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0036695 Reactome Transport and synthesis of PAPS R-DME-174362 FBgn0036695 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0036698 Reactome Androgen biosynthesis R-DME-193048 FBgn0036698 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0036698 Reactome Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-DME-193775 FBgn0036698 Reactome Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-DME-193807 FBgn0036698 Reactome Mineralocorticoid biosynthesis R-DME-193993 FBgn0036698 Reactome Glucocorticoid biosynthesis R-DME-194002 FBgn0036702 Reactome Processing of SMDT1 R-DME-8949664 FBgn0036706 Reactome Respiratory electron transport R-DME-611105 FBgn0036706 Reactome Complex I biogenesis R-DME-6799198 FBgn0266669 Reactome Insulin processing R-DME-264876 FBgn0266669 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0042641 Reactome Formation of the active cofactor, UDP-glucuronate R-DME-173599 FBgn0042641 Reactome Keratan sulfate biosynthesis R-DME-2022854 FBgn0042641 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0042641 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0036728 Reactome Respiratory electron transport R-DME-611105 FBgn0036733 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036735 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0259174 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0259174 Reactome Downregulation of ERBB4 signaling R-DME-1253288 FBgn0259174 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0259174 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0259174 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0259174 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0025455 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0025455 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0025455 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0025455 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0025455 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0025455 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0025455 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0036740 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0036747 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0036747 Reactome Surfactant metabolism R-DME-5683826 FBgn0052183 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0052183 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0036751 Reactome Surfactant metabolism R-DME-5683826 FBgn0036751 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036752 Reactome Surfactant metabolism R-DME-5683826 FBgn0036752 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261998 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0261998 Reactome Surfactant metabolism R-DME-5683826 FBgn0052190 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0052190 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0036754 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0001134 Reactome GABA A receptor activation R-DME-977441 FBgn0036762 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0036762 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0036762 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0036762 Reactome Glycine degradation R-DME-6783984 FBgn0036762 Reactome Pyruvate metabolism R-DME-70268 FBgn0036762 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0036762 Reactome Lysine catabolism R-DME-71064 FBgn0036762 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0036764 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0036765 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0036765 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0036765 Reactome CS/DS degradation R-DME-2024101 FBgn0036765 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036768 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0036768 Reactome The activation of arylsulfatases R-DME-1663150 FBgn0036768 Reactome CS/DS degradation R-DME-2024101 FBgn0036768 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036770 Reactome Transport and synthesis of PAPS R-DME-174362 FBgn0036770 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0000568 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0036787 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0013717 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0036801 Reactome Myosin phosphatase dephosphoylates SQH R-DME-350384 FBgn0036807 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0036807 Reactome Organic anion transporters R-DME-428643 FBgn0036807 Reactome Gluconeogenesis R-DME-70263 FBgn0036808 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0036808 Reactome Organic anion transporters R-DME-428643 FBgn0036808 Reactome Gluconeogenesis R-DME-70263 FBgn0036809 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0036809 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0036809 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0036813 Reactome Macroautophagy R-DME-1632852 FBgn0001078 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0001078 Reactome SUMOylation of intracellular receptors R-DME-4090294 FBgn0000261 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0000261 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000261 Reactome Peroxisomal protein import R-DME-9033241 FBgn0036816 Reactome Sodium-coupled sulphate, di- and tri-carboxylate transporters R-DME-433137 FBgn0025807 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0014075 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0036821 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0036821 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0036821 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0036824 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0036825 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0036825 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0036825 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0036825 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0036825 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0036825 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0027057 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0027057 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0027057 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027057 Reactome Neddylation R-DME-8951664 FBgn0036828 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036828 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0036844 Reactome RAF-independent MAPK1/3 activation R-DME-112409 FBgn0036844 Reactome ERKs are inactivated R-DME-202670 FBgn0036844 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0036847 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0036848 Reactome Nicotinamide salvaging R-DME-197264 FBgn0016797 Reactome Phosphorylation of ARR R-DME-209387 FBgn0016797 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0016797 Reactome Assembly of receptor complex R-DME-209472 FBgn0036853 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036853 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0026630 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0026630 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0026630 Reactome Acyl chain remodelling of PE R-DME-1482839 FBgn0260857 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260857 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0260857 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0036857 Reactome Choline catabolism R-DME-6798163 FBgn0036857 Reactome Lysine catabolism R-DME-71064 FBgn0003089 Reactome Dermatan sulfate biosynthesis R-DME-2022923 FBgn0023395 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0036875 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036876 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036877 Reactome Neutrophil degranulation R-DME-6798695 FBgn0262517 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0005564 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0005564 Reactome Phase 1 - inactivation of fast Na+ channels R-DME-5576894 FBgn0010417 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010417 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0010417 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010417 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010417 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010417 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0260655 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0036897 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0036897 Reactome Degradation of AXIN R-DME-4641257 FBgn0036897 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0036897 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0022774 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0262516 Reactome TRP channels R-DME-3295583 FBgn0262516 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0261283 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0024889 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0023094 Reactome Degradation of TIM R-DME-432395 FBgn0023094 Reactome Transcription regulation of cwo gene R-DME-432408 FBgn0023094 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0023094 Reactome Degradation of PER R-DME-432524 FBgn0023094 Reactome Transcription activation by CLK:CYC and repression by VRI R-DME-432560 FBgn0023094 Reactome Dephosphorylation of PER R-DME-432620 FBgn0023094 Reactome Degradation of CLK R-DME-538848 FBgn0023094 Reactome Dephosphorylation of CLK R-DME-538909 FBgn0020389 Reactome Transport and synthesis of PAPS R-DME-174362 FBgn0262518 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0262519 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0014037 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0014037 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0014037 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0014037 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0014037 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0036915 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0036916 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0036916 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0036916 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0028695 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028695 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028695 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028695 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028695 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028695 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028695 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028695 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028695 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028695 Reactome Downstream TCR signaling R-DME-202424 FBgn0028695 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028695 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028695 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028695 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028695 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028695 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028695 Reactome Degradation of TIM R-DME-432395 FBgn0028695 Reactome Degradation of PER R-DME-432524 FBgn0028695 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028695 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028695 Reactome Degradation of AXIN R-DME-4641257 FBgn0028695 Reactome Degradation of DVL R-DME-4641258 FBgn0028695 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028695 Reactome Degradation of CLK R-DME-538848 FBgn0028695 Reactome Degradation of CRY R-DME-538864 FBgn0028695 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028695 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028695 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028695 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028695 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028695 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028695 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028695 Reactome UCH proteinases R-DME-5689603 FBgn0028695 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028695 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028695 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028695 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028695 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028695 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028695 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028695 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028695 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028695 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028695 Reactome Neddylation R-DME-8951664 FBgn0028695 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028695 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0036919 Reactome Golgi Cisternae Pericentriolar Stack Reorganization R-DME-162658 FBgn0036919 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0036921 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0036921 Reactome Rho GTPase cycle R-DME-194840 FBgn0036921 Reactome RHO1 GTPase cycle R-DME-350407 FBgn0004852 Reactome Glucagon signaling in metabolic regulation R-DME-163359 FBgn0004852 Reactome PKA activation R-DME-163615 FBgn0004852 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0004852 Reactome Adenylate cyclase activating pathway R-DME-170660 FBgn0004852 Reactome Adenylate cyclase inhibitory pathway R-DME-170670 FBgn0004852 Reactome G alpha (s) signalling events R-DME-418555 FBgn0004852 Reactome G alpha (z) signalling events R-DME-418597 FBgn0004852 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0004852 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0036927 Reactome Degradation of GABA R-DME-916853 FBgn0036928 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0036932 Reactome Macroautophagy R-DME-1632852 FBgn0036932 Reactome mTOR signalling R-DME-165159 FBgn0036932 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0036932 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0036932 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0036932 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036932 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0036939 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0036939 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0005198 Reactome Macroautophagy R-DME-1632852 FBgn0005198 Reactome Inhibition of TSC complex formation by PKB R-DME-165181 FBgn0005198 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0005198 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0005198 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0005198 Reactome TBC/RABGAPs R-DME-8854214 FBgn0036941 Reactome Fructose catabolism R-DME-70350 FBgn0036942 Reactome Fructose catabolism R-DME-70350 FBgn0261556 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0261556 Reactome Rho GTPase cycle R-DME-194840 FBgn0261556 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0260397 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0260397 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0024814 Reactome Gap junction degradation R-DME-190873 FBgn0024814 Reactome Formation of annular gap junctions R-DME-196025 FBgn0024814 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0024814 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0024814 Reactome Recycling pathway of L1 R-DME-437239 FBgn0024814 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0024814 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0024814 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0024814 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0024814 Reactome LDL clearance R-DME-8964038 FBgn0036959 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0265959 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0036967 Reactome Neddylation R-DME-8951664 FBgn0003124 Reactome Polo-like kinase mediated events R-DME-156711 FBgn0003124 Reactome Golgi Cisternae Pericentriolar Stack Reorganization R-DME-162658 FBgn0003124 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0003124 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0003124 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0003124 Reactome Regulation of PLK1 Activity at G2/M Transition R-DME-2565942 FBgn0003124 Reactome Mitotic Telophase/Cytokinesis R-DME-68884 FBgn0003124 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0250791 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0250791 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0250791 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0250791 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0250791 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0036973 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0036973 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0036973 Reactome Neddylation R-DME-8951664 FBgn0036974 Reactome Eukaryotic Translation Termination R-DME-72764 FBgn0036974 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0036974 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0024887 Reactome Protein methylation R-DME-8876725 FBgn0036978 Reactome PI3K Cascade R-DME-109704 FBgn0036978 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0036978 Reactome Toll Like Receptor 9 (TLR9) Cascade R-DME-168138 FBgn0036978 Reactome Toll Like Receptor 10 (TLR10) Cascade R-DME-168142 FBgn0036978 Reactome Toll Like Receptor 7/8 (TLR7/8) Cascade R-DME-168181 FBgn0036978 Reactome Neutrophil degranulation R-DME-6798695 FBgn0036978 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0036978 Reactome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-DME-975138 FBgn0036978 Reactome MyD88 dependent cascade initiated on endosome R-DME-975155 FBgn0001259 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0001247 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0001247 Reactome Peroxisomal protein import R-DME-9033241 FBgn0036980 Reactome Rho GTPase cycle R-DME-194840 FBgn0027565 Reactome Macroautophagy R-DME-1632852 FBgn0027565 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0036986 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0036986 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0029158 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0284421 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0284421 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0284421 Reactome Neutrophil degranulation R-DME-6798695 FBgn0284421 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0284421 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0036990 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0036990 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0036992 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0036996 Reactome Digestion of dietary lipid R-DME-192456 FBgn0036996 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0037000 Reactome Metal ion SLC transporters R-DME-425410 FBgn0037001 Reactome Respiratory electron transport R-DME-611105 FBgn0037001 Reactome Complex I biogenesis R-DME-6799198 FBgn0037008 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0037010 Reactome Synthesis of PS R-DME-1483101 FBgn0001323 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0001323 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0001323 Reactome Transcriptional regulation of white adipocyte differentiation R-DME-381340 FBgn0001323 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0001323 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0001323 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0001320 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0001320 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0001320 Reactome Transcriptional regulation of white adipocyte differentiation R-DME-381340 FBgn0001320 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0001320 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0001320 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0037020 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0037020 Reactome Peroxisomal protein import R-DME-9033241 FBgn0037022 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0037024 Reactome Pyruvate metabolism R-DME-70268 FBgn0259243 Reactome PKA activation R-DME-163615 FBgn0259243 Reactome PKA activation in glucagon signalling R-DME-164378 FBgn0259243 Reactome DARPP-32 events R-DME-180024 FBgn0259243 Reactome Vasopressin regulates renal water homeostasis via Aquaporins R-DME-432040 FBgn0259243 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0259243 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0027055 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0027055 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0027055 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027055 Reactome Neddylation R-DME-8951664 FBgn0037044 Reactome Ubiquinol biosynthesis R-DME-2142789 FBgn0037045 Reactome Protein methylation R-DME-8876725 FBgn0037051 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0041100 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0041100 Reactome Josephin domain DUBs R-DME-5689877 FBgn0041100 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037061 Reactome Methylation R-DME-156581 FBgn0037061 Reactome Eukaryotic Translation Termination R-DME-72764 FBgn0004865 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0037063 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0037064 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0012034 Reactome Ethanol oxidation R-DME-71384 FBgn0027945 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0027945 Reactome Glycine degradation R-DME-6783984 FBgn0003042 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0003042 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0003042 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0003042 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0003042 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0003042 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0086913 Reactome Neutrophil degranulation R-DME-6798695 FBgn0086913 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0037073 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0002842 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0283479 Reactome Synthesis of PA R-DME-1483166 FBgn0283479 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0283479 Reactome Digestion R-DME-8935690 FBgn0037084 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0037084 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0015239 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0037093 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0037093 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015283 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0015283 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0015283 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0015283 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0015283 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0015283 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0015283 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0015283 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0015283 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0015283 Reactome Downstream TCR signaling R-DME-202424 FBgn0015283 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0015283 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0015283 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0015283 Reactome Nuclear CI is degraded R-DME-216167 FBgn0015283 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0015283 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0015283 Reactome Degradation of TIM R-DME-432395 FBgn0015283 Reactome Degradation of PER R-DME-432524 FBgn0015283 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0015283 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0015283 Reactome Degradation of AXIN R-DME-4641257 FBgn0015283 Reactome Degradation of DVL R-DME-4641258 FBgn0015283 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0015283 Reactome Degradation of CLK R-DME-538848 FBgn0015283 Reactome Degradation of CRY R-DME-538864 FBgn0015283 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0015283 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0015283 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0015283 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0015283 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0015283 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0015283 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0015283 Reactome UCH proteinases R-DME-5689603 FBgn0015283 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0015283 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015283 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0015283 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0015283 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0015283 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0015283 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0015283 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0015283 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0015283 Reactome Neddylation R-DME-8951664 FBgn0015283 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0015283 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028663 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028663 Reactome Insulin receptor recycling R-DME-77387 FBgn0028663 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028663 Reactome Ion channel transport R-DME-983712 FBgn0037100 Reactome Class A/1 (Rhodopsin-like receptors) R-DME-373076 FBgn0037100 Reactome G alpha (s) signalling events R-DME-418555 FBgn0261953 Reactome Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-DME-8864260 FBgn0261953 Reactome Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-DME-8866904 FBgn0261953 Reactome Activation of the TFAP2 (AP-2) family of transcription factors R-DME-8866907 FBgn0261953 Reactome TFAP2 (AP-2) family regulates transcription of cell cycle factors R-DME-8866911 FBgn0037105 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0037105 Reactome ATF6 (ATF6-alpha) activates chaperones R-DME-381033 FBgn0037105 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0037105 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0037109 Reactome Generic Transcription Pathway R-DME-212436 FBgn0037109 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0037110 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037116 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0037121 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0037121 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0037121 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0037121 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0037121 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0037121 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0037121 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0037121 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0037121 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0037121 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0037121 Reactome mRNA Capping R-DME-72086 FBgn0037121 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037121 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0037121 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0037121 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0037121 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0037121 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0037121 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0037121 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0037121 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0037121 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0037121 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0000560 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0000560 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0000560 Reactome Transcriptional regulation of white adipocyte differentiation R-DME-381340 FBgn0000560 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0000560 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0000560 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0022936 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0022936 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0022936 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0022936 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0022936 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0022936 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0022936 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0022936 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0022936 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0022936 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0022936 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0022936 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0022936 Reactome mRNA Capping R-DME-72086 FBgn0022936 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0022936 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0022936 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0022936 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0022936 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0022936 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0022936 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0037138 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0037138 Reactome Proline catabolism R-DME-70688 FBgn0262737 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0262737 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0037140 Reactome Organic cation transport R-DME-549127 FBgn0037141 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0037141 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0037144 Reactome Organic cation transport R-DME-549127 FBgn0037146 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0000100 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0000100 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0000100 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0000100 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0000100 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0000100 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0028500 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0028500 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0004179 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011771 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0011771 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0011771 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0011771 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037163 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0037164 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0037165 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0037166 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0037167 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0037170 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0037172 Reactome Respiratory electron transport R-DME-611105 FBgn0037172 Reactome Complex I biogenesis R-DME-6799198 FBgn0037182 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0037186 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0052451 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0010348 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0010348 Reactome Clathrin derived vesicle budding R-DME-421837 FBgn0010348 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0010348 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0010348 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0010348 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0037202 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0037202 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0037202 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0037202 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0037202 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0037202 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0037202 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0037202 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0037202 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0037202 Reactome mRNA Capping R-DME-72086 FBgn0037202 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0037202 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0037202 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0037202 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0037202 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0037202 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0037203 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0266347 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0266347 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0266347 Reactome Highly calcium permeable nicotinic acetylcholine receptors R-DME-629597 FBgn0266347 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037215 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037215 Reactome Lysosomal oligosaccharide catabolism R-DME-8853383 FBgn0037218 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0037218 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0261436 Reactome Purine catabolism R-DME-74259 FBgn0037220 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015331 Reactome STING mediated induction of host immune responses R-DME-1834941 FBgn0250821 Reactome Nephrin family interactions R-DME-373753 FBgn0250821 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037231 Reactome Macroautophagy R-DME-1632852 FBgn0037231 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0037236 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0037236 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0037236 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0037236 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0037236 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0037236 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0037236 Reactome Neddylation R-DME-8951664 FBgn0037236 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037238 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0003882 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0003882 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0003882 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0003882 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0003882 Reactome Adaptor protein complex binds to TL receptor at the plasma membrane R-DME-214863 FBgn0003882 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0003882 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0037249 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037249 Reactome Translation initiation complex formation R-DME-72649 FBgn0037249 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037249 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0037249 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0037249 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0037251 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0051522 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0051522 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0051522 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037255 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037255 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037255 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037255 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0087012 Reactome Serotonin receptors R-DME-390666 FBgn0037262 Reactome Generic Transcription Pathway R-DME-212436 FBgn0263346 Reactome Neddylation R-DME-8951664 FBgn0263346 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037270 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037270 Reactome Translation initiation complex formation R-DME-72649 FBgn0037270 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037270 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0037270 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0037270 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0010750 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0010750 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010750 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0260794 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0026417 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0004913 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0004913 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0004913 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0004913 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0004913 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0004913 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0004913 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0004913 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0004913 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0004913 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0004913 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0004913 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0004913 Reactome Polymerase switching R-DME-69091 FBgn0265082 Reactome SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-DME-399955 FBgn0004436 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0004436 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037293 Reactome TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-DME-6803205 FBgn0037293 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0037297 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0037297 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0037298 Reactome Platelet degranulation R-DME-114608 FBgn0037299 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0260462 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0037305 Reactome Methionine salvage pathway R-DME-1237112 FBgn0037307 Reactome Mitochondrial protein import R-DME-1268020 FBgn0264785 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0037310 Reactome Mitochondrial protein import R-DME-1268020 FBgn0250746 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0250746 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0250746 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0250746 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0250746 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0250746 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0250746 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0250746 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0250746 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0250746 Reactome Downstream TCR signaling R-DME-202424 FBgn0250746 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0250746 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0250746 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0250746 Reactome Nuclear CI is degraded R-DME-216167 FBgn0250746 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0250746 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0250746 Reactome Degradation of TIM R-DME-432395 FBgn0250746 Reactome Degradation of PER R-DME-432524 FBgn0250746 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0250746 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0250746 Reactome Degradation of AXIN R-DME-4641257 FBgn0250746 Reactome Degradation of DVL R-DME-4641258 FBgn0250746 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0250746 Reactome Degradation of CLK R-DME-538848 FBgn0250746 Reactome Degradation of CRY R-DME-538864 FBgn0250746 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0250746 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0250746 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0250746 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0250746 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0250746 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0250746 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0250746 Reactome UCH proteinases R-DME-5689603 FBgn0250746 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0250746 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0250746 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0250746 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0250746 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0250746 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0250746 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0250746 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0250746 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0250746 Reactome Neddylation R-DME-8951664 FBgn0250746 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0250746 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037315 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0037323 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0037323 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0037323 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0037327 Reactome PERK regulates gene expression R-DME-381042 FBgn0037328 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037328 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0037328 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037328 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0037328 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0037328 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037330 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0037330 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0011715 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0037332 Reactome Biotin transport and metabolism R-DME-196780 FBgn0051550 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0051547 Reactome Cation-coupled Chloride cotransporters R-DME-426117 FBgn0010051 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0010051 Reactome Elevation of cytosolic Ca2+ levels R-DME-139853 FBgn0010051 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0010051 Reactome Ion homeostasis R-DME-5578775 FBgn0010051 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0010399 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0010399 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0010399 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0010399 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0086768 Reactome Protein repair R-DME-5676934 FBgn0037338 Reactome Nonhomologous End-Joining (NHEJ) R-DME-5693571 FBgn0037339 Reactome Synthesis of PIPs at the ER membrane R-DME-1483248 FBgn0037339 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0037339 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0037339 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0037341 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0023023 Reactome Pyrimidine catabolism R-DME-73621 FBgn0037345 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0037345 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0037345 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0014366 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0283535 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0283535 Reactome Insulin receptor recycling R-DME-77387 FBgn0283535 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0283535 Reactome Ion channel transport R-DME-983712 FBgn0017550 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0019637 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0019637 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0019637 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0019637 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0037351 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037351 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0037351 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037351 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0037351 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0037351 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0027951 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0262125 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0262125 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0262125 Reactome Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-DME-983170 FBgn0037359 Reactome Generic Transcription Pathway R-DME-212436 FBgn0046222 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0046222 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0046222 Reactome mRNA 3'-end processing R-DME-72187 FBgn0046222 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0037363 Reactome Macroautophagy R-DME-1632852 FBgn0037364 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0261261 Reactome Translocation of SLC2A4 (GLUT4) to the plasma membrane R-DME-1445148 FBgn0037370 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0037371 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037371 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037371 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037371 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0027497 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0037372 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0266672 Reactome Insulin processing R-DME-264876 FBgn0266672 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0037376 Reactome HATs acetylate histones R-DME-3214847 FBgn0028690 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028690 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028690 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028690 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028690 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028690 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028690 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028690 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028690 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028690 Reactome Downstream TCR signaling R-DME-202424 FBgn0028690 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028690 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028690 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028690 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028690 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028690 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028690 Reactome Degradation of TIM R-DME-432395 FBgn0028690 Reactome Degradation of PER R-DME-432524 FBgn0028690 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028690 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028690 Reactome Degradation of AXIN R-DME-4641257 FBgn0028690 Reactome Degradation of DVL R-DME-4641258 FBgn0028690 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028690 Reactome Degradation of CLK R-DME-538848 FBgn0028690 Reactome Degradation of CRY R-DME-538864 FBgn0028690 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028690 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028690 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028690 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028690 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028690 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028690 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028690 Reactome UCH proteinases R-DME-5689603 FBgn0028690 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028690 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028690 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028690 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028690 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028690 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028690 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028690 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028690 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028690 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028690 Reactome Neddylation R-DME-8951664 FBgn0028690 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028690 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037382 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037382 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0037382 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037383 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0037386 Reactome Cellular hexose transport R-DME-189200 FBgn0037386 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0037386 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0037387 Reactome Cellular hexose transport R-DME-189200 FBgn0037387 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0037387 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0028436 Reactome Complex I biogenesis R-DME-6799198 FBgn0037391 Reactome Platelet degranulation R-DME-114608 FBgn0003261 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0003261 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003261 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0037396 Reactome Collagen degradation R-DME-1442490 FBgn0037396 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0037396 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0037396 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0037396 Reactome Assembly of collagen fibrils and other multimeric structures R-DME-2022090 FBgn0037396 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0037396 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037402 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0037402 Reactome Insulin receptor recycling R-DME-77387 FBgn0037402 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0037402 Reactome Ion channel transport R-DME-983712 FBgn0037431 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0037431 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0037432 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0037432 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0037433 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0037433 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0261789 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261789 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0010282 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0010282 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0010282 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010282 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0010282 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0010282 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0010282 Reactome mRNA Capping R-DME-72086 FBgn0010282 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0010282 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0010282 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0010282 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010282 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010282 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010282 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0010282 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0010282 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0010282 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0010355 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010355 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010355 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010355 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010355 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0026566 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0024289 Reactome Fructose biosynthesis R-DME-5652227 FBgn0024289 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0037467 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003884 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0003884 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0003884 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0086372 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0086372 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0086372 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0037485 Reactome Cellular hexose transport R-DME-189200 FBgn0037485 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0037485 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0037486 Reactome Cellular hexose transport R-DME-189200 FBgn0037486 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0037486 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0028400 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0028400 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0037498 Reactome Neutrophil degranulation R-DME-6798695 FBgn0017456 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0017456 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0015831 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0015831 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0003885 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0003885 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0003885 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0083963 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0051146 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0037513 Reactome Pyrimidine catabolism R-DME-73621 FBgn0051472 Reactome Vitamins B6 activation to pyridoxal phosphate R-DME-964975 FBgn0037529 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0037529 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0024909 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0024909 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0024909 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0024909 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0024909 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0004901 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0014930 Reactome Vitamin B2 (riboflavin) metabolism R-DME-196843 FBgn0037533 Reactome Basigin interactions R-DME-210991 FBgn0037533 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0037533 Reactome Tryptophan catabolism R-DME-71240 FBgn0037534 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037534 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037534 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037540 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0037543 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0037546 Reactome Histamine receptors R-DME-390650 FBgn0037546 Reactome G alpha (i) signalling events R-DME-418594 FBgn0243512 Reactome RAF-independent MAPK1/3 activation R-DME-112409 FBgn0243512 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0037550 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0037550 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0037550 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0037550 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037551 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001138 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0001138 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0001138 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0001138 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0037554 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0037554 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0037555 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0010173 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0010173 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0010173 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0010173 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0010173 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0010173 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0010173 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0010173 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0010173 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0010173 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0010173 Reactome Gap-filling DNA repair synthesis and ligation in GG-NER R-DME-5696397 FBgn0010173 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0010173 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0010173 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0010173 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0010173 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0014861 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0014861 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0014861 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0014861 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0014861 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0037566 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0037566 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0265351 Reactome GDP-fucose biosynthesis R-DME-6787639 FBgn0265351 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0037569 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037569 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0037569 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037573 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037573 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0037573 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0037573 Reactome Deadenylation of mRNA R-DME-429947 FBgn0037573 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037573 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037573 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037574 Reactome Mitochondrial protein import R-DME-1268020 FBgn0037574 Reactome Ubiquinol biosynthesis R-DME-2142789 FBgn0261108 Reactome Macroautophagy R-DME-1632852 FBgn0020249 Reactome Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-DME-446388 FBgn0261929 Reactome Serotonin receptors R-DME-390666 FBgn0024326 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0024326 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0024326 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0000447 Reactome Pyrimidine biosynthesis R-DME-500753 FBgn0037603 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0037608 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0037608 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0037612 Reactome LDL clearance R-DME-8964038 FBgn0037622 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037632 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0037632 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0037637 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0037644 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037647 Reactome Macroautophagy R-DME-1632852 FBgn0037647 Reactome mTOR signalling R-DME-165159 FBgn0037647 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0037647 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0037647 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0037647 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0027503 Reactome UCH proteinases R-DME-5689603 FBgn0027503 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0037648 Reactome Macroautophagy R-DME-1632852 FBgn0051100 Reactome Cellular hexose transport R-DME-189200 FBgn0051100 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0051100 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0026380 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0026380 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0026380 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0026380 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0026380 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0026380 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0026380 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0026380 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0026380 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026380 Reactome Downstream TCR signaling R-DME-202424 FBgn0026380 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0026380 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0026380 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0026380 Reactome Nuclear CI is degraded R-DME-216167 FBgn0026380 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0026380 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0026380 Reactome Degradation of TIM R-DME-432395 FBgn0026380 Reactome Degradation of PER R-DME-432524 FBgn0026380 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0026380 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0026380 Reactome Degradation of AXIN R-DME-4641257 FBgn0026380 Reactome Degradation of DVL R-DME-4641258 FBgn0026380 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0026380 Reactome Degradation of CLK R-DME-538848 FBgn0026380 Reactome Degradation of CRY R-DME-538864 FBgn0026380 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0026380 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0026380 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0026380 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0026380 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0026380 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0026380 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0026380 Reactome UCH proteinases R-DME-5689603 FBgn0026380 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0026380 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0026380 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0026380 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0026380 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0026380 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0026380 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0026380 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0026380 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0026380 Reactome Neddylation R-DME-8951664 FBgn0026380 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0026380 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037653 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037655 Reactome Neutrophil degranulation R-DME-6798695 FBgn0264075 Reactome Regulation of gene expression by Hypoxia-inducible Factor R-DME-1234158 FBgn0264075 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0264075 Reactome Endogenous sterols R-DME-211976 FBgn0264075 Reactome Xenobiotics R-DME-211981 FBgn0264075 Reactome Aryl hydrocarbon receptor signalling R-DME-8937144 FBgn0037657 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0037657 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0037657 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0037657 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0037657 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0014018 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0014018 Reactome RIP-mediated NFkB activation via ZBP1 R-DME-1810476 FBgn0014018 Reactome Downstream TCR signaling R-DME-202424 FBgn0014018 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0014018 Reactome NF-kB is activated and signals survival R-DME-209560 FBgn0014018 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0014018 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0014018 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0014018 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0014018 Reactome DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-DME-3134963 FBgn0014018 Reactome TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-DME-445989 FBgn0014018 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0014018 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0014018 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0014018 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0014018 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014018 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0014018 Reactome TRAF6 mediated NF-kB activation R-DME-933542 FBgn0037659 Reactome Neddylation R-DME-8951664 FBgn0037659 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037661 Reactome Abacavir metabolism R-DME-2161541 FBgn0037661 Reactome Purine salvage R-DME-74217 FBgn0260935 Reactome PI3K Cascade R-DME-109704 FBgn0260935 Reactome Macroautophagy R-DME-1632852 FBgn0260935 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0260935 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0260935 Reactome Synthesis of PIPs at the late endosome membrane R-DME-1660517 FBgn0260935 Reactome Toll Like Receptor 9 (TLR9) Cascade R-DME-168138 FBgn0260935 Reactome RHO GTPases Activate NADPH Oxidases R-DME-5668599 FBgn0037665 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0037671 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037675 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0037677 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0037677 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037677 Reactome Antimicrobial peptides R-DME-6803157 FBgn0037678 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0037678 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037678 Reactome Antimicrobial peptides R-DME-6803157 FBgn0037679 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0037686 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037686 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0037686 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037686 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0037686 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0037686 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037687 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003889 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0003889 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0003889 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0037690 Reactome TWIK-releated acid-sensitive K+ channel (TASK) R-DME-1299316 FBgn0037690 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0011740 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0037696 Reactome Glutathione conjugation R-DME-156590 FBgn0037696 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0037696 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0037697 Reactome Glutathione conjugation R-DME-156590 FBgn0037697 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0037697 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0043791 Reactome Synthesis of PA R-DME-1483166 FBgn0043791 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0043791 Reactome Digestion R-DME-8935690 FBgn0267790 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0267790 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0267790 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0003205 Reactome SHC1 events in ERBB4 signaling R-DME-1250347 FBgn0003205 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0003205 Reactome GRB2 events in EGFR signaling R-DME-179812 FBgn0003205 Reactome SHC1 events in EGFR signaling R-DME-180336 FBgn0003205 Reactome GRB2 events in ERBB2 signaling R-DME-1963640 FBgn0003205 Reactome Tie2 Signaling R-DME-210993 FBgn0003205 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0003205 Reactome DAP12 signaling R-DME-2424491 FBgn0003205 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0003205 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0003205 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0003205 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0003205 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0003205 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0003205 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0003205 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0003205 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0003205 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0003205 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0003205 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0003205 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0003205 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0003205 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0003205 Reactome RAF activation R-DME-5673000 FBgn0003205 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0003205 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0003205 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0003205 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003205 Reactome PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-DME-8849471 FBgn0014023 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0014023 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0037703 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0037705 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037707 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0037707 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0037707 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037707 Reactome mRNA 3'-end processing R-DME-72187 FBgn0037707 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037709 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0037709 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0024833 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0024833 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0024833 Reactome Neutrophil degranulation R-DME-6798695 FBgn0027950 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0027950 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0261049 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0261049 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0037718 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0037718 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037718 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0037721 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0005585 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0037723 Reactome Metabolism of polyamines R-DME-351202 FBgn0003334 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0003334 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0003334 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0003334 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0003334 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0003334 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0069242 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0069242 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0037734 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0037742 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0037742 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0037742 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0037742 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0037742 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0037742 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0037742 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0037742 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0037742 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0037742 Reactome Downstream TCR signaling R-DME-202424 FBgn0037742 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0037742 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0037742 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0037742 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0037742 Reactome Degradation of AXIN R-DME-4641257 FBgn0037742 Reactome Degradation of DVL R-DME-4641258 FBgn0037742 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0037742 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0037742 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0037742 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0037742 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0037742 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0037742 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0037742 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0037742 Reactome UCH proteinases R-DME-5689603 FBgn0037742 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0037742 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0037742 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0037742 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0037742 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0037742 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0037742 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0037742 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0037742 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0037742 Reactome Neddylation R-DME-8951664 FBgn0037742 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0037742 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037743 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0286506 Reactome Synthesis of GDP-mannose R-DME-446205 FBgn0266720 Reactome Other interleukin signaling R-DME-449836 FBgn0266720 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037749 Reactome Heme degradation R-DME-189483 FBgn0261599 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261599 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261599 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261599 Reactome Translation initiation complex formation R-DME-72649 FBgn0261599 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261599 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0261599 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0261599 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261599 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261599 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037759 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0037760 Reactome Neddylation R-DME-8951664 FBgn0037760 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037761 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037761 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037761 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037762 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037762 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037762 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037763 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037763 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037763 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037764 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037764 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037764 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037765 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0037765 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0037765 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0037770 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0027524 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0027524 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0027524 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0027524 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0037777 Reactome Complex I biogenesis R-DME-6799198 FBgn0037786 Reactome Synthesis of PA R-DME-1483166 FBgn0037786 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0037786 Reactome Digestion R-DME-8935690 FBgn0266721 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0266721 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0266721 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0266721 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0266721 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0037801 Reactome Glycine degradation R-DME-6783984 FBgn0037807 Reactome Vitamin C (ascorbate) metabolism R-DME-196836 FBgn0024957 Reactome Iron uptake and transport R-DME-917937 FBgn0037815 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0037815 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0037815 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0001235 Reactome Transcriptional activation by YKI R-DME-390193 FBgn0037818 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0020385 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0037828 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0004841 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0004841 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051390 Reactome Generic Transcription Pathway R-DME-212436 FBgn0010421 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0010421 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0010421 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010421 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0010421 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0010421 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0010421 Reactome mRNA Capping R-DME-72086 FBgn0010421 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0010421 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0010421 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0010421 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010421 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010421 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010421 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0010421 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0010421 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0010421 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0261380 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0261380 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0037834 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0037834 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0037834 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0017577 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0017577 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0017577 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0017577 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0017577 Reactome Switching of origins to a post-replicative state R-DME-69052 FBgn0037836 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0037836 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0037836 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0037836 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0037836 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0037836 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0037836 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0037836 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0037836 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0037836 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0037836 Reactome mRNA Capping R-DME-72086 FBgn0037836 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037836 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0037836 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0037836 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0037836 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0037836 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0037836 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0037836 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0037836 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0037836 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0037845 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0037845 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0037846 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0037846 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0011768 Reactome Abacavir metabolism R-DME-2161541 FBgn0011768 Reactome RA biosynthesis pathway R-DME-5365859 FBgn0011768 Reactome Ethanol oxidation R-DME-71384 FBgn0022359 Reactome Fructose biosynthesis R-DME-5652227 FBgn0022359 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0037852 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0042094 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0042094 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0037860 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0037862 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0037873 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0086472 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0086472 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0086472 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0086472 Reactome Translation initiation complex formation R-DME-72649 FBgn0086472 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0086472 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0086472 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0086472 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0086472 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0086472 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0020910 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0020910 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0020910 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0020910 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0020910 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0020910 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0037880 Reactome Complex I biogenesis R-DME-6799198 FBgn0037881 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0037883 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0037884 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0037891 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0037891 Reactome Lysine catabolism R-DME-71064 FBgn0037891 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0037892 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0037892 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0002906 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0037895 Reactome Cellular hexose transport R-DME-189200 FBgn0037895 Reactome Inositol transporters R-DME-429593 FBgn0037895 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0037896 Reactome Choline catabolism R-DME-6798163 FBgn0037900 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037906 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037906 Reactome Antimicrobial peptides R-DME-6803157 FBgn0037911 Reactome Phosphate bond hydrolysis by NUDT proteins R-DME-2393930 FBgn0263316 Reactome Platelet degranulation R-DME-114608 FBgn0263316 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0037915 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0037916 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0037917 Reactome TBC/RABGAPs R-DME-8854214 FBgn0262081 Reactome GAB1 signalosome R-DME-180292 FBgn0262081 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0262081 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0011290 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0011290 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0011290 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0011290 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0011290 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0037933 Reactome Heme degradation R-DME-189483 FBgn0037933 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037933 Reactome Iron uptake and transport R-DME-917937 FBgn0037939 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0037939 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0037939 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0037939 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0037939 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0037939 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0037942 Reactome Vitamin B1 (thiamin) metabolism R-DME-196819 FBgn0037944 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0037944 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0037944 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0037950 Reactome Neurotransmitter receptors and postsynaptic signal transmission R-DME-112314 FBgn0025802 Reactome Synthesis of PIPs at the ER membrane R-DME-1483248 FBgn0025802 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0051116 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0037955 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0037955 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0037955 Reactome Tryptophan catabolism R-DME-71240 FBgn0037958 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0051368 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0051368 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0051368 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0051368 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0260743 Reactome Organic anion transporters R-DME-428643 FBgn0037970 Reactome Organic anion transporters R-DME-428643 FBgn0260746 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0260746 Reactome Keratan sulfate degradation R-DME-2022857 FBgn0260746 Reactome HS-GAG degradation R-DME-2024096 FBgn0260746 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037979 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0051358 Reactome Nephrin family interactions R-DME-373753 FBgn0051358 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037986 Reactome Nephrin family interactions R-DME-373753 FBgn0037986 Reactome Neutrophil degranulation R-DME-6798695 FBgn0037988 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0037994 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0037994 Reactome Translation initiation complex formation R-DME-72649 FBgn0037994 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0037994 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0037994 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0037994 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0037995 Reactome Purine salvage R-DME-74217 FBgn0037998 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0037998 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0037999 Reactome Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-DME-77350 FBgn0037999 Reactome Beta oxidation of butanoyl-CoA to acetyl-CoA R-DME-77352 FBgn0263755 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0003651 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0038016 Reactome HATs acetylate histones R-DME-3214847 FBgn0038016 Reactome Regulation of TP53 Activity through Association with Co-factors R-DME-6804759 FBgn0038018 Reactome Mitochondrial protein import R-DME-1268020 FBgn0286075 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0286075 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0038037 Reactome Miscellaneous substrates R-DME-211958 FBgn0038037 Reactome Eicosanoids R-DME-211979 FBgn0038037 Reactome Xenobiotics R-DME-211981 FBgn0038037 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0038037 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0038037 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0038038 Reactome Platelet degranulation R-DME-114608 FBgn0038045 Reactome Sialic acid metabolism R-DME-4085001 FBgn0038046 Reactome Neutrophil degranulation R-DME-6798695 FBgn0086134 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0086134 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0086134 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0086134 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0086134 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0086134 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0086134 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0086134 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0086134 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0086134 Reactome Downstream TCR signaling R-DME-202424 FBgn0086134 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0086134 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0086134 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0086134 Reactome Nuclear CI is degraded R-DME-216167 FBgn0086134 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0086134 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0086134 Reactome Degradation of TIM R-DME-432395 FBgn0086134 Reactome Degradation of PER R-DME-432524 FBgn0086134 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0086134 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0086134 Reactome Degradation of AXIN R-DME-4641257 FBgn0086134 Reactome Degradation of DVL R-DME-4641258 FBgn0086134 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0086134 Reactome Degradation of CLK R-DME-538848 FBgn0086134 Reactome Degradation of CRY R-DME-538864 FBgn0086134 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0086134 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0086134 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0086134 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0086134 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0086134 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0086134 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0086134 Reactome UCH proteinases R-DME-5689603 FBgn0086134 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0086134 Reactome Neutrophil degranulation R-DME-6798695 FBgn0086134 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0086134 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0086134 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0086134 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0086134 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0086134 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0086134 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0086134 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0086134 Reactome Neddylation R-DME-8951664 FBgn0086134 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0086134 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038056 Reactome Neddylation R-DME-8951664 FBgn0038056 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038063 Reactome Serotonin receptors R-DME-390666 FBgn0038063 Reactome G alpha (s) signalling events R-DME-418555 FBgn0005671 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0005671 Reactome Insulin receptor recycling R-DME-77387 FBgn0005671 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0005671 Reactome Ion channel transport R-DME-983712 FBgn0260444 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0038067 Reactome Digestion of dietary lipid R-DME-192456 FBgn0038067 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0038068 Reactome Digestion of dietary lipid R-DME-192456 FBgn0038068 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0038069 Reactome Digestion of dietary lipid R-DME-192456 FBgn0038069 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0038070 Reactome Digestion of dietary lipid R-DME-192456 FBgn0038070 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0038074 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0026207 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0026207 Reactome snRNP Assembly R-DME-191859 FBgn0026207 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0026207 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0026207 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0026207 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0026207 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0005355 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0005355 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0005355 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0005355 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0011745 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0011745 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011745 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0011745 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0016693 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0038080 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0002905 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0038106 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038106 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0038110 Reactome ERBB2 Regulates Cell Motility R-DME-6785631 FBgn0020496 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0020496 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0020496 Reactome Repression of WNT target genes R-DME-4641265 FBgn0003308 Reactome Purine catabolism R-DME-74259 FBgn0003308 Reactome Vitamins B6 activation to pyridoxal phosphate R-DME-964975 FBgn0003450 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0260962 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0260962 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0260962 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0260962 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0260962 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0260962 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0260962 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0260962 Reactome Neddylation R-DME-8951664 FBgn0000024 Reactome Neurotransmitter clearance R-DME-112311 FBgn0000024 Reactome Synthesis of PC R-DME-1483191 FBgn0038139 Reactome Class A/1 (Rhodopsin-like receptors) R-DME-373076 FBgn0038139 Reactome G alpha (s) signalling events R-DME-418555 FBgn0038140 Reactome Class A/1 (Rhodopsin-like receptors) R-DME-373076 FBgn0038140 Reactome G alpha (s) signalling events R-DME-418555 FBgn0027610 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0027610 Reactome Organic anion transporters R-DME-428643 FBgn0027610 Reactome Gluconeogenesis R-DME-70263 FBgn0023495 Reactome Digestion of dietary lipid R-DME-192456 FBgn0023495 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0038145 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0038146 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038149 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0004049 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0263396 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0263396 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0263396 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0004587 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0004587 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0004587 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004587 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0004587 Reactome mRNA 3'-end processing R-DME-72187 FBgn0038165 Reactome TWIK-releated acid-sensitive K+ channel (TASK) R-DME-1299316 FBgn0038165 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0038166 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0038166 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0038166 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0038166 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0038166 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0038166 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0038166 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0038166 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0038166 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0038166 Reactome Downstream TCR signaling R-DME-202424 FBgn0038166 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0038166 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0038166 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0038166 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0038166 Reactome Degradation of AXIN R-DME-4641257 FBgn0038166 Reactome Degradation of DVL R-DME-4641258 FBgn0038166 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0038166 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0038166 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0038166 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0038166 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0038166 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0038166 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0038166 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0038166 Reactome UCH proteinases R-DME-5689603 FBgn0038166 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0038166 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0038166 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0038166 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0038166 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0038166 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0038166 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0038166 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0038166 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0038166 Reactome Neddylation R-DME-8951664 FBgn0038166 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0038166 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038168 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0002937 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0002937 Reactome Retinoid metabolism and transport R-DME-975634 FBgn0038172 Reactome Surfactant metabolism R-DME-5683826 FBgn0038172 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038173 Reactome Surfactant metabolism R-DME-5683826 FBgn0038173 Reactome Neutrophil degranulation R-DME-6798695 FBgn0267383 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0267383 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0016672 Reactome Synthesis of IP2, IP, and Ins in the cytosol R-DME-1855183 FBgn0015270 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0015270 Reactome Assembly of the ORC complex at the origin of replication R-DME-68616 FBgn0015270 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0015270 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0015270 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0015270 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015270 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0264493 Reactome Nuclear CI is degraded R-DME-216167 FBgn0264493 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0038194 Reactome Miscellaneous substrates R-DME-211958 FBgn0038194 Reactome Eicosanoids R-DME-211979 FBgn0038194 Reactome Xenobiotics R-DME-211981 FBgn0038194 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0038194 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0038194 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0038197 Reactome Insulin signaling pathway R-DME-110478 FBgn0038197 Reactome Signaling by NODAL R-DME-1181150 FBgn0038197 Reactome AKT phosphorylates targets in the nucleus R-DME-198693 FBgn0038197 Reactome AKT-mediated inactivation of FOXO1A R-DME-211163 FBgn0038197 Reactome MAPK6/MAPK4 signaling R-DME-5687128 FBgn0038197 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0038201 Reactome Class A/1 (Rhodopsin-like receptors) R-DME-373076 FBgn0038201 Reactome G alpha (s) signalling events R-DME-418555 FBgn0020510 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0020510 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0020510 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0010340 Reactome Complex I biogenesis R-DME-6799198 FBgn0262955 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0262955 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0262955 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0262955 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0262955 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0262955 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0262955 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0262955 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0262955 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0262955 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0262955 Reactome mRNA Capping R-DME-72086 FBgn0262955 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0262955 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0262955 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0262955 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0262955 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0262955 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0262955 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0262955 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0262955 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0262955 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0011582 Reactome Dopamine receptors R-DME-390651 FBgn0011582 Reactome G alpha (s) signalling events R-DME-418555 FBgn0003862 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0003862 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0004855 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0004855 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0004855 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0004855 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0004855 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0004855 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0004855 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0004855 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0004855 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0004855 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0004855 Reactome mRNA Capping R-DME-72086 FBgn0004855 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004855 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0004855 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0004855 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0004855 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0004855 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0004855 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0004855 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0004855 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0004855 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0011474 Reactome PKMTs methylate histone lysines R-DME-3214841 FBgn0003480 Reactome Homologous DNA Pairing and Strand Exchange R-DME-5693579 FBgn0285955 Reactome Rho GTPase cycle R-DME-194840 FBgn0038234 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038234 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0038235 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0020299 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0020299 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0020299 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0003169 Reactome Signaling by BMP R-DME-201451 FBgn0025808 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0262127 Reactome Signaling by Hippo R-DME-2028269 FBgn0038256 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0011217 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0011217 Reactome Downstream TCR signaling R-DME-202424 FBgn0011217 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0011217 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0011217 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0011217 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0011217 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0011217 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0011217 Reactome E3 ubiquitin ligases ubiquitinate target proteins R-DME-8866654 FBgn0011217 Reactome Neddylation R-DME-8951664 FBgn0011217 Reactome Peroxisomal protein import R-DME-9033241 FBgn0011217 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038258 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038258 Reactome Glycolysis R-DME-70171 FBgn0038269 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038271 Reactome Respiratory electron transport R-DME-611105 FBgn0038271 Reactome Processing of SMDT1 R-DME-8949664 FBgn0004597 Reactome Generic Transcription Pathway R-DME-212436 FBgn0004597 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0038272 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0038274 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0038274 Reactome snRNP Assembly R-DME-191859 FBgn0038274 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0038274 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0038274 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0038274 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0038274 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0262514 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0262514 Reactome Insulin receptor recycling R-DME-77387 FBgn0262514 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0262514 Reactome Ion channel transport R-DME-983712 FBgn0038277 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0038277 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0038277 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038277 Reactome Translation initiation complex formation R-DME-72649 FBgn0038277 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0038277 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0038277 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0038277 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0038277 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0038277 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0038281 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0038281 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0038281 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0038281 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0038281 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0038281 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0038286 Reactome Neddylation R-DME-8951664 FBgn0261859 Reactome Neutrophil degranulation R-DME-6798695 FBgn0266064 Reactome Glycogen synthesis R-DME-3322077 FBgn0038296 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038300 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0038302 Reactome Interconversion of polyamines R-DME-351200 FBgn0038303 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0038303 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0263979 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0263979 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0263979 Reactome HATs acetylate histones R-DME-3214847 FBgn0263979 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0263979 Reactome Neddylation R-DME-8951664 FBgn0263979 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0038306 Reactome RMTs methylate histone arginines R-DME-3214858 FBgn0038306 Reactome Protein methylation R-DME-8876725 FBgn0038307 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038307 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0045035 Reactome DNA Damage/Telomere Stress Induced Senescence R-DME-2559586 FBgn0045035 Reactome Sensing of DNA Double Strand Breaks R-DME-5693548 FBgn0045035 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0045035 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0045035 Reactome Regulation of TP53 Activity through Phosphorylation R-DME-6804756 FBgn0266599 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0266599 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0266599 Reactome Attenuation phase R-DME-3371568 FBgn0266599 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0266599 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0266599 Reactome Neutrophil degranulation R-DME-6798695 FBgn0266599 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0266599 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0263740 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0263740 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0263740 Reactome Translation initiation complex formation R-DME-72649 FBgn0263740 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0263740 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0263740 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0263740 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0016691 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0016691 Reactome Cristae formation R-DME-8949613 FBgn0038312 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0003721 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0004117 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0000533 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0038319 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038319 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0038320 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0038320 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0038320 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0038320 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038321 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0019925 Reactome Neutrophil degranulation R-DME-6798695 FBgn0019925 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0266722 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0266722 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0038325 Reactome Macroautophagy R-DME-1632852 FBgn0038326 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0026634 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0026634 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0038327 Reactome Small interfering RNA (siRNA) biogenesis R-DME-426486 FBgn0262483 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0038337 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0286071 Reactome O-glycosylation of TSR domain-containing proteins R-DME-5173214 FBgn0019940 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0019940 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0019940 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0019940 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0019940 Reactome G alpha (i) signalling events R-DME-418594 FBgn0019940 Reactome Opsins R-DME-419771 FBgn0019940 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0038354 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0038361 Reactome Heme biosynthesis R-DME-189451 FBgn0262527 Reactome HATs acetylate histones R-DME-3214847 FBgn0038365 Reactome Platelet degranulation R-DME-114608 FBgn0038365 Reactome Common Pathway of Fibrin Clot Formation R-DME-140875 FBgn0038365 Reactome Integrin cell surface interactions R-DME-216083 FBgn0038365 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0038365 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0038365 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0038365 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0038365 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0038365 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0038369 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0038369 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0038369 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0038373 Reactome Creatine metabolism R-DME-71288 FBgn0038376 Reactome Mitochondrial ABC transporters R-DME-1369007 FBgn0038385 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0038385 Reactome Neddylation R-DME-8951664 FBgn0038385 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038390 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0038390 Reactome G0 and Early G1 R-DME-1538133 FBgn0038390 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0038390 Reactome Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69200 FBgn0038390 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0038390 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0038390 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0002783 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0010379 Reactome Insulin signaling pathway R-DME-110478 FBgn0010379 Reactome TOR signaling pathway R-DME-110523 FBgn0010379 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0010379 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0010379 Reactome Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-DME-1474151 FBgn0010379 Reactome Activation of AKT2 R-DME-165158 FBgn0010379 Reactome mTOR signalling R-DME-165159 FBgn0010379 Reactome Inhibition of TSC complex formation by PKB R-DME-165181 FBgn0010379 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0010379 Reactome AKT phosphorylates targets in the nucleus R-DME-198693 FBgn0010379 Reactome Negative regulation of the PI3K/AKT network R-DME-199418 FBgn0010379 Reactome eNOS activation R-DME-203615 FBgn0010379 Reactome AKT-mediated inactivation of FOXO1A R-DME-211163 FBgn0010379 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0010379 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0010379 Reactome CTLA4 inhibitory signaling R-DME-389513 FBgn0010379 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0010379 Reactome KSRP (KHSRP) binds and destabilizes mRNA R-DME-450604 FBgn0010379 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0010379 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0010379 Reactome Regulation of TP53 Activity through Acetylation R-DME-6804758 FBgn0010379 Reactome Regulation of TP53 Activity through Association with Co-factors R-DME-6804759 FBgn0010379 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0010379 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0010379 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0010379 Reactome Negative regulation of NOTCH4 signaling R-DME-9604323 FBgn0038407 Reactome Organic cation transport R-DME-549127 FBgn0020407 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0261286 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038412 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0003513 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0003513 Reactome Endogenous sterols R-DME-211976 FBgn0003513 Reactome Xenobiotics R-DME-211981 FBgn0003513 Reactome Aryl hydrocarbon receptor signalling R-DME-8937144 FBgn0038426 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038426 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0038432 Reactome Glycerophospholipid catabolism R-DME-6814848 FBgn0027053 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0027053 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0027053 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027053 Reactome Neddylation R-DME-8951664 FBgn0004087 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0038438 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0038438 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0038438 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0028381 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0028381 Reactome Signaling by Hippo R-DME-2028269 FBgn0028381 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0028381 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0028381 Reactome Apoptotic cleavage of cell adhesion proteins R-DME-351906 FBgn0028381 Reactome Breakdown of the nuclear lamina R-DME-352238 FBgn0028381 Reactome Caspase activation via Dependence Receptors in the absence of ligand R-DME-418889 FBgn0028381 Reactome Other interleukin signaling R-DME-449836 FBgn0027562 Reactome Platelet degranulation R-DME-114608 FBgn0027562 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0027562 Reactome Neutrophil degranulation R-DME-6798695 FBgn0027562 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027562 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0038449 Reactome Wax biosynthesis R-DME-8848584 FBgn0038450 Reactome Wax biosynthesis R-DME-8848584 FBgn0038451 Reactome Wax biosynthesis R-DME-8848584 FBgn0038453 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0038453 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0038453 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038453 Reactome Translation initiation complex formation R-DME-72649 FBgn0038453 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0038453 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0038453 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0038453 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0038453 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0038453 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0038454 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015019 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0015019 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0015230 Reactome Cellular hexose transport R-DME-189200 FBgn0015230 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0015230 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0038458 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0038458 Reactome Insulin receptor recycling R-DME-77387 FBgn0038458 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0038458 Reactome Ion channel transport R-DME-983712 FBgn0015011 Reactome Bicarbonate transporters R-DME-425381 FBgn0015011 Reactome Ion homeostasis R-DME-5578775 FBgn0038463 Reactome Formation of xylulose-5-phosphate R-DME-5661270 FBgn0266917 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0038467 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0020493 Reactome Signaling by BMP R-DME-201451 FBgn0020493 Reactome Downregulation of TGF-beta receptor signaling R-DME-2173788 FBgn0020493 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0038474 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038474 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0038475 Reactome Neddylation R-DME-8951664 FBgn0038475 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0266465 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0266465 Reactome Apoptotic execution phase R-DME-75153 FBgn0014141 Reactome Platelet degranulation R-DME-114608 FBgn0014141 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0038485 Reactome Activation of Matrix Metalloproteinases R-DME-1592389 FBgn0038485 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038485 Reactome Antimicrobial peptides R-DME-6803157 FBgn0264291 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0038490 Reactome Cleavage of the damaged pyrimidine R-DME-110329 FBgn0038490 Reactome Displacement of DNA glycosylase by APEX1 R-DME-110357 FBgn0262871 Reactome Neddylation R-DME-8951664 FBgn0262871 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0025456 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038505 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0038505 Reactome Surfactant metabolism R-DME-5683826 FBgn0038506 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0038506 Reactome Surfactant metabolism R-DME-5683826 FBgn0038507 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0038507 Reactome Surfactant metabolism R-DME-5683826 FBgn0261046 Reactome DSCAM interactions R-DME-376172 FBgn0261046 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0038515 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038516 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0038519 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0038524 Reactome Transport and synthesis of PAPS R-DME-174362 FBgn0038524 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0038532 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0261885 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0038539 Reactome Macroautophagy R-DME-1632852 FBgn0038539 Reactome TBC/RABGAPs R-DME-8854214 FBgn0262562 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0262562 Reactome Rho GTPase cycle R-DME-194840 FBgn0262562 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0038546 Reactome PI5P Regulates TP53 Acetylation R-DME-6811555 FBgn0038552 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0010389 Reactome PI3K Cascade R-DME-109704 FBgn0010389 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0010389 Reactome FGFR4 ligand binding and activation R-DME-190322 FBgn0010389 Reactome FGFR1b ligand binding and activation R-DME-190370 FBgn0010389 Reactome FGFR3b ligand binding and activation R-DME-190371 FBgn0010389 Reactome FGFR3c ligand binding and activation R-DME-190372 FBgn0010389 Reactome FGFR1c ligand binding and activation R-DME-190373 FBgn0010389 Reactome FGFR2c ligand binding and activation R-DME-190375 FBgn0010389 Reactome FGFR2b ligand binding and activation R-DME-190377 FBgn0010389 Reactome Signal transduction by L1 R-DME-445144 FBgn0010389 Reactome Phospholipase C-mediated cascade: FGFR1 R-DME-5654219 FBgn0010389 Reactome Phospholipase C-mediated cascade; FGFR2 R-DME-5654221 FBgn0010389 Reactome Phospholipase C-mediated cascade; FGFR3 R-DME-5654227 FBgn0010389 Reactome Phospholipase C-mediated cascade; FGFR4 R-DME-5654228 FBgn0010389 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0010389 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0010389 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0010389 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0010389 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0010389 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0010389 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0010389 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0010389 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0010389 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0010389 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0010389 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0010389 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0010389 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0010389 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0010389 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0010389 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0010389 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0022943 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0022943 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0022943 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0022943 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0022943 Reactome snRNP Assembly R-DME-191859 FBgn0022943 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0022943 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0022943 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0022943 Reactome mRNA Capping R-DME-72086 FBgn0022943 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0022943 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0022943 Reactome mRNA 3'-end processing R-DME-72187 FBgn0022943 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0022943 Reactome SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-DME-77588 FBgn0022943 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0022943 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0022943 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0042693 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0042693 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0042693 Reactome ERK/MAPK targets R-DME-198753 FBgn0042693 Reactome ERKs are inactivated R-DME-202670 FBgn0042693 Reactome CTLA4 inhibitory signaling R-DME-389513 FBgn0042693 Reactome RAF activation R-DME-5673000 FBgn0042693 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0042693 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0038576 Reactome UCH proteinases R-DME-5689603 FBgn0038576 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0038578 Reactome Generic Transcription Pathway R-DME-212436 FBgn0038586 Reactome Neddylation R-DME-8951664 FBgn0262559 Reactome Gluconeogenesis R-DME-70263 FBgn0262559 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0020238 Reactome Translocation of SLC2A4 (GLUT4) to the plasma membrane R-DME-1445148 FBgn0020238 Reactome Signaling by Hippo R-DME-2028269 FBgn0020238 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0020238 Reactome HSF1 activation R-DME-3371511 FBgn0020238 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0020238 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0020238 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0020238 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0020238 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0020238 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0038597 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0024432 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038603 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0038609 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0038609 Reactome snRNP Assembly R-DME-191859 FBgn0038609 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0038609 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0038609 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0038609 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0038609 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0264751 Reactome Platelet degranulation R-DME-114608 FBgn0038621 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0038621 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0027841 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0027841 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0027841 Reactome mRNA 3'-end processing R-DME-72187 FBgn0027841 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0261065 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0261065 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261065 Reactome mRNA 3'-end processing R-DME-72187 FBgn0261065 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0038641 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0038641 Reactome Transport of bile salts and organic acids, metal ions and amine compounds R-DME-425366 FBgn0000303 Reactome Synthesis of PC R-DME-1483191 FBgn0000303 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0038652 Reactome Cellular hexose transport R-DME-189200 FBgn0038652 Reactome Inositol transporters R-DME-429593 FBgn0038652 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0038653 Reactome Adrenoceptors R-DME-390696 FBgn0038653 Reactome Adrenaline signalling through Alpha-2 adrenergic receptor R-DME-392023 FBgn0038653 Reactome Adrenaline,noradrenaline inhibits insulin secretion R-DME-400042 FBgn0038653 Reactome G alpha (i) signalling events R-DME-418594 FBgn0038653 Reactome G alpha (z) signalling events R-DME-418597 FBgn0003248 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0003248 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0003248 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0003248 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0003248 Reactome G alpha (i) signalling events R-DME-418594 FBgn0003248 Reactome Opsins R-DME-419771 FBgn0003248 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0038659 Reactome EGFR downregulation R-DME-182971 FBgn0038659 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0038659 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0038659 Reactome Recycling pathway of L1 R-DME-437239 FBgn0038659 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0038659 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0038660 Reactome HS-GAG degradation R-DME-2024096 FBgn0022338 Reactome Pyrimidine salvage R-DME-73614 FBgn0022338 Reactome Purine salvage R-DME-74217 FBgn0261792 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0027785 Reactome Respiratory electron transport R-DME-611105 FBgn0027785 Reactome Complex I biogenesis R-DME-6799198 FBgn0038678 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038678 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0016120 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0016120 Reactome Cristae formation R-DME-8949613 FBgn0261285 Reactome Coenzyme A biosynthesis R-DME-196783 FBgn0038686 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0025680 Reactome Degradation of TIM R-DME-432395 FBgn0025680 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0025680 Reactome Degradation of CRY R-DME-538864 FBgn0267975 Reactome PI and PC transport between ER and Golgi membranes R-DME-1483196 FBgn0038693 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0000463 Reactome NOTCH2 Activation and Transmission of Signal to the Nucleus R-DME-2979096 FBgn0000463 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0086613 Reactome UCH proteinases R-DME-5689603 FBgn0086613 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0038708 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0038721 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0038721 Reactome Neutrophil degranulation R-DME-6798695 FBgn0283536 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0283536 Reactome Insulin receptor recycling R-DME-77387 FBgn0283536 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0283536 Reactome Ion channel transport R-DME-983712 FBgn0038722 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0038722 Reactome snRNP Assembly R-DME-191859 FBgn0038722 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0038722 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0038722 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0038722 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0038722 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0014135 Reactome PI3K Cascade R-DME-109704 FBgn0014135 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0014135 Reactome FGFR4 ligand binding and activation R-DME-190322 FBgn0014135 Reactome FGFR1b ligand binding and activation R-DME-190370 FBgn0014135 Reactome FGFR3b ligand binding and activation R-DME-190371 FBgn0014135 Reactome FGFR3c ligand binding and activation R-DME-190372 FBgn0014135 Reactome FGFR1c ligand binding and activation R-DME-190373 FBgn0014135 Reactome FGFR2c ligand binding and activation R-DME-190375 FBgn0014135 Reactome FGFR2b ligand binding and activation R-DME-190377 FBgn0014135 Reactome Syndecan interactions R-DME-3000170 FBgn0014135 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0014135 Reactome Phospholipase C-mediated cascade: FGFR1 R-DME-5654219 FBgn0014135 Reactome Phospholipase C-mediated cascade; FGFR2 R-DME-5654221 FBgn0014135 Reactome Phospholipase C-mediated cascade; FGFR3 R-DME-5654227 FBgn0014135 Reactome Phospholipase C-mediated cascade; FGFR4 R-DME-5654228 FBgn0014135 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0014135 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0014135 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0014135 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0014135 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0014135 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0014135 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0014135 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0014135 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0014135 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0014135 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0014135 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0014135 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0014135 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0014135 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0014135 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0014135 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0014135 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0038735 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0038735 Reactome Processing of SMDT1 R-DME-8949664 FBgn0261984 Reactome IRE1alpha activates chaperones R-DME-381070 FBgn0038740 Reactome Platelet degranulation R-DME-114608 FBgn0038740 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0038742 Reactome Beta oxidation of hexanoyl-CoA to butanoyl-CoA R-DME-77350 FBgn0038742 Reactome Beta oxidation of butanoyl-CoA to acetyl-CoA R-DME-77352 FBgn0014006 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0002940 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0002940 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0002940 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0002940 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0002940 Reactome G alpha (i) signalling events R-DME-418594 FBgn0002940 Reactome Opsins R-DME-419771 FBgn0002940 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0038744 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0038744 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0038744 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0038747 Reactome Rho GTPase cycle R-DME-194840 FBgn0038751 Reactome Wax biosynthesis R-DME-8848584 FBgn0038755 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0051213 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0051213 Reactome Surfactant metabolism R-DME-5683826 FBgn0038760 Reactome Generic Transcription Pathway R-DME-212436 FBgn0038763 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0038771 Reactome Glutathione conjugation R-DME-156590 FBgn0003249 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0003249 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0003249 Reactome Activation of the phototransduction cascade R-DME-2485179 FBgn0003249 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0003249 Reactome G alpha (i) signalling events R-DME-418594 FBgn0003249 Reactome Opsins R-DME-419771 FBgn0003249 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0038773 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0038773 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0038773 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0038773 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0083975 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0261550 Reactome Acyl chain remodelling of PS R-DME-1482801 FBgn0038795 Reactome Carnitine synthesis R-DME-71262 FBgn0038796 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0038796 Reactome Translation initiation complex formation R-DME-72649 FBgn0038796 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0038796 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0038796 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0038796 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0038797 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0038797 Reactome Organic anion transporters R-DME-428643 FBgn0038797 Reactome Gluconeogenesis R-DME-70263 FBgn0016917 Reactome Interleukin-6 signaling R-DME-1059683 FBgn0016917 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0016917 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0016917 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0016917 Reactome Formation of the activated STAT92E dimer and transport to the nucleus R-DME-209228 FBgn0016917 Reactome Transcriptional activtion and repression of REL-68 target genes R-DME-209394 FBgn0016917 Reactome Transcriptional repression by nuclear factors R-DME-210671 FBgn0016917 Reactome Transcriptional activation by phosphorylated STAT92E dimer R-DME-210675 FBgn0016917 Reactome Dephosphorylation by PTP61F phosphatases R-DME-210688 FBgn0016917 Reactome STAT92E dimer dephosphorylated in the nucleus and transported to the cytosol R-DME-210693 FBgn0016917 Reactome Signaling by Leptin R-DME-2586552 FBgn0016917 Reactome STAT6-mediated induction of chemokines R-DME-3249367 FBgn0016917 Reactome Interleukin-3, Interleukin-5 and GM-CSF signaling R-DME-512988 FBgn0016917 Reactome Interleukin-10 signaling R-DME-6783783 FBgn0016917 Reactome Interleukin-4 and Interleukin-13 signaling R-DME-6785807 FBgn0016917 Reactome Interferon gamma signaling R-DME-877300 FBgn0016917 Reactome Regulation of IFNG signaling R-DME-877312 FBgn0016917 Reactome Interleukin-20 family signaling R-DME-8854691 FBgn0016917 Reactome Interleukin-15 signaling R-DME-8983432 FBgn0016917 Reactome Interleukin-35 Signalling R-DME-8984722 FBgn0016917 Reactome Interleukin-9 signaling R-DME-8985947 FBgn0016917 Reactome Interleukin-37 signaling R-DME-9008059 FBgn0016917 Reactome Interleukin-2 signaling R-DME-9020558 FBgn0016917 Reactome Interleukin-12 signaling R-DME-9020591 FBgn0016917 Reactome Interleukin-23 signaling R-DME-9020933 FBgn0016917 Reactome Interleukin-27 signaling R-DME-9020956 FBgn0016917 Reactome Interferon alpha/beta signaling R-DME-909733 FBgn0016917 Reactome Growth hormone receptor signaling R-DME-982772 FBgn0038805 Reactome Mitochondrial transcription initiation R-DME-163282 FBgn0023212 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0023212 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0023212 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0023212 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0023212 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0023212 Reactome Neddylation R-DME-8951664 FBgn0023212 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038808 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0038808 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038810 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0015279 Reactome PI3K Cascade R-DME-109704 FBgn0015279 Reactome Insulin signaling pathway R-DME-110478 FBgn0015279 Reactome IRS-mediated signalling R-DME-112399 FBgn0015279 Reactome GPVI-mediated activation cascade R-DME-114604 FBgn0015279 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0015279 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0015279 Reactome PI3K/AKT activation R-DME-198203 FBgn0015279 Reactome Tie2 Signaling R-DME-210993 FBgn0015279 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0015279 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0015279 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0015279 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0015279 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0015279 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0004107 Reactome G0 and Early G1 R-DME-1538133 FBgn0004107 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0004107 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0004107 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0004107 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0004107 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0004107 Reactome G2 Phase R-DME-68911 FBgn0004107 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0004107 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0004107 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0004107 Reactome Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-DME-69200 FBgn0004107 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0004107 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0265606 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0265606 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0265606 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0265606 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0265606 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0265606 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0265606 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0265606 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0265606 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0265606 Reactome Downstream TCR signaling R-DME-202424 FBgn0265606 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0265606 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0265606 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0265606 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0265606 Reactome Degradation of AXIN R-DME-4641257 FBgn0265606 Reactome Degradation of DVL R-DME-4641258 FBgn0265606 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0265606 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0265606 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0265606 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0265606 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0265606 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0265606 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0265606 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0265606 Reactome UCH proteinases R-DME-5689603 FBgn0265606 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0265606 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0265606 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0265606 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0265606 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0265606 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0265606 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0265606 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0265606 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0265606 Reactome Neddylation R-DME-8951664 FBgn0265606 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0265606 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038826 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0038826 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0038826 Reactome Formation of the Editosome R-DME-75094 FBgn0038829 Reactome Transport to the Golgi and subsequent modification R-DME-948021 FBgn0019936 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0019936 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0019936 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0019936 Reactome Translation initiation complex formation R-DME-72649 FBgn0019936 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0019936 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0019936 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0019936 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0019936 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0019936 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0027493 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0053094 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0038834 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0038834 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0038834 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038834 Reactome Translation initiation complex formation R-DME-72649 FBgn0038834 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0038834 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0038834 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0038834 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0038834 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0038834 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0038837 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0038837 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0038840 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0038840 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0038845 Reactome Synthesis of PA R-DME-1483166 FBgn0038845 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0038845 Reactome Digestion R-DME-8935690 FBgn0026056 Reactome Rho GTPase cycle R-DME-194840 FBgn0011672 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0011672 Reactome Metal ion SLC transporters R-DME-425410 FBgn0011672 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011672 Reactome Ion influx/efflux at host-pathogen interface R-DME-6803544 FBgn0011672 Reactome Iron uptake and transport R-DME-917937 FBgn0000083 Reactome Platelet degranulation R-DME-114608 FBgn0000083 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003257 Reactome Pyrimidine biosynthesis R-DME-500753 FBgn0038853 Reactome Rho GTPase cycle R-DME-194840 FBgn0266674 Reactome Insulin processing R-DME-264876 FBgn0266674 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0015790 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0015790 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0283468 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0283468 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0283468 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0283468 Reactome Downstream TCR signaling R-DME-202424 FBgn0283468 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0283468 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0283468 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0283468 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0283468 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0283468 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0283468 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0283468 Reactome Neddylation R-DME-8951664 FBgn0283468 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0283468 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0038858 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0038862 Reactome Downregulation of ERBB2:ERBB3 signaling R-DME-1358803 FBgn0038862 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0260004 Reactome Platelet degranulation R-DME-114608 FBgn0260004 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0260004 Reactome Neutrophil degranulation R-DME-6798695 FBgn0260004 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0260004 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0264357 Reactome Macroautophagy R-DME-1632852 FBgn0264357 Reactome AMPK inhibits chREBP transcriptional activation activity R-DME-163680 FBgn0264357 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0264357 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0264357 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0038872 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0038872 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0038872 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0038872 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0038872 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0285937 Reactome Golgi Cisternae Pericentriolar Stack Reorganization R-DME-162658 FBgn0285937 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0285937 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0285937 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0285937 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0285937 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0043012 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0043012 Reactome Recycling pathway of L1 R-DME-437239 FBgn0043012 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0043012 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0043012 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0043012 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0043012 Reactome LDL clearance R-DME-8964038 FBgn0038876 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0038890 Reactome Synthesis of PIPs at the early endosome membrane R-DME-1660516 FBgn0283499 Reactome Insulin signaling pathway R-DME-110478 FBgn0283499 Reactome Insulin receptor recycling R-DME-77387 FBgn0011766 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0011766 Reactome G2 Phase R-DME-68911 FBgn0011766 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0011766 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0259113 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0259113 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0259113 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0259113 Reactome DNA replication initiation R-DME-68952 FBgn0259113 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0259113 Reactome Polymerase switching R-DME-69091 FBgn0259113 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0259113 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0027575 Reactome Activation of G protein gated Potassium channels R-DME-1296041 FBgn0027575 Reactome G alpha (i) signalling events R-DME-418594 FBgn0027575 Reactome Class C/3 (Metabotropic glutamate/pheromone receptors) R-DME-420499 FBgn0027575 Reactome GABA B receptor activation R-DME-977444 FBgn0027575 Reactome Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-DME-997272 FBgn0038903 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0013759 Reactome Dopamine Neurotransmitter Release Cycle R-DME-212676 FBgn0013759 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0260940 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0038912 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038915 Reactome ARL13B-mediated ciliary trafficking of INPP5E R-DME-5624958 FBgn0038918 Reactome Platelet degranulation R-DME-114608 FBgn0038918 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0038918 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038918 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0038919 Reactome Platelet degranulation R-DME-114608 FBgn0038919 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0038919 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038919 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0038922 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0038923 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0038923 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0019957 Reactome Respiratory electron transport R-DME-611105 FBgn0019957 Reactome Complex I biogenesis R-DME-6799198 FBgn0038927 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0038927 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0038927 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0038927 Reactome mRNA 3'-end processing R-DME-72187 FBgn0038928 Reactome Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214397 FBgn0038928 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0038928 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0038928 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0038947 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0038947 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0038947 Reactome Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-DME-983170 FBgn0038948 Reactome HDMs demethylate histones R-DME-3214842 FBgn0267385 Reactome Neutrophil degranulation R-DME-6798695 FBgn0267385 Reactome Glycolysis R-DME-70171 FBgn0038952 Reactome Neutrophil degranulation R-DME-6798695 FBgn0038952 Reactome Glycolysis R-DME-70171 FBgn0263048 Reactome Synthesis of PA R-DME-1483166 FBgn0038957 Reactome Glycolysis R-DME-70171 FBgn0038964 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0038965 Reactome Signaling by Hippo R-DME-2028269 FBgn0038965 Reactome Formation of the Hippo kinase cassette R-DME-390089 FBgn0038965 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0038965 Reactome Negative regulation of TH R-DME-390197 FBgn0038966 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0038966 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0038966 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0028688 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028688 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028688 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028688 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028688 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028688 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028688 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028688 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028688 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028688 Reactome Downstream TCR signaling R-DME-202424 FBgn0028688 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028688 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028688 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028688 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028688 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028688 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028688 Reactome Degradation of TIM R-DME-432395 FBgn0028688 Reactome Degradation of PER R-DME-432524 FBgn0028688 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028688 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028688 Reactome Degradation of AXIN R-DME-4641257 FBgn0028688 Reactome Degradation of DVL R-DME-4641258 FBgn0028688 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028688 Reactome Degradation of CLK R-DME-538848 FBgn0028688 Reactome Degradation of CRY R-DME-538864 FBgn0028688 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028688 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028688 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028688 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028688 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028688 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028688 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028688 Reactome UCH proteinases R-DME-5689603 FBgn0028688 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028688 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028688 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028688 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028688 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028688 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028688 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028688 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028688 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028688 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028688 Reactome Neddylation R-DME-8951664 FBgn0028688 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028688 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263351 Reactome Gap junction degradation R-DME-190873 FBgn0263351 Reactome Formation of annular gap junctions R-DME-196025 FBgn0263351 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0263351 Reactome Recycling pathway of L1 R-DME-437239 FBgn0263351 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0263351 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0263351 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0263351 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0263351 Reactome LDL clearance R-DME-8964038 FBgn0038972 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0038972 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0038973 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0038973 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0038974 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0038975 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0003676 Reactome Association of TriC/CCT with target proteins during biosynthesis R-DME-390471 FBgn0003676 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0038980 Reactome Serotonin receptors R-DME-390666 FBgn0038980 Reactome G alpha (s) signalling events R-DME-418555 FBgn0038983 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0038983 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0038983 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0260942 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0260942 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0260942 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0038986 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0038986 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0038986 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0053110 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0053110 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0053110 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0028837 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0028837 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0028837 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0028837 Reactome Neddylation R-DME-8951664 FBgn0024558 Reactome Synthesis of diphthamide-EEF2 R-DME-5358493 FBgn0051159 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0039003 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0039003 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0039004 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0039004 Reactome snRNP Assembly R-DME-191859 FBgn0039004 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0039004 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0039004 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0039004 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0039004 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0039006 Reactome Miscellaneous substrates R-DME-211958 FBgn0039006 Reactome Eicosanoids R-DME-211979 FBgn0039006 Reactome Xenobiotics R-DME-211981 FBgn0039006 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0039006 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039006 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0039010 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0024958 Reactome Iron uptake and transport R-DME-917937 FBgn0039013 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039015 Reactome Ca2+ pathway R-DME-4086398 FBgn0039015 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0039015 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0039016 Reactome MicroRNA (miRNA) biogenesis R-DME-203927 FBgn0039016 Reactome Small interfering RNA (siRNA) biogenesis R-DME-426486 FBgn0039019 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0039025 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0039030 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0039030 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0039030 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0263390 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0039045 Reactome Transport of inorganic cations/anions and amino acids/oligopeptides R-DME-425393 FBgn0039045 Reactome Miscellaneous transport and binding events R-DME-5223345 FBgn0039049 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039050 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039051 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039052 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039053 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039055 Reactome Negative regulation of HPO R-DME-390115 FBgn0004644 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0004644 Reactome Formation and transport of the N-HH ligand R-DME-209471 FBgn0004644 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0004644 Reactome Release of Hh-Np from the secreting cell R-DME-5362798 FBgn0004644 Reactome Ligand-receptor interactions R-DME-5632681 FBgn0004395 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039058 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0039058 Reactome Insulin receptor recycling R-DME-77387 FBgn0039058 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0039058 Reactome Ion channel transport R-DME-983712 FBgn0265042 Reactome Activation of G protein gated Potassium channels R-DME-1296041 FBgn0265042 Reactome Classical Kir channels R-DME-1296053 FBgn0265042 Reactome Potassium transport channels R-DME-1296067 FBgn0265042 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0265042 Reactome Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-DME-997272 FBgn0262975 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0011596 Reactome Pink/Parkin Mediated Mitophagy R-DME-5205685 FBgn0011596 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0039064 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039064 Reactome Antigen Presentation: Folding, assembly and peptide loading of class I MHC R-DME-983170 FBgn0039066 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0039066 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0039066 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0039066 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0025781 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0025781 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0025781 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0025781 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0025781 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0025781 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0025781 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0025781 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0025781 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0025781 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0025781 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0025781 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0025781 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003118 Reactome Oncogene Induced Senescence R-DME-2559585 FBgn0264326 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0264326 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0264326 Reactome PCNA-Dependent Long Patch Base Excision Repair R-DME-5651801 FBgn0264326 Reactome Termination of translesion DNA synthesis R-DME-5656169 FBgn0264326 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0264326 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0264326 Reactome DNA replication initiation R-DME-68952 FBgn0264326 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0016119 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0016119 Reactome Cristae formation R-DME-8949613 FBgn0002622 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0002622 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0002622 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0002622 Reactome Translation initiation complex formation R-DME-72649 FBgn0002622 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0002622 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0002622 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0002622 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0002622 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0002622 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039073 Reactome Regulation of Complement cascade R-DME-977606 FBgn0039081 Reactome Activation of G protein gated Potassium channels R-DME-1296041 FBgn0039081 Reactome Classical Kir channels R-DME-1296053 FBgn0039081 Reactome Potassium transport channels R-DME-1296067 FBgn0039081 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0039081 Reactome Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits R-DME-997272 FBgn0051145 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0051145 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0039098 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0039099 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0040227 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0040227 Reactome Translation initiation complex formation R-DME-72649 FBgn0040227 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0040227 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0040227 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0040227 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039102 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0027512 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0270928 Reactome Acetylcholine Neurotransmitter Release Cycle R-DME-264642 FBgn0270928 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0270928 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0051148 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0039106 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0039106 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0039106 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0039107 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0039107 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0039107 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0002922 Reactome CDO in myogenesis R-DME-375170 FBgn0039109 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0028691 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028691 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028691 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028691 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028691 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028691 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028691 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028691 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028691 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028691 Reactome Downstream TCR signaling R-DME-202424 FBgn0028691 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028691 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028691 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028691 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028691 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028691 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028691 Reactome Degradation of TIM R-DME-432395 FBgn0028691 Reactome Degradation of PER R-DME-432524 FBgn0028691 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028691 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028691 Reactome Degradation of AXIN R-DME-4641257 FBgn0028691 Reactome Degradation of DVL R-DME-4641258 FBgn0028691 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028691 Reactome Degradation of CLK R-DME-538848 FBgn0028691 Reactome Degradation of CRY R-DME-538864 FBgn0028691 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028691 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028691 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028691 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028691 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028691 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028691 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028691 Reactome UCH proteinases R-DME-5689603 FBgn0028691 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028691 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028691 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028691 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028691 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028691 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028691 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028691 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028691 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028691 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028691 Reactome Neddylation R-DME-8951664 FBgn0028691 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028691 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263782 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0028684 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028684 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028684 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028684 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028684 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028684 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028684 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028684 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028684 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028684 Reactome Downstream TCR signaling R-DME-202424 FBgn0028684 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028684 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028684 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028684 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028684 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028684 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028684 Reactome Degradation of TIM R-DME-432395 FBgn0028684 Reactome Degradation of PER R-DME-432524 FBgn0028684 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028684 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028684 Reactome Degradation of AXIN R-DME-4641257 FBgn0028684 Reactome Degradation of DVL R-DME-4641258 FBgn0028684 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028684 Reactome Degradation of CLK R-DME-538848 FBgn0028684 Reactome Degradation of CRY R-DME-538864 FBgn0028684 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028684 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028684 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028684 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028684 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028684 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028684 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028684 Reactome UCH proteinases R-DME-5689603 FBgn0028684 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028684 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028684 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028684 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028684 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028684 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028684 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028684 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028684 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028684 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028684 Reactome Neddylation R-DME-8951664 FBgn0028684 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028684 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028475 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028475 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028475 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0039112 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0039116 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039120 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0039120 Reactome snRNP Assembly R-DME-191859 FBgn0039120 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0039120 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0039120 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0039120 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0039120 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0260634 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0260634 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0260634 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0260634 Reactome Deadenylation of mRNA R-DME-429947 FBgn0260634 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0260634 Reactome Translation initiation complex formation R-DME-72649 FBgn0260634 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0260634 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0260634 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0260634 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0260634 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0025574 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0025574 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0025574 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0013347 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0013347 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0013347 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0013347 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0013347 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0013347 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0013347 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0016754 Reactome UCH proteinases R-DME-5689603 FBgn0039125 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0039125 Reactome snRNP Assembly R-DME-191859 FBgn0039125 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0039125 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0039125 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0039125 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0039125 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0015282 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0015282 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0015282 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0015282 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0015282 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0015282 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0015282 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0015282 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0015282 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0015282 Reactome Downstream TCR signaling R-DME-202424 FBgn0015282 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0015282 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0015282 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0015282 Reactome Nuclear CI is degraded R-DME-216167 FBgn0015282 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0015282 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0015282 Reactome Degradation of TIM R-DME-432395 FBgn0015282 Reactome Degradation of PER R-DME-432524 FBgn0015282 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0015282 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0015282 Reactome Degradation of AXIN R-DME-4641257 FBgn0015282 Reactome Degradation of DVL R-DME-4641258 FBgn0015282 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0015282 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0015282 Reactome Degradation of CLK R-DME-538848 FBgn0015282 Reactome Degradation of CRY R-DME-538864 FBgn0015282 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0015282 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0015282 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0015282 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0015282 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0015282 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0015282 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0015282 Reactome UCH proteinases R-DME-5689603 FBgn0015282 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0015282 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0015282 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0015282 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0015282 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0015282 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0015282 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0015282 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0015282 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0015282 Reactome Neddylation R-DME-8951664 FBgn0015282 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0015282 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039129 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039129 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039129 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039129 Reactome Translation initiation complex formation R-DME-72649 FBgn0039129 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039129 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0039129 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039129 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039129 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039129 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0001098 Reactome Transcriptional activation of mitochondrial biogenesis R-DME-2151201 FBgn0001098 Reactome Amino acid synthesis and interconversion (transamination) R-DME-70614 FBgn0039131 Reactome Wax biosynthesis R-DME-8848584 FBgn0039132 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0039132 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0051140 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0015795 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015795 Reactome TBC/RABGAPs R-DME-8854214 FBgn0015795 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0015795 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0051184 Reactome mRNA decay by 5' to 3' exoribonuclease R-DME-430039 FBgn0051184 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039139 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0039140 Reactome Rho GTPase cycle R-DME-194840 FBgn0039140 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0264325 Reactome Macroautophagy R-DME-1632852 FBgn0264325 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0039145 Reactome Sulfide oxidation to sulfate R-DME-1614517 FBgn0040283 Reactome Establishment of Sister Chromatid Cohesion R-DME-2468052 FBgn0040283 Reactome Cohesin Loading onto Chromatin R-DME-2470946 FBgn0040283 Reactome Resolution of Sister Chromatid Cohesion R-DME-2500257 FBgn0013343 Reactome Other interleukin signaling R-DME-449836 FBgn0039147 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0039147 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0039147 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0026317 Reactome Macroautophagy R-DME-1632852 FBgn0026317 Reactome Inhibition of TSC complex formation by PKB R-DME-165181 FBgn0026317 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0026317 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0026317 Reactome TBC/RABGAPs R-DME-8854214 FBgn0266673 Reactome Insulin processing R-DME-264876 FBgn0266673 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0039155 Reactome FGFR1c ligand binding and activation R-DME-190373 FBgn0039155 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0015765 Reactome NOD1/2 Signaling Pathway R-DME-168638 FBgn0015765 Reactome p38MAPK events R-DME-171007 FBgn0015765 Reactome ERK/MAPK targets R-DME-198753 FBgn0015765 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0015765 Reactome CDO in myogenesis R-DME-375170 FBgn0015765 Reactome DSCAM interactions R-DME-376172 FBgn0015765 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0015765 Reactome Platelet sensitization by LDL R-DME-432142 FBgn0015765 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0015765 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0015765 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039158 Reactome TBC/RABGAPs R-DME-8854214 FBgn0039159 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0039159 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0026598 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0026598 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026598 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0026598 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0026598 Reactome Phosphorylation of CI R-DME-209190 FBgn0026598 Reactome Phosphorylation of SMO R-DME-209214 FBgn0026598 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0026598 Reactome Phosphorylation of ARM R-DME-209396 FBgn0026598 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0026598 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0026598 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0026598 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0026598 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0026598 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0011725 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0039170 Reactome Generic Transcription Pathway R-DME-212436 FBgn0011225 Reactome Gap junction degradation R-DME-190873 FBgn0086365 Reactome Organic cation transport R-DME-549127 FBgn0019952 Reactome Organic cation transport R-DME-549127 FBgn0263398 Reactome Pyrimidine salvage R-DME-73614 FBgn0011785 Reactome Interleukin-7 signaling R-DME-1266695 FBgn0011785 Reactome Chromatin modifying enzymes R-DME-3247509 FBgn0039182 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039183 Reactome mRNA decay by 3' to 5' exoribonuclease R-DME-429958 FBgn0039183 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0039184 Reactome Synthesis of Ketone Bodies R-DME-77111 FBgn0000036 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0000036 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0000036 Reactome Highly calcium permeable nicotinic acetylcholine receptors R-DME-629597 FBgn0000036 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000039 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0000039 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0000039 Reactome Highly calcium permeable nicotinic acetylcholine receptors R-DME-629597 FBgn0000039 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004118 Reactome Highly sodium permeable acetylcholine nicotinic receptors R-DME-629587 FBgn0004118 Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-DME-629594 FBgn0004118 Reactome Highly calcium permeable nicotinic acetylcholine receptors R-DME-629597 FBgn0004118 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003134 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0039205 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0039207 Reactome Platelet degranulation R-DME-114608 FBgn0039207 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0039212 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0039214 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0039214 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0000139 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0000139 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0020018 Reactome Heme biosynthesis R-DME-189451 FBgn0039218 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0039218 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0039218 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0039218 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0039218 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0039218 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0039218 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0039218 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0039218 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0039218 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0039218 Reactome mRNA Capping R-DME-72086 FBgn0039218 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039218 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0039218 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0039218 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0039218 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0039218 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0039218 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0039218 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0039218 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0039218 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0039218 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0039219 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0004885 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0004885 Reactome Crosslinking of collagen fibrils R-DME-2243919 FBgn0003719 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0003719 Reactome Crosslinking of collagen fibrils R-DME-2243919 FBgn0039227 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0027617 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039229 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0013953 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0039234 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0039234 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0039234 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039234 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0039234 Reactome Noncanonical activation of NOTCH3 R-DME-9017802 FBgn0039241 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0039252 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0020626 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0020626 Reactome Synthesis of bile acids and bile salts R-DME-192105 FBgn0039254 Reactome Nicotinate metabolism R-DME-196807 FBgn0039258 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0045866 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0045866 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0266719 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039269 Reactome Dopamine Neurotransmitter Release Cycle R-DME-212676 FBgn0039271 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0039271 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0039271 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0039274 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0046214 Reactome Platelet degranulation R-DME-114608 FBgn0039280 Reactome Molybdenum cofactor biosynthesis R-DME-947581 FBgn0039293 Reactome Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-DME-446193 FBgn0039300 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039300 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039300 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039300 Reactome Translation initiation complex formation R-DME-72649 FBgn0039300 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039300 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0039300 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039300 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039300 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039300 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039301 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0039301 Reactome snRNP Assembly R-DME-191859 FBgn0039301 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0039301 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0039301 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0039301 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0039301 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0039302 Reactome Basigin interactions R-DME-210991 FBgn0039302 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039304 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0039306 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039331 Reactome Respiratory electron transport R-DME-611105 FBgn0039331 Reactome Complex I biogenesis R-DME-6799198 FBgn0039341 Reactome Arachidonic acid metabolism R-DME-2142753 FBgn0039343 Reactome Neddylation R-DME-8951664 FBgn0039347 Reactome Basigin interactions R-DME-210991 FBgn0039347 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039348 Reactome Translesion Synthesis by POLH R-DME-110320 FBgn0039349 Reactome Degradation of GABA R-DME-916853 FBgn0027508 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0027508 Reactome Degradation of AXIN R-DME-4641257 FBgn0027508 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0027508 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0039357 Reactome Transport of inorganic cations/anions and amino acids/oligopeptides R-DME-425393 FBgn0039358 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0039359 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039359 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039359 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039359 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039359 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039359 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039360 Reactome Acyl chain remodelling of PG R-DME-1482925 FBgn0039360 Reactome Synthesis of CL R-DME-1483076 FBgn0051092 Reactome Reelin signalling pathway R-DME-8866376 FBgn0051092 Reactome VLDLR internalisation and degradation R-DME-8866427 FBgn0051092 Reactome LDL clearance R-DME-8964038 FBgn0039378 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0039379 Reactome Other interleukin signaling R-DME-449836 FBgn0039380 Reactome Phase 1 - inactivation of fast Na+ channels R-DME-5576894 FBgn0027865 Reactome Platelet degranulation R-DME-114608 FBgn0028717 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0028717 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0051089 Reactome Digestion of dietary lipid R-DME-192456 FBgn0051089 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0250757 Reactome Cellular hexose transport R-DME-189200 FBgn0250757 Reactome Inositol transporters R-DME-429593 FBgn0250757 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0015269 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0001139 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0001139 Reactome Transcription activation by ARM R-DME-209421 FBgn0001139 Reactome WG ligand not bound to FZ receptors R-DME-209441 FBgn0001139 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0001139 Reactome Repression of WNT target genes R-DME-4641265 FBgn0266668 Reactome Insulin processing R-DME-264876 FBgn0266668 Reactome VxPx cargo-targeting to cilium R-DME-5620916 FBgn0039402 Reactome Macroautophagy R-DME-1632852 FBgn0039402 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0039402 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0028833 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0039403 Reactome Unwinding of DNA R-DME-176974 FBgn0039406 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039406 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039406 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039406 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039406 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039406 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000064 Reactome Platelet degranulation R-DME-114608 FBgn0000064 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000064 Reactome Glycolysis R-DME-70171 FBgn0000064 Reactome Gluconeogenesis R-DME-70263 FBgn0000064 Reactome Fructose catabolism R-DME-70350 FBgn0039420 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0039420 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039421 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0039421 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0039425 Reactome Platelet degranulation R-DME-114608 FBgn0039425 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039425 Reactome Glycolysis R-DME-70171 FBgn0039425 Reactome Gluconeogenesis R-DME-70263 FBgn0039425 Reactome Fructose catabolism R-DME-70350 FBgn0042710 Reactome Regulation of Glucokinase by Glucokinase Regulatory Protein R-DME-170822 FBgn0042710 Reactome Neutrophil degranulation R-DME-6798695 FBgn0042710 Reactome Glycolysis R-DME-70171 FBgn0039427 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039431 Reactome CDO in myogenesis R-DME-375170 FBgn0039431 Reactome Ligand-receptor interactions R-DME-5632681 FBgn0039451 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0262473 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0262473 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0262473 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0262473 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0262473 Reactome Adaptor protein complex binds to TL receptor at the plasma membrane R-DME-214863 FBgn0262473 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0262473 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0051072 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0051072 Reactome Neutrophil degranulation R-DME-6798695 FBgn0051072 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0051072 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0051072 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0039459 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0027889 Reactome Initiation of Nuclear Envelope Reformation R-DME-2995383 FBgn0001197 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0001197 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0001197 Reactome SIRT1 negatively regulates rRNA expression R-DME-427359 FBgn0001197 Reactome NoRC negatively regulates rRNA expression R-DME-427413 FBgn0001197 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0001197 Reactome Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-DME-5625886 FBgn0001197 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0001197 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0026562 Reactome Platelet degranulation R-DME-114608 FBgn0026562 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0026562 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0004903 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0004903 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004903 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0004510 Reactome Transcriptional activation of mitochondrial biogenesis R-DME-2151201 FBgn0039464 Reactome Pyrimidine salvage R-DME-73614 FBgn0039464 Reactome Pyrimidine catabolism R-DME-73621 FBgn0003495 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0003495 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0003495 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0003495 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0003495 Reactome Adaptor protein complex binds to TL receptor at the plasma membrane R-DME-214863 FBgn0003495 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0003495 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0004197 Reactome Activated NOTCH1 Transmits Signal to the Nucleus R-DME-2122948 FBgn0004197 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0261995 Reactome Synthesis of dolichyl-phosphate-glucose R-DME-480985 FBgn0051064 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0005696 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0005696 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0005696 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0005696 Reactome DNA replication initiation R-DME-68952 FBgn0005696 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0005696 Reactome Polymerase switching R-DME-69091 FBgn0005696 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0005696 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0010441 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0010441 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0010441 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0010441 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0010441 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0010441 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0010441 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0010441 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0010441 Reactome IRAK1 recruits IKK complex R-DME-937039 FBgn0010441 Reactome IRAK2 mediated activation of TAK1 complex R-DME-937042 FBgn0010441 Reactome TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-DME-975110 FBgn0010441 Reactome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-DME-975138 FBgn0010441 Reactome IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-DME-975144 FBgn0010441 Reactome MyD88 dependent cascade initiated on endosome R-DME-975155 FBgn0010441 Reactome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-DME-975163 FBgn0011289 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0011289 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0011289 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0011289 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0011289 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0011289 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0011289 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0039505 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0039509 Reactome ChREBP activates metabolic gene expression R-DME-163765 FBgn0039518 Reactome Synthesis of glycosylphosphatidylinositol (GPI) R-DME-162710 FBgn0039519 Reactome Miscellaneous substrates R-DME-211958 FBgn0039519 Reactome Eicosanoids R-DME-211979 FBgn0039519 Reactome Xenobiotics R-DME-211981 FBgn0039519 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0039519 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0039519 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0027492 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0027492 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0027492 Reactome CTLA4 inhibitory signaling R-DME-389513 FBgn0027492 Reactome Dephosphorylation of PER R-DME-432620 FBgn0027492 Reactome Dephosphorylation of CLK R-DME-538909 FBgn0027492 Reactome RAF activation R-DME-5673000 FBgn0027492 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0027492 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0039530 Reactome Neddylation R-DME-8951664 FBgn0027494 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0027494 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0027494 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0027494 Reactome Translation initiation complex formation R-DME-72649 FBgn0027494 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0027494 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0027494 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0027494 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0027494 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0027494 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0002772 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0002772 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0039536 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0003330 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0003330 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0003330 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0003330 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0003330 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0003330 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0003330 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0045862 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0045862 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0045862 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0045862 Reactome mRNA 3'-end processing R-DME-72187 FBgn0045862 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039543 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0039543 Reactome Peroxisomal protein import R-DME-9033241 FBgn0039555 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0039555 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0039558 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003279 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0003279 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0003279 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0003279 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0003279 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0003279 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039559 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0039562 Reactome Trafficking and processing of endosomal TLR R-DME-1679131 FBgn0039562 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0039562 Reactome Interleukin-4 and Interleukin-13 signaling R-DME-6785807 FBgn0039562 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0039566 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039566 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0039576 Reactome Respiratory electron transport R-DME-611105 FBgn0039580 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0000659 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0001215 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0001215 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0001215 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0039596 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0039601 Reactome Neddylation R-DME-8951664 FBgn0024273 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0024273 Reactome NOSTRIN mediated eNOS trafficking R-DME-203641 FBgn0024273 Reactome Nephrin family interactions R-DME-373753 FBgn0024273 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0024273 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0024273 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0024273 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0264324 Reactome Factors involved in megakaryocyte development and platelet production R-DME-983231 FBgn0039620 Reactome Wax biosynthesis R-DME-8848584 FBgn0039622 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0039622 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039622 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0039622 Reactome Deadenylation of mRNA R-DME-429947 FBgn0039622 Reactome Translation initiation complex formation R-DME-72649 FBgn0039622 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0039622 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039622 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039625 Reactome Lactose synthesis R-DME-5653890 FBgn0039625 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039625 Reactome N-Glycan antennae elongation R-DME-975577 FBgn0027873 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0027873 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0027873 Reactome mRNA 3'-end processing R-DME-72187 FBgn0027873 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0039626 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0039626 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0039626 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039626 Reactome mRNA 3'-end processing R-DME-72187 FBgn0003093 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0003093 Reactome SHC1 events in ERBB2 signaling R-DME-1250196 FBgn0003093 Reactome DAG and IP3 signaling R-DME-1489509 FBgn0003093 Reactome Role of phospholipids in phagocytosis R-DME-2029485 FBgn0039632 Reactome Downregulation of ERBB2 signaling R-DME-8863795 FBgn0039632 Reactome Neddylation R-DME-8951664 FBgn0039632 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039634 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0039635 Reactome Regulation of pyruvate dehydrogenase (PDH) complex R-DME-204174 FBgn0039635 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0039635 Reactome Signaling by Retinoic Acid R-DME-5362517 FBgn0039635 Reactome Pyruvate metabolism R-DME-70268 FBgn0039636 Reactome Macroautophagy R-DME-1632852 FBgn0039637 Reactome Synthesis of PC R-DME-1483191 FBgn0039637 Reactome Transport of bile salts and organic acids, metal ions and amine compounds R-DME-425366 FBgn0039637 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028671 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028671 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028671 Reactome Insulin receptor recycling R-DME-77387 FBgn0028671 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028671 Reactome Ion channel transport R-DME-983712 FBgn0039640 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039641 Reactome Transport of nucleotide sugars R-DME-727802 FBgn0014869 Reactome Neutrophil degranulation R-DME-6798695 FBgn0014869 Reactome Glycolysis R-DME-70171 FBgn0014869 Reactome Gluconeogenesis R-DME-70263 FBgn0041186 Reactome SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-DME-77588 FBgn0028692 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0028692 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0028692 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0028692 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0028692 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0028692 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0028692 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0028692 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0028692 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0028692 Reactome Downstream TCR signaling R-DME-202424 FBgn0028692 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0028692 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0028692 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0028692 Reactome Nuclear CI is degraded R-DME-216167 FBgn0028692 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0028692 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0028692 Reactome Degradation of TIM R-DME-432395 FBgn0028692 Reactome Degradation of PER R-DME-432524 FBgn0028692 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0028692 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0028692 Reactome Degradation of AXIN R-DME-4641257 FBgn0028692 Reactome Degradation of DVL R-DME-4641258 FBgn0028692 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0028692 Reactome Degradation of CLK R-DME-538848 FBgn0028692 Reactome Degradation of CRY R-DME-538864 FBgn0028692 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0028692 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0028692 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0028692 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0028692 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0028692 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0028692 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0028692 Reactome UCH proteinases R-DME-5689603 FBgn0028692 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0028692 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028692 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0028692 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0028692 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0028692 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0028692 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0028692 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0028692 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0028692 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028692 Reactome Neddylation R-DME-8951664 FBgn0028692 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0028692 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039644 Reactome Platelet degranulation R-DME-114608 FBgn0039644 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0039645 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0039645 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0039645 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0039645 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0039651 Reactome Respiratory electron transport R-DME-611105 FBgn0028476 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0003525 Reactome Polo-like kinase mediated events R-DME-156711 FBgn0003525 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0003525 Reactome RHO GTPases activate PKNs R-DME-5625740 FBgn0003525 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0003525 Reactome Cyclin E associated events during G1/S transition R-DME-69202 FBgn0003525 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0003525 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0003525 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0003525 Reactome Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-DME-75035 FBgn0039668 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0039669 Reactome Respiratory electron transport R-DME-611105 FBgn0039669 Reactome Complex I biogenesis R-DME-6799198 FBgn0086361 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0086361 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0039674 Reactome Gluconeogenesis R-DME-70263 FBgn0025457 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0025457 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0025457 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0025457 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0039680 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0039681 Reactome Acyl chain remodelling of PC R-DME-1482788 FBgn0024841 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0039688 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0039688 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039688 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0039688 Reactome NOTCH3 Activation and Transmission of Signal to the Nucleus R-DME-9013507 FBgn0039689 Reactome Complex I biogenesis R-DME-6799198 FBgn0039690 Reactome Synthesis of UDP-N-acetyl-glucosamine R-DME-446210 FBgn0039691 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0020235 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0020235 Reactome Cristae formation R-DME-8949613 FBgn0019972 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0019972 Reactome Signaling by Hippo R-DME-2028269 FBgn0019972 Reactome Activation of DNA fragmentation factor R-DME-211227 FBgn0019972 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0019972 Reactome Apoptotic cleavage of cell adhesion proteins R-DME-351906 FBgn0019972 Reactome Breakdown of the nuclear lamina R-DME-352238 FBgn0019972 Reactome Caspase activation via Dependence Receptors in the absence of ligand R-DME-418889 FBgn0019972 Reactome Other interleukin signaling R-DME-449836 FBgn0039697 Reactome Respiratory electron transport R-DME-611105 FBgn0039698 Reactome Cytosolic sulfonation of small molecules R-DME-156584 FBgn0039710 Reactome HATs acetylate histones R-DME-3214847 FBgn0039710 Reactome UCH proteinases R-DME-5689603 FBgn0039710 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0039713 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039713 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039713 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039713 Reactome Translation initiation complex formation R-DME-72649 FBgn0039713 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039713 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0039713 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039713 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039713 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039713 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0003861 Reactome TRP channels R-DME-3295583 FBgn0003861 Reactome Ion homeostasis R-DME-5578775 FBgn0003861 Reactome Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-DME-983695 FBgn0051040 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0051040 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0039726 Reactome Recycling of eIF2:GDP R-DME-72731 FBgn0004622 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0004622 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0039736 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0039738 Reactome Reactions specific to the complex N-glycan synthesis pathway R-DME-975578 FBgn0039739 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039739 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039739 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039739 Reactome Translation initiation complex formation R-DME-72649 FBgn0039739 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039739 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0039739 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039739 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039739 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039739 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0026597 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0026597 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0026597 Reactome TCF dependent signaling in response to WNT R-DME-201681 FBgn0026597 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0026597 Reactome Phosphorylation of CI R-DME-209190 FBgn0026597 Reactome Phosphorylation of SMO R-DME-209214 FBgn0026597 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0026597 Reactome Phosphorylation of ARM R-DME-209396 FBgn0026597 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0026597 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0026597 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0026597 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0026597 Reactome Degradation of AXIN R-DME-4641257 FBgn0026597 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0026597 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0002626 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0002626 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0002626 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0002626 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0002626 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0002626 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0003479 Reactome Presynaptic phase of homologous DNA pairing and strand exchange R-DME-5693616 FBgn0266411 Reactome Regulation of gene expression by Hypoxia-inducible Factor R-DME-1234158 FBgn0266411 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0266411 Reactome Neddylation R-DME-8951664 FBgn0086355 Reactome Glycolysis R-DME-70171 FBgn0086355 Reactome Gluconeogenesis R-DME-70263 FBgn0039747 Reactome Adenosine P1 receptors R-DME-417973 FBgn0039747 Reactome G alpha (s) signalling events R-DME-418555 FBgn0039747 Reactome G alpha (i) signalling events R-DME-418594 FBgn0039747 Reactome Surfactant metabolism R-DME-5683826 FBgn0260860 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0260860 Reactome Neutrophil degranulation R-DME-6798695 FBgn0260860 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0039754 Reactome Fatty acyl-CoA biosynthesis R-DME-75105 FBgn0039757 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039757 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039757 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0039757 Reactome Translation initiation complex formation R-DME-72649 FBgn0039757 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039757 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0039757 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039757 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039757 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039757 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039765 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0039765 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0039767 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028646 Reactome Gluconeogenesis R-DME-70263 FBgn0039773 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0039773 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0039774 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0082582 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0039787 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0039788 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0039788 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0039788 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0039788 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0039788 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0039788 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0039788 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0039788 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0039788 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0039788 Reactome Downstream TCR signaling R-DME-202424 FBgn0039788 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0039788 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0039788 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0039788 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0039788 Reactome Degradation of AXIN R-DME-4641257 FBgn0039788 Reactome Degradation of DVL R-DME-4641258 FBgn0039788 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0039788 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0039788 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0039788 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0039788 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0039788 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0039788 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0039788 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0039788 Reactome UCH proteinases R-DME-5689603 FBgn0039788 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0039788 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0039788 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0039788 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0039788 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0039788 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0039788 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0039788 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0039788 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0039788 Reactome Neddylation R-DME-8951664 FBgn0039788 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0039788 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039789 Reactome Multifunctional anion exchangers R-DME-427601 FBgn0039797 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039797 Reactome Translation initiation complex formation R-DME-72649 FBgn0039797 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0039797 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0039797 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0011739 Reactome Signaling by Hippo R-DME-2028269 FBgn0011739 Reactome Negative regulation of WTS R-DME-390024 FBgn0011739 Reactome Formation of the Hippo kinase cassette R-DME-390089 FBgn0011739 Reactome Phosphorylation-dependent inhibition of YKI R-DME-390098 FBgn0011739 Reactome Negative regulation of TH R-DME-390197 FBgn0011739 Reactome Phosphorylation-independent inhibition of YKI R-DME-451806 FBgn0027598 Reactome EGFR downregulation R-DME-182971 FBgn0027598 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0027598 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0027598 Reactome Reelin signalling pathway R-DME-8866376 FBgn0003720 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0000416 Reactome Platelet degranulation R-DME-114608 FBgn0000416 Reactome Glycosphingolipid metabolism R-DME-1660662 FBgn0000416 Reactome Peptide ligand-binding receptors R-DME-375276 FBgn0000416 Reactome G alpha (i) signalling events R-DME-418594 FBgn0000416 Reactome Surfactant metabolism R-DME-5683826 FBgn0000416 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015032 Reactome Endogenous sterols R-DME-211976 FBgn0015032 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0004573 Reactome Serotonin receptors R-DME-390666 FBgn0004573 Reactome G alpha (s) signalling events R-DME-418555 FBgn0010015 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0010015 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0010015 Reactome Ca2+ pathway R-DME-4086398 FBgn0010015 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763 FBgn0016123 Reactome Synthesis of PA R-DME-1483166 FBgn0016123 Reactome Intra-Golgi traffic R-DME-6811438 FBgn0016123 Reactome Digestion R-DME-8935690 FBgn0002413 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0002413 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0002413 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0002413 Reactome Phosphorylation of CI R-DME-209190 FBgn0002413 Reactome Phosphorylation of SMO R-DME-209214 FBgn0002413 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0002413 Reactome Phosphorylation of ARM R-DME-209396 FBgn0002413 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0002413 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0002413 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0002413 Reactome Subcellular localisation of D R-DME-390023 FBgn0002413 Reactome Degradation of TIM R-DME-432395 FBgn0002413 Reactome Nuclear import of PER and TIM R-DME-432490 FBgn0002413 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0002413 Reactome Degradation of PER R-DME-432524 FBgn0002413 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0002413 Reactome Dephosphorylation of PER R-DME-432620 FBgn0002413 Reactome Positive regulation of FT and DS R-DME-451850 FBgn0002413 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0002413 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0261395 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0261395 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0261395 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0261395 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0261395 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0261395 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0261395 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0261395 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0261395 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0261395 Reactome Downstream TCR signaling R-DME-202424 FBgn0261395 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0261395 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0261395 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0261395 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0261395 Reactome Degradation of AXIN R-DME-4641257 FBgn0261395 Reactome Degradation of DVL R-DME-4641258 FBgn0261395 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0261395 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0261395 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0261395 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0261395 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0261395 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0261395 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0261395 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0261395 Reactome UCH proteinases R-DME-5689603 FBgn0261395 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0261395 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0261395 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0261395 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0261395 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0261395 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0261395 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0261395 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0261395 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0261395 Reactome Neddylation R-DME-8951664 FBgn0261395 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0261395 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0039827 Reactome Glyoxylate metabolism and glycine degradation R-DME-389661 FBgn0039830 Reactome Mitochondrial protein import R-DME-1268020 FBgn0039830 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0039830 Reactome Cristae formation R-DME-8949613 FBgn0051005 Reactome Ubiquinol biosynthesis R-DME-2142789 FBgn0039835 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0039835 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0039844 Reactome Basigin interactions R-DME-210991 FBgn0039844 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0039849 Reactome Methionine salvage pathway R-DME-1237112 FBgn0028968 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0028968 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0043900 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0043900 Reactome Transport of ARM to the nucleus R-DME-209407 FBgn0043900 Reactome Transcription activation by ARM R-DME-209421 FBgn0039854 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0039855 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0039856 Reactome Mitochondrial Fatty Acid Beta-Oxidation R-DME-77289 FBgn0039857 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0039857 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0039857 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0039857 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0039857 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0039857 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0011655 Reactome Signaling by NODAL R-DME-1181150 FBgn0011655 Reactome Signaling by Activin R-DME-1502540 FBgn0011655 Reactome TGF-beta receptor signaling activates SMADs R-DME-2173789 FBgn0011655 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0011655 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0011655 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0011655 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0039862 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0039864 Reactome The retinoid cycle in cones (daylight vision) R-DME-2187335 FBgn0039864 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0039864 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0039867 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0039867 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0039867 Reactome mRNA 3'-end processing R-DME-72187 FBgn0039867 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0000557 Reactome HSF1 activation R-DME-3371511 FBgn0000557 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000557 Reactome Protein methylation R-DME-8876725 FBgn0000150 Reactome Interconversion of nucleotide di- and triphosphates R-DME-499943 FBgn0000150 Reactome Neutrophil degranulation R-DME-6798695 FBgn0261479 Reactome Hypusine synthesis from eIF5A-lysine R-DME-204626 FBgn0039872 Reactome Cellular hexose transport R-DME-189200 FBgn0039872 Reactome Inositol transporters R-DME-429593 FBgn0039872 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0017448 Reactome Cellular hexose transport R-DME-189200 FBgn0017448 Reactome Inositol transporters R-DME-429593 FBgn0017448 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0039873 Reactome Cellular hexose transport R-DME-189200 FBgn0039873 Reactome Inositol transporters R-DME-429593 FBgn0039873 Reactome Intestinal hexose absorption R-DME-8981373 FBgn0270927 Reactome HS-GAG degradation R-DME-2024096 FBgn0270927 Reactome Hyaluronan uptake and degradation R-DME-2160916 FBgn0270927 Reactome Neutrophil degranulation R-DME-6798695 FBgn0039875 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0039875 Reactome ER Quality Control Compartment (ERQC) R-DME-901032 FBgn0005632 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0005632 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0005632 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0005632 Reactome Peroxisomal protein import R-DME-9033241 FBgn0039877 Reactome Biotin transport and metabolism R-DME-196780 FBgn0039877 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0039877 Reactome Neddylation R-DME-8951664 FBgn0250755 Reactome Neddylation R-DME-8951664 FBgn0039882 Reactome Vitamin B2 (riboflavin) metabolism R-DME-196843 FBgn0266268 Reactome Heme biosynthesis R-DME-189451 FBgn0039883 Reactome Rho GTPase cycle R-DME-194840 FBgn0025740 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0025740 Reactome Other semaphorin interactions R-DME-416700 FBgn0004859 Reactome Assembly of the CI containing complexes R-DME-209159 FBgn0004859 Reactome Phosphorylation of CI R-DME-209190 FBgn0004859 Reactome Phosphorylation of SMO R-DME-209214 FBgn0004859 Reactome Assembly of the 'signalling complexes' R-DME-209338 FBgn0004859 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0004859 Reactome N-HH ligand not bound to PTC receptor complex R-DME-209446 FBgn0004859 Reactome Activation of CI R-DME-216119 FBgn0004859 Reactome Nuclear CI is degraded R-DME-216167 FBgn0004859 Reactome Activation of SMO R-DME-216217 FBgn0004859 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0004859 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0004859 Reactome Hedgehog 'off' state R-DME-5610787 FBgn0004859 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0017545 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0017545 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0017545 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0017545 Reactome Translation initiation complex formation R-DME-72649 FBgn0017545 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0017545 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0017545 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0017545 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0017545 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0017545 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0085432 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0085432 Reactome Transcription activation by ARM R-DME-209421 FBgn0085432 Reactome WG ligand not bound to FZ receptors R-DME-209441 FBgn0085432 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0085432 Reactome Ca2+ pathway R-DME-4086398 FBgn0085432 Reactome Repression of WNT target genes R-DME-4641265 FBgn0085432 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0039890 Reactome ABC transporters in lipid homeostasis R-DME-1369062 FBgn0039890 Reactome Linoleic acid (LA) metabolism R-DME-2046105 FBgn0039890 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0039890 Reactome Beta-oxidation of very long chain fatty acids R-DME-390247 FBgn0024811 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0024811 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0024811 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0051999 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0259214 Reactome Reduction of cytosolic Ca++ levels R-DME-418359 FBgn0259214 Reactome Ion homeostasis R-DME-5578775 FBgn0259214 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0039904 Reactome HATs acetylate histones R-DME-3214847 FBgn0039904 Reactome UCH proteinases R-DME-5689603 FBgn0039907 Reactome Transport of ARM to the nucleus R-DME-209407 FBgn0039907 Reactome Transcription activation by ARM R-DME-209421 FBgn0026262 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0026262 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0026262 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0026262 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0026262 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0004607 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0026869 Reactome Cleavage of the damaged pyrimidine R-DME-110329 FBgn0026869 Reactome Displacement of DNA glycosylase by APEX1 R-DME-110357 FBgn0026869 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0026869 Reactome TET1,2,3 and TDG demethylate DNA R-DME-5221030 FBgn0083981 Reactome RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-DME-8877330 FBgn0083981 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0083981 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0083981 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0083981 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0083981 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0083981 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0083981 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0083981 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0083981 Reactome RUNX2 regulates osteoblast differentiation R-DME-8940973 FBgn0083981 Reactome RUNX2 regulates bone development R-DME-8941326 FBgn0083981 Reactome RUNX3 regulates CDKN1A transcription R-DME-8941855 FBgn0083981 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0083981 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0083981 Reactome RUNX3 regulates WNT signaling R-DME-8951430 FBgn0083981 Reactome RUNX3 regulates YAP1-mediated transcription R-DME-8951671 FBgn0083981 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0016975 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0016975 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0040324 Reactome EPH-Ephrin signaling R-DME-2682334 FBgn0040324 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0040324 Reactome Ephrin signaling R-DME-3928664 FBgn0040324 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0040056 Reactome CREB phosphorylation through the activation of CaMKK R-DME-442717 FBgn0025936 Reactome EPH-Ephrin signaling R-DME-2682334 FBgn0025936 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0025936 Reactome EPHA-mediated growth cone collapse R-DME-3928663 FBgn0025936 Reactome Ephrin signaling R-DME-3928664 FBgn0025936 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0039915 Reactome Na+/Cl- dependent neurotransmitter transporters R-DME-442660 FBgn0039915 Reactome Reuptake of GABA R-DME-888593 FBgn0051992 Reactome Post-transcriptional silencing by small RNAs R-DME-426496 FBgn0051992 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0039920 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0005666 Reactome Platelet degranulation R-DME-114608 FBgn0039923 Reactome Generic Transcription Pathway R-DME-212436 FBgn0002521 Reactome UCH proteinases R-DME-5689603 FBgn0002521 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0002521 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0039925 Reactome Intraflagellar transport R-DME-5620924 FBgn0005561 Reactome RUNX1 regulates transcription of genes involved in BCR signaling R-DME-8939245 FBgn0264607 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0264607 Reactome Ca2+ pathway R-DME-4086398 FBgn0264607 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0264607 Reactome CREB phosphorylation through the activation of CaMKII R-DME-442729 FBgn0264607 Reactome Ion homeostasis R-DME-5578775 FBgn0264607 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0039930 Reactome Peroxisomal protein import R-DME-9033241 FBgn0019985 Reactome G alpha (i) signalling events R-DME-418594 FBgn0019985 Reactome Class C/3 (Metabotropic glutamate/pheromone receptors) R-DME-420499 FBgn0019985 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0023213 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0023213 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0023213 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0023213 Reactome Deadenylation of mRNA R-DME-429947 FBgn0023213 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0023213 Reactome Translation initiation complex formation R-DME-72649 FBgn0023213 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0023213 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0023213 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0023213 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0023213 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0039938 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0261617 Reactome Regulation of gene expression by Hypoxia-inducible Factor R-DME-1234158 FBgn0261617 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0261617 Reactome HATs acetylate histones R-DME-3214847 FBgn0261617 Reactome Attenuation phase R-DME-3371568 FBgn0261617 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0261617 Reactome Metalloprotease DUBs R-DME-5689901 FBgn0261617 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0261617 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0261617 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0261617 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0261617 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0261617 Reactome RUNX1 regulates transcription of genes involved in differentiation of myeloid cells R-DME-8939246 FBgn0261617 Reactome RUNX3 regulates NOTCH signaling R-DME-8941856 FBgn0261617 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0261617 Reactome RUNX3 regulates p14-ARF R-DME-8951936 FBgn0261617 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0267791 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0267791 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0267791 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0024733 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0024733 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0024733 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0024733 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0024733 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0024733 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0003204 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003204 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0085447 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0085447 Reactome Rho GTPase cycle R-DME-194840 FBgn0085447 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0085447 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0085447 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0023169 Reactome Macroautophagy R-DME-1632852 FBgn0023169 Reactome AMPK inhibits chREBP transcriptional activation activity R-DME-163680 FBgn0023169 Reactome Import of palmitoyl-CoA into the mitochondrial matrix R-DME-200425 FBgn0023169 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0023169 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0024187 Reactome CDO in myogenesis R-DME-375170 FBgn0003415 Reactome Generic Transcription Pathway R-DME-212436 FBgn0025571 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0025592 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0026181 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0026181 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0026181 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0026181 Reactome Sema4D induced cell migration and growth-cone collapse R-DME-416572 FBgn0026181 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0026181 Reactome RHO GTPases Activate ROCKs R-DME-5627117 FBgn0026181 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028380 Reactome Nucleobase catabolism R-DME-8956319 FBgn0029155 Reactome Pyruvate metabolism R-DME-70268 FBgn0029155 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0003321 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0261563 Reactome Laminin interactions R-DME-3000157 FBgn0010350 Reactome Synthesis of PG R-DME-1483148 FBgn0010350 Reactome Synthesis of PI R-DME-1483226 FBgn0013531 Reactome Generic Transcription Pathway R-DME-212436 FBgn0023496 Reactome Digestion of dietary lipid R-DME-192456 FBgn0023496 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0024277 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0024277 Reactome Rho GTPase cycle R-DME-194840 FBgn0024277 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0024277 Reactome G alpha (q) signalling events R-DME-416476 FBgn0024277 Reactome G alpha (12/13) signalling events R-DME-416482 FBgn0024277 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0067861 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0067861 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0067861 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0026379 Reactome Insulin signaling pathway R-DME-110478 FBgn0026379 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0026379 Reactome Synthesis of IP3 and IP4 in the cytosol R-DME-1855204 FBgn0026379 Reactome Negative regulation of the PI3K/AKT network R-DME-199418 FBgn0026379 Reactome Downstream TCR signaling R-DME-202424 FBgn0026379 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0026379 Reactome Regulation of PTEN localization R-DME-8948747 FBgn0026379 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0028978 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0028978 Reactome Activation of AKT2 R-DME-165158 FBgn0028978 Reactome Negative regulation of the PI3K/AKT network R-DME-199418 FBgn0028978 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0028978 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0028982 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0028982 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0028982 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0029118 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0029121 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0001187 Reactome Regulation of Glucokinase by Glucokinase Regulatory Protein R-DME-170822 FBgn0001187 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001187 Reactome Glycolysis R-DME-70171 FBgn0003076 Reactome Glycogen synthesis R-DME-3322077 FBgn0003076 Reactome Neutrophil degranulation R-DME-6798695 FBgn0003076 Reactome Glycogen breakdown (glycogenolysis) R-DME-70221 FBgn0003076 Reactome Galactose catabolism R-DME-70370 FBgn0003464 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0010909 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0267698 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0267698 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0267698 Reactome DSCAM interactions R-DME-376172 FBgn0267698 Reactome CD28 dependent Vav1 pathway R-DME-389359 FBgn0267698 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0267698 Reactome Ephrin signaling R-DME-3928664 FBgn0267698 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0267698 Reactome Signal transduction by L1 R-DME-445144 FBgn0267698 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0267698 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0267698 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0267698 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0267698 Reactome MAPK6/MAPK4 signaling R-DME-5687128 FBgn0015296 Reactome SHC1 events in ERBB2 signaling R-DME-1250196 FBgn0015296 Reactome SHC1 events in ERBB4 signaling R-DME-1250347 FBgn0015296 Reactome Signalling to RAS R-DME-167044 FBgn0015296 Reactome SHC1 events in EGFR signaling R-DME-180336 FBgn0015296 Reactome Tie2 Signaling R-DME-210993 FBgn0015296 Reactome DAP12 signaling R-DME-2424491 FBgn0015296 Reactome SHC-related events triggered by IGF1R R-DME-2428933 FBgn0015296 Reactome Role of LAT2/NTAL/LAB on calcium mobilization R-DME-2730905 FBgn0015296 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0015296 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0015296 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0015296 Reactome SHC-mediated cascade:FGFR1 R-DME-5654688 FBgn0015296 Reactome SHC-mediated cascade:FGFR2 R-DME-5654699 FBgn0015296 Reactome SHC-mediated cascade:FGFR3 R-DME-5654704 FBgn0015296 Reactome SHC-mediated cascade:FGFR4 R-DME-5654719 FBgn0015296 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0015296 Reactome Signal attenuation R-DME-74749 FBgn0015296 Reactome Insulin receptor signalling cascade R-DME-74751 FBgn0015296 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0267384 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0267384 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0086710 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0086710 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0086710 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0086710 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0086710 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0086710 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0267488 Reactome Platelet degranulation R-DME-114608 FBgn0267488 Reactome Intrinsic Pathway of Fibrin Clot Formation R-DME-140837 FBgn0267488 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0267488 Reactome Initial triggering of complement R-DME-166663 FBgn0267488 Reactome Alternative complement activation R-DME-173736 FBgn0267488 Reactome Rho GTPase cycle R-DME-194840 FBgn0267488 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0267488 Reactome Neutrophil degranulation R-DME-6798695 FBgn0267488 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0267488 Reactome Regulation of Complement cascade R-DME-977606 FBgn0020255 Reactome Regulation of cholesterol biosynthesis by SREBP (SREBF) R-DME-1655829 FBgn0020255 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0021825 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0021825 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0021825 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0024179 Reactome Signaling by BMP R-DME-201451 FBgn0024189 Reactome Nephrin family interactions R-DME-373753 FBgn0024194 Reactome Formation and transport of the N-HH ligand R-DME-209471 FBgn0024194 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0025814 Reactome Glutathione conjugation R-DME-156590 FBgn0025814 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0025814 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0025814 Reactome Neutrophil degranulation R-DME-6798695 FBgn0030018 Reactome RAF activation R-DME-5673000 FBgn0027348 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0264848 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0264848 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0264848 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0264848 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0264848 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0264848 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0264848 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0264848 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0264848 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0264848 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0264848 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0264848 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0264848 Reactome Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-DME-8866652 FBgn0264848 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029082 Reactome Nephrin family interactions R-DME-373753 FBgn0029152 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0029152 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029152 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0029161 Reactome TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-DME-6803204 FBgn0010100 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0010611 Reactome Cholesterol biosynthesis R-DME-191273 FBgn0010611 Reactome Synthesis of Ketone Bodies R-DME-77111 FBgn0003654 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0003654 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0003654 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0015393 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0015393 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015393 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0015808 Reactome Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-DME-193368 FBgn0015808 Reactome alpha-linolenic acid (ALA) metabolism R-DME-2046106 FBgn0015808 Reactome Beta-oxidation of pristanoyl-CoA R-DME-389887 FBgn0015808 Reactome Peroxisomal protein import R-DME-9033241 FBgn0017567 Reactome Respiratory electron transport R-DME-611105 FBgn0017567 Reactome Complex I biogenesis R-DME-6799198 FBgn0021967 Reactome Respiratory electron transport R-DME-611105 FBgn0021967 Reactome Complex I biogenesis R-DME-6799198 FBgn0023097 Reactome Generic Transcription Pathway R-DME-212436 FBgn0023097 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0024698 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0024698 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0024698 Reactome mRNA 3'-end processing R-DME-72187 FBgn0024698 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0261602 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261602 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261602 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261602 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261602 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261602 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0261530 Reactome DNA Damage/Telomere Stress Induced Senescence R-DME-2559586 FBgn0261530 Reactome HDR through MMEJ (alt-NHEJ) R-DME-5685939 FBgn0261530 Reactome Sensing of DNA Double Strand Breaks R-DME-5693548 FBgn0261530 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0261530 Reactome Processing of DNA double-strand break ends R-DME-5693607 FBgn0026250 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0026250 Reactome Translation initiation complex formation R-DME-72649 FBgn0026250 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0026250 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0026250 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0026250 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0026259 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0026369 Reactome Signaling by BMP R-DME-201451 FBgn0026369 Reactome TGF-beta receptor signaling activates SMADs R-DME-2173789 FBgn0029088 Reactome Formation and transport of the N-HH ligand R-DME-209471 FBgn0029088 Reactome Release of Hh-Np from the secreting cell R-DME-5362798 FBgn0029123 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0000119 Reactome Disassembly of the destruction complex and recruitment of AXIN to the membrane R-DME-4641262 FBgn0000711 Reactome Regulation of PLK1 Activity at G2/M Transition R-DME-2565942 FBgn0000711 Reactome Myosin phosphatase dephosphoylates SQH R-DME-350384 FBgn0000711 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0000711 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0000711 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0001248 Reactome NADPH regeneration R-DME-389542 FBgn0001248 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001248 Reactome Peroxisomal protein import R-DME-9033241 FBgn0262736 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0262736 Reactome Neutrophil degranulation R-DME-6798695 FBgn0262736 Reactome Insulin receptor recycling R-DME-77387 FBgn0262736 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0262736 Reactome Ion channel transport R-DME-983712 FBgn0010014 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0010014 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0010014 Reactome Ca2+ pathway R-DME-4086398 FBgn0010014 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763 FBgn0011787 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0011787 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0013983 Reactome Assembly of the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214397 FBgn0013983 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0013983 Reactome REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214411 FBgn0013983 Reactome Phosphorylated REL is cleaved by and dissociates from DREDD R-DME-214416 FBgn0015295 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0015295 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0285963 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015794 Reactome Neutrophil degranulation R-DME-6798695 FBgn0015794 Reactome COPI-independent Golgi-to-ER retrograde traffic R-DME-6811436 FBgn0015794 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0015794 Reactome RAB GEFs exchange GTP for GDP on RABs R-DME-8876198 FBgn0020371 Reactome Mitochondrial protein import R-DME-1268020 FBgn0021906 Reactome Respiratory electron transport R-DME-611105 FBgn0283652 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0022942 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0022942 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0022942 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0022942 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0022942 Reactome snRNP Assembly R-DME-191859 FBgn0022942 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0022942 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0022942 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0022942 Reactome mRNA Capping R-DME-72086 FBgn0022942 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0022942 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0022942 Reactome mRNA 3'-end processing R-DME-72187 FBgn0022942 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0022942 Reactome SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-DME-77588 FBgn0022942 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0022942 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0022942 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0024222 Reactome AKT phosphorylates targets in the cytosol R-DME-198323 FBgn0024222 Reactome Activation of the IkappaB kinase complex, KEY:IRD5 dimer:KEY R-DME-209447 FBgn0024222 Reactome Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex' R-DME-214399 FBgn0024222 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0024222 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0024222 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0024230 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0024509 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0025825 Reactome Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-DME-400206 FBgn0026441 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0026441 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0026441 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0028422 Reactome Activation of Na-permeable kainate receptors R-DME-451307 FBgn0028422 Reactome Presynaptic function of Kainate receptors R-DME-500657 FBgn0264000 Reactome COPII-mediated vesicle transport R-DME-204005 FBgn0264000 Reactome Activation of AMPA receptors R-DME-399710 FBgn0264000 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0264000 Reactome Unblocking of NMDA receptors, glutamate binding and activation R-DME-438066 FBgn0264000 Reactome Cargo concentration in the ER R-DME-5694530 FBgn0264000 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0002543 Reactome Signaling by ROBO receptors R-DME-376176 FBgn0002543 Reactome Regulation of commissural axon pathfinding by SLIT and ROBO R-DME-428542 FBgn0002543 Reactome Role of ABL in ROBO-SLIT signaling R-DME-428890 FBgn0002543 Reactome Regulation of expression of SLITs and ROBOs R-DME-9010553 FBgn0004914 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0011566 Reactome PKMTs methylate histone lysines R-DME-3214841 FBgn0013987 Reactome p38MAPK events R-DME-171007 FBgn0013987 Reactome CREB phosphorylation R-DME-199920 FBgn0013987 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0013987 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0013987 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0013987 Reactome activated TAK1 mediates p38 MAPK activation R-DME-450302 FBgn0013987 Reactome Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-DME-450385 FBgn0014903 Reactome Carnitine synthesis R-DME-71262 FBgn0015589 Reactome Apoptotic cleavage of cellular proteins R-DME-111465 FBgn0015589 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0015589 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0015589 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0015589 Reactome Ovarian tumor domain proteases R-DME-5689896 FBgn0015622 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0259745 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0261933 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261933 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0259938 Reactome Transcription regulation of cwo gene R-DME-432408 FBgn0017581 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0035909 Reactome Transport to the Golgi and subsequent modification R-DME-948021 FBgn0021944 Reactome Heme biosynthesis R-DME-189451 FBgn0022097 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0022097 Reactome Neutrophil degranulation R-DME-6798695 FBgn0022097 Reactome Insulin receptor recycling R-DME-77387 FBgn0022097 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0022097 Reactome Ion channel transport R-DME-983712 FBgn0024330 Reactome Generic Transcription Pathway R-DME-212436 FBgn0026252 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0026602 Reactome Purine salvage R-DME-74217 FBgn0261608 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0261608 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0261608 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0261608 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0261608 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0261608 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0000018 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0000229 Reactome NRAGE signals death through JNK R-DME-193648 FBgn0000229 Reactome Formation of the cytosolic BSK 'scaffolding complex' R-DME-209397 FBgn0000229 Reactome Formation of the nuclear AP-1 transcription factor 'scaffolding complex' R-DME-209409 FBgn0000229 Reactome Transcriptional activtion by AP-1 transcription factor R-DME-209425 FBgn0000229 Reactome Dephosphorylation of BSK R-DME-209478 FBgn0000229 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0000229 Reactome FCERI mediated MAPK activation R-DME-2871796 FBgn0000229 Reactome DSCAM interactions R-DME-376172 FBgn0000229 Reactome JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-DME-450321 FBgn0000229 Reactome Activation of the AP-1 family of transcription factors R-DME-450341 FBgn0000229 Reactome Interleukin-38 signaling R-DME-9007892 FBgn0000721 Reactome Rap1 signalling R-DME-392517 FBgn0001324 Reactome Generic Transcription Pathway R-DME-212436 FBgn0003117 Reactome Surfactant metabolism R-DME-5683826 FBgn0003312 Reactome Mineralocorticoid biosynthesis R-DME-193993 FBgn0003312 Reactome Glucocorticoid biosynthesis R-DME-194002 FBgn0003312 Reactome Pregnenolone biosynthesis R-DME-196108 FBgn0003312 Reactome Endogenous sterols R-DME-211976 FBgn0004657 Reactome Platelet degranulation R-DME-114608 FBgn0004657 Reactome Cross-presentation of particulate exogenous antigens (phagosomes) R-DME-1236973 FBgn0004657 Reactome Elastic fibre formation R-DME-1566948 FBgn0004657 Reactome Fibronectin matrix formation R-DME-1566977 FBgn0004657 Reactome Cell surface interactions at the vascular wall R-DME-202733 FBgn0004657 Reactome Basigin interactions R-DME-210991 FBgn0004657 Reactome Molecules associated with elastic fibres R-DME-2129379 FBgn0004657 Reactome Integrin cell surface interactions R-DME-216083 FBgn0004657 Reactome Syndecan interactions R-DME-3000170 FBgn0004657 Reactome ECM proteoglycans R-DME-3000178 FBgn0004657 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0004657 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0004657 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0004657 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0004657 Reactome Signal transduction by L1 R-DME-445144 FBgn0004657 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0004657 Reactome Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-DME-446343 FBgn0004657 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0004657 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004797 Reactome Acyl chain remodeling of DAG and TAG R-DME-1482883 FBgn0004797 Reactome Neutrophil degranulation R-DME-6798695 FBgn0004797 Reactome Triglyceride biosynthesis R-DME-75109 FBgn0004860 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0004860 Reactome SUMOylation of DNA damage response and repair proteins R-DME-3108214 FBgn0004860 Reactome SUMOylation of transcription cofactors R-DME-3899300 FBgn0004860 Reactome SUMOylation of RNA binding proteins R-DME-4570464 FBgn0004860 Reactome RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8939243 FBgn0004860 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0004860 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0259676 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0259676 Reactome Polymerase switching on the C-strand of the telomere R-DME-174411 FBgn0259676 Reactome Telomere C-strand synthesis initiation R-DME-174430 FBgn0259676 Reactome DNA replication initiation R-DME-68952 FBgn0259676 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0259676 Reactome Polymerase switching R-DME-69091 FBgn0259676 Reactome Removal of the Flap Intermediate R-DME-69166 FBgn0259676 Reactome Processive synthesis on the lagging strand R-DME-69183 FBgn0263598 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0263598 Reactome Insulin receptor recycling R-DME-77387 FBgn0263598 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0263598 Reactome Ion channel transport R-DME-983712 FBgn0024288 Reactome Deactivation of the beta-catenin transactivating complex R-DME-3769402 FBgn0024288 Reactome Transcriptional regulation by RUNX2 R-DME-8878166 FBgn0261458 Reactome Neutrophil degranulation R-DME-6798695 FBgn0267252 Reactome G alpha (s) signalling events R-DME-418555 FBgn0267252 Reactome G alpha (i) signalling events R-DME-418594 FBgn0267252 Reactome G alpha (z) signalling events R-DME-418597 FBgn0028662 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0028662 Reactome Insulin receptor recycling R-DME-77387 FBgn0028662 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0028662 Reactome Ion channel transport R-DME-983712 FBgn0028704 Reactome Sodium/Calcium exchangers R-DME-425561 FBgn0028969 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0028969 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0029093 Reactome Collagen degradation R-DME-1442490 FBgn0029093 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0029093 Reactome Surfactant metabolism R-DME-5683826 FBgn0029093 Reactome Neutrophil degranulation R-DME-6798695 FBgn0029134 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0029134 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0029134 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0029134 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0029134 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0029134 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0029134 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0029134 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0029134 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0029134 Reactome Downstream TCR signaling R-DME-202424 FBgn0029134 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0029134 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0029134 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0029134 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0029134 Reactome Degradation of AXIN R-DME-4641257 FBgn0029134 Reactome Degradation of DVL R-DME-4641258 FBgn0029134 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0029134 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0029134 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0029134 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0029134 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0029134 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0029134 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0029134 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0029134 Reactome UCH proteinases R-DME-5689603 FBgn0029134 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0029134 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0029134 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0029134 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0029134 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0029134 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0029134 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0029134 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0029134 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0029134 Reactome Neddylation R-DME-8951664 FBgn0029134 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0029134 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0000382 Reactome PI3K Cascade R-DME-109704 FBgn0000382 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0000382 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0000382 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0000382 Reactome GAB1 signalosome R-DME-180292 FBgn0000382 Reactome Tie2 Signaling R-DME-210993 FBgn0000382 Reactome PI-3K cascade:FGFR1 R-DME-5654689 FBgn0000382 Reactome FRS-mediated FGFR1 signaling R-DME-5654693 FBgn0000382 Reactome PI-3K cascade:FGFR2 R-DME-5654695 FBgn0000382 Reactome FRS-mediated FGFR2 signaling R-DME-5654700 FBgn0000382 Reactome FRS-mediated FGFR3 signaling R-DME-5654706 FBgn0000382 Reactome PI-3K cascade:FGFR3 R-DME-5654710 FBgn0000382 Reactome FRS-mediated FGFR4 signaling R-DME-5654712 FBgn0000382 Reactome PI-3K cascade:FGFR4 R-DME-5654720 FBgn0000382 Reactome Negative regulation of FGFR1 signaling R-DME-5654726 FBgn0000382 Reactome Negative regulation of FGFR2 signaling R-DME-5654727 FBgn0000382 Reactome Negative regulation of FGFR3 signaling R-DME-5654732 FBgn0000382 Reactome Negative regulation of FGFR4 signaling R-DME-5654733 FBgn0000382 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0000382 Reactome Regulation of RUNX1 Expression and Activity R-DME-8934593 FBgn0001085 Reactome Phosphorylation of ARR R-DME-209387 FBgn0001085 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0001085 Reactome Assembly of receptor complex R-DME-209472 FBgn0001085 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0001085 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0001085 Reactome Homo-/heterophilic binding of transmembrane components R-DME-350379 FBgn0001085 Reactome Formation and asymmetric localisation of transmembrane complexes R-DME-350411 FBgn0001085 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0284408 Reactome Degradation of the extracellular matrix R-DME-1474228 FBgn0284408 Reactome A tetrasaccharide linker sequence is required for GAG synthesis R-DME-1971475 FBgn0284408 Reactome HS-GAG biosynthesis R-DME-2022928 FBgn0284408 Reactome HS-GAG degradation R-DME-2024096 FBgn0284408 Reactome Integrin cell surface interactions R-DME-216083 FBgn0284408 Reactome Laminin interactions R-DME-3000157 FBgn0284408 Reactome Non-integrin membrane-ECM interactions R-DME-3000171 FBgn0284408 Reactome ECM proteoglycans R-DME-3000178 FBgn0034968 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0034968 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0034968 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0034968 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0034968 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0034968 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0002917 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0003090 Reactome Activation of RHO1 by FZ:DSH complex R-DME-350368 FBgn0003090 Reactome Negative feedback loop regulates asymmetric localisation R-DME-350369 FBgn0003090 Reactome Activation of RAC1:GTP by FZ:DSH complex R-DME-350376 FBgn0003090 Reactome Formation and asymmetric localisation of transmembrane complexes R-DME-350411 FBgn0003090 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0003090 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0004373 Reactome Synthesis of PIPs at the Golgi membrane R-DME-1660514 FBgn0010548 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0010548 Reactome Phase I - Functionalization of compounds R-DME-211945 FBgn0010548 Reactome Alpha-oxidation of phytanate R-DME-389599 FBgn0010548 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011227 Reactome Respiratory electron transport R-DME-611105 FBgn0011569 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0011569 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0011569 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0011569 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0011569 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0011569 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0015218 Reactome TOR signaling pathway R-DME-110523 FBgn0015218 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0015218 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0015218 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0015218 Reactome Deadenylation of mRNA R-DME-429947 FBgn0015218 Reactome Translation initiation complex formation R-DME-72649 FBgn0015218 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0015218 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0015218 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0015714 Reactome Miscellaneous substrates R-DME-211958 FBgn0015714 Reactome Eicosanoids R-DME-211979 FBgn0015714 Reactome Xenobiotics R-DME-211981 FBgn0015714 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0015714 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0015714 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0041147 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0041147 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0041147 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0041147 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0041147 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0041147 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0041147 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0041147 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0041147 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0041147 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0041147 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0041147 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0041147 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0016013 Reactome Phenylalanine and tyrosine catabolism R-DME-71182 FBgn0016694 Reactome Transcription repression by PER and activation by PDP1 R-DME-432501 FBgn0016694 Reactome Transcription activation by CLK:CYC and repression by VRI R-DME-432560 FBgn0265262 Reactome ROS, RNS production in phagocytes R-DME-1222556 FBgn0265262 Reactome Insulin receptor recycling R-DME-77387 FBgn0265262 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0265262 Reactome Ion channel transport R-DME-983712 FBgn0022023 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0022023 Reactome Translation initiation complex formation R-DME-72649 FBgn0022023 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0022023 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0022023 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0022023 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0023550 Reactome Wax biosynthesis R-DME-8848584 FBgn0025724 Reactome COPI-mediated anterograde transport R-DME-6807878 FBgn0025724 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0263121 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0263121 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0263121 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0263121 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0263121 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0263121 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0263121 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0263121 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0263121 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0263121 Reactome Downstream TCR signaling R-DME-202424 FBgn0263121 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0263121 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0263121 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0263121 Reactome Nuclear CI is degraded R-DME-216167 FBgn0263121 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0263121 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0263121 Reactome Degradation of TIM R-DME-432395 FBgn0263121 Reactome Degradation of PER R-DME-432524 FBgn0263121 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0263121 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0263121 Reactome Degradation of AXIN R-DME-4641257 FBgn0263121 Reactome Degradation of DVL R-DME-4641258 FBgn0263121 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0263121 Reactome Degradation of CLK R-DME-538848 FBgn0263121 Reactome Degradation of CRY R-DME-538864 FBgn0263121 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0263121 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0263121 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0263121 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0263121 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0263121 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0263121 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0263121 Reactome UCH proteinases R-DME-5689603 FBgn0263121 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0263121 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0263121 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0263121 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0263121 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0263121 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0263121 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0263121 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0263121 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0263121 Reactome Neddylation R-DME-8951664 FBgn0263121 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0263121 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0028990 Reactome Platelet degranulation R-DME-114608 FBgn0028990 Reactome Formation of the trans-membrane 'signalling complex' R-DME-209442 FBgn0000017 Reactome Regulation of actin dynamics for phagocytic cup formation R-DME-2029482 FBgn0000017 Reactome CDO in myogenesis R-DME-375170 FBgn0000017 Reactome Role of ABL in ROBO-SLIT signaling R-DME-428890 FBgn0000017 Reactome RHO GTPases Activate WASPs and WAVEs R-DME-5663213 FBgn0000017 Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-DME-5693565 FBgn0000017 Reactome RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939236 FBgn0000239 Reactome Purine ribonucleoside monophosphate biosynthesis R-DME-73817 FBgn0001186 Reactome Regulation of Glucokinase by Glucokinase Regulatory Protein R-DME-170822 FBgn0001186 Reactome Neutrophil degranulation R-DME-6798695 FBgn0001186 Reactome Glycolysis R-DME-70171 FBgn0001258 Reactome Pyruvate metabolism R-DME-70268 FBgn0001296 Reactome Amino acid transport across the plasma membrane R-DME-352230 FBgn0001296 Reactome Transport of organic anions R-DME-879518 FBgn0002791 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0002791 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0002791 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0002791 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0002791 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0002791 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0002791 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0002791 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0002791 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0002791 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0002791 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0002791 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0002791 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003011 Reactome Neurotransmitter receptors and postsynaptic signal transmission R-DME-112314 FBgn0262699 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0262699 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0262699 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0262699 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0262699 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0262699 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0262699 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0262699 Reactome Cyclin A:Cdk2-associated events at S phase entry R-DME-69656 FBgn0262699 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0003392 Reactome Gap junction degradation R-DME-190873 FBgn0003392 Reactome Formation of annular gap junctions R-DME-196025 FBgn0003392 Reactome NOSTRIN mediated eNOS trafficking R-DME-203641 FBgn0003392 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0003392 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0003392 Reactome Recycling pathway of L1 R-DME-437239 FBgn0003392 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0004177 Reactome Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-113501 FBgn0004177 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0004177 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0004177 Reactome Beta-catenin phosphorylation cascade R-DME-196299 FBgn0004177 Reactome ERK/MAPK targets R-DME-198753 FBgn0004177 Reactome ERKs are inactivated R-DME-202670 FBgn0004177 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0004177 Reactome Phosphorylation of CI R-DME-209190 FBgn0004177 Reactome Phosphorylation of SMO R-DME-209214 FBgn0004177 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0004177 Reactome Phosphorylation of ARM R-DME-209396 FBgn0004177 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0004177 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0004177 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0004177 Reactome CTLA4 inhibitory signaling R-DME-389513 FBgn0004177 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0004177 Reactome Dephosphorylation of PER R-DME-432620 FBgn0004177 Reactome Dephosphorylation of CLK R-DME-538909 FBgn0004177 Reactome RAF activation R-DME-5673000 FBgn0004177 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0004177 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0004177 Reactome Cyclin D associated events in G1 R-DME-69231 FBgn0004177 Reactome Cyclin A/B1/B2 associated events during G2/M transition R-DME-69273 FBgn0004372 Reactome G0 and Early G1 R-DME-1538133 FBgn0260399 Reactome MASTL Facilitates Mitotic Progression R-DME-2465910 FBgn0010225 Reactome Caspase-mediated cleavage of cytoskeletal proteins R-DME-264870 FBgn0010225 Reactome Neutrophil degranulation R-DME-6798695 FBgn0010488 Reactome ISG15 antiviral mechanism R-DME-1169408 FBgn0010520 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0010531 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0010551 Reactome Processing of SMDT1 R-DME-8949664 FBgn0010590 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0010590 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0010590 Reactome Cross-presentation of soluble exogenous antigens (endosomes) R-DME-1236978 FBgn0010590 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0010590 Reactome SCF-beta-TrCP mediated degradation of Emi1 R-DME-174113 FBgn0010590 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0010590 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0010590 Reactome SCF(Skp2)-mediated degradation of p27/p21 R-DME-187577 FBgn0010590 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0010590 Reactome Downstream TCR signaling R-DME-202424 FBgn0010590 Reactome FCERI mediated NF-kB activation R-DME-2871837 FBgn0010590 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0010590 Reactome AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-450408 FBgn0010590 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0010590 Reactome Degradation of AXIN R-DME-4641257 FBgn0010590 Reactome Degradation of DVL R-DME-4641258 FBgn0010590 Reactome Hedgehog ligand biogenesis R-DME-5358346 FBgn0010590 Reactome Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607761 FBgn0010590 Reactome CLEC7A (Dectin-1) signaling R-DME-5607764 FBgn0010590 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0010590 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0010590 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0010590 Reactome Regulation of RAS by GAPs R-DME-5658442 FBgn0010590 Reactome NIK-->noncanonical NF-kB signaling R-DME-5676590 FBgn0010590 Reactome UCH proteinases R-DME-5689603 FBgn0010590 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0010590 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0010590 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0010590 Reactome Ubiquitin-dependent degradation of Cyclin D1 R-DME-69229 FBgn0010590 Reactome Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-69601 FBgn0010590 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0010590 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0010590 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0010590 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0010590 Reactome Neddylation R-DME-8951664 FBgn0010590 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0010590 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0010591 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0263120 Reactome Synthesis of very long-chain fatty acyl-CoAs R-DME-75876 FBgn0010612 Reactome Formation of ATP by chemiosmotic coupling R-DME-163210 FBgn0010612 Reactome Cristae formation R-DME-8949613 FBgn0259978 Reactome Smooth Muscle Contraction R-DME-445355 FBgn0259978 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0259978 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0010638 Reactome XBP1(S) activates chaperone genes R-DME-381038 FBgn0010660 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0010660 Reactome snRNP Assembly R-DME-191859 FBgn0010660 Reactome Nuclear Pore Complex (NPC) Disassembly R-DME-3301854 FBgn0010660 Reactome Regulation of HSF1-mediated heat shock response R-DME-3371453 FBgn0010660 Reactome SUMOylation of chromatin organization proteins R-DME-4551638 FBgn0010660 Reactome SUMOylation of DNA replication proteins R-DME-4615885 FBgn0010660 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0010786 Reactome Heme biosynthesis R-DME-189451 FBgn0010926 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0011205 Reactome Coenzyme A biosynthesis R-DME-196783 FBgn0011230 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011230 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0011270 Reactome Neutrophil degranulation R-DME-6798695 FBgn0011270 Reactome Glycolysis R-DME-70171 FBgn0011270 Reactome Gluconeogenesis R-DME-70263 FBgn0011455 Reactome Respiratory electron transport R-DME-611105 FBgn0011455 Reactome Complex I biogenesis R-DME-6799198 FBgn0013548 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0013548 Reactome Neddylation R-DME-8951664 FBgn0014417 Reactome HS-GAG degradation R-DME-2024096 FBgn0014427 Reactome Serine biosynthesis R-DME-977347 FBgn0015614 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0015614 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0015614 Reactome Ca2+ pathway R-DME-4086398 FBgn0015614 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763 FBgn0023535 Reactome Neutrophil degranulation R-DME-6798695 FBgn0023535 Reactome Urea cycle R-DME-70635 FBgn0000996 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0000996 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0000996 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0000996 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0002719 Reactome Pyruvate metabolism R-DME-70268 FBgn0002719 Reactome Citric acid cycle (TCA cycle) R-DME-71403 FBgn0002891 Reactome Translesion synthesis by REV1 R-DME-110312 FBgn0002891 Reactome Translesion synthesis by POLK R-DME-5655862 FBgn0002891 Reactome Translesion synthesis by POLI R-DME-5656121 FBgn0004403 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0004403 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0004403 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0004403 Reactome Translation initiation complex formation R-DME-72649 FBgn0004403 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0004403 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0004403 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0004403 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0004403 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0004403 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0004404 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0004404 Reactome SRP-dependent cotranslational protein targeting to membrane R-DME-1799339 FBgn0004404 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0004404 Reactome Translation initiation complex formation R-DME-72649 FBgn0004404 Reactome Formation of a pool of free 40S subunits R-DME-72689 FBgn0004404 Reactome Formation of the ternary complex, and subsequently, the 43S complex R-DME-72695 FBgn0004404 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0004404 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0004404 Reactome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975956 FBgn0004404 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0021796 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0021796 Reactome Macroautophagy R-DME-1632852 FBgn0021796 Reactome mTOR signalling R-DME-165159 FBgn0021796 Reactome mTORC1-mediated signalling R-DME-166208 FBgn0021796 Reactome HSF1-dependent transactivation R-DME-3371571 FBgn0021796 Reactome Energy dependent regulation of mTOR by LKB1-AMPK R-DME-380972 FBgn0021796 Reactome CD28 dependent PI3K/Akt signaling R-DME-389357 FBgn0021796 Reactome VEGFR2 mediated vascular permeability R-DME-5218920 FBgn0021796 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0021796 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0021814 Reactome Endosomal Sorting Complex Required For Transport (ESCRT) R-DME-917729 FBgn0021895 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0261854 Reactome TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-DME-2173791 FBgn0261854 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0022160 Reactome Synthesis of PA R-DME-1483166 FBgn0022160 Reactome Triglyceride catabolism R-DME-163560 FBgn0028970 Reactome TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain R-DME-6803205 FBgn0028970 Reactome RAB geranylgeranylation R-DME-8873719 FBgn0029174 Reactome HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-3371497 FBgn0000079 Reactome Digestion of dietary carbohydrate R-DME-189085 FBgn0004643 Reactome COPI-dependent Golgi-to-ER retrograde traffic R-DME-6811434 FBgn0004889 Reactome Phosphorylation of AXN and APC R-DME-209155 FBgn0004889 Reactome Phosphorylation of CI R-DME-209190 FBgn0004889 Reactome Phosphorylation of SMO R-DME-209214 FBgn0004889 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0004889 Reactome Phosphorylation of ARM R-DME-209396 FBgn0004889 Reactome Assembly of the 'destruction complex' R-DME-209413 FBgn0004889 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0004889 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0004889 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0004889 Reactome Dephosphorylation of PER R-DME-432620 FBgn0010222 Reactome Metabolism of folate and pterines R-DME-196757 FBgn0010356 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0010356 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0010356 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0010356 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0010356 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0010356 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0010549 Reactome Platelet degranulation R-DME-114608 FBgn0010549 Reactome ABC-family proteins mediated transport R-DME-382556 FBgn0026533 Reactome Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-DME-8864260 FBgn0011232 Reactome Retrograde transport at the Trans-Golgi-Network R-DME-6811440 FBgn0020887 Reactome PRC2 methylates histones and DNA R-DME-212300 FBgn0020887 Reactome Oxidative Stress Induced Senescence R-DME-2559580 FBgn0020887 Reactome Regulation of PTEN gene transcription R-DME-8943724 FBgn0020887 Reactome Transcriptional Regulation by E2F6 R-DME-8953750 FBgn0000109 Reactome Neutrophil degranulation R-DME-6798695 FBgn0000109 Reactome Purine salvage R-DME-74217 FBgn0000477 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0003091 Reactome Calmodulin induced events R-DME-111933 FBgn0003091 Reactome Disinhibition of SNARE formation R-DME-114516 FBgn0003091 Reactome Activation of NF-kappaB in B cells R-DME-1169091 FBgn0003091 Reactome SHC1 events in ERBB2 signaling R-DME-1250196 FBgn0003091 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0003091 Reactome EGFR Transactivation by Gastrin R-DME-2179392 FBgn0003091 Reactome Syndecan interactions R-DME-3000170 FBgn0003091 Reactome Acetylcholine regulates insulin secretion R-DME-399997 FBgn0003091 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0003091 Reactome Depolymerisation of the Nuclear Lamina R-DME-4419969 FBgn0003091 Reactome HuR (ELAVL1) binds and stabilizes mRNA R-DME-450520 FBgn0003091 Reactome VEGFR2 mediated cell proliferation R-DME-5218921 FBgn0003091 Reactome Response to elevated platelet cytosolic Ca2+ R-DME-76005 FBgn0003275 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0003275 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0003275 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0003275 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0003275 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0003275 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0003275 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0003275 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0003275 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0003275 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0003275 Reactome mRNA Capping R-DME-72086 FBgn0003275 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0003275 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0003275 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0003275 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0003275 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0003275 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0003275 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0003275 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0003275 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0003275 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0003275 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0000032 Reactome Neutrophil degranulation R-DME-6798695 FBgn0264492 Reactome WNT mediated activation of DVL R-DME-201688 FBgn0264492 Reactome Phosphorylation of CI R-DME-209190 FBgn0264492 Reactome Phosphorylation of SMO R-DME-209214 FBgn0264492 Reactome Condensation of Prometaphase Chromosomes R-DME-2514853 FBgn0264492 Reactome Phosphorylation of PER and TIM R-DME-432553 FBgn0264492 Reactome Signal transduction by L1 R-DME-445144 FBgn0264492 Reactome Regulation of TP53 Activity through Phosphorylation R-DME-6804756 FBgn0264492 Reactome Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-DME-6814122 FBgn0264492 Reactome Receptor Mediated Mitophagy R-DME-8934903 FBgn0264492 Reactome Regulation of PTEN stability and activity R-DME-8948751 FBgn0003132 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0004237 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0004237 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0004237 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0005278 Reactome Methylation R-DME-156581 FBgn0005278 Reactome Sulfur amino acid metabolism R-DME-1614635 FBgn0005278 Reactome Metabolism of ingested SeMet, Sec, MeSec into H2Se R-DME-2408508 FBgn0011224 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0011224 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0011224 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0001970 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0001986 Reactome Major pathway of rRNA processing in the nucleolus and cytosol R-DME-6791226 FBgn0001986 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0001990 Reactome DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' R-DME-214842 FBgn0001990 Reactome DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' R-DME-214844 FBgn0001990 Reactome Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' R-DME-214862 FBgn0001990 Reactome Adaptor protein complex binds to TL receptor at the plasma membrane R-DME-214863 FBgn0001990 Reactome Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' R-DME-214869 FBgn0001990 Reactome PLL kinase binds to TUB in the TL receptor 'signalling complex' R-DME-214874 FBgn0002022 Reactome Zinc influx into cells by the SLC39 gene family R-DME-442380 FBgn0262733 Reactome Nuclear signaling by ERBB4 R-DME-1251985 FBgn0262733 Reactome Spry regulation of FGF signaling R-DME-1295596 FBgn0262733 Reactome Signaling by SCF-KIT R-DME-1433557 FBgn0262733 Reactome Regulation of KIT signaling R-DME-1433559 FBgn0262733 Reactome GAB1 signalosome R-DME-180292 FBgn0262733 Reactome Fc epsilon receptor (FCERI) signaling R-DME-2454202 FBgn0262733 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0262733 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0262733 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0262733 Reactome Nephrin family interactions R-DME-373753 FBgn0262733 Reactome NCAM signaling for neurite out-growth R-DME-375165 FBgn0262733 Reactome EPHB-mediated forward signaling R-DME-3928662 FBgn0262733 Reactome EPHA-mediated growth cone collapse R-DME-3928663 FBgn0262733 Reactome Ephrin signaling R-DME-3928664 FBgn0262733 Reactome EPH-ephrin mediated repulsion of cells R-DME-3928665 FBgn0262733 Reactome ADP signalling through P2Y purinoceptor 1 R-DME-418592 FBgn0262733 Reactome DCC mediated attractive signaling R-DME-418885 FBgn0262733 Reactome GP1b-IX-V activation signalling R-DME-430116 FBgn0262733 Reactome Recycling pathway of L1 R-DME-437239 FBgn0262733 Reactome VEGFA-VEGFR2 Pathway R-DME-4420097 FBgn0262733 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0262733 Reactome CD209 (DC-SIGN) signaling R-DME-5621575 FBgn0262733 Reactome RAF activation R-DME-5673000 FBgn0262733 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0262733 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0262733 Reactome Neutrophil degranulation R-DME-6798695 FBgn0262733 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0262733 Reactome Reelin signalling pathway R-DME-8866376 FBgn0262733 Reactome Receptor Mediated Mitophagy R-DME-8934903 FBgn0262733 Reactome Regulation of RUNX3 expression and activity R-DME-8941858 FBgn0262733 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0262733 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0262733 Reactome Regulation of signaling by CBL R-DME-912631 FBgn0261988 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0005536 Reactome Regulation of PLK1 Activity at G2/M Transition R-DME-2565942 FBgn0005536 Reactome Myosin phosphatase dephosphoylates SQH R-DME-350384 FBgn0005536 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0005536 Reactome RHO GTPases activate PAKs R-DME-5627123 FBgn0261437 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0261437 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0261437 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0261437 Reactome Neddylation R-DME-8951664 FBgn0002031 Reactome RAF activation R-DME-5673000 FBgn0002031 Reactome Processing of SMDT1 R-DME-8949664 FBgn0003227 Reactome Activation of ATR in response to replication stress R-DME-176187 FBgn0003227 Reactome CDC6 association with the ORC:origin complex R-DME-68689 FBgn0003227 Reactome CDT1 association with the CDC6:ORC:origin complex R-DME-68827 FBgn0003227 Reactome Assembly of the pre-replicative complex R-DME-68867 FBgn0003227 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0003227 Reactome Activation of the pre-replicative complex R-DME-68962 FBgn0004103 Reactome Myosin phosphatase dephosphoylates SQH R-DME-350384 FBgn0004103 Reactome Activation of non-muscle Myosin II R-DME-350480 FBgn0004103 Reactome Dephosphorylation of TIM R-DME-538898 FBgn0263006 Reactome Reduction of cytosolic Ca++ levels R-DME-418359 FBgn0263006 Reactome Ion homeostasis R-DME-5578775 FBgn0263006 Reactome Ion transport by P-type ATPases R-DME-936837 FBgn0001995 Reactome Mitochondrial translation elongation R-DME-5389840 FBgn0001995 Reactome Mitochondrial translation termination R-DME-5419276 FBgn0015949 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0015949 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0015949 Reactome mRNA 3'-end processing R-DME-72187 FBgn0015949 Reactome Processing of Intronless Pre-mRNAs R-DME-77595 FBgn0250823 Reactome Phosphorylation of ARR R-DME-209387 FBgn0250823 Reactome Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209440 FBgn0250823 Reactome Assembly of receptor complex R-DME-209472 FBgn0005777 Reactome Negative regulation of MAPK pathway R-DME-5675221 FBgn0262734 Reactome L13a-mediated translational silencing of Ceruloplasmin expression R-DME-156827 FBgn0262734 Reactome Translation initiation complex formation R-DME-72649 FBgn0262734 Reactome Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-DME-72662 FBgn0262734 Reactome Ribosomal scanning and start codon recognition R-DME-72702 FBgn0262734 Reactome GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-72706 FBgn0025674 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0025674 Reactome SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-DME-2173796 FBgn0025674 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0025674 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0025674 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0025674 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0013773 Reactome Miscellaneous substrates R-DME-211958 FBgn0013773 Reactome Eicosanoids R-DME-211979 FBgn0013773 Reactome Xenobiotics R-DME-211981 FBgn0013773 Reactome Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-DME-2162123 FBgn0013773 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0013773 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0027588 Reactome N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-DME-532668 FBgn0027588 Reactome Calnexin/calreticulin cycle R-DME-901042 FBgn0040534 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0040534 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0040705 Reactome Respiratory electron transport R-DME-611105 FBgn0040705 Reactome Complex I biogenesis R-DME-6799198 FBgn0040752 Reactome Neurexins and neuroligins R-DME-6794361 FBgn0040780 Reactome Macroautophagy R-DME-1632852 FBgn0029830 Reactome Trafficking of GluR2-containing AMPA receptors R-DME-416993 FBgn0040918 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0040929 Reactome UCH proteinases R-DME-5689603 FBgn0040929 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0266666 Reactome Ubiquitination and proteolysis of phosphorylated CI R-DME-209360 FBgn0266666 Reactome Degradation of NF-kappa-B inhibitor, CACT R-DME-209406 FBgn0266666 Reactome Ubiquitination and degradation of phosphorylated ARM R-DME-209461 FBgn0266666 Reactome Nuclear CI is degraded R-DME-216167 FBgn0266666 Reactome Degradation of TIM R-DME-432395 FBgn0266666 Reactome Degradation of PER R-DME-432524 FBgn0266666 Reactome Degradation of CLK R-DME-538848 FBgn0266666 Reactome Degradation of CRY R-DME-538864 FBgn0040066 Reactome HATs acetylate histones R-DME-3214847 FBgn0040066 Reactome RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-DME-8936459 FBgn0040066 Reactome Neddylation R-DME-8951664 FBgn0040238 Reactome Stimuli-sensing channels R-DME-2672351 FBgn0040235 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0040078 Reactome Formation of the beta-catenin:TCF transactivating complex R-DME-201722 FBgn0040078 Reactome UCH proteinases R-DME-5689603 FBgn0040078 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0040078 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0040273 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0040273 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0040273 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0040273 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0040273 Reactome mRNA Capping R-DME-72086 FBgn0040273 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0040273 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0283477 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0283477 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0283477 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0283477 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0283477 Reactome mRNA 3'-end processing R-DME-72187 FBgn0265298 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0265298 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0265298 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0265298 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0265298 Reactome mRNA 3'-end processing R-DME-72187 FBgn0040291 Reactome Recognition of DNA damage by PCNA-containing replication complex R-DME-110314 FBgn0040291 Reactome Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1234176 FBgn0040291 Reactome Degradation of beta-catenin by the destruction complex R-DME-195253 FBgn0040291 Reactome Nuclear CI is degraded R-DME-216167 FBgn0040291 Reactome Degradation of DVL R-DME-4641258 FBgn0040291 Reactome Degradation of GLI1 by the proteasome R-DME-5610780 FBgn0040291 Reactome GLI3 is processed to GLI3R by the proteasome R-DME-5610785 FBgn0040291 Reactome Hedgehog 'on' state R-DME-5632684 FBgn0040291 Reactome DNA Damage Recognition in GG-NER R-DME-5696394 FBgn0040291 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0040291 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0040291 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0040291 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0040291 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0040291 Reactome Orc1 removal from chromatin R-DME-68949 FBgn0040291 Reactome FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8854050 FBgn0040291 Reactome Regulation of RUNX2 expression and activity R-DME-8939902 FBgn0040291 Reactome Neddylation R-DME-8951664 FBgn0040291 Reactome Interleukin-1 signaling R-DME-9020702 FBgn0040291 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263236 Reactome Neutrophil degranulation R-DME-6798695 FBgn0040299 Reactome The canonical retinoid cycle in rods (twilight vision) R-DME-2453902 FBgn0040206 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0040206 Reactome Lysosome Vesicle Biogenesis R-DME-432720 FBgn0040206 Reactome Golgi Associated Vesicle Biogenesis R-DME-432722 FBgn0040206 Reactome Thrombin signalling through proteinase activated receptors (PARs) R-DME-456926 FBgn0040206 Reactome WNT5A-dependent internalization of FZD4 R-DME-5099900 FBgn0040206 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0040206 Reactome Ub-specific processing proteases R-DME-5689880 FBgn0040206 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0040206 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0040230 Reactome Neddylation R-DME-8951664 FBgn0040230 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0263934 Reactome Asymmetric localization of PCP proteins R-DME-4608870 FBgn0041087 Reactome Sphingolipid de novo biosynthesis R-DME-1660661 FBgn0040232 Reactome Kinesins R-DME-983189 FBgn0040237 Reactome Neutrophil degranulation R-DME-6798695 FBgn0028427 Reactome Localization of the PINCH-ILK-PARVIN complex to focal adhesions R-DME-446343 FBgn0040308 Reactome Neutrophil degranulation R-DME-6798695 FBgn0040309 Reactome TP53 Regulates Metabolic Genes R-DME-5628897 FBgn0040319 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0040212 Reactome Synthesis of PA R-DME-1483166 FBgn0040212 Reactome Plasmalogen biosynthesis R-DME-75896 FBgn0040212 Reactome Peroxisomal protein import R-DME-9033241 FBgn0263829 Reactome Cleavage of Growing Transcript in the Termination Region R-DME-109688 FBgn0263829 Reactome Transport of Mature mRNA derived from an Intron-Containing Transcript R-DME-159236 FBgn0263829 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0263829 Reactome mRNA 3'-end processing R-DME-72187 FBgn0263829 Reactome Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-DME-975957 FBgn0085412 Reactome Synthesis of PIPs at the plasma membrane R-DME-1660499 FBgn0085371 Reactome Wax biosynthesis R-DME-8848584 FBgn0260008 Reactome Respiratory electron transport R-DME-611105 FBgn0085436 Reactome TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-DME-6804115 FBgn0087011 Reactome Platelet degranulation R-DME-114608 FBgn0087011 Reactome Common Pathway of Fibrin Clot Formation R-DME-140875 FBgn0087011 Reactome Tie2 Signaling R-DME-210993 FBgn0087011 Reactome Integrin cell surface interactions R-DME-216083 FBgn0087011 Reactome Integrin alphaIIb beta3 signaling R-DME-354192 FBgn0087011 Reactome GRB2:SOS provides linkage to MAPK signaling for Integrins R-DME-354194 FBgn0087011 Reactome p130Cas linkage to MAPK signaling for integrins R-DME-372708 FBgn0087011 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0087011 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0087011 Reactome MAP2K and MAPK activation R-DME-5674135 FBgn0087011 Reactome Neutrophil degranulation R-DME-6798695 FBgn0087011 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0085428 Reactome Detoxification of Reactive Oxygen Species R-DME-3299685 FBgn0085386 Reactome Inactivation, recovery and regulation of the phototransduction cascade R-DME-2514859 FBgn0086917 Reactome Methylation R-DME-156581 FBgn0086917 Reactome Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-DME-211957 FBgn0086917 Reactome Endogenous sterols R-DME-211976 FBgn0086917 Reactome Xenobiotics R-DME-211981 FBgn0086917 Reactome Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-DME-2142670 FBgn0086917 Reactome Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-DME-2142816 FBgn0086917 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0086917 Reactome Biosynthesis of protectins R-DME-9018681 FBgn0086917 Reactome Biosynthesis of maresin-like SPMs R-DME-9027307 FBgn0085413 Reactome Effects of PIP2 hydrolysis R-DME-114508 FBgn0085450 Reactome Downregulation of SMAD2/3:SMAD4 transcriptional activity R-DME-2173795 FBgn0085242 Reactome Nuclear Receptor transcription pathway R-DME-383280 FBgn0085397 Reactome Axonal growth inhibition (RHOA activation) R-DME-193634 FBgn0085397 Reactome Receptor-type tyrosine-protein phosphatases R-DME-388844 FBgn0085397 Reactome Synaptic adhesion-like molecules R-DME-8849932 FBgn0085638 Reactome MHC class II antigen presentation R-DME-2132295 FBgn0266100 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0266100 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0085480 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0263606 Reactome Mitochondrial iron-sulfur cluster biogenesis R-DME-1362409 FBgn0085212 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0262954 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0262954 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0262954 Reactome Transcriptional regulation by small RNAs R-DME-5578749 FBgn0262954 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0262954 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0262954 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0262954 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0262954 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0262954 Reactome FGFR2 alternative splicing R-DME-6803529 FBgn0262954 Reactome RNA polymerase II transcribes snRNA genes R-DME-6807505 FBgn0262954 Reactome mRNA Capping R-DME-72086 FBgn0262954 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0262954 Reactome mRNA Splicing - Minor Pathway R-DME-72165 FBgn0262954 Reactome Processing of Capped Intron-Containing Pre-mRNA R-DME-72203 FBgn0262954 Reactome RNA Polymerase I Transcription Initiation R-DME-73762 FBgn0262954 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0262954 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0262954 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0262954 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0262954 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0262954 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0262954 Reactome Estrogen-dependent gene expression R-DME-9018519 FBgn0085395 Reactome Voltage gated Potassium channels R-DME-1296072 FBgn0085395 Reactome Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-DME-381676 FBgn0025837 Reactome Glutathione synthesis and recycling R-DME-174403 FBgn0025837 Reactome Synthesis of Leukotrienes (LT) and Eoxins (EX) R-DME-2142691 FBgn0025837 Reactome Aflatoxin activation and detoxification R-DME-5423646 FBgn0250903 Reactome Inactivation of APC/C via direct inhibition of the APC/C complex R-DME-141430 FBgn0250903 Reactome APC/C:Cdc20 mediated degradation of Cyclin B R-DME-174048 FBgn0250903 Reactome Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174084 FBgn0250903 Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174178 FBgn0250903 Reactome Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-174184 FBgn0250903 Reactome Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-DME-176407 FBgn0250903 Reactome Regulation of APC/C activators between G1/S and early anaphase R-DME-176408 FBgn0250903 Reactome APC/C:Cdc20 mediated degradation of mitotic proteins R-DME-176409 FBgn0250903 Reactome Phosphorylation of the APC/C R-DME-176412 FBgn0250903 Reactome APC-Cdc20 mediated degradation of Nek2A R-DME-179409 FBgn0250903 Reactome Senescence-Associated Secretory Phenotype (SASP) R-DME-2559582 FBgn0250903 Reactome CDK-mediated phosphorylation and removal of Cdc6 R-DME-69017 FBgn0250903 Reactome Antigen processing: Ubiquitination & Proteasome degradation R-DME-983168 FBgn0085481 Reactome O-linked glycosylation of mucins R-DME-913709 FBgn0042137 Reactome Synthesis of Lipoxins (LX) R-DME-2142700 FBgn0042137 Reactome Biosynthesis of D-series resolvins R-DME-9018676 FBgn0042137 Reactome Biosynthesis of E-series 18(S)-resolvins R-DME-9018896 FBgn0042138 Reactome eNOS activation R-DME-203615 FBgn0042185 Reactome Mitochondrial calcium ion transport R-DME-8949215 FBgn0042185 Reactome Processing of SMDT1 R-DME-8949664 FBgn0042207 Reactome Digestion of dietary lipid R-DME-192456 FBgn0042207 Reactome Formation of the cornified envelope R-DME-6809371 FBgn0042083 Reactome Biotin transport and metabolism R-DME-196780 FBgn0042083 Reactome Branched-chain amino acid catabolism R-DME-70895 FBgn0043025 Reactome Surfactant metabolism R-DME-5683826 FBgn0043025 Reactome Neutrophil degranulation R-DME-6798695 FBgn0024248 Reactome PI3K Cascade R-DME-109704 FBgn0024248 Reactome Insulin signaling pathway R-DME-110478 FBgn0024248 Reactome IRS-mediated signalling R-DME-112399 FBgn0024248 Reactome SOS-mediated signalling R-DME-112412 FBgn0024248 Reactome PIP3 activates AKT signaling R-DME-1257604 FBgn0024248 Reactome PI3K/AKT activation R-DME-198203 FBgn0024248 Reactome RAF/MAP kinase cascade R-DME-5673001 FBgn0024248 Reactome PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-6811558 FBgn0024248 Reactome Signal attenuation R-DME-74749 FBgn0024248 Reactome Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-DME-9027276 FBgn0024248 Reactome Erythropoietin activates RAS R-DME-9027284 FBgn0039977 Reactome mRNA Splicing - Major Pathway R-DME-72163 FBgn0265968 Reactome Formation of RNA Pol II elongation complex R-DME-112382 FBgn0265968 Reactome Formation of the Early Elongation Complex R-DME-113418 FBgn0265968 Reactome Formation of Incision Complex in GG-NER R-DME-5696395 FBgn0265968 Reactome Dual Incision in GG-NER R-DME-5696400 FBgn0265968 Reactome RNA Polymerase II Pre-transcription Events R-DME-674695 FBgn0265968 Reactome Formation of TC-NER Pre-Incision Complex R-DME-6781823 FBgn0265968 Reactome Dual incision in TC-NER R-DME-6782135 FBgn0265968 Reactome Gap-filling DNA repair synthesis and ligation in TC-NER R-DME-6782210 FBgn0265968 Reactome TP53 Regulates Transcription of DNA Repair Genes R-DME-6796648 FBgn0265968 Reactome mRNA Capping R-DME-72086 FBgn0265968 Reactome RNA Polymerase II Promoter Escape R-DME-73776 FBgn0265968 Reactome RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-DME-73779 FBgn0265968 Reactome RNA Polymerase II Transcription Initiation R-DME-75953 FBgn0265968 Reactome RNA Polymerase II Transcription Elongation R-DME-75955 FBgn0265968 Reactome RNA Polymerase II Transcription Initiation And Promoter Clearance R-DME-76042 FBgn0265968 Reactome RNA Pol II CTD phosphorylation and interaction with CE R-DME-77075 FBgn0259244 Reactome Collagen degradation R-DME-1442490 FBgn0259244 Reactome Collagen biosynthesis and modifying enzymes R-DME-1650814 FBgn0259244 Reactome Integrin cell surface interactions R-DME-216083 FBgn0259244 Reactome Collagen chain trimerization R-DME-8948216 FBgn0259821 Reactome Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-381426 FBgn0259821 Reactome Post-translational protein phosphorylation R-DME-8957275 FBgn0259242 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0259242 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0261361 Reactome TRP channels R-DME-3295583 FBgn0261361 Reactome Transferrin endocytosis and recycling R-DME-917977 FBgn0085736 Reactome Respiratory electron transport R-DME-611105 FBgn0085736 Reactome Complex I biogenesis R-DME-6799198 FBgn0261260 Reactome Cargo recognition for clathrin-mediated endocytosis R-DME-8856825 FBgn0261260 Reactome Clathrin-mediated endocytosis R-DME-8856828 FBgn0260953 Reactome Neutrophil degranulation R-DME-6798695 FBgn0265047 Reactome Platelet degranulation R-DME-114608 FBgn0260971 Reactome TWIK-related spinal cord K+ channel (TRESK) R-DME-1299344 FBgn0260971 Reactome Phase 4 - resting membrane potential R-DME-5576886 FBgn0267912 Reactome Calcineurin activates NFAT R-DME-2025928 FBgn0267912 Reactome FCERI mediated Ca+2 mobilization R-DME-2871809 FBgn0267912 Reactome Ca2+ pathway R-DME-4086398 FBgn0267912 Reactome CLEC7A (Dectin-1) induces NFAT activation R-DME-5607763