# l(2)21D-22A Nineteen lethally mutable loci, including S, defined by com- plementation analysis of 55 ethyl-methanesulfonate-induced recessive lethal mutations uncovered by Df(2L)S2 (Roberts, Brock, Rudden, and Evans-Roberts, 1985, Genetics 109: 145- 56). genetic cytological locus location location included in excluded from synonym _________________________________________________________________ l(2)21Da 21D1-2 Df(2L)S3 Df(2L)ast3 l(2)neh1 l(2)21Db 21D1-2 Df(2L)ast3 Df(2L)ast4 l(2)neh2 l(2)21Dc 21D1-2 Df(2L)ast3 Df(2L)ast4 l(2)neh3 l(2)21Dd 21D1-E1 Df(2L)ast4 Df(2L)ast6 l(2)neh4 l(2)21De 21D1-E1 Df(2L)ast4 Df(2L)ast6 l(2)neh5 l(2)21Df 21D1-E1 Df(2L)ast4 Df(2L)ast6 l(2)neh6 l(2)21Dg 21D1-E1 Df(2L)ast4 Df(2L)ast6 l(2)neh7 l(2)21Ea 21E1-2 Df(2L)ast6 Df(2L)ast5 l(2)neh8 l(2)21Eb 2-1.3 21E1-2 Df(2L)ast5 S Df(2L)ast6 l(2)21Fa 21E2-22A1 Df(2L)ast5 Df(2L)ast6 l(2)neh9 l(2)21Fb 21E2-22A1 Df(2L)ast5 Df(2L)ast6 l(2)neh10 l(2)21Fc 21E2-22A1 Df(2L)ast5 Df(2L)ast6 l(2)neh11 l(2)21Fd 21E2-22A1 Df(2L)ast5 Df(2L)ast6 l(2)neh12 l(2)21Fe 22A1-2 Df(2L)ast10 Df(2L)S3 l(2)neh13 allele origin ref ( synonym ____________________________________________ l(2)21Da1 EMS 1 l(2)neh-137-L l(2)21Db1 EMS 1 l(2)neh-2J4-4 l(2)21Dc1 EMS 1 l(2)neh-3S3-1 l(2)21Dd1 EMS 1 l(2)neh-427-A l(2)21Dd2 EMS 1 l(2)neh-4I4-4 l(2)21De1 EMS 1 l(2)neh-5I1-3 l(2)21De2 EMS 1 l(2)neh-5S3-2 l(2)21De3 EMS 1 l(2)neh-5I4-C l(2)21De4 EMS 1 l(2)neh-535-A l(2)21De5 EMS 1 l(2)neh-5I2-L l(2)21Df1 EMS 1 l(2)neh-6J4-1 l(2)21Dg1 EMS 1 l(2)neh-724-B l(2)21Dg2 EMS 1 l(2)neh-7I4-5 l(2)21Ea1 EMS 1 l(2)neh-8Y2-1 l(2)21Ea2 EMS 1 l(2)neh-8Y5-2 l(2)21Ea3 EMS 1 l(2)neh-84K l(2)21Ea4 EMS 1 l(2)neh-8F l(2)21Fa1 EMS 1 l(2)neh-9J2-6 l(2)21Fa2 EMS 1 l(2)neh-9H1-3 l(2)21Fa3 EMS 1 l(2)neh-920-M l(2)21Fa4 EMS 1 l(2)neh-9S2-2 l(2)21Fa5 EMS 1 l(2)neh-9E-2 l(2)21Fb1 EMS 1 l(2)neh-1024-1 l(2)21Fc1 EMS 1 l(2)neh-1128-K l(2)21Fd1 EMS 1 l(2)neh-12Y5-1 l(2)21Fd2 EMS 1 l(2)neh-12M1-4 l(2)21Fd3 EMS 1 l(2)neh-1227-K l(2)21Fd4 EMS 1 l(2)neh-1224-K l(2)21Fd5 EMS 1 l(2)neh-12J3-3 l(2)21Fe1 EMS 1 l(2)neh-13X1-1 ( 1 = Roberts, Brock, Rudden, and Evans-Roberts, 1985, Genet- ics 109: 145-56. cytological locus location included in excluded from synonym ________________________________________________________ l(2)22Aa 22A1-B1 Df(2L)S2 Df(2L)ast10 l(2)neh14 l(2)22Ab 22A1-B1 Df(2L)S2 Df(2L)ast10 l(2)neh15 l(2)22Ac 22A1-B1 Df(2L)S2 Df(2L)ast10 l(2)neh16 l(2)22Ad 22A1-B1 Df(2L)S2 Df(2L)ast10 l(2)neh17 l(2)22Ae 22A1-B1 Df(2L)S2 Df(2L)ast10 l(2)neh18 allele origin synonym ____________________________________ l(2)22Aa1 EMS l(2)neh-1425-K l(2)22Aa2 EMS l(2)neh-14J4-3 l(2)22Aa3 EMS l(2)neh-14H5-2 l(2)22Aa4 EMS l(2)neh-1426-K l(2)22Aa5 EMS l(2)neh-145-K l(2)22Aa6 EMS l(2)neh-1437K l(2)22Ab1 EMS l(2)neh-15V l(2)22Ab2 EMS l(2)neh-15L2-1 l(2)22Ab3 EMS l(2)neh-15L1-2 l(2)22Ab4 EMS l(2)neh-15F2 l(2)22Ab5 EMS l(2)neh-15 l(2)22Ab6 EMS l(2)neh-15X3-2 l(2)22Ac1 EMS l(2)neh-1621Q l(2)22Ac2 EMS l(2)neh-1638K l(2)22Ac3 EMS l(2)neh-1638L l(2)22Ac4 EMS l(2)neh-16G l(2)22Ac5 EMS l(2)neh-16H l(2)22Ad1 EMS l(2)neh-17J2-8 l(2)22Ad2 EMS l(2)neh-175L l(2)22Ae1 EMS l(2)neh-18X1-3 # l(2)22F A series of eighteen ethyl methanesulfonate-induced reces- sive lethals falling into three complementation groups in the region uncovered by Df(2L)dpp14 = Df(2L)22E4-F1;22F3-23A1 (Spencer, Hoffman, and Gelbart, 1982, Cell 28: 451-61). genetic cytological locus location location included in excluded from synonym _______________________________________________________________ l(2)22Fa 2-4.0 22F1-2 Df(2L)dpp19 dpp l(2)22Fb 2-{4} 22F3 Df(2L)dpp19 l(2)ND1 l(2)22Fc 2-{4} 22F4-23A1 Df(2L)dpp14 Dp(2;2)DTD48 l(2)ND2 l(2)22Fd 2-{4} 22F4-23A1 Df(2L)dpp14 Dp(2;2)DTD48 l(2)ND3 # DEFICIENCY MAP OF REGION 21D-22A side breakpoint variant _________________________________ net right 21B2-4 Df(2L)PM44 right 21B2-4 Df(2L)PM82 l(2)21Ba l(2)21Bb right 21B3-5 Df(2L)PM1 right 21B3-5 Df(2L)PM51 right 21B3-5 Df(2L)PM59 GsI right 21B4-6 Df(2L)PMG right 21B4-6 Df(2L)PM91 right 21B4-6 Df(2L)PM45 l(2)21Bd right 21B4-6 Df(2L)TE75 al left 21C6-D1 Df(2L)S2 left 21C7-8 Df(2L)ast1 left 21D1-2 Df(2L)ast2 ds left 21D2-3 Df(2L)ast10 left 21D2 Df(2L)S3 l(2)21Da left 21D1-2 Df(2L)ast3 l(2)21Db l(2)21Dc left 21D1-2 Df(2L)ast4 l(2)21Dd l(2)21De l(2)21Df Lsp1| l(2)21Dg left 21E1-2 Df(2L)ast6 l(2)21Ea left 21E1-2 Df(2L)ast5 S right 21E1-2 Df(2L)ast3 right 21E1-2 Df(2L)ast4 right 21E1-2 Df(2L)ast6 l(2)21Fa l(2)21Fb l(2)21Fc l(2)21Fd right 21F3-22A1 Df(2L)ast5 right 21F3-22A1 Df(2L)S3 l(2)21Fe right 22A1-2 Df(2L)ast10 l(2)22Aa l(2)22Ab l(2)22Ac l(2)22Ad l(2)22Ae right 22A6-B1 Df(2L)S2 right 22B2-3 Df(2L)ast2 left 22E2-4 Dp(2;2)DTD48 22F1-2 dppsv 22F1-2 dppHin left 22E4-F2 Df(2L)dpp14 right 22F1-2 Dp(2;2)F21 left 22F2-3 Df(2L)dpp19 22F1-2 dpp 22F2-3 l(2)22Fb right 22F3-4 Df(2L)dpp19 right 22F4-23A1 Dp(2;2)DTD48 22F4-23A1 l(2)22Fc 22F4-23A1 l(2)22Fd right 22F3-23A1 Df(2L)dpp14 # l(2)24D-F A series of lethal complementation groups covered by Dp(2;1)B19 by Szidonya and Reuter (1988, Genet. Res. 51: 197-208). These lethals and those in the same region [l(2)24EF] recovered by Roy, Manna, and Duttagupta (1984, J. Biosci. 6: 87-95) not tested for complementation. genetic cytological locus location location included in excluded from synonym ______________________________________________________________________ l(2)24Da 2-12.0 24D4-8 Df(2L)sc19-1 Df(2L)M24F ft, l(2)fd l(2)24Db 2-{12} 24D4-8 Df(2L)sc19-1 Df(2L)M24F M(2)24D l(2)24Dc 2-{12} 24D4-8 Df(2L)sc19-1 Df(2L)M24F l(2)jf1 l(2)24Dd 2-{12} 24D4-8 Df(2L)sc19-1 Df(2L)M24F l(2)jf2 l(2)24De 2-{12} 24D4-8 Df(2L)sc19-1 Df(2L)M24F l(2)jf3 l(2)24Df 2-{12} 24D8-E3 Df(2L)M24F Df(2)sc19-3 l(2)jf4 l(2)24Ea 2-{13} 24E5-F2 Df(2L)dp-h19 Df(2L)sc19-6 l(2)jf5 l(2)24Fa 2-{13} 24F1-25A1 Df(2L)sc19-6 Df(2L)dp-h24 l(2)jf6 l(2)24Fb 2-12.9 24F1-25A1 Df(2L)dp-h24 Df(2L)dp-cl-h3 M(2)24F l(2)24Fc 2-{13} 24F1-25A1 Df(2L)dp-h24 Df(2L)dp-cl-h3 l(2)jf7 l(2)24Fd 2-13.0 24F7-25A1 Df(2L)dp-cl-h3 Df(2L)M24F dp allele synonym _________________________ l(2)24Dc1 l(2)jf1sz5 l(2)24De1 l(2)jf2a6 l(2)24De2 l(2)jf2b8 l(2)24Df1 l(2)jf3b25 l(2)24Df2 l(2)jf3sz11 l(2)24Df3 l(2)jf3sz49 l(2)24Df4 l(2)jf3sz56 l(2)24Ea1 l(2)jf4b11 l(2)24Fa l(2)jf6sz3 l(2)24Fc1 l(2)jf7h6 l(2)24Fc2 l(2)jf7h32 l(2)24Fc3 l(2)jf7h36 l(2)24Fc4 l(2)jf7h39 # l(2)24EF A series of mutants recovered by virtue of their lethal phenotype in combination with Df(2L)M24F by Roy, Manna, and Duttagupta (1984, J. Biosci. 6: 87-95). Not tested against alleles recovered by Szidonya and Reuter. Deficiencies inferred by failure to complement more than a single comple- mentation group not detected cytologically. The order of loci a, b, c, and d with respect to each other, but not their polarity, inferred from these deficiencies; the order of the remaining loci with respect to both a through d and each other unknown. Despite the presence of dw-24E and dp in region mon- itored, the authors report recovery of no visible mutations. genetic cytological locus location location included in excluded from synonym ______________________________________________________________________ l(2)24EFa 1-{13} 24E1-25A1 Df(2L)RMD202 Df(2L)RMD239 l(2)Gr.I l(2)24EFb 1-{13} 24E1-25A1 Df(2L)RMD239 Df(2L)RMD113 l(2)Gr.II l(2)24EFc 1-{13} 24E1-25A1 Df(2L)RMD239 l(2)Gr.III Df(2L)RMD113 l(2)24EFd 1-{13} 24E1-25A1 Df(2L)RMD113 Df(2L)RMD239 l(2)Gr.IV l(2)24EFe 1-{13} 24E1-25A1 Df(2L)M24F Df(2L)RMD42 l(2)Gr.V l(2)24EFf 1-{13} 24E1-25A1 Df(2L)M24F Df(2L)RMD42 l(2)Gr.VI l(2)24EFg 1-{13} 24E1-25A1 Df(2L)M24F Df(2L)RMD42 l(2)Gr.VII l(2)24EFh 2-12.9 24E1-25A1 Df(2L)M24F Df(2L)RMD42 M(2)24F allele origin synonym ________________________________ l(2)24EFa1 EMS l(2)32 l(2)24EFa2 EMS l(2)55 l(2)24EFa3 EMS l(2)103 l(2)24EFb1 EMS l(2)378 l(2)24EFb2 EMS l(2)387 l(2)24EFc1 X ray l(2)03 l(2)24EFc2 EMS l(2)05 l(2)24EFc3 EMS l(2)71 l(2)24EFc4 EMS l(2)72 l(2)24EFc5 EMS l(2)83 l(2)24EFc6 EMS l(2)92 l(2)24EFc7 EMS l(2)112 l(2)24EFc8 EMS l(2)125 l(2)24EFc9 EMS l(2)126 l(2)24EFc10 EMS l(2)144 l(2)24EFc11 EMS l(2)193 l(2)24EFc12 EMS l(2)241 l(2)24EFc13 EMS l(2)243 l(2)24EFc14 EMS l(2)256 l(2)24EFc15 EMS l(2)257 l(2)24EFc16 EMS l(2)268 l(2)24EFc17 EMS l(2)279 l(2)24EFc18 EMS l(2)320 l(2)24EFc19 X ray l(2)336 l(2)24EFc20 EMS l(2)346 l(2)24EFc21 EMS l(2)785 l(2)24EFd1 X ray l(2)381 l(2)24EFe1 EMS l(2)2296 l(2)24EFf1 EMS l(2)162 l(2)24EFg1 EMS l(2)178 # DEFICIENCY MAP OF REGION 24D, E, and F side breakpoint variant ( variant | _____________________________________________ right 24D4 Dp(2;1)B19 ed left 24C3-5 Df(2L)ed-dp-h1 left 24D2-4 Df(2L)sc19-11 left 24D3-4 Df(2L)M11 left 24D4-5 Df(2L)sc19-1 ft M(2)24D l(2)24Dc l(2)24Dd l(2)24De left 24D7-8 Df(2L)dp-h28 left 24D8-E1 Df(2L)M24F Df(2L)M24F left Df(2L)RMD42 left Df(2L)RMD202 left Df(2L)RMD261 left Df(2L)RMD269 l(2)24EFa left Df(2L)RMD149 left Df(2L)RMD239 l(2)24EFb left Df(2L)RMD113 l(2)24EFc right Df(2L)RMD113 right Df(2L)RMD239 right Df(2L)RMD202 right Df(2L)RMD261 l(2)24EFd right Df(2L)RMD42 right Df(2L)RMD149 l(2)24EFe l(2)24EFf l(2)24Df left 24E2-3 Df(2L)sc19-3 left 24E2-4 Df(2L)dp-h25 left 24E2-4 Df(2L)sc19-13 dw24E left 24E5-F1 Df(2L)dp-h19 l(2)24Ea left 24F1-2 Df(2L)sc19-6 l(2)24Fa left Df(2L)dp-h24 M(2)24F M(2)24F l(2)24Fc left 24F7-25A1 Df(2L)dp-cl-h3 Su(var)2-8 dp right 24F7-25A1 Df(2L)dp-h28 right 24F7-25A1 Df(2L)M24F Df(2L)M24F right Df(2L)RMD269 right 24F7-25A1 Df(2L)dp-h19 right Df(2L)dp-h24 ( Search of Szidonya and Reuter (1988, Genet. Res. 51: 197- 208). | Search of Roy, Manna, and Duttagupta (1984, J. Biosci. 6: 87-95). Variants common to the two searches occupy the same lines in the table. # l(2)25 The entire region screened extensively for lethal mutations by Szidonya and Reuter (1988, Genet, Res. 51: 197-208). In addition, the region deleted by Df(2L)GpdhA, which is defi- cient for 25E through 26A has yielded seventeen lethally mut- able loci in the region (Kotarski, Pickert, and MacIntyre, 1983, Genetics 105: 371-86). Complementation tests have not been carried out between mutations isolated in the two screens. # l(2)25A & B Nine lethally mutable loci, the most distal of which is slf. genetic cytological locus location location included in excluded from synonym ___________________________________________________________________ l(2)25Aa 2-15 25A4-B1 Df(2L)sc19-4 slf Df(2L)sc19-3 l(2)25Ab 2-{13} 25A4-B1 Df(2L)sc19-4 l(2)jf9 Df(2L)sc19-3 l(2)25Ba 2-{13} 25A7-B4 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf10 l(2)25Bb 2-{13} 25A7-B4 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf11 l(2)25Bc 2-{13} 25B2-B5 Df(2L)sc19-13 Df(2L)sc19-11 l(2)jf12 l(2)25Bd 2-{13} 25B2-C1 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf13 l(2)25Be 2-{13} 25B2-C1 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf14 l(2)25Bf 2-{13} 25B2-C1 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf15 l(2)25Bg 2-{13} 25B2-C1 Df(2L)sc19-11 Df(2L)sc19-3 l(2)jf16 allele origin synonym ___________________________________ l(2)25Ab1 EMS l(1)jf9b26 l(2)25Ba1 EMS l(2)jf10a9 l(2)25Bb1 EMS l(1)jf11sz59 l(2)25Bc1 EMS l(1)jf12sz17 l(2)25Bc2 EMS l(1)jf12sz27 l(2)25Bd1 EMS l(1)jf13h4 l(2)25Bd2 EMS l(1)jf13sz18 l(2)25Bd3 EMS l(1)jf13sz19 l(2)25Be1 EMS l(1)jf14h7 l(2)25Be2 EMS l(1)jf14h21 l(2)25Bf1 EMS l(1)jf15a4 l(2)25Bf2 EMS l(1)jf15h12 l(2)25Bg1 EMS l(1)jf16a11 l(2)25Bg2 EMS l(1)jf16b15 # l(2)25C & D Eleven lethally mutable loci including M(2)25C and tkv; also, l(2)25Ca has dominant temperature-sensitive alleles and was described originally as DTS. genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)25Ca 2-{15} 25B9-C3 Dp(2;2)B17 Df(2L)sc19-10 DTS l(2)25Cb 2-{15} 25B9-C3 Df(1)sc19-7 Dp(2;2)B17 M(2)25C l(2)25Cc 2-{15} 25B9-C3 Df(1)sc19-7 Dp(2;2)B17 l(2)jf17 l(2)25Cd 2-{15} 25B9-C3 Df(1)sc19-7 Dp(2;2)B17 l(2)jf18 l(2)25Ce 2-{15} 25C3-5 Df(2L)sc19-6 Df(1)sc19-7 l(2)jf19 l(2)25Cf 2-{15} 25C3-5 Df(2L)sc19-6 Df(1)sc19-7 l(2)jf20 l(2)25Cg 2-{15} 25C3-8 Df(2L)sc19-8 Df(1)sc19-6 l(2)jf21 l(2)25Ch 2-{15} 25C8-9 Df(2L)sc19-1 Df(1)sc19-8 l(2)jf22 l(2)25Da 2-16 25D2-6 Df(2L)cl2 tkv Df(2L)tkv-sz3 l(2)25Db 2-{16} 25D2-6 Df(2L)tkv-sz3 l(2)jf23 Df(1)cl7 l(2)25Dc 2-{16} 25D5-E1 Df(2L)cl7 Df(1)c4 l(2)jf24 # l(2)25Ca location: 2-{15}. origin: Induced by ethyl methanesulfonate; selected as dominant temperature-sensitive, dominant cold-sensitive lethal, or recessive lethal mutations. references: Suzuki and Procunier, 1969, Proc. Nat. Acad. Sci. USA 62: 369-76. Rosenbluth, Ezell, and Suzuki, 1972, Genetics 70: 75-86. Szidonya and Reuter, 1988, Genet. Res. 51: 197-208. phenotype: Heterozygotes for dominant temperature-sensitive alleles lethal or nearly so when raised at 29 but survive at 25; +/+/l heterozygotes survive development at 29. Heterozy- gotes for dominant cold-sensitive alleles lethal or nearly so when raised at 17 but survive at 22; adults insensitive to 17. Heat-sensitive period 18-24 hr after ovoposition; lethal phase varies, but most frequently at 75-90 hr for heat-sensitive alleles and late in development, but highly variable for cold-sensitive alleles. Heterozygotes for alleles selected as recessive lethals are mostly not dominant temperature- sensitives. alleles: allele origin synonym ref ( comments _______________________________________________________________ l(2)25Ca1 EMS DTS-L2 2 dominant heat sensitive l(2)25Ca2 EMS DTS-L3 2 dominant heat sensitive l(2)25Ca3 EMS DTS-L4 2 dominant heat sensitive l(2)25Ca4 EMS DTS-L5 2 dominant heat sensitive l(2)25Ca5 EMS DTS-L7 2 dominant heat sensitive l(2)25Ca6 EMS DTS-L10 2 dominant heat sensitive l(2)25Ca7 EMS DTS-L11 2 dominant heat sensitive l(2)25Ca8 EMS DTS-L12 2 dominant heat sensitive l(2)25Ca9 EMS DTS-L13 2 dominant heat sensitive l(2)25Ca10 EMS DTS-L14 2 dominant heat sensitive l(2)25Ca11 EMS DTS-L16 2 dominant heat sensitive l(2)25Ca12 EMS DCS-L1 1 dominant cold sensitive l(2)25Ca13 EMS DCS-L2 1 dominant cold sensitive l(2)25Ca14 EMS DCS-L3 1 dominant cold sensitive l(2)25Ca15 EMS DCS-L4 1 dominant cold sensitive l(2)25Ca16 EMS DCS-L5 1 dominant cold sensitive l(2)25Ca17 EMS DCS-L6 1 dominant cold sensitive l(2)25Ca18 EMS DCS-L7 1 dominant cold sensitive l(2)25Ca19 EMS DCS-L8 1 dominant cold sensitive l(2)25Ca20 EMS DCS-L9 1 dominant cold sensitive l(2)25Ca21 EMS DCS-L10 1 dominant cold sensitive l(2)25Ca22 EMS DCS-L11 1 dominant cold sensitive l(2)25Ca23 EMS DCS-L12 1 dominant cold sensitive l(2)25Ca24 EMS DCS-L13 1 dominant cold sensitive l(2)25Ca25 EMS DCS-L14 1 dominant cold sensitive l(2)25Ca26 EMS DCS-L15 1 dominant cold sensitive l(2)25Ca27 EMS DCS-L16 1 dominant cold sensitive l(2)25Ca28 EMS DCS-L17 1 dominant cold sensitive l(2)25Ca29 EMS DCS-L18 1 dominant cold sensitive l(2)25Ca30 EMS DCS-L19 1 dominant cold sensitive l(2)25Ca31 EMS DCS-L20 1 dominant cold sensitive l(2)25Ca32 EMS DCS-L21 1 dominant cold sensitive l(2)25Ca33 EMS DCS-L22 1 dominant cold sensitive l(2)25Ca34 EMS DCS-L23 1 dominant cold sensitive l(2)25Ca35 EMS l(2)a30 1 dominant heat sensitive l(2)25Ca36 EMS l(2)b9 3 slight dominant heat sensitive l(2)25Ca37 EMS l(2)ab14 3 not dominant conditional l(2)25Ca38 EMS l(2)b17 3 slight dominant heat sensitive l(2)25Ca39 EMS l(2)b29 3 not dominant conditional l(2)25Ca40 EMS l(2)b32 3 not dominant conditional l(2)25Ca41 EMS l(2)b35 3 not dominant conditional l(2)25Ca42 EMS l(2)h12 3 not dominant conditional l(2)25Ca43 EMS l(2)h30 3 not dominant conditional l(2)25Ca44 EMS l(2)sz6 3 not dominant conditional l(2)25Ca45 EMS l(2)sz14 3 not dominant conditional l(2)25Ca46 EMS l(2)sz74 3 not dominant conditional l(2)25Ca47 EMS l(2)sz78 3 not dominant conditional ( 1 = Rosenbluth, Ezell, and Suzuki, 1972, Genetics 70: 75- 86; 2 = Suzuki and Procunier, 1969, Proc. Nat. Acad. Sci. USA 62: 369-76; 3 = Szidonya and Reuter, 1988, Genet. Res. 51: 197-208. other information: Interallelic complementation of heat- sensitive alleles observed at 25; complementation map circular with a tail. Circular complementation map also observed for cold-sensitive alleles at 22. Cold-sensitive alleles fail to complement heat-sensitive allele l(2)25Ca3. Alleles selected as recessive lethals form a linear complementation map with dominant heat-sensitive alleles (Szidonya and Reuter, 1988). allele origin synonym __________________________________ l(2)25Cc1 EMS l(2)jf17b60 l(2)25Cd1 EMS l(2)jf18sz77 l(2)25Ce1 EMS l(2)jf19sz53 l(2)25Cf1 EMS l(2)jf20sz70 l(2)25Cg1 EMS l(2)jf21a2 l(2)25Cg2 EMS l(2)jf21a8 l(2)25Cg3 EMS l(2)jf21a16 l(2)25Ch1 EMS l(2)jf22sz75 l(2)25Db1 EMS l(2)jf23sz7 l(2)25Db2 EMS l(2)jf23sz36 l(2)25Dc1 EMS l(2)jf24a1 l(2)25Dc2 EMS l(2)jf24a9 l(2)25Dc3 EMS l(2)jf24b19 l(2)25Dc4 EMS l(2)jf24h25 l(2)25Dc5 EMS l(2)jf24sz20 # l(2)25E Seven lethally mutable loci including midline (mid). Iso- lated in a saturation study of the region uncovered by Df(2L)GpdhA by Kotarski, Pickert, and MacIntyre (1983, Genet- ics 105: 371-86). The mutation study of Szidonya and Reuter (1988, Genet. Res. 51: 197-208) also extends into the region. The deficiency maps from the two studies are highly concor- dant; however, there have been no complementation crosses between mutants from the two studies. Although each study groups six loci together as l(2)25Ea to l(2)25Ef, there is no reason to believe that they have been designated in the same order; nevertheless, we have designated them Ea and Ea , Eb and Eb , etc. with the understanding that complementation tests are required in order to establish that the primed and nonprimed alleles are in fact allelic. genetic cytological locus location location included in excluded from synonym _____________________________________________________________________ l(2)25Ea 25D7-E2 Df(2L)GpdhA l(2)gdh11 YP2DB236 l(2)25Eb 25D7-E2 Df(2L)GpdhA l(2)gdh12 YP2DB236 l(2)25Ec 25D7-E4 YP2DH164 YP2DB236 l(2)gdh7 l(2)25Ed 25D7-E4 YP2DH164 YP2DB236 l(2)gdh8 l(2)25Ee 25D7-E4 YP2DH164 YP2DB236 l(2)gdh9 l(2)25Ef 25D7-E4 YP2DH164 YP2DB236 l(2)gdh10 l(2)25Eg 2-17.91 25E1-F1 YP2DH164 mid, l(2)gdh1 Df(2L)sc19-4 allele origin synonym ref ( ______________________________________________ l(2)25Ea1 EMS l(2)gdh-1107 1 l(2)25Ea2 EMS l(2)jf25b24 2 l(2)25Eb1 EMS l(2)gdh-1240 1 l(2)25Eb2 EMS l(2)gdh-123701 1 l(2)25Eb3 EMS l(2)jf26sz15 2 l(2)25Ec1 EMS l(2)gdh-725A 1 l(2)25Ec2 EMS l(2)gdh-7901 1 l(2)25Ec3 EMS l(2)jf27a7 2 l(2)25Ec4 EMS l(2)jf27sz9 2 l(2)25Ec5 EMS l(2)jf27sz18 2 l(2)25Ed1 EMS l(2)gdh-8001 1 l(2)25Ed2 EMS l(2)gdh-826 1 l(2)25Ed3 EMS l(2)gdh-829 1 l(2)25Ed4 EMS l(2)gdh-838 1 l(2)25Ed5 EMS l(2)gdh-81501 1 l(2)25Ed6 EMS l(2)jf28b2 2 l(2)25Ed7 EMS l(2)jf28sz63 2 l(2)25Ee1 EMS l(2)gdh-901 1 l(2)25Ee2 EMS l(2)gdh-916 1 l(2)25Ee3 EMS l(2)gdh-9701 1 l(2)25Ee4 EMS l(2)gdh-92901 1 l(2)25Ee5 EMS l(2)jf29b7 2 l(2)25Ef1 EMS l(2)gdh-1003 1 l(2)25Ef2 EMS l(2)gdh-1041 1 l(2)25Ef3 EMS l(2)gdh-10201 1 l(2)25Ef4 EMS l(2)jf30a26 2 l(2)25Ef5 EMS l(2)jf30b23 2 ( 1 = Kotarski, Pickert, and MacIntyre, 1983, Genetics 105: 371-86; 2 = Szidonya and Reuter, 1988, Genet. Res. 51: 197-208. # l(2)25F genetic cytological locus location location included in excluded from synonym _____________________________________________________________________ l(2)25Fa 2-{17} 25F2-3 Df(2L)H151 Df(2L)50075a l(2)gdh-14 l(2)25Fb 2-{17} 25F2-3 Df(2L)H151 Df(2L)50075a l(2)gdh-17 l(2)25Fc 2-{17} 25F2-26A1 Df(2L)50075a l(2)gdh-15 Df(2L)2802 l(2)25Fd 2-{17} 25F2-26A1 Df(2L)50075a l(2)gdh-16 Df(2L)2802 l(2)25Fe 2-18.46 25F4-26A1 Df(2L)50075a Df(2L)2802 l(2)gdh-3 allele origin synonym ref ( ______________________________________________ l(2)25Fa1 EMS l(2)gdh-1413 1 l(2)25Fa2 EMS l(2)gdh-1415 1 l(2)25Fa3 EMS l(2)gdh-1433B 1 l(2)25Fa4 EMS l(2)gdh-14301 1 l(2)25Fa5 EMS l(2)gdh-14802 1 l(2)25Fa6 EMS l(2)gdh-142001 1 l(2)25Fa7 EMS l(2)gdh-143102 1 l(2)25Fa8 EMS l(2)TE9 2 l(2)25Fb1 EMS l(2)gdh-1710 1 l(2)25Fc1 EMS l(2)gdh-153002 1 l(2)25Fd1 EMS l(2)gdh-1625B 1 l(2)25Fe1 EMS l(2)gdh-33301 1 ( 1 = Kotarski, Pickert, and MacIntyre, 1983, Genetics 105: 371-86; 2 = Szidonya and Reuter, 1988, Genet. Res. 51: 197-208. # l(2)26A Five lethally mutable genes isolated by virtue of their failure to complement Df(2L)GpdhA (Kotarski, Pickert, and MacIntyre, 1983, Genetics 105: 371-86). genetic cytological locus location location included in excluded from synonym _____________________________________________________________________ l(2)26Aa ( 2-{20} 25F4-26A8 Df(2L)cl7 Df(2L)50075a lx l(2)26Ab 2-20.55 26A7-9 Df(2L)GpdhA Df(2L)cl7 l(2)gdh-2 l(2)26Ac 2-{20} 26A7-9 Df(2L)GpdhA Df(2L)cl7 l(2)gdh-4 l(2)26Ad 2-{20} 26A7-9 Df(2L)GpdhA Df(2L)cl7 l(2)gdh-5 l(2)26Ae 2-{20} 26A7-9 Df(2L)GpdhA Df(2L)cl7 l(2)gdh-6 l(2)26Cf 2-{20} 26B9-27A1 YP2DJ136 YP2DJ70 l(2)gdh-13 ( At least one lethally mutable locus inferred from the lethality of YP2DD222/APYDH69/Df(2L)GpdhA as well as the normal survival of T(Y;2)D222/Df(2L)GpdhA and T(Y;2)H69- /Df(2L)GpdhA; no mutant alleles recovered. allele origin synonym comments _______________________________________________________ l(2)26Ab1 EMS l(2)gdh-2801 l(2)26Ab2 EMS l(2)gdh-21301 l(2)26Ab3 EMS l(2)gdh-22002 l(2)26Ac1 EMS l(2)gdh-4401a also l(2)26Cf1 l(2)26Ac2 EMS l(2)gdh-41601 l(2)26Ac3 EMS l(2)gdh-43101 l(2)26Ad1 EMS l(2)gdh-52201 l(2)26Ae1 EMS l(2)gdh-6502 l(2)26Ae2 EMS l(2)gdh-61401 l(2)26Ae3 EMS l(2)gdh-63001 l(2)26Ae4 EMS l(2)gdh-63501 l(2)26Cf1 EMS l(2)gdh-13401b also l(2)26Ac1 # DEFICIENCY MAP OF REGION 25 & 26A side breakpoint variant ( variant | _____________________________________________ right 25A2-3 Df(2L)ed-dp-h1 right 25A2-3 Df(2L)M11 left 25A4-5 Df(2L)sc19-10 left 25A4-5 Df(2L)sc19-5 left 25A4-5 Df(2L)sc19-4 left 25A4-5 Df(2L)sc19-12 left 25A4-5 Df(2L)tkv-sz3 slf l(2)25Ab right 25A7 B1 Df(2L)sc19-3 l(2)25Ba l(2)25Bb right 25B2-4 Df(2L)sc19-11 right 25B2-5 Df(2L)dp-h25 l(2)25Bc right 25B2-5 Df(2L)sc19-13 l(2)25Bd l(2)25Be l(2)25Bf l(2)25Bg right 25B9-C1 Df(2L)sc19-10 l(2)25Ca right 25C3-8 Dp(2;2)B17 M(2)25C l(2)25Cc l(2)25Cd right 25C2-3 Df(2L)sc19-7 l(2)25Ce l(2)25Cf right 25C3-5 Df(2L)sc19-6 l(2)25Cg right 25C8-9 Df(2L)sc19-8 l(2)25Ch right 25C8-9 Df(2L)sc19-1 left 25D2-4 Df(2L)cl1 left 25D2-4 Df(2L)cl2 left 25D2-4 Df(2L)cl-h1 left 25D2-4 Df(2L)cl-h3 left 25D2-4 Df(2L)tkv-sz2 tkv right 25D5-E1 Df(2L)tkv-sz-3 l(2)25Db left 25D5-6 Df(2L)cl7 left 25D5-6 Df(2L)cl-h2 right 25D5-7 Df(2L)sc19-5 l(2)25Dc left 25D6-E1 Df(2L)cl-h4 left 25D7-E1 Df(2L)GpdhA l(2)25Ea l(2)25Ea l(2)25Eb l(2)25Eb 25D7-E2 T(Y;2)B236 cl cl l(2)25Ec l(2)25Ec l(2)25Ed l(2)25Ed l(2)25Ee l(2)25Ee l(2)25Ef l(2)25Ef right 25E1-2 Df(2L)D6 25E1-4 T(Y;2)H164 right 25D6-E1 Df(2L)tkv-sz2 right 25E5-F1 Df(2L)cl-h4 mid l(2)25Eg right 25E5-F1 Df(2L)sc19-4 Df(2L)sc19-4 right 25F1-2 Df(2L)cl-h1 E(var) right 25F2-4 Df(2L)cl2 Df(2L)c12 right 25F2-4 Df(2L)cl1 Df(2L)c11 right 25F2 Dp(2;1)B19 left 25F2-3 Df(2L)2802 left 25F2-3 Df(2L)H151 l(2)25Fa l(2)25Fa left 25F2-3 Df(2L)50075a left 25F2-3 Df(2L)50078a l(2)25Fb l(2)25Fc right 25F4-26A1 Df(2L)2802 25F4-5 Df(2L)cl-h2 l(2)25Fd 25F5 ( Gpdh right 25F4-26A1 Df(2L)50075a right 25F4-26A1 Df(2L)50078a 26A2-3 T(Y;2)D222 l(2)26Aa 26A4-5 T(Y;2)H69 right 26A7-8 Df(2L)cl7 Df(2L)cl7 26A8 | Gal 26A8 l(2)26Ab 26A8 l(2)26Ac 26A8 l(2)26Ad 26A8 l(2)26Ae right 26A8-9 Df(2L)GpdhA right 26B2-5 Df(2L)cl-h3 26B2-5 T(Y;2)D211 26B9-C1 T(Y;2)J70 l(2)26Cf 26E4-27A1 T(Y;2)J136 27C1-E1 spd 27C9-E1 T(Y;2)A171 ( Szidonya and Reuter, 1988, Genet. Res. 51: 197-208. | Kotarski, Pickert, and MacIntyre, 1983, Genetics 103: 371- 86. # l(2)34D genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(2)34Da 2-48.3 34D1-2 Df(2L)b82a1 Df(2L)b75 l(2)br38 l(2)34Db 2-{48.3} 34D3 Df(2L)b75 Df(2L)Sco7 l(2)br20 l(2)br18 l(2)34Dc 2-{48.4} 34D4-5 Df(2L)Sco7 Df(2L)82a3 l(2)br32 l(2)34Dd 2-{48.3} 34D4-5 Df(2L)b82a3 l(2)br5 Df(2L)b81h1 l(2)34De 2-{48.6} 34D6-8 Df(2L)b83l1 Df(2L)b81h1 l(2)br16 l(2)34Df 2-{48.6} 34D6-8 Df(2L)b83l1 Df(2L)b81h1 l(2)br39 l(2)34Dg 2-{48.6} 34D6-8 Df(2L)b83l1 Df(2L)b81h1 l(2)br17 l(2)34Ea 2-{48.6} 34E1-2 Df(2L)b84a9 Df(2L)b83l1 l(2)br24 l(2)br25 l(2)34Eb 2-{48.6} 34E3 Df(2L)b80f1 Df(2L)b84a9 l(2)br31 Df(2L)fn7 l(2)34Fa 2-{48.8} 34F1-2 Df(2L)fn7 Df(2L)fn1 l(2)br30 l(2)34Fb 2-{48.9} 34F3-4 Df(2L)fn1 Df(2L)A217 wb l(2)br1 l(2)34Fc 2-{48.9} 34F4-35A1 Df(2L)A217 Df(2L)TE35A-7 l(2)br8 l(2)34Fd 2-{49.0} 34F4-35A1 Df(2L)A217 Df(2L)TE35A-7 l(2)br15 # l(2)34Da allele origin discoverer synonym _________________________________________ l(2)34Da1 TE Ising TE13 l(2)34Da2 TE Ising TE60 l(2)34Da3 TE Ising TE94 # l(2)34Db phenotype: Some combinations of alleles [i.e., l(2)34Db8/l(2)34Db9] may escape; escapers have rough eyes (variable), etched wing costae, and show loss of ocellar, anterior alar and posterior scutellar bristles; bristles thin. Male and female sterile. allele origin discoverer synonym ref ( __________________________________________________ l(2)34Db1 EMS Ashburner SF2 1 l(2)34Db2 EMS Ashburner SF14 1 l(2)34Db3 EMS Ashburner SF29 1 l(2)34Db4 EMS Maroni GM14 l(2)34Db5 EMS Maroni GM15 l(2)34Db6 EMS O'Donnell CH5 l(2)34Db7 EMS O'Donnell CH7 l(2)34Db8 EMS O'Donnell CH13 l(2)34Db9 EMS O'Donnell CH16 l(2)34Db10 EMS Lindsley 64-639 l(2)34Db11 EMS Lindsley 64-668 l(2)34Db12 EMS Lindsley 64-1316 ( 1 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)34Dc phenotype: l(2)34Dc3 produces about 1% escapers in heterozygous combination with both l(2)34Dc1 and l(2)34Dc2. allele origin discoverer synonym ref ( comments _______________________________________________________ l(2)34Dc1 EMS O'Donnell CH60 l(2)34Dc2 EMS O'Donnell CH69 l(2)34Dc3 spont Woodruff SW27 l(2)34Dd1 EMS Bodmer and BMW29 Walker l(2)34Dd2 EMS Ashburner SF22 1 l(2)34Dd3 EMS Ashburner SF23 1 l(2)34Dd4 EMS Ashburner SF28 1 l(2)34Dd5 EMS O'Donnell CH28 l(2)34Dd6 EMS O'Donnell CH40 l(2)34Dd7 EMS O'Donnell CH58 l(2)34Dd8 EMS Lindsley 64-449 l(2)34De1 EMS Ashburner SF1 1 l(2)34De2 spont? Ashburner SF16 1 on In(2LR)Gla l(2)34De3 EMS O'Donnell CH30 l(2)34Df1 spont Woodruff BG1 l(2)34Df2 EMS Lindsley 64-480 l(2)34Dg1 EMS Ashburner SF10 1 l(2)34Dg1 EMS O'Donnell CH17 ( 1 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)34Ea phenotype: Recessive lethal or semilethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes. allele origin discoverer synonym ref ( comments ________________________________________________________ l(2)34Ea1 EMS Bodmer and BMW7 strong allele Walker l(2)34Ea2 EMS Bodmer and BMW19 strong allele Walker l(2)34Ea3 EMS Harrington HG14 strong allele l(2)34Ea4 EMS Harrington HG16 strong allele l(2)34Ea5 EMS Ashburner SF4 1 weaker allele l(2)34Ea6 EMS Ashburner SF15 1 strong allele l(2)34Ea7 EMS O'Donnell DM7 strong allele l(2)34Ea8 EMS O'Donnell CH18 strong allele l(2)34Ea9 EMS O'Donnell CH14 l(2)34Ea10 EMS O'Donnell CH24 weaker allele l(2)34Ea11 EMS Maroni GM8 weaker allele l(2)34Ea12 EMS Maroni GM9 weaker allele l(2)34Ea13 EMS Lindsley 64-408 strong allele l(2)34Ea14 EMS Lindsley 64-460 weaker allele l(2)34Ea15 EMS Lindsley 64-465 strong allele l(2)34Ea16 EMS Lindsley 64-504 strong allele l(2)34Ea17 EMS Lindsley 64-509 strong allele l(2)34Ea18 EMS Lindsley 64-734 strong allele l(2)34Ea19 EMS Lindsley 64-1216 strong allele l(2)34Ea20 EMS Lindsley 64-1253 strong allele ( 1 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)34Eb phenotype: Heteroallelic combinations escape about 10% with thin bristles; female fertile; male sterile. allele origin discoverer synonym _________________________________________ l(2)34Eb1 EMS O'Donnell CH61 l(2)34Eb2 EMS O'Donnell DM12 # l(2)34F allele origin discoverer synonym ref ( _________________________________________________ l(2)34Fa1 EMS Harrington HG15 l(2)34Fc1 EMS Bodmer and BMW18 Walker l(2)34Fc2 EMS Bodmer and BMW23 Walker l(2)34Fc3 EMS Ashburner CR3 2 l(2)34Fc4 EMS Harrington HG20 l(2)34Fc5 EMS Harrington HG28 l(2)34Fc6 EMS Ashburner SF9 2 l(2)34Fc7 EMS Ashburner SF13 2 l(2)34Fc8 EMS O'Donnell CH43 1 l(2)34Fc9 EMS O'Donnell CH45 1 ( 1 = O'Donnell, Mandel, Krauss, and Sofer, l977, Genetics 86: 553-66; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)34Fd phenotype: Recessive lethal, but some heteroallelic combina- tions [e.g., l(2)34Fd3/l(2)34Fd6] complement for viability but emerge very late. allele origin discoverer synonym ref ( _________________________________________________ l(2)34Fd1 EMS Bodmer and BMW10 Walker l(2)34Fd2 EMS Ashburner CR5 2 l(2)34Fd3 EMS Harrington HG6 l(2)34Fd4 EMS Harrington HG11 l(2)34Fd5 EMS Harrington HG13 l(2)34Fd6 EMS Harrington HG23 l(2)34Fd7 EMS O'Donnell DM4 1 l(2)34Fd8 EMS O'Donnell OK15 1 l(2)34Fd8 EMS Lindsley 64-1589 ( 1 = O'Donnell, Mandel, Krauss, and Sofer, l977, Genetics 86: 553-66; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # DEFICIENCY MAP OF REGION 34 side breakpoint variant ____________________________________ left Df(2L)b82a1 left Df(2L)b84h50 left 34C3 Df(2L)b80f1 left 34C3 Df(2L)b84a2 left 34C4 Df(2L)b80e3 left 34C4 Df(2L)b80e4 left 34D1-2 Df(2L)b82a2 34C4-D1 l(2)34Da left Df(2L)b74c6 left Df(2L)b78j left Df(2L)b79b3 left Df(2L)b79b4 left Df(2L)b79d5 left Df(2L)b81h1 left Df(2L)b81l42 left Df(2L)b83d29a left Df(2L)b83l1 left Df(2L)b84h14 left Df(2L)el28 left 34C1 Df(2L)b81l1 left 34C4-5 Df(2L)85fa left 34C6-7 Df(2L)fn30 left 34D1-2 Df(2L)64j left 34D1-2 Df(2L)TE35BC-23 left 34D2 Df(2L)TE35A-5 left 34D3 Df(2L)fn31 left 34D3 Df(2L)b-L left 34D3 Df(2L)b80c1 left 34D3 Df(2L)b81a1 left 34D3 Df(2L)b81a6 left 34D3 Df(2L)b81f1 left 34D3 Df(2L)b84a3 left 34D3 Df(2L)b84a4 left 34D3 Df(2L)b84a8 left 34D3-4 Df(2L)b75 left 34D3 Df(2L)b84a5 left 34D3-6 Df(2L)TE35BC-6 34D3 l(2)34Db left Df(2L)84h1 left 34D3 Df(2L)b84a9 left 34D5 Df(2L)Sco7 left 34D7-E1 Df(2L)b36f 34D4-5 l(2)34Dd left Df(2L)b82a3 34D4-5 l(2)34Dc b right Df(2L)b79d5 right Df(2L)b81h1 right Df(2L)b82a3 34D6-8 l(2)34De 34D6-8 l(2)34Df 34D6-8 l(2)34Dg right Df(2L)b83l1 34E1-2 l(2)34Ea right Df(2L)b81l42 right Df(2L)b84a9 right 34D7-E1 Df(2L)b36f left 34E1 Df(2L)A47 left 34E1-2 Df(2L)el80i1 left 34E1-2 Df(2L)el82f1 34E3-5 l(2)34Eb right Df(2L)b82a1 right 34D8-E1 Df(2L)b80f1 right 34D8-E1 Df(2L)b80c1 left 34E1-2 Df(2L)fn7 left 34E3 Df(2L)fn26 j left 34D3 Df(2L)fn12 right 34E1-2 Df(2L)b82a2 left 34E3 Df(2L)A376 left 34E3 Df(2L)el80f1 left 34E4-5 Df(2L)TE35A-8 34E3-5 rk right 34E4-5 Df(2L)b-L left Df(2L)Adh-BR41 left 34E3 Df(2L)noc11 left 34E5-F1 Df(2L)A263 left 34F1 Df(2L)TE35A-9 left 34F1-2 Df(2L)noc10 left 34F1-2 Df(2L)noc20 left 34F1-2 Df(2L)Sco23 left 34F1-2 Df(2L)TE35A-4 left 34F3 Df(2L)GT4 left 34F5 Df(2L)TE35A-3 left 34F5 Df(2L)osp141 left 35A3 Df(2L)W 34F1-2 l(2)34Fa right Df(2L)b79b3 right Df(2L)b84h14 right 34E5-6 Df(2L)b75 left 34F1-4 Df(2L)A377 left 34F4 Df(2L)A246 left 34E4 Df(2L)el20 left 34F4 Df(2L)TE35A-2 left 34F4 Df(2L)TE35A-15 left 34F4-35A1 Df(2L)fn1 left 34F5 Df(2L)el81i1 left 34F5 Df(2L)fn5 left 34F5 Df(2L)TE35A-10 left 34F5 Df(2L)TE35BC-31 left 35A1-2 Df(2L)noc13 left 35A1-2 Df(2L)osp38 left 35A1-3 Df(2L)el77 left 35A3 Df(2L)A215 left 35A3 Df(2L)fn36 left 34F5 Df(2L)TE35BC-29 left 35B Df(2L)el18 34F3 wb right Df(2L)b78j right Df(2L)b79b4 right 34F5 Df(2)b85f1 left 34F5 Df(2L)A217 left 35B1 Df(2L)do1 left 35B1-2 Df(2L)el15 right 35B2 Df(2L)b81f1A 34F4-35A1 l(2)34Fc 34F4-35A1 l(2)34Fd 34F4-35A1 ms(2)34F left 35A3-4 Df(2L)TE35A-7 # l(2)35 Extensive mutagenesis experiments carried out in this region by Ashburner and his colleagues and to a lesser extent in the laboratory of Sofer. references: O'Donnell, Mandel, Krauss, and Sofer, l977, Genet- ics 86: 553-66. Woodruff and Ashburner, 1979, Genetics 92: 133-49. Ashburner, Aaron, and Tsubota, 1982, Genetics 102: 421-35. Ashburner, Tsubota, and Woodruff, 1982, Genetics 102: 401-20. Gubb, Shelton, Roote, McGill, and Ashburner, 1984, Chromosoma 91: 54-64. genetic cytological locus location location included in excluded from synonym ___________________________________________________________________ l(2)35Aa 2-{49.0} 35A3-4 Df(2L)TE35A-7 Df(2L)A400 l(2)br12 l(2)35Ba 2-{50.0} 35B1 Df(2L)A400 Df(2L)A446 l(2)br22 l(2)35Bb 2-{50.36} 35B4 Df(2L)A446 l(2)br3 Df(2L)fn3 l(2)br23 l(2)35Bc 2-{50.5} 35B5-8 Df(2L)fn31 Df(2L)fn3 l(2)br4 l(2)br11 l(2)br13 l(2)35Bd 2-{50.6} 35B5-8 Df(2L)fn31 Df(2L)fn3 l(2)br9 l(2)35Be 2-{50.6} 35B5-8 Df(2L)fn31 Df(2L)fn3 l(2)br10 l(2)35Bf 2-{50.6} 35B5-8 Df(2L)fn31 Df(2L)fn3 l(2)br2 l(2)35Bg 2-{50.9} 35B9-10 Df(2L)AR-R1 Df(2L)fn31 l(2)br26 l(2)35Bh 2-{50.5} 35B9-10 Df(2L)AR-R1 Df(2L)fn31 Su(H), l(2)br7 # l(2)35A allele origin discoverer synonym ref ( _________________________________________________ l(2)35Aa1 EMS Harrington HG8 l(2)35Aa2 EMS Harrington HG12 l(2)35Aa3 EMS Ashburner SF12 2 l(2)35Aa4 EMS Ashburner SF32 2 l(2)35Aa5 EMS O'Donnell CH32 1 l(2)35Aa6 EMS O'Donnell DM16 1 l(2)35Aa7 EMS O'Donnell DM18 1 ( 1 = O'Donnell, Mandel, Krauss, and Sofer, l977, Genetics 86: 553-66; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)35Ba phenotype: l(2)35Ba1 may escape in combination with deficiency for the locus; escapers are weak elbow in phenotype if defi- ciency includes el, but not if it does not. All alleles express weak elbow in combination with el1; heteroallelic escapers [i.e., l(2)35Ba4 in combination with other alleles] are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27; also show weak noc phenotype in combination with strong noc alleles. allele origin discoverer synonym ref ( _________________________________________________ l(2)35Ba1 EMS Ashburner AR10 1, 2 l(2)35Ba2 EMS Ashburner FT1 1 l(2)35Ba3 EMS Harrington HG33 1 l(2)35Ba4 EMS Harrington HG46 1 ( 1 = Ashburner, Tsubota, and Woodruff, 1982, Genetics 102: 401-20; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)35Bb phenotype: Rare survivors to adulthood in l(2)35Bb5/Df(2L)fn3. allele origin discoverer synonym ref ( comments _______________________________________________________________ l(2)35Bb1 EMS Ashburner AR2 2 l(2)35Bb2 EMS Bodmer and BMW33 Walker l(2)35Bb3 EMS Harrington HG5 l(2)35Bb4 EMS Littlewood LT4 l(2)35Bb5 EMS Ashburner SF21 2 l(2)35Bb6 spont Ashburner TA2 2 in In(2LR)Gla l(2)35Bb7 EMS O'Donnell DM11 1 l(2)35Bb8 EMS O'Donnell OK19 1 l(2)35Bb9 EMS Lindsley 64-692 l(2)35Bc1 EMS Ashburner AR1 2 noncomplementing l(2)35Bc2 EMS Ashburner AR6 2 complements l(2)35Bc3 l(2)35Bc3 EMS Ashburner AR7 2 l(2)35Bc4 EMS Harrington HG1 noncomplementing l(2)35Bc5 EMS Harrington HG94 noncomplementing l(2)35Bc6 EMS Ashburner SF17 2 noncomplementing l(2)35Bc7 EMS O'Donnell CH23 complements l(2)35Bc3 l(2)35Bc8 EMS Lindsley 64-605 complements l(2)35Bc3 l(2)35Bd1 EMS Ashburner AR4 2 l(2)35Bd2 EMS Ashburner AR13 2 l(2)35Bd3 EMS Littlewood LT8 l(2)35Bd4 EMS Ashburner SF6 2 l(2)35Bd5 EMS O'Donnell CH48 1 l(2)35Bd6 EMS O'Donnell OK4 1 l(2)35Be1 EMS Ashburner AR3 2 noncomplementing l(2)35Be2 EMS Ashburner AR5 2 noncomplementing l(2)35Be3 EMS Harrington HG37 l(2)35Be4 EMS Ashburner SF5 2 complements l(2)35Be3 l(2)35Be5 EMS O'Donnell CH55 1 complements l(2)35Be3 l(2)35Be6 EMS O'Donnell OK20 1 l(2)35Be7 EMS Lindsley 64-346 noncomplementing ( 1 = O'Donnell, Mandel, Krauss, and Sofer, l977, Genetics 86: 553-66; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-149. # l(2)35Bf phenotype: Escapers show thin, short bristles and outstretched wings. l(2)35Bf3 partially complements l(2)35Bf1 and l(2)35Bf2 for viability; female-sterile alleles recovered by Lindsley. allele origin discoverer synonym ref ( comments __________________________________________________________________ l(2)35Bf1 EMS Bodmer and BMW12 Walker l(2)35Bf2 EMS Bodmer and BMW20 Walker l(2)35Bf3 EMS Harrington HG27 l(2)35Bf4 EMS Littlewood LT1 2 l(2)35Bf5 EMS Ashburner SF18 2 l(2)35Bf6 EMS Ashburner SF19B 2 l(2)35Bf7 EMS Maroni GM11 l(2)35Bf8 EMS Lindsley 64-720 female sterile l(2)35Bg1 EMS Harrington HG21 l(2)35Bg2 EMS O'Donnell OK5 1 ( 1 = O'Donnell, Mandel, Krauss, and Sofer, l977, Genetics 86: 553-66; 2 = Woodruff and Ashburner, 1979, Genetics 92: 133-49. # l(2)35C genetic cytological locus location location included in excluded from synonym ____________________________________________________________________ l(2)35Ca 2-{51.0} 35C1-2 Df(2L)A267 Df(2L)AR-R1 ck, l(2)br27 l(2)35Cb 2-{51.2} 35C1-2 Df(2L)A400 Df(2L)A267 l(2)br33 l(2)35Cc 2-{51.2} 35C3 Df(2L)A215 Df(2L)A400 l(2)br50 l(2)35Cd 2-{51.2} 35C4-5 Df(2L)A263 Df(2L)A215 l(2)br34 l(2)35Ce 2-{51.3} 35C4-5 Df(2L)A376 Df(2L)A263 l(2)br43 # l(2)35Cb phenotype: l(2)35Cb1 escapes in heterozygous combination with Df(2L)Sco4, but not with other l(2)35Cb deficiencies. allele origin discoverer synonym comments ____________________________________________________________ l(2)35Cb1 EMS Harrington HG38 l(2)35Cb2 EMS Simpson A12 l(2)35Cb3 EMS Simpson A14 l(2)35Cb4 EMS Simpson B12 l(2)35Cb5 EMS Simpson B21 l(2)35Cb6 X ray Ashburner AM9 with In(2L)shv22 # l(2)35Cc phenotype: No known alleles; existence inferred from lethality associated with Df(2L)rd9. # l(2)35Cd phenotype: l(2)35Cd2, but not other alleles, fails to comple- ment In(2LR)Scorv1. allele origin discoverer synonym _________________________________________ l(2)35Cd1 EMS Harrington HG43 l(2)35Cd2 EMS Harrington HG39 l(2)35Cd3 EMS Simpson B8 l(2)35Cd4 EMS Simpson B14 l(2)35Cd5 EMS Simpson B29 l(1)35Ce1 EMS Simpson VS2 l(1)35Ce2 EMS Simpson VS4 l(1)35Ce3 EMS Simpson VS8 # l(2)35D genetic cytological locus location location included in excluded from synonym ______________________________________________________________________________ l(2)35Da 2-{51.3} 35D1-2 Df(2L)el20 Df(2L)A376 l(2)br35 l(2)35Db 2-{51.3} 35D1-2 Df(2L)do1 Df(2L)el20 sna; l(2)br28 l(2)35Dc 2-{51.4} 35D3-4 Df(2L)fn27 Df(2L)do1 lace; l(2)br36 l(2)35Dd 2-{51.4} 35D5-7 Df(2L)TE35BC-34 Df(2L)fn27 l(2)br37 l(2)35De 2-{51.4} 35D3-4 Df(2L)A246 Df(2L)TE35BC-34 l(2)br46 l(2)35Df 2-{51.4} 35D5-7 Df(2L)A246 Df(2L)TE35BC-34 l(2)br44 l(2)35Dg 2-{51.4} 35D4 Df(2L)A246 Df(2L)TE35BC-34 l(2)br45 allele origin discoverer synonym comments ___________________________________________________________ l(2)35Da1 EMS Harrington HG35 l(2)35Da2 EMS Simpson A4 l(2)35Da3 EMS Simpson B7 l(2)35Da4 EMS Simpson B27 l(2)35Dd1 X ray Ashburner GE1 associated with breakpoint of T(2;3)Ha16 l(2)35Dd2 EMS El Messal P28 l(2)35Dd3 EMS El Messal P41 l(2)35Dd4 insert Ising TE116 l(2)35De1 Ashburner AM2 associated with breakpoint of In(2L)NS l(2)35Df1 EMS El Messal P15 l(2)35Df2 EMS El Messal P32 l(2)35Df3 EMS El Messal P36 l(2)35Df4 EMS Grau RX1 l(2)35Dg1 EMS El Messal P29 l(2)35Dg2 EMS El Messal P31 l(2)35Dg3 EMS El Messal P34 l(2)35Dg4 EMS El Messal P40 # l(2)35E genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(2)35Ea 2-{51} 35E1-2 Df(2L)fn26 Df(2L)A246 l(2)br47 l(2)35Eb 2-{51} 35E3-6 Df(2L)A446 Df(2L)fn26 l(2)br48 l(2)35Ec 2-{51} 35E3-6 Df(2L)PA4 Df(2L)A446 l(2)br49 allele discoverer synonym comments __________________________________________________________ l(2)35Ea1 Ashburner AM3 associated with right breakpoint of In(2L)dpp36; semilethal l(2)35Eb1 Ashburner AM4 associated with but proximal to In(2L)C163.41; semilethal l(2)35Ec1 Ashburner AM5 associated with breakpoint of T(2;3)DTD14 # DEFICIENCY MAP OF REGION 35A-E side breakpoint variant molecular coordinates (kb) ( ____________________________________________________________________ left 35A3-4 Df(2L)TE35A-7 35A3-4 l(2)35Aa left Df(2L)TE35A-12 left 35A1-4 Df(2L)A400 right 35A4 Df(2L)b80e3 right 35A4 Df(2L)b84h1 left 35B1-2 Df(2L)TE35A-13 35A4 pu right Df(2L)b83d29a left Df(2L)fn15 left 35A3-4 Df(2L)ARR1 left 35A3-4 Df(2L)fn2 left 35A4 Df(2L)TE35A-14 left 35B1 Df(2L)TE35A-6 left 35B1-2 Df(2L)TE35A-1 left 35B1-2 Df(2L)TE35BC-8 el left Df(2L)el16 left 35A4 Df(2L)A245 -137.8 to -134.8 left 35B1 Df(2L)fn3 -126 to -125 right 35A4 Df(2L)b84a2 -125 to -121.8 right 35B Df(2L)el18 left 35B1 Df(2L)Adh78l3 -120 to -117.8 left 35B1-2 Df(2L)A260 left 35A2-3 Df(2L)A266 left 35A4 Df(2L)A245 35B1 l(2)35Ba left Df(2L)A178 -113 to -110.8 left 35B1-2 Df(2L)osp204 left 35B1-3 Df(2L)A446 -117 to -114 left 35B1 Df(2L)fn27 -103 left invisible Df(2L)A445 -73 left 35B3 Df(2L)TE35BC-7 -70.8 to -68.3 left Df(2L)osp144 -68.3 to -67.1 left 35B1-3 Df(2L)A379 -66.2 to -61.8 left 35B2-3 Df(2L)A267 -66.2 to -61.8 noc right 35B2 Df(2L)GT4 right invisible Df(2L)TE35A-12 -103 to -98 left 35B3 Df(2L)nNXF1 -86.6 to -79 right 35A1-2 Df(2L)TE35A-4 -79 to -75.5 right 35B1-2 Df(2L)b81a1 -79 to -75.5 right 35B2 Df(2L)TE35A-10 -79 to -75.5 left 35B3 Df(2L)nNxF2 -73 left Df(2L)fn52 -58 right 35B1-2 Df(2L)b84a8 -52.8 to -43.8 right 35B1-2 Df(2L)b84a4 -42.5 to -37.5 left 35B1-2 Df(2L)osp18 -37.5 left 35B1-2 Df(2L)A220 -28.4 to -24.6 left 35B1-3 Df(2L)A264 -24.8 to -24.6 left invisible Df(2L)A63 -18.2 to -13.1 left 35B2-3 Df(2L)A48 -0.7 to 0 left 35B2-3 Df(2L)A72 +0.7 to +1.3 right 35B3-4 Df(2L)b84a5 35B1-2 osp right Df(2L)osp204 right 35B1-2 Df(2L)TE35A-8 -15.9 to -11.2 right invisible Df(2L)osp144 -8.3 35B3 Adh right Df(2L)A63 right Df(2L)A178 right Df(2L)A445 right Df(2L)Adh-BR41 right Df(2L)fn52 right Df(2L)PA4 right Df(2L)TE35A-11 right Df(2L)TE35A-50 left Df(2L)TE35A-48 left Df(2L)TE35A-54 +10 to +30 right 35A4 Df(2L)el17 right 35B1 Df(2L)A47 right 35B1-2 Df(2L)A260 right 35B1-2 Df(2L)el81i1 right 35B1-2 Df(2L)noc10 right 35B1-2 Df(2L)b84a1 right 35B1-2 Df(2L)b84a7 right 35B1-3 Df(2L)A379 left 35B1-3 Df(2L)osp29 right 35B2 Df(2L)A245 right 35B2 Df(2L)fn2 right 35B2 Df(2L)noc13 right 35B2 Df(2L)noc20 +11.8 to +13.7 left 35B2 Df(2L)TE35BC-28 left 35B2 Df(2L)TE35BC-35 right 35B2 Df(2L)TE35A-9 right 35B2 Df(2L)TE35A-15 right 35B2 Df(2L)TE35A-7 right 35B2-3 Df(2L)A266 right 35B3 Df(2L)A217 right 35B3 Df(2L)el77 right 35B3 Df(2L)TE35A-3 right 35B3-5 Df(2L)fn7 right 35B3-5 Df(2L)W right 35B4 Df(2L)b81l1 right 35B4 Df(2L)fn36 left 35B4 Df(2L)TE35BC-4 left 35B4 Df(2L)TE35BC-34 right 35B5 Df(2L)osp141 35B4 l(2)35Bb right Df(2L)b74c6? right 35B3-4 Df(2L)fn3 35B4-8 l(2)35Bc 35B4-8 l(2)35Bd 35B5-8 l(2)35Be 35B5-8 l(2)35Bf right 35B3-4 Df(2L)b84a3 right 35B4 Df(2L)~~1a1 left 35B4-6 Df(2L)TE35BC-24 right 35B3-5 Df(2L)fn31 right 35B6-7 Df(2L)b84a6 left 35C1 Df(2L)TE35BC-1 35B9-10 l(2)35Bg 35B9-10 Su(H) right 35B9-C1 Df(2L)ARR1 left 35C1 Df(2L)TE35BC-3 35C1-2 ck right 35B7 Df(2L)TE35BC-28 right 35B7-C5 Df(2L)fn15 right 35B8-C1 Df(2L)64j right 35B9-10 Df(2L)TE35BC-7 right 35B10 Df(2L)A267 right 35B10 Df(2L)fn12 right 35B10 Df(2L)TE35BC-31 right 35B10-11 Df(2L)TE35BC-23 right 35C1 Df(2L)TE35BC-29 right 35D1 Df(2L)TE35BC-1 35C1-2 vasa right 35B9-C1 Df(2L)fn30 35C1-2 l(2)35Cb left Df(2L)rd9 right 35B7-8 Df(2L)A72 right 35B8-9 Df(2L)A264 right 35B9 Df(2L)A220 right 35B10 Df(2L)A400 right 35B10 Df(2L)nNXF1 right 35B10 Df(2L)nNXF2 right 35C1 Df(2L)TE35A-5 right 35C1 Df(2L)TE35A-6 right 35C1 Df(2L)TE35BC-6 right 35C2-3 Df(2L)el80i1 right 35C3 Df(2L)fn5 right 35C5 Df(2L)el15 35C3 l(2)35Cc left Df(2L)snaS1 35C3 rd right Df(2L)rd9 right 35B7-8 Df(2L)A215 35C4-5 l(2)35Cd right 35A2 Df(2L)noc11 right 35C3-5 Df(2L)A263 right 35C4-5 Df(2L)osp38 35C4-5 l(2)35Ce right 35C3-5 Df(2L)el82f1 35C4-5 dgl right 35C3 Df(2L)TE35BC-4 right 35C4-5 Df(2L)A376 right 35C3-4 Df(2L)osp18 right 35C4-5 Df(2L)TE35A-1 35D1-2 l(2)35Da right 35C5 Df(2L)el20 left 35D1-2 Df(2L)PA4 35D1-2 sna right 35D1-2 Df(2L)b80e4 right 35D2 Df(2L)do1 35D3-4 lace right 35D1-2 Df(2L)fn27 right 35D2 Df(2L)TE35BC-3 right 35D4 Df(2L)TE35A-14 right 35D4 Df(2L)TE35BC-35 right 35D5-7 Df(2L)A48 right 35D5-7 Df(2L)fn1 right 35D7 Df(2L)el80f1 l(2)35Dd right 35D4 Df(2L)TE35BC-34 35D5-7 l(2)35De 35D5-7 l(2)35Df 35D5-7 l(2)35Dg right Df(2L)sna-S1 right Df(2L)TE35A-13 right 35D3-4 Df(2L)A246 right 35D5-7 Df(2L)Adh78l3 right 35D7 Df(2L)TE35A-2 right 35E1-2 Df(2L)TE35BC-8 right 35F1-2 Df(2L)A377 35E1-2 l(2)35Ea right 35D8-E1 Df(2L)fn26 right 35E1-2 Df(2L)TE35BC-24 35E3-6 l(2)35Eb right 35E6 Df(2L)osp29 right 35F1-2 Df(2L)A446 35E3-6 l(2)35Ec right Df(2L)PA4 left 36A7-10 Df(2L)H20 ( Origin of coordinates at EcoRI site 5 to Adh; coordinates are negative in the direction of the telomere and positive in the direction of the centromere (McGill, Chia, Karp, and Ashburner, 1988, Genetics 119: 647-61) and are not neces- sarily correlated with cytological breakpoints. # l(2)36 references: Steward and Nusslein-Volhard, 1986, Genetics 113: 665-78. # l(2)36A Five lethally mutable loci, including Mhc; map order not determined. genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)36Aa 2-{52} 36A7-B2 Df(2L)H20 Df(2L)H68 l(2L)HT-5 l(2)36Ab 2-{52} 36A7-B2 Df(2L)H20 Df(2L)H68 l(2L)HT-6 l(2)36Ac 2-{52} 36A7-B2 Df(2L)H20 Df(2L)H68 l(2L)HT-9 l(2)36Ad 2-{52} 36A7-B2 Df(2L)H20 Df(2L)H68 l(2L)HT-11 l(2)36Ae 2-52.2 36A7-B2 Df(2L)H20 Df(2L)H68 Mhc # l(2)36Aa, b, and c phenotype: Larval lethals. allele origin __________________ l(2)36Aa1 EMS l(2036Ab1 EMS l(2)36Ab2 EMS l(2)36Ab3 EMS l(2)36Ac1 EMS l(2)36Ac2 EMS l(2)36Ad1 EMS l(2)36Ad2 EMS # l(2)36B, C, and D genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)36Ba 2-{52} 36B3-C4 Df(2L)H68 Df(2L)T317 l(2L)HT-4 l(2)36Bb 2-{52} 36B3-C4 Df(2L)H68 Df(2L)T317 l(2L)HT-7 l(2)36Bc 2-{52} 36B3-C4 Df(2L)H68 Df(2L)T317 l(2L)HT-10 l(2)36Bd 2-{52} 36B3-C4 Df(2L)T317 Df(2L)TW137 l(2L)HT-2 l(2)36Ca 2-{52} 36C2-D1 Df(2L)TW137 Df(2L)VA18 l(2L)HT-1 l(2)36Da 2-53.1 36D Df(2L)VA18 Df(2L)VA22 l(2)Bld l(2)36Db 2-{53} 36D1-2 Df(2L)b10-1 # l(2)36Ba phenotype: Larval lethal. allele origin __________________ l(2)36Ba1 EMS l(2)36Ba2 EMS l(2)36Ba3 EMS # l(2)36Bb phenotype: Rare survivors to adulthood show a naked phenotype with reduced bristles on the scutum and scutellum. allele origin __________________ l(2)36Bb1 EMS l(2)36Bb2 EMS l(2)36Bb3 EMS l(2)36Bb4 EMS l(2)36Bb5 EMS l(2)36Bb6 EMS l(2)36Bb7 EMS # l(2)36Bc phenotype: Larval lethal. allele origin __________________ l(2)36Bc1 EMS # l(2)36Bd phenotype: Larval lethal. allele origin __________________ l(2)36Bd1 EMS l(2)36Bd2 EMS l(2)36Bd3 EMS l(2)36Bd4 EMS l(2)36Bd5 EMS l(2)36Bd6 EMS l(2)36Bd7 EMS l(2)36Bd8 EMS l(2)36Bd9 EMS # l(2)36Ca phenotype: Larval lethal. allele origin __________________ l(2)36Ca1 EMS l(2)36Ca2 EMS l(2)36Ca3 EMS l(2)36Ca4 EMS l(2)36Ca5 EMS # l(2)36Da phenotype: Larval lethal. allele origin discoverer synonym ref ( _________________________________________________ l(2)36Da1 spont Bridges l(2)Bld 1 l(2)36Da2 EMS 2 l(2)36Da3 EMS 2 l(2)36Da4 EMS 2 l(2)36Da5 EMS 2 l(2)36Da6 EMS 2 ( 1 = CP627; 2 = Steward and Nusslein-Volhard, l986, Genetics 113: 665-78. # l(2)36D6 phenotype: Inferred from the lethality of Df(2L)b10-1. # l(2)36F A series of ethyl-methanesulfonate-induced mutants compris- ing nine complementation groups, including M(2)36F recovered by Wright and co-workers (Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310). genetic cytological locus location location included in excluded from synonym ________________________________________________________________________ l(2)36Fa 2-54 36F2-6 Df(2L)TW202 Df(2L)hk18 M(2)36F, M(2)m l(2)36Fb 2-53.9 36F4-6 Df(2L)hk18 Df(2L)E71 l(2)E70 l(2)36Fc 2-53.9 36F4-37A1 Df(2L)E71 Df(2L)TW3 l(2)E53 l(2)36Fd 2-53.9 36F7-9 Df(2L)TW3 l(2)E51 Df(2L)M36F-S5 l(2)36Fe 2-53.9 36F7-9 Df(2L)TW3 l(2)E134 Df(2L)M36F-S5 l(2)36Ff 2-{54} 36F7-37A1 Df(2L)M36F-S6 Df(2L)M36F-S5 l(2)E47 l(2)36Fg 2-{54} 36F7-37A1 Df(2L)M36F-S6 Df(2L)M36F-S5 l(2)E20 l(2)36Fh 2-{54} 36F7-37A1 Df(2L)M36F-S6 Df(2L)M36F-S5 l(2)E50 l(2)36Fi 2-{54} 36F7-37A1 Df(2L)M36F-S6 Df(2L)M36F-S5 l(2)E105 allele synonym ______________________ l(2)36Fb1 l(2)E70 l(2)36Fb2 l(2)E36 l(2)36Fb3 l(2)E48 l(2)36Fb4 l(2)E64 l(2)36Fc1 l(2)E122 l(2)36Fc2 l(2)E31 l(2)36Fd1 l(2)E51 l(2)36Fe1 l(2)E134 l(2)36Ff1 l(2)E47 l(2)36Ff2 l(2)E52 l(2)36Fg1 l(2)E20 l(2)36Fh1 l(2)E50 l(2)36Fi1 l(2)E105 # DEFICIENCY MAP OF REGION 36 side breakpoint variant _____________________________________ left 36A7-10 Df(2L)H20 l(2)36Aa l(2)36Ab l(2)36Ac l(2)36Ad Mhc plo left 36B2-C1 Df(2L)H68 left 36B3-8 Df(2L)M18 l(2)36Ba l(2)36Bb l(2)36Bc left Df(2L)T317 l(2)36Bd left Df(2L)A92 left 36C2-4 Df(2L)B7 left Df(2L)B131 left invisible Df(2L)TW119 left 36C2-4 Df(2L)TW137 l(2)36Ca dl Bic-D qua left Df(2L)A33 left Df(2L)D143 left Df(2L)l131 left 36D Df(2L)M36F-S5 left 36E4-F1 Df(2L)TW203 left 36C4-D1 Df(2L)VA18 left Df(2L)VA21 left Df(2L)VA22 l(2)36Da right 36D Df(2L)M18 left Df(2L)B11 left 36E-F Df(2L)TW201 left Df(2L)TW330 5 or 3 rdo left Df(2L)B10-1 3 or 5 rdo right invisible Df(2L)TW119 36D1-2 Arr1 l(2)36Db right ( Df(2L)B10-1 36E1-2 Fas3 kel right Df(2L)l131 36D1-E4 nina-D right 36E4-F1 Df(2L)H20 right Df(2L)T317 left 36E4-F1 Df(2L)TW50 left | 34E6-F1 Df(2L)M36F-S6 left 37F2-5 Df(2L)TW202 M(2)36F left | 36E4-6 Df(2L)hk18 l(2)36Fb left 36F2-6 Df(2L)E71 left Df(2L)E53 l(2)36Fc left 36F7-37A1 Df(2L)TW3 msl-1 right 36F7-37A1 Df(2L)E53 left | Df(2L)OD15 l(2)36Fd l(2)36Fe right 36F7-9 Df(2L)M36F-S6 left | Df(2L)VA16 right | 37A Df(2L)TW201 right | 36F6-37A1 Df(2L)hk39 ( Positions of Fas3 and kel with respect to the right break- point of Df(2L)B10-1 are not determined. | Breakpoint not localized with respect to neighboring lethal mutations. # l(2)37 More than eighty lethal alleles at 37 loci, including Dox- A2, Amd, and Ddc, in the region uncovered by Df(2L)TW50 = Df(2L)36E4-F2;38A6-7 recovered and deficiency mapped by Wright, Bewley and Sherald (1976, Genetics 84: 287-310). Detailed analysis of those under Df(2L)TW130 = Df(2L)37B9- C1;37D1-2 presented in other work involving 204 mutants (Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58). Additional mutants in more proximal part of region 37 recovered and analyzed by Gay and Contamine. Allelic information for this region are as yet incomplete. # l(2)37A Three complementation groups represented by one ethyl- methanesulfonate-induced allele each; recovered by Wright and coworkers (Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310). genetic cytological locus location location included in excluded from synonym ___________________________________________________________________ l(2)37Aa 2-53.1-53.9 36F8-37B7 Df(2L)TW3 Df(2L)M36F-S6 l(2)E41 l(2)37Ab 2-53.1-53.9 36F8-37B7 Df(2L)TW3 Df(2L)M36F-S6 l(2)E129 l(2)37Ac 2-53.1-53.9 36F8-37B7 Df(2L)TW3 Df(2L)M36F-S6 l(2)E145 # l(2)37B Ten complementation groups located between the proximal breakpoint of Df(2L)TW203 and the distal breakpoint of Df(2L)VA17 in the distal half of the Dopa-decarboxylase region. Amd, which is listed in 37B could be in 37C1-2 (Wright, 1987, Adv. Genet. 24: 127-222). genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)37Ba 2-53.9 37B10-13 Df(2L)OD15 Df(2L)TW203 l(2)37Bb 2-53.9 37B10-13 Df(2L)hk-UC1 Df(2L)OD15 l(2)E58 l(2)37Bc 2-53.9 37B10-13 Df(2L)OD15 Df(2L)TW203 l(2)E13 l(2)37Bd 2-53.9+ 37B13-C1 Df(2L)NST Df(2L)VA17 l(2)37Be 2-53.9 37B10-13 Df(2L)OD15 Df(2L)TW203 l(2)37Bf 2-53.9 37B10-13 Df(2L)hk-UC1 Df(2L)OD15 Dox-A2 l(2)37Bg 2-53.9 37B13-C1 Df(2L)VA18 Df(2L)hk18 Df(2L)NST l(2)37Bi 2-53.9 37B3-7 Df(2L)TW137 Df(2L)TW3 l(2)E131 Df(2L)TW158 l(2)37Bj 2-53.9 37B3-7 Df(2L)TW137 Df(2L)TW3 l(2)E35 Df(2L)TW158 l(2)37Bk 2-53.9+ 37B13-C1 Df(2L)NST Df(2L)VA17 Amd # l(2)37Ba phenotype: Variably late lethal; death occurs at larval [l(2)37Ba2], or pupal [l(2)37Ba2, l(2)37Ba4, l(2)37Ba8, l(2)37Ba9] stage with pharate adults; l(2)37Ba2 produces some adults, which are male sterile or female sterile; l(2)37Ba4 produces many adults, which are male or female sterile; l(2)37Bfs1 is a normally viable, female-sterile allele. Melanotic tumors noted in l(2)37Ba4 and l(2)37Ba8; pharate adults display incompletely developed abdominal cuticle in l(2)37Ba2, l(2)37Ba4, and l(2)37Ba8 (Wright, 1987, Adv. Genet. 24: 127-222). alleles: allele origin discoverer synonym ref ( comments ___________________________________________________________________ l(2)37Ba1 EMS Wright l(2)261 1 l(2)37Ba2 EMS+HCOH Wright l(2)342 1 *l(2)37Ba3 EMS+/ ray Wright l(2)501 1 l(2)37Ba4 EMS Wright l(2)606 1 *l(2)37Ba6 EMS Wright l(2)619 1 *l(2)37Ba7 EMS Wright l(2)624 1 l(2)37Ba8 EMS+/ ray Wright l(2)7101 2 l(2)37Ba9 EMS Lindsley l(2)50-584 *l(2)37Ba10 EMS Lindsley l(2)50-283 l(2)37Ba11 EMS+/ ray Cecil l(2)BB45 l(2)37Ba12 EMS+/ ray Cecil l(2)A6 l(2)37Bafs1 EMS Wright fs(2)R female sterile ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Bb phenotype: Larval lethal; third instar larvae survive until day eight to thirteen, and at least in the case of l(2)37Bb1 they are small with small imaginal discs, salivary glands, and fat bodies. alleles: allele origin discoverer synonym ref ( comments ______________________________________________________________________ l(2)37Bb 1 EMS Wright l(2)E58 2 l(2)37Bb 2 EMS Wright l(2)E138 2 *l(2)37Bb 3 EMS Wright l(2)E152 2 *l(2)37Bb 4 EMS Wright l(2)E154 2 l(2)37Bb 5 EMS Wright l(2)235 1 *l(2)37Bb 6 EMS Wright l(2)242 1 *l(2)37Bb 7 EMS Wright l(2)252 1 l(2)37Bb 8 EMS Wright l(2)278 1 heat sensitive l(2)37Bb 9 EMS+HCOH Wright l(2)393 1 l(2)37Bb 10 EMS Wright l(2)647 1 l(2)37Bb 11 EMS+/ ray Wright l(2)7447 3 400 base-pair intragenic deletion ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Bc phenotype: Larval lethal. l(2)37Bc1 produces many dead col- lapsed larvae at 48 h; l(2)37Bc20 displays small, still-living larvae at 144 h; l(2)37Bc11 pupal lethal with melanized puparia and pharate adults, with incomplete head and thoracic cuticle, no abdominal cuticle, and no eyes or bristles. Melanotic tumors in l(2)37Bc9/l(2)37Bc20 and l(2)37Bc9- /l(2)37Bcfs1 adults. allele origin discoverer synonym ref ( comments ___________________________________________________________________________ l(2)37Bc1 EMS Wright l(2)E13 2 l(2)37Bc2 EMS Wright l(2)E59 2 l(2)37Bc3 EMS Wright l(2)E130 2 l(2)37Bc4 EMS Wright l(2)E132 2 l(2)37Bc5 EMS Wright l(2)216 1 l(2)37Bc6 EMS Wright l(2)225 1 l(2)37Bc7 EMS Wright l(2)257 1 l(2)37Bc8 EMS Wright l(2)271 1 l(2)37Bc9 EMS Wright l(2)290 1 l(2)37Bc10 spont Wright l(2)BL106 1 l(2)37Bc11 EMS+HCOH Wright l(2)316 1 l(2)37Bc12 EMS+HCOH Wright l(2)380 1 l(2)37Bc13 EMS+HCOH Wright l(2)386 1 l(2)37Bc14 EMS+HCOH Wright l(2)399 1 l(2)37Bc15 EMS Wright l(2)614 1 l(2)37Bc16 EMS Wright l(2)625 1 l(2)37Bc17 EMS Wright l(2)626 1 l(2)37Bc18 EMS Wright l(2)641 1 l(2)37Bc19 EMS Wright l(2)642 1 semilethal l(2)37Bc20 EMS+/ ray Wright l(2)7417 3 l(2)37Bc21 EMS+/ ray Wright l(2)7444 3 l(2)37Bc22 EMS Lindsley l(2)158-1559 l(2)37Bc23 EMS+/ ray Cecil l(2)B4 l(2)37Bc24 EMS+/ ray Cecil l(2)B90 l(2)37Bc25 EMS+/ ray Cecil l(2)BB5 l(2)37Bcfs1 EMS+/ ray Wright l(2)7602 female sterile l(2)37Bcfs2 EMS+/ ray Wright l(2)7607 female sterile l(2)37Bcfs3 EMS Schupbach l(2)QT50 female sterile | l(2)37Bcts1 EMS Wright l(2)202ts temperature sensitive ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26, 45-58. | Homozygous females lay tiny eggs which remain unfertilized. # l(2)37Bd phenotype: Larval-pupal lethal; l(2)37Bd2 and l(2)37Bd6 are strong alleles in which second and third instar larvae persist until days eight and nine; few survive to pharate-adult stage with incomplete sclerotization; l(2)37Bd7 similar, but with more pharate adults. l(2)37Bd4 semilethal; l(2)37Bd4- /l(2)37Bd7 phenotype similar to that of l(2)37Bd7. allele origin discoverer synonym ref ( ____________________________________________________________ l(2)37Bd1 EMS Wright l(2)285 1 l(2)37Bd2 EMS+HCOH Wright l(2)322 1 *l(2)37Bd3 EMS+HCOH Wright l(2)331 1 l(2)37Bd4 EMS+HCOH Wright l(2)385 1 l(2)37Bd5 EMS+HCOH Wright l(2)401 1 l(2)37Bd6 EMS Wright l(2)621 1 l(2)37Bd7 EMS+/ ray Wright l(2)7408 2 l(2)37Bd8 EMS Lindsley l(2)158-1440 l(2)37Bd9 EMS Lindsley l(2)158-2032 ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Be phenotype: Embryonic lethal l(2)37Be1 and l(2)37Be2 uniformly die as embryos; l(2)37Be3, on the other hand, dies as embryos or larvae, with a few reaching the pharate adult stage with incomplete abdominal cuticle, and some even surviving as fer- tile adults. allele origin discoverer synonym ref ( comments ____________________________________________________________________ l(2)37Be1 EMS Wright l(2)601 1 l(2)37Be2 EMS Wright l(2)665 1 l(2)37Be3 EMS+/ ray Wright l(2)7401 2 l(2)37Be4 EMS+/ ray Wright l(2)7446 2 l(2)37Be5 EMS+/ ray Cecil l(2)A1 0.8-1.0-kb deletion ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Bg phenotype: Pupal lethal; on the seventh day large third-instar larvae begin to form large, darker tan pupae; eye-antennal discs evert, but only the genital disc derivatives form cuti- cle; eyes, antennae, legs, and wing discs form no cuticle. Pupae form a large [l(2)37Bg1] or numerous small [l(2)37Bg2] melanotic tumors. allele origin discoverer synonym ref ( _________________________________________________________ l(2)37Bg1 EMS+/ ray Wright l(2)7420 1 l(2)37Bg2 EMS Lindsley l(2)50-564 ( 1 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. allele origin discoverer synonym ref ( ____________________________________________________ l(2)37Bi1 EMS Wright l(2)E131 1 l(2)37Bi2 EMS Wright l(2)E46 1 l(2)37Bi3 EMS Wright l(2)E133 1 l(2)37Bj1 EMS Wright l(2)E35 1 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # l(2)37C genetic cytological locus location location included in excluded from synonym _____________________________________________________________________ l(2)37Ca 2-53.9+ 37C2-4 Df(2L)VA21 Df(2L)hk-UC2 l(2)E11 Df(2L)VA17 Df(2L)VA12 l(2)37Cb 2-53.9+ 37C2-4 Df(2L)hk-UC2 Df(2L)VA18 l(2)E104 l(2)37Cc 2-53.9+ 37C2-4 Df(2L)VA17 Df(2L)VA18 l(2)37Cd 2-53.9+ 37C2-4 Df(2L)VA21 Df(2L)hk-UC2 Df(2L)VA17 Df(2L)VA12 l(2)37Ce 2-53.9+ 37C2-4 Df(2L)VA21 Df(2L)hk-UC2 l(2)E62 Df(2L)VA17 Df(2L)VA12 l(2)37Cf 2-53.95 37C3-7 Df(2L)TE37C-B7 Df(2L)VA21 l(2)E60 Df(2L)Sd57 Df(2L)Sd77 l(2)37Cg 2-53.9+ 37C2-4 Df(2L)VA21 Df(2L)hk-UC2 Df(2L)VA17 Df(2L)VA12 l(2)37Ch 2-53.9+ 37C1-2 Df(2L)VA17 Df(2L)VA12 Ddc # l(2)37Ca phenotype: l(2)37Cats1/Df(2L)TW130 eclosed adults at 25 have incompletely sclerotized thoracic cuticle, which deforms when the indirect flight muscles contract; wings rarely completely expanded. X-ray-induced abdominal clones hemizygous for the amorphic allele l(2)37Ca4, produce bristles one-third wild- type size. allele origin discoverer synonym ref ( comments ___________________________________________________________________________ l(2)37Ca1 EMS Wright l(2)E11 2 l(2)37Ca2 EMS Wright l(2)E56 2 l(2)37Ca3 EMS Wright l(2)E125 2 larval lethal l(2)37Ca4 EMS Wright l(2)217 1 *l(2)37Ca5 EMS Wright l(2)230 1 *l(2)37Ca6 EMS Wright l(2)240 1 *l(2)37Ca7 EMS Wright l(2)246 1 l(2)37Ca8 EMS Wright l(2)253 1 heat sensitive; leaky at 30 *l(2)37Ca9 EMS Wright l(2)264 1 l(2)37Ca10 EMS Wright l(2)266 1 larval lethal *l(2)37Ca11 EMS Wright l(2)267 1 heat sensitive; leaky at 30 *l(2)37Ca12 EMS Wright l(2)268 1 *l(2)37Ca13 EMS Wright l(2)269 1 l(2)37Ca14 EMS+HCOH Wright l(2)312 1 *l(2)37Ca15 EMS+HCOH Wright l(2)313 1 l(2)37Ca16 EMS+HCOH Wright l(2)314 1 l(2)37Ca17 EMS+HCOH Wright l(2)319 1 l(2)37Ca18 EMS+HCOH Wright l(2)334 1 l(2)37Ca19 EMS+HCOH Wright l(2)3452 1 *l(2)37Ca20 EMS+HCOH Wright l(2)3462 1 *l(2)37Ca21 EMS+HCOH Wright l(2)352 1 *l(2)37Ca22 EMS+HCOH Wright l(2)402 1 *l(2)37Ca23 EMS+HCOH Wright l(2)403 1 *l(2)37Ca24 EMS+HCOH Wright l(2)407 1 *l(2)37Ca25 EMS Wright l(2)610 1 *l(2)37Ca26 EMS Wright l(2)612 1 l(2)37Ca27 EMS Wright l(2)613 1 l(2)37Ca28 EMS Wright l(2)622 1 larval lethal *l(2)37Ca29 EMS Wright l(2)629 1 *l(2)37Ca30 EMS Wright l(2)639 1 l(2)37Ca31 EMS Wright l(2)680 1 *l(2)37Ca32 EMS+/ ray Wright l(2)7303 3 *l(2)37Ca33 EMS+/ ray Wright l(2)7404 3 *l(2)37Ca34 EMS+/ ray Wright l(2)7425 3 *l(2)37Ca35 EMS Brittnacher l(2)L2 l(2)37Ca36 / ray Cecil l(2)PC *l(2)37Ca37 EMS L. Hall l(2)P3 l(2)37Ca38 EMS Wright l(2)620 chromosome lethal over Ddc alleles l(2)37Ca39 | EMS+/ ray Wright l(2)7431 *l(2)37Ca40 EMS+/ ray Cecil l(2)AA7 *l(2)37Ca41 EMS+/ ray Cecil l(2)A2 *l(2)37Cats1 EMS Wright l(2)209ts 1 temperature sensitive l(2)37Cats2 EMS+/ ray Wright l(2)7432rts 3 temperature sensitive l(2)37Cats3 EMS+HCOH Wright l(2)3500ts 1 temperature sensitive ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. | Induced simultaneously with and not separated from l(2)37Cb30; lethal over many l(2)37Ca and l(2)37Cb alleles; male and female sterile in those combinations that complement. # l(2)37Cb allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(2)37Cb1 EMS Wright l(2)E104 2 larval lethal l(2)37Cb2 EMS Wright l(2)E118 2 l(2)37Cb3 EMS Wright l(2)222 1 heat sensitive *l(2)37Cb4 EMS Wright l(2)241 1 *l(2)37Cb5 EMS Wright l(2)274 1 *l(2)37Cb6 EMS+HCOH Wright l(2)3488 1 *l(2)37Cb7 EMS+HCOH Wright l(2)3510 1 l(2)37Cb8 EMS+HCOH Wright l(2)394 1 larval lethal l(2)37Cb9 EMS+/ ray Wright l(2)503 1 *l(2)37Cb10 EMS Wright l(2)603 1 *l(2)37Cb11 EMS Wright l(2)609 1 *l(2)37Cb12 EMS Wright l(2)611 1 *l(2)37Cb13 EMS Wright l(2)618 1 l(2)37Cb14 EMS Wright l(2)627 1 *l(2)37Cb15 EMS Wright l(2)630 1 *l(2)37Cb16 EMS Wright l(2)631 1 *l(2)37Cb17 EMS Wright l(2)648 1 l(2)37Cb18 EMS+/ ray Wright l(2)7406 3 170-bp intra- genic deletion l(2)37Cb19 EMS+/ ray Wright l(2)7419 3 l(2)37Cb20 EMS+/ ray Wright l(2)7424 3 larval lethal *l(2)37Cb21 EMS+/ ray Wright l(2)7427 3 *l(2)37Cb22 EMS+/ ray Wright l(2)7428 3 l(2)37Cb23 EMS+/ ray Wright l(2)7448 3 l(2)37Cb24 EMS Lindsley l(2)158-1652 *l(2)37Cb25 EMS Lindsley l(2)50-569 *l(2)37Cb26 EMS Lindsley l(2)50-586 l(2)37Cb27 EMS Brittnacher l(2)L1 *l(2)37Cb28 EMS Brittnacher l(2)L12 *l(2)37Cb29 EMS Brittnacher l(2)L16 l(2)37Cb30 | EMS+/ ray Wright l(2)7431 l(2)37Cbts1 EMS Wright l(2)232ts 1 temperature sensitive *l(2)37Cbts2 EMS+HCOH Wright l(2)383ts 1 temperature sensitive ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. | Induced simultaneously with and not separated from l(2)37Ca39; lethal over many l(2)37Ca and l(2)37Cb alleles; male and female sterile in those combinations that comple- ment. # l(2)37Cc phenotype: Many different complementing heteroallelic genotypes exhibit opaque wings, often incompletely expanded, moderate Minute-like bristles, and a lighter tan body color. allele origin discoverer synonym ref ( comments ___________________________________________________________________________ l(2)37Cc1 EMS Wright l(2)236 1 l(2)37Cc2 EMS Wright l(2)244 1 l(2)37Cc3 EMS Wright l(2)284 1 l(2)37Cc4 EMS Wright l(2)286 1 *l(2)37Cc5 EMS Wright l(2)289 1 l(2)37Cc6 EMS+HCOH Wright l(2)395 1 heat sensitive; posterior half of unexpanded wings heavily melanized l(2)37Cc7 EMS Wright l(2)658 1 larval lethal *l(2)37Cc8 EMS Wright l(2)686 1 l(2)37Cc9 EMS Steward l(2)RS1 l(2)37Cc10 EMS+/ ray Wright l(2)7421 2 larval lethal -L2 and L3 *l(2)37Cc11 EMS+/ ray Wright l(2)7434 2 l(2)37Cc12 EMS+/ ray Wright l(2)7449 2 l(2)37Cc13 EMS+/ ray Wright l(2)7450 2 dominant female sterile l(2)37Cc14 EMS Lindsley l(2)50-947 larval lethal l(2)37Cc15 EMS Lindsley l(2)158-1683 larval-pupal lethal; leaky; adult escapers female sterile and Minute *l(2)37Cc16 EMS Lindsley l(2)50-546 *l(2)37Cc17 EMS Lindsley l(2)50-5 *l(2)37Cc18 EMS Brittnacher l(2)L4 *l(2)37Cc19 EMS Brittnacher l(2)L13 l(2)37Cc20 DEB Cecil l(2)DEB12 30-bp intragenic deletion l(2)37Ccts1 EMS+HCOH Wright l(2)350ts 1 temperature sensitive l(2)37Ccts2 EMS+HCOH Wright l(2)392ts 1 temperature sensitive l(2)37Ccfs1 EMS Schupbach fs(2)HH32 female sterile ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Cd phenotype: Late third-instar larval lethal; some form unsclero- tized pseudopupae after ten days; imaginal discs and central nervous system half normal size; melanotic tumors [l(2)37Cd4]. allele origin discoverer synonym ref ( comments ______________________________________________________________________ *l(2)37Cd1 EMS Wright l(2)234 1 melanotic tumors l(2)37Cd2 EMS+HCOH Wright l(2)335 1 *l(2)37Cd3 EMS+HCOH Wright l(2)343 1 l(2)37Cd4 EMS+HCOH Wright l(2)369 1 l(2)37Cd5 EMS Wright l(2)636 1 pupal lethal l(2)37Cd6 EMS Wright l(2)678 1 melanotic tumors l(2)37Cd7 EMS+/ ray Wright l(2)7001 2 larval lethal; melanotic tumors; 600 bp deletion l(2)37Cd8 EMS+/ ray Wright l(2)7405 2 l(2)37Cd9 EMS+/ ray Wright l(2)7451 2 l(2)37Cd10 EMS+/ ray Cecil l(2)B10 l(2)37Cdts1 EMS+HCOH Wright l(2)321ts 1 ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Ce phenotype: Most alleles are pupal lethals; abdominal cuticle absent and melanotic tumors recorded for l(2)37Ce1 and l(2)37Ce5. allele origin discoverer synonym ref ( comments _____________________________________________________________ l(2)37Ce1 EMS Wright l(2)E62 2 l(2)37Ce2 EMS Wright l(2)E111 2 l(2)37Ce3 EMS Wright l(2)255 1 semilethal l(2)37Ce4 EMS+HCOH Wright l(2)3514 1 l(2)37Ce5 EMS Wright l(2)635 1 l(2)37Ce6 EMS Brittnacher l(2)L18 l(2)37Ce7 EMS+/ ray Cecil l(2)AA5 l(2)37Ce8 EMS+/ ray Cecil l(2)BB6 ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310. # l(2)37Cf phenotype: Lethality occurs as pharate adults. Third-instar larvae of 13 of 14 alleles examined display enlarged brains-up to eight times normal volume; greatest in presumptive optic center (Hankins and Wright). Brain fragments transplanted into normal adults show uncontrolled proliferation and metas- tatic invasion of other tissues (Gateff). Escapers [l(2)37Cf1/l(2)37Cfts3] lethargic and sterile in both sexes [Wright, 1987, Results and Problems in Cell Differentiation (W. Hennig, ed.). Springer-Verlag, Berlin, Heidelberg, pp. 95-120]. Homozygous females [l(2)37Cffs2] retain eggs in ovaries (Schupbach). allele origin discoverer synonym ref ( comments ___________________________________________________________________________ l(2)37Cf1 EMS Wright l(2)E60 2 l(2)37Cf2 EMS Wright l(2)E127 2 l(2)37Cf3 EMS Wright l(2)223 1 l(2)37Cf4 EMS Wright l(2)243 1 l(2)37Cf5 EMS Wright l(2)251 1 l(2)37Cf6 EMS Wright l(2)259 1 l(2)37Cf7 EMS Wright l(2)291 1 l(2)37Cf8 EMS+HCOH Wright l(2)320A 1 l(2)37Cf9 EMS+HCOH Wright l(2)3450 1 semilethal *l(2)37Cf10 EMS+HCOH Wright l(2)3454 1 l(2)37Cf11 EMS+HCOH Wright l(2)347 1 l(2)37Cf12 EMS Wright l(2)608 1 few adults l(2)37Cf13 EMS Wright l(2)643 1 l(2)37Cf14 EMS Wright l(2)649 1 few adults l(2)37Cf15 EMS Wright l(2)684 1 l(2)37Cf16 EMS+/ ray Wright l(2)7403 3 some adults l(2)37Cf17 EMS+/ ray Wright l(2)7418 3 few adults l(2)37Cf18 EMS+/ ray Wright l(2)7429 3 1-kb deletion l(2)37Cf19 EMS Lindsley l(2)158-1725 l(2)37Cf20 DEB Cecil l(2)DEB18 l(2)37Cf21 EMS Schupbach l(2)RS53 l(2)37Cf22 EMS+/ ray Cecil l(2)AA2 l(2)37Cf23 EMS+/ ray Cecil l(2)C2 l(2)37Cf24 EMS+/ ray Cecil l(2)CC5 l(2)37Cffs1 EMS Wright fs(2)E60 1 female-sterile allele l(2)37Cffs2 EMS Schupbach fs(2)PI123 female-sterile allele larval brains normal size l(2)37Cffs3 EMS Schupbach fs(2)PM43 female-sterile allele l(2)37Cfts1 EMS Wright l(2)E29ts 2 temperature sensitive l(2)37Cfts2 EMS+HCOH Wright l(2)336ts 1 temperature sensitive l(2)37Cfts3 EMS Lindsley l(2)50-899 temperature sensitive ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37Cg allele origin discoverer synonym ref ( comments _____________________________________________________________________________ l(2)37Cg1 EMS+/ ray Wright l(2)7414 3 lethal in L2 after 7 days l(2)37Cg2 EMS Wright l(2)615 2 larval lethal; melanotic tumors l(2)37Cgts1 EMS+HCOH Wright l(2)354ts 1 temperature sensitive ( 1 = Wright, Beerman, Marsh, Bishop, Steward, Black, Tomsett, and Wright, 1981, Chromosoma 83: 45-58; 2 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287-310; 3 = Wright, Black, Bishop, Marsh, Pentz, Steward, and Wright, 1982, Mol. Gen. Genet. 188: 18-26. # l(2)37D-E Eleven lethally mutable loci identified, ten in 37D and one in 37E. In addition to the alleles identified below, Wright, Bewley, and Sherald (1976, Genetics 84: 287-310) report seven mutants between the right break of Df(2L)TW130 and the left break of Df(2L)TW2 (designated E27, E29, E56, E107, E137, E142M, and E151) plus four between the left breakpoint of Df(2L)TW2 and the right breakpoint of Df(2L)TW158 (designated E12, E34, E68, and E144M) that were not tested for complemen- tation. genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)37Da 2-{54} 37D2-7 Df(2L)prA14 Df(2L)Sd2 l(2)OE23 l(2)37Db 2-{54} 37D2-E1 Df(2L)Sd2 Df(2L)TW330 l(2)E19 Df(2L)VA15 l(2)37Dc 2-{54} 37D2-E1 Df(2L)Sd37 Df(2L)pr26 l(2)E106 l(2)37Dd 2-{54} 37D2-E1 Df(2L)Sd37 Df(2L)pr26 l(2)OE36 l(2)37De 2-{54} 37D2-E1 Df(2L)Sd37 Df(2L)pr26 l(2)OE30 l(2)37Df 2-{54} 37D2-E1 Df(2L)Sd37 Df(2L)pr26 l(2)OD8 l(2)37Dg 2-{54} 37D2-E1 Df(2L)pr26 Df(2L)TW2 l(2)OE39 l(2)37Dh 2-{54} 37D2-F4 Df(2L)TW2 Df(2L)TW9 l(2)E1 l(2)37Di 2-{54} 37D2-E1 Df(2L)TW2 Df(2L)TW9 l(2)E103 l(2)37Dj 2-{54} 37D2-E1 Df(2L)TW2 Df(2L)TW9 l(2)OE31 l(2)37Ea 2-{54} 37E2-F4 Df(2L)TW9 l(2)E124 Df(2L)TW158 # l(2)37Da phenotype: Semilethal, temperature-sensitive alleles. Escapers have a straight body and extended genital plates. allele origin discoverer synonym ________________________________________________ l(2)37Da1 EMS Gay, Contamine l(2)OE23 l(2)37Da2 EMS Gay, Contamine l(2)OE68 l(2)37Da3 EMS Gay, Contamine l(2)OE78 l(2)37Da4 EMS Gay, Contamine l(2)OE80 l(2)37Da5 DEB Gay, Contamine l(2)OD5 l(2)37Da6 DEB Gay, Contamine l(2)OD32 allele origin discoverer synonym ref ( __________________________________________________________ l(2)37Db1 EMS Wright l(2)E19 1 l(2)37Db2 EMS Wright l(2)E63 1 l(2)37Db3 EMS Wright l(2)E109 1 l(2)37Db4 EMS Wright l(2)E139 1 l(2)37Db5 EMS Gay, Contamine l(2)OE34 l(2)37Db6 EMS Gay, Contamine l(2)OE43 l(2)37Db7 EMS Gay, Contamine l(2)OE44 l(2)37Db8 EMS Gay, Contamine l(2)OE47 l(2)37Db9 EMS Gay, Contamine l(2)OE48 l(2)37Db10 EMS Gay, Contamine l(2)OE65 l(2)37Db11 EMS Gay, Contamine l(2)OE87 l(2)37Db12 EMS Gay, Contamine l(2)OE90 l(2)37Db13 EMS Gay, Contamine l(2)OE95 l(2)37Db14 EMS Gay, Contamine l(2)OE97 l(2)37Db15 DEB Gay, Contamine l(2)OD2 l(2)37Db16 DEB Gay, Contamine l(2)OD26 l(2)37Db17 DEB Gay, Contamine l(2)OD33 l(2)37Db18 EMS Gay, Contamine l(2)PE1 l(2)37Db19 EMS Gay, Contamine l(2)PE6 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. allele origin discoverer synonym ref ( comments ___________________________________________________________ l(2)37Dc1 EMS Wright l(2)E106 1 l(2)37Dc2 EMS Gay, Contamine l(2)OE11 l(2)37Dc3 EMS Gay, Contamine l(2)OE20 l(2)37Dc4 EMS Gay, Contamine l(2)OE24 l(2)37Dc5 EMS Gay, Contamine l(2)OE28 l(2)37Dc6 EMS Gay, Contamine l(2)OE53 l(2)37Dc7 EMS Gay, Contamine l(2)OE64 l(2)37Dc8 EMS Gay, Contamine l(2)OE74 l(2)37Dc9 EMS Gay, Contamine l(2)OE93 l(2)37Dc10 DEB Gay, Contamine l(2)OD18 l(2)37Dc11 DEB Gay, Contamine l(2)OD23 l(2)37Dd1 EMS Gay, Contamine l(2)OE36 1 semilethal ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # l(2)37De alleles: Interallelic complementation between all Gay and Con- tamine alleles, except l(2)De18, and l(2)De1, l(2)De2, and l(2)De4. allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(2)37De1 EMS Wright l(2)E2 1 l(2)37De2 EMS Wright l(2)E8 1 l(2)37De3 EMS Wright l(2)E39 1 l(2)37De4 EMS Wright l(2)E102 1 l(2)37De5 EMS Wright l(2)E108 1 l(2)37De6 EMS Gay, Contamine l(2)OE1 l(2)37De7 EMS Gay, Contamine l(2)OE4 l(2)37De8 EMS Gay, Contamine l(2)OE6 l(2)37De9 EMS Gay, Contamine l(2)OE7 l(2)37De10 EMS Gay, Contamine l(2)OE8 l(2)37De11 EMS Gay, Contamine l(2)OE9 l(2)37De12 EMS Gay, Contamine l(2)OE10 l(2)37De13 EMS Gay, Contamine l(2)OE15 l(2)37De14 EMS Gay, Contamine l(2)OE19 l(2)37De15 EMS Gay, Contamine l(2)OE21 l(2)37De16 EMS Gay, Contamine l(2)OE25 l(2)37De17 EMS Gay, Contamine l(2)OE29 complex aberration l(2)37De18 EMS Gay, Contamine l(2)OE30 l(2)37De19 EMS Gay, Contamine l(2)OE35 l(2)37De20 EMS Gay, Contamine l(2)OE37 l(2)37De21 EMS Gay, Contamine l(2)OE38 temperature sensitive l(2)37De22 EMS Gay, Contamine l(2)OE41 temperature sensitive l(2)37De23 EMS Gay, Contamine l(2)OE42 l(2)37De24 EMS Gay, Contamine l(2)OE46 Glued-like phenotype l(2)37De25 EMS Gay, Contamine l(2)OE50 temperature sensitive l(2)37De26 EMS Gay, Contamine l(2)OE54 l(2)37De27 EMS Gay, Contamine l(2)OE57 l(2)37De28 EMS Gay, Contamine l(2)OE69 l(2)37De29 EMS Gay, Contamine l(2)OE79 l(2)37De30 EMS Gay, Contamine l(2)OE82 l(2)37De31 EMS Gay, Contamine l(2)OE85 l(2)37De32 EMS Gay, Contamine l(2)OE91 l(2)37De33 EMS Gay, Contamine l(2)OE98 l(2)37De34 EMS Gay, Contamine l(2)OE99 l(2)37De35 EMS Gay, Contamine l(2)OE100 l(2)37De36 DEB Gay, Contamine l(2)OD1 l(2)37De37 DEB Gay, Contamine l(2)OD19 l(2)37De38 DEB Gay, Contamine l(2)OD27 l(2)37De39 DEB Gay, Contamine l(2)OD28 l(2)37De40 EMS Gay, Contamine l(2)PE3 l(2)37De41 EMS Gay, Contamine l(2)PE4 l(2)37De42 EMS Gay, Contamine l(2)PE5 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. allele origin discoverer synonym comments _____________________________________________________________ l(2)37Df1 DEB Gay, Contamine l(2)OD8 semilethal l(2)37Dg1 EMS Gay, Contamine l(2)OE39 l(2)37Dg2 EMS Gay, Contamine l(2)OE62 # l(2)37Dh phenotype: Interferes with M and M-like mutants. allele origin discoverer synonym ref ( ________________________________________________________ l(2 37Dh1 EMS Wright l(2)E1 1 l(2)37Dh2 EMS Gay, Contamine l(2)OE2 l(2)37Dh3 EMS Gay, Contamine l(2)OE13 l(2)37Dh4 EMS Gay, Contamine l(2)OE22 l(2)37Dh5 EMS Gay, Contamine l(2)OE27 l(2)37Dh6 EMS Gay, Contamine l(2)OE77 l(2)37Dh7 EMS Gay, Contamine l(2)OE83 l(2)37Dh8 DEB Gay, Contamine l(2)OD10 l(2)37Dh9 DEB Gay, Contamine l(2)OD30 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(2)37Di1 EMS Wright l(2)E103 1 l(2)37Di2 EMS Gay, Contamine l(2)OE16 l(2)37Di3 EMS Gay, Contamine l(2)OE32 l(2)37Di4 EMS Gay, Contamine l(2)OE49 l(2)37Di5 EMS Gay, Contamine l(2)OE51 l(2)37Di6 EMS Gay, Contamine l(2)OE52 l(2)37Di7 EMS Gay, Contamine l(2)OE61 l(2)37Di8 EMS Gay, Contamine l(2)OE63 l(2)37Di9 EMS Gay, Contamine l(2)OE66 l(2)37Di10 EMS Gay, Contamine l(2)OE67 l(2)37Di11 EMS Gay, Contamine l(2)OE73 l(2)37Di12 EMS Gay, Contamine l(2)OE81 l(2)37Di13 EMS Gay, Contamine l(2)OE86 l(2)37Di14 EMS Gay, Contamine l(2)OE89 l(2)37Di15 EMS Gay, Contamine l(2)OE94 l(2)37Di16 DEB Gay, Contamine l(2)OD4 l(2)37Dj1 EMS Gay, Contamine l(2)OE31 l(2)37Dj2 EMS Gay, Contamine l(2)OE40 l(2)37Dj3 EMS Gay, Contamine l(2)OE58 l(2)37Dj4 EMS Gay, Contamine l(2)OE59 l(2)37Dj5 EMS Gay, Contamine l(2)OE72 l(2)37Dj6 DEB Gay, Contamine l(2)OD25 l(2)37Dj7 DEB Gay, Contamine l(2)OD31 l(2)37Ea1 EMS l(2)E124 1 l(2)37Ea2 EMS Gay, Contamine l(2)OE17 l(2)37Ea3 EMS Gay, Contamine l(2)OE56 temperature sensitive l(2)37Ea4 EMS Gay, Contamine l(2)OE75 temperature sensitive l(2)37Ea5 EMS Gay, Contamine l(2)OE88 l(2)37Ea6 EMS Gay, Contamine l(2)OE102 l(2)37Ea7 DEB Gay, Contamine l(2)OD3 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # l(2)37F genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)37Fa 2-{54} 37E3-38A1 Df(2L)TW12 Df(2L)OD21 l(2)OE92 l(2)37Fb 2-{54} 37E3-38A1 Df(2L)TW12 Df(2L)OD21 l(2)E146 l(2)37Fc 2-{54} 37E3-38A1 Df(2L)OD21 Df(2L)TW84 l(2)E42 l(2)37Fd 2-{54} 37E3-38A1 Df(2L)TW84 l(2)OE55 Df(2L)E55 l(2)37Fe 2-{54} 37F5-38A1 Df(2L)TW150 Df(2L)E55 l(2)E3 Df(2L)TW65 l(2)37Ff 2-{54} 37F5-38A1 Df(2L)TW65 Df(2L)H1 l(2)E43 Df(2L)TW65 l(2)37Fg 2-{54} 37F5-38A1 Df(2L)TW150 Df(2L)E55 l(2)O9 Df(2L)Cpp2R l(2)37Fh 2-{54} 37F5-38A1 Df(2L)E55 Df(2L)TW65 l(2)C188 Df(2L)TW150 allele origin discoverer synonym ref ( _________________________________________________________ l(2)37Fa1 EMS Gay, Contamine l(2)OE92 l(2)37Fa2 DEB Gay, Contamine l(2)OD7 l(2)37Fa3 DEB Gay, Contamine l(2)OD24 l(2)37Fb1 EMS Wright l(2)E146 1 l(2)37Fb2 EMS Gay, Contamine l(2)OE18 l(2)37Fb3 EMS Gay, Contamine l(2)OE26 l(2)37Fb4 EMS Gay, Contamine l(2)OE33 l(2)37Fb5 EMS Gay, Contamine l(2)OE60 l(2)37Fb6 EMS Gay, Contamine l(2)OE71 l(2)37Fb7 EMS Gay, Contamine l(2)OE101 l(2)37Fb8 EMS Gay, Contamine l(2)PE7 l(2)37Fb9 DEB Gay, Contamine l(2)OD29 l(2)37Fc1 EMS Wright l(2)E42 1 l(2)37Fc2 EMS Wright l(2)E72 1 l(2)37Fc3 EMS Gay, Contamine l(2)OE14 l(2)37Fc4 EMS Gay, Contamine l(2)OE76 l(2)37Fc5 EMS Gay, Contamine l(2)OE96 l(2)37Fc6 DEB Gay, Contamine l(2)OD6 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # l(2)37Fd phenotype: Semilethal with opaque wings. allele origin discoverer synonym _________________________________________________ l(2)37Fd1 EMS Gay, Contamine l(2)OE55 l(2)37Fd2 EMS Gay, Contamine l(2)OE103 l(2)37Fd3 EMS Gay, Contamine l(2)OE104 l(2)37Fd4 DEB Gay, Contamine l(2)OD11 allele origin discoverer synonym ref ( ________________________________________________________ l(2)37Fe EMS Wright l(2)E3 1 l(2)37Ff EMS Wright l(2)E43 1 l(2)37Fg Gay, Contamine l(2)O9 l(2)37Fh1 Gay, Contamine l(2)C188 l(2)37Fh2 Gay, Contamine l(2)OD11 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # l(2)38A genetic cytological locus location location included in synonym ____________________________________________________ l(2)38Aa 2-{54} 38A6-C1 Df(2L)pr49 l(2)E124P Df(2L)TW150 l(2)38Ab 2-{54} 38A6-C1 Df(2L)pr49 l(2)A113 Df(2L)TW150 allele origin discoverer synonym ref ( _______________________________________________________ l(2)38Aa1 EMS Wright l(2)E124P 1 l(2)38Ab1 Gay, Contamine l(2)A113 ( 1 = Wright, Bewley, and Sherald, 1976, Genetics 84: 287- 310. # DEFICIENCY MAP OF REGION 37-38 side breakpoint variant DNA coordinates ( _________________________________________________________ right 36F1-37A1 Df(2L)M36F-S5 left | Df(2L)VA20 right 37A Df(2L)TW202 left | Df(2L)VA14 left | Df(2L)VA15 left | Df(2L)VA25 l(2)37Aa l(2)37Ab l(2)37Ac right | 37A1-B1 Df(2L)H68 right 37B2-8 Df(2L)TW3 l(2)37Bi l(2)37Bj left 37B2-8 Df(2L)TW158 left | Df(2L)VA24 left | Df(2L)prA16 right 37B9-C1 Df(2L)TW137 left Df(2L)hk-UC1 left Df(2L)hk-UC2 left 37B3-7 Df(2L)Sd68 left 37B9-C1 Df(2L)TW130 left 37B9-C1 Df(2L)VA23 hk -84.95 right 37B9-C1 Df(2L)TW203 -83.25 to -81.35 l(2)37Be -79.35 to -74.75 l(2)37Bc -74.05 to -72.25 l(2)37Ba -72.35 to -66.60 right Df(2L)OD15 -67.37 to -67.25 TU37B2 / -67.36 to -66.63 l(2)37Bb -66.68 to -64.92 Dox-A2 -64.63 to -62.92 TU37B1 / -62.15 to -57.15 right Df(2L)hk-UC1 -56.75 to -54.95 right 37B9-C1 Df(2L)hk18 -52.15 to -50.55 l(2)37Bg -43.35 to -34.95 l(2)37Bd -39.35 to -13.65 left Df(2L)NST -38.35 to -29.85 TU37B3 / -15.05 to -13.65 amd -4.85 to -2.42 TU37C1 / -1.74 to +0.02 left 37B9-C1 Df(2L)VA17 +2.75 to +3.35 37C1-2 Ddc -0.06 to +3.76 l(2)37Cc +5.85 to +8.15 right 37C2-5 Df(2L)VA18 +6.05 to +6.55 l(2)37Cb +8.15 to +10.95 right Df(2L)hk-UC2 +8.15 to +10.95 l(2)37Cd +10.25 to +12.95 l(2)37Ca +14.25 to +20.95 l(2)37Cg +14.25 to +20.95 l(2)37Ce +14.25 to +20.95 left 37C2-5 Df(2L)TE42-1 +26.45 to +29.05 left Df(2L)TE42B7 left 37C2-5 Df(2L)VA12 +26.45 to +29.05 right Df(2L)VA21 +27.95 to +30.75 left 37C2-D1 Df(2L)VA19 +30.75 to +31.75 left Df(2L)VA13 +31.65 to +36.35 left 37D1-2 Df(2L)Sd57 +38.55 to +40.55 l(2)37Cf left 37D1-2 Df(2L)Sd77 +47.05 to +52.55 fs(2)TW1 +47.05 to +58.25 right Df(2L)TE42B7 right Df(2L)NST right 37C6-D1 Df(2L)E71 right 37D1-2 Df(2L)hk39 right 37D1-2 Df(2L)TW130 right Df(2L)VA14 right Df(2L)VA16 left Df(2L)E55 +52.55 to +58.25 left Df(2L)VA6 +52.55 to +58.25 right Df(2L)VA25 left Df(2L)VA8 right Df(2L)VA22 left 37D2-E1? Df(2L)prA14 left 37D1-2 Df(2L)Sd37 right Df(2L)TW330 l(2)37Da left 37D1-2 Df(2L)Sd2 left 37D1-2 Df(2L)Sd14 37D2-6 Sd l(2)37Db right 37D2-E1 Df(2L)VA15 right 37D2-E1 Df(2L)VA20 right 37D2-E1 Df(2L)VA23 37D2-6 Top2 l(2)37Dc l(2)37Dd l(2)37De l(2)37Df left 37D5-6 Df(2L)pr26 l(2)37Dg left 37D2-E1 Df(2L)TW2 fs(2)37D mfs(2)37D l(2)37Dh l(2)37Di l(2)37Dj right Df(2L)OD9 left Df(2L)ODP5 left Dp(2;Y)G-F280 left 37E2-F4 Df(2L)TW9 l(2)37Ea right 37E2-F4 Df(2L)TW158 37E3-F1 Dp(1;Y)G-M15 37E3-F1 ref(2)P left 37E3-F1 Df(2L)CPP2R left Dp(2;Y)G-H3 left 37E3-F1 Df(2L)pr21 left 37E2-F4 Df(2L)TW12 left Df(2L)OD12 l(2)37Fa l(2)37Fb left Df(2L)OD21 l(2)37Fc left 37F5-38A1 Df(2L)TW84 left 37F5-38A1 Df(2L)TW150 left Df(2L)OD16 l(2)37Fd right Df(2L)ODP5 right Df(2L)VA17 l(2)37Fh right 37F5-38A1 Df(2L)E55 l(2)37Fe l(2)37Ff left 37F5-38A1 Df(2L)TW65 l(2)37Fg left Df(2L)H1 right Df(2L)CPP2R right Df(2L)OD16 left 38A3-4 Df(2L)prA20 left 38A3-5 Df(2L)pr65 left 38A5-8 Df(2L)pr67 right 38A6-7 Df(2L)TW50 right 38A6-B2 Df(2L)Sd37 left Df(2L)pr-B12 left 38A6-B1 Df(2L)TW161 left 38A6-B1 Df(2L)TW1 left 38B1-2 Df(2L)pr47 left 38B1-2 Df(2L)pr69 left 38B3-6 Df(2L)pr49 38B1-2 pr right | 38A6-C1 Df(2L)TW9 l(2)38Ba l(2)38Bb right 38B2-C1 Df(2L)TW150 right 38B2-C1 Df(2L)VA12 right 38B6-C1 Df(2L)pr-A20 right 38C1-2 Df(2L)pr47 right 38C1-2 Df(2L)Sd14 right 38C1-2 Df(2L)Sd57 right 38C1-2 Df(2L)Sd77 right 38C5-6 Df(2L)pr69 38C6-9 ms(2)38C right 38C6-10 Df(2L)pr21 right 38C6-10 Df(2L)pr49 right 38C8-10 Df(2L)pr26 right 38D3-5 Df(2L)pr65 right 38D2-E1 Df(2L)pr-A16 right 38D2-E1 Df(2L)Sd2 right 38E3-5 Df(2L)Sd68 right 38F2-39A1 Df(2L)VA6 Bl right 38E6-9 Df(2L)TW2 right 38F5-39A1 Df(2L)VA8 right 38F5-39A1 Df(2L)TE37C-1 ( Coordinates of restriction fragments containing the genes and breakpoints in question; 0 is the axis of symmetry of the HpaI site near the terminus of the Ddc coding sequence. The origin of this set of coordinates is approximately 950 base pairs to the left of that used by Hersh and Wright, and their coordinates have been adjusted accordingly. | Breakpoint not localized with respect to neighboring lethal mutations. / TU = transcription unit. # l(2)39a location: 2-50 (right of Bl ?). origin: Spontaneous. discoverer: Curry, 39a. references: 1939, DIS 12: 45. # l(2)40F Twenty-eight ethyl-methanesulfonate-induced recessive lethal mutations that are not complemented by Df(2L)C', which is thought to delete only 2L heterochromatin (Hilliker, 1976, Genetics 83: 765-82). All seven loci are localized to heterochromatic segment h35 (Pimpinelli). genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(2)40Fa 2-55.0 40F Df(2L)C Df(2L)C l(2)40Fb 2-55.0 40F Df(2L)C Df(2L)D lt l(2)40Fc 2-55.0 40F Df(2L)C Df(2L)D l(2)40Fd 2-55.0 40F Df(2L)C Df(2L)D l(2)40Fe 2-55.0 40F Df(2L)D Df(2L)D l(2)40Ff 2-55.0 40F Df(2L)D Df(2L)D l(2)40Fg 2-55.0 40F Df(2L)D # l(2)40Fa phenotype: Hemizygotes pupate, but subsequently undergo com- plete autolysis with no adult structures present and larval tissues being reduced to an oily mass at the bottom of the pupal case. allele synonym __________________________ l(2)40Fa1 l(2)EMS40-18 l(2)40Fa2 l(2)EMS56-09 l(2)40Fc1 l(2)EMS40-02 l(2)40Fc2 l(2)EMS56-06 l(2)40Fc3 l(2)EMS56-32 l(2)40Fd1 l(2)EMS40-06 l(2)40Fd2 l(2)EMS40-07 l(2)40Fd3 l(2)EMS40-08 l(2)40Fd4 l(2)EMS40-20 l(2)40Fd5 l(2)EMS40-21 l(2)40Fd6 l(2)EMS56-01 l(2)40Fd7 l(2)EMS56-02 l(2)40Fd8 l(2)EMS56-05 l(2)40Fd9 l(2)EMS56-07 l(2)40Fd10 l(2)EMS56-09 l(2)40Fd11 l(2)EMS56-10 l(2)40Fd12 l(2)EMS56-16 l(2)40Fd13 l(2)EMS56-20 l(2)40Fd14 l(2)EMS56-27 # l(2)40Fe Only one allele; complements all other mutations in the region. Hemizygote shows 2% viability. allele synonym ________________________ l(2)40Fe1 l(2)EMS56-24 # l(2)40Ff l(2)40Ff4 semilethal; exhibits 20%, 33%, 26%, and 35% sur- vival in combination with a deficiency, l(2)40Ff1, l(2)40Ff2, and l(2)40Ff3, respectively; these combinations late eclosing. allele synonym comments _____________________________________ l(2)40Ff1 l(2)EMS56-04 l(2)40Ff2 l(2)EMS56-14 l(2)40Ff3 l(2)EMS56-15 l(2)40Ff4 l(2)EMS40-22 semilethal # l(2)40Fg phenotype: Rare escapers are late eclosing and although normal in external phenotype are greatly reduced in size. allele synonym ________________________ l(2)40Fg1 l(2)EMS40-05 l(2)40Fg2 l(2)EMS56-19 # DEFICIENCY MAP OF REGION 40 side breakpoint variant ______________________________ left 40F Df(2L)F left 40F Df(2L)C l(2)40Fa right 40F Df(2L)F left 40F Df(2L)C lt l(2)40Fc l(2)40Fd mat(2)cta left 40F Df(2L)D l(2)40Fe l(2)40Ff left 40F Df(2L)D l(2)40Fg right 40F Df(2L)C right 40F Df(2L)D # l(2)41A A series of 85 ethyl-methanesulfonate-induced recessive lethal mutations comprising seven complementation groups, including rl, uex, and M(2)41A, detected by virtue of their inability to complement Df(2R)M41A and other deficiencies for the proximal heterochromatin of 2R. All mutants occupy but a single complementation group, and no mutant alleles of M(2)41A, which lies in the region, were recovered (Hilliker, 1976, Genetics 83: 765-82). genetic cytological locus location location included in excluded from synonym _________________________________________________________________________ l(2)41Aa 2-55.1 41A Df(2R)B l(2)41Ab 2-55.1 41A Df(2R)B l(2)41Ac 2-55.1 41A Df(2R)A Df(2R)B rl l(2)41Ad 2-55.1 41A Df(2R)A Df(2R)A uex l(2)41Ae 2-55.1 41A Df(2R)A Df(2R)A l(2)41Af 2-55.1 41A Df(2R)A Df(2R)A l(2)41Ag 2-55.1 41A Df(2R)A Df(2R)A M(2)41A l(2)41Ah 2-55.1 41A Df(2R)M41A Df(2R)A # l(2)41Aa phenotype: In heterozygous combination with Df(2L)B dies as late third-instar larvae exhibiting one or more large and numerous small melanotic masses in the hemocoel. allele synonym _____________________ l(2)41Aa1 l(2)EMS31 # l(2)41Ab phenotype: Late larval lethal, but without melanotic masses. Alleles apparently form a circular complementation map. allele synonym ________________________ l(2)41Ab1 l(2)EMS45-10 l(2)41Ab2 l(2)EMS45-84 l(2)41Ab3 l(2)EMS45-87 l(2)41Ab4 l(2)EMS45-91 # l(2)41Ae phenotype: Heterozygotes not Minute. Complementation map shaped like a figure eight and highly complex. Four heteroal- lelic combinations exhibit partial complementation: l(2)41Ae10/l(2)41Ae15 shows 17% survival, l(2)41Ae10- /l(2)41Ae19 8% survival, l(2)41Ae9/l(2)41Ae28 10% survival, and l(2)41Ae21/l(2)41Ae28 21% viability. The remaining combi- nations exhibit noncomplementation or complete complementa- tion. In spite of the fact that among alleles l(2)41Ae35 to l(2)41Ae40, there is only one noncomplementing pair of alleles, l(2)41Ae35 and l(2)41Ae36, these mutants are desig- nated alleles of l(2)41Ae on the basis of their inclusion in Df(2R)M41A-4, Df(2R)M41A-8, Df(2R)M41A-10, and Df(2R)M41A-50j and the extensive complementation characteristic of l(2)41Ae alleles. allele synonym ref ( __________________________________ l(2)41Ae1 l(2)EMS34-02 1 l(2)41Ae2 l(2)EMS34-03 1 l(2)41Ae3 l(2)EMS34-08 1 l(2)41Ae4 l(2)EMS34-10 1 l(2)41Ae5 l(2)EMS34-11 1 l(2)41Ae6 l(2)EMS34-13 1 l(2)41Ae7 l(2)EMS34-14 1 l(2)41Ae8 l(2)EMS34-25 1 l(2)41Ae9 l(2)EMS34-26 1 l(2)41Ae10 l(2)EMS34-28 1 l(2)41Ae11 l(2)EMS45-03 1 l(2)41Ae12 l(2)EMS45-04 1 l(2)41Ae13 l(2)EMS45-09 1 l(2)41Ae14 l(2)EMS45-11 1 l(2)41Ae15 l(2)EMS45-16 1 l(2)41Ae16 l(2)EMS45-20 1 l(2)41Ae17 l(2)EMS45-23 1 l(2)41Ae18 l(2)EMS45-27 1 l(2)41Ae19 l(2)EMS45-28 1 l(2)41Ae20 l(2)EMS45-33 1 l(2)41Ae21 l(2)EMS45-34 1 l(2)41Ae22 l(2)EMS45-35 1 l(2)41Ae23 l(2)EMS45-53 1 l(2)41Ae24 l(2)EMS45-60 1 l(2)41Ae25 l(2)EMS45-61 1 l(2)41Ae26 l(2)EMS45-64 1 l(2)41Ae27 l(2)EMS45-70 1 l(2)41Ae28 l(2)EMS45-71 1 l(2)41Ae29 l(2)EMS45-83 1 l(2)41Ae30 l(2)EMS45-86 1 l(2)41Ae31 l(2)EMS187 1 l(2)41Ae32 l(2)EMS693 1 l(2)41Ae33 l(2)EMS788 1 l(2)41Ae34 l(2)EMS885 1 l(2)41Ae35 l(2)C113 3 l(2)41Ae36 l(2)C114 3 l(2)41Ae37 l(2)C143 3 l(2)41Ae38 l(2)C515 3 l(2)41Ae39 l(2)Sp9b | 2 l(2)41Ae40 l(2)Sp11 / 2 ( 1 = Hilliker, l976, Genetics 83: 765-82; 2 = Spiess, Hel- ling, and Capenos, 1963, Genetics 48: 1377-88; 3 = Tano, 1966, Jpn. J. Genet. 41: 299-308. | l(2)C147 of Tano. / l(2)C124 of Tano. # l(2)41Af A single mutation that deficiency maps to the same region as M(2)41A and l(2)41Ae, but complements all alleles of the latter, and exhibits no Minute phenotype. allele synonym ________________________ l(2)41Af1 l(2)EMS4--72 # l(2)41Ah Located very close to the heterochromatic-euchromatic junc- tion of 2R. Complementation map circular, with the majority of mutants falling into a single complementation group that is complemented by only three of the thirty alleles. l(2)41Ah8/l(2)41Ah12 survives and has wings uniformly spread from the body at a 45 angle; l(2)41Ah3/l(2)41Ah12 survivors have in addition misshapen, unpigmented or absent ocelli. l(2)41Ah31 to l(2)41Ah34 not tested against the remaining alleles; designated alleles because they are mutually noncom- plementing, and they are included in Df(2R)M41A-4, Df(2R)M41A-8, and Df(2R)M41A-10, but not Df(2R)M41A-50j. allele synonym ref ( _________________________________ l(2)41Ah1 l(2)EMS34-04 1 l(2)41Ah2 l(2)EMS34-12 1 l(2)41Ah3 l(2)EMS34-20 1 l(2)41Ah4 l(2)EMS34-21 1 l(2)41Ah5 l(2)EMS34-22 1 l(2)41Ah6 l(2)EMS34-23 1 l(2)41Ah7 l(2)EMS34-27 1 l(2)41Ah8 l(2)EMS45-08 1 l(2)41Ah9 l(2)EMS45-15 1 l(2)41Ah10 l(2)EMS45-19 1 l(2)41Ah11 l(2)EMS45-21 1 l(2)41Ah12 l(2)EMS45-26 1 l(2)41Ah13 l(2)EMS45-29 1 l(2)41Ah14 l(2)EMS45-45 1 l(2)41Ah15 l(2)EMS45-48 1 l(2)41Ah16 l(2)EMS45-49 1 l(2)41Ah17 l(2)EMS45-50 1 l(2)41Ah18 l(2)EMS45-57 1 l(2)41Ah19 l(2)EMS45-58 1 l(2)41Ah20 l(2)EMS45-59 1 l(2)41Ah21 l(2)EMS45-62 1 l(2)41Ah22 l(2)EMS45-67 1 l(2)41Ah23 l(2)EMS45-68 1 l(2)41Ah24 l(2)EMS45-75 1 l(2)41Ah25 l(2)EMS45-78 1 l(2)41Ah26 l(2)EMS45-80 1 l(2)41Ah27 l(2)EMS45-89 1 l(2)41Ah28 l(2)EMS45-90 1 l(2)41Ah28 l(2)EMS45-93 1 l(2)41Ah30 l(2)EMS172 1 l(2)41Ah31 l(2)C31 3 l(2)41Ah32 l(2)C404 3 l(2)41Ah33 l(2)Sp15 | 2, 3 ( 1 = Hilliker, l976, Genetics 83: 765-82; 2 = Spiess, Hel- ling, and Capenos, 1963, Genetics 48: 1377-88; 3 = Tano, 1966, Jpn. J. Genet. 41: 299-308. | l(2)C123 of Tano. # DEFICIENCY MAP OF REGION 41 side breakpoint variant __________________________________ left 41A Df(2R)A left 41A Df(2R)Rsp11 left 41A Df(2R)Rsp31 h39 Rsp left 41A Df(2R)M41A10 left 41A Df(2R)A left 41A Df(2R)B l(2)41Aa l(2)41Ab right 41A Df(2R)B left 41A Df(2R)Rsp1 rl right 41A Df(2R)A right 41A Df(2R)Rsp1 right 41A Df(2R)Rsp11 uex right 41A Df(2R)Rsp31 right 41A Df(2R)A left 41A Df(2R)M41A4 left 41A Df(2R)M41A8 l(2)41Ae l(2)41Af M(2)41A right 41A Df(2R)A l(2)41Ah right 41A Df(2R)M41A10 stw right 41A Df(2R)M41A8 ap right 41A Df(2R)M41A4 # l(2)49D-F Seventeen complementation groups defined by fifty-eight recessive alleles uncovered by Df(2R)vg-B (Lasko and Pardue, 1988, Genetics 120: 495-502). genetic cytological locus location location included in excluded from synonym __________________________________________________________________ l(2)49Da 2-{66} 49D3-E1 Df(2R)vg-B Df(2R)vg56 l(2)vr22 l(2)49Db 2-{66} 49D3-E1 Df(2R)vg-B Df(2R)vg56 l(2)vr1 l(2)49Dc 2-67.1 49D3-E1 Df(2R)vg56 Df(2R)vg135 l(2)C l(2)49Ea 2-{67} 49E7-F2 Df(2R)vg-D Df(2R)vg-C l(2)vr14 l(2)49Fa 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr3 l(2)49Fb 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr4 l(2)49Fc 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr5 l(2)49Fd 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr6 l(2)49Ff 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr9 l(2)49Fg 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr11 l(2)49Fh 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr13 l(2)49Fi 2-{68} 49E7-F13 Df(2R)vg56 Df(2R)vg-D l(2)vr20 l(2)49Fj 2-{68} 49E7-F13 Df(2R)vg106 Df(2R)vg56 l(2)vr19 l(2)49Fk 2-{68} 49E7-F13 Df(2R)vg104 Df(2R)vg106 l(2)vr10 l(2)49Fl 2-{68} 49F13-50A3 Df(2R)vg33 Df(2R)vg104 l(2)vr15 l(2)49Fm 2-{68} 49F13-50A3 Df(2R)vg33 Df(2R)vg104 l(2)vr18 l(2)49Fn 2-67.2 49F13-50A3 Df(2R)vg-B Df(2R)vg33 cos1 l(2)49Fo 2-{68} 49F13-50A3 Df(2R)vg-B Df(2R)vg33 l(2)vr16 # l(2)49D allele origin discoverer synonym ref ( comments ________________________________________________________________________ l(2)49Da1 HD Lasko l(2)P3 1, 2 dominant enhancer of maternal effect of BicD l(2)49Db1 EMS Lasko l(2)20 1 l(2)49Db2 EMS Lasko l(2)27 1 l(2)49Dc1 spont Curry, 34a21 l(2)C 3 lethal before pupation l(2)49Dc2 EMS Lasko l(2)C10 1 l(2)49Dc3 EMS Lasko l(2)C39 1 l(2)49Dc4 EMS J. Mohler l(2)CIF34 ( 1 = Lasko and Pardue, 1988, Genetics 120: 495-502; 2 = Mohler and Wieschaus, 1986, Genetics 112: 803-22; 3 = Mor- gan, Bridges, and Schultz, 1938, Carnegie Inst. Wash. Year Book 37: 306. # l(2)49Ea A member of the Su(z)2 complex (Wu, Jones, Lasko, and Gel- bart, 1989, Mol. Gen. Genet. 218: 559-64). Alleles recovered by Lasko and Pardue (1988, Genetics 120: 495-502). allele origin discoverer synonym comments _______________________________________________________________ l(2)49Ea1 EMS Lasko l(2)8 recessive semilethal l(2)49Ea2 EMS Lasko l(2)33 recessive semilethal; dominant bristle loss l(2)49Ea3 EMS Lasko l(2)45 weak dominant bristle loss l(2)49Ea4 HD Lasko l(2)P4 recessive semilethal; dominant bristle loss # l(2)49F alleles: Recovery of alleles described by Lasko and Pardue (1988, Genetics 120: 495-502). allele origin discoverer synonym comments ______________________________________________________________________ l(2)49Fa1 EMS Lasko l(2)2 l(2)49Fa2 EMS Lasko l(2)4 l(2)49Fa3 EMS Lasko l(2)16 l(2)49Fa4 EMS Lasko l(2)21 l(2)49Fa5 EMS Lasko l(2)25 temperature-sensitive semilethal l(2)49Fa6 EMS Lasko l(2)31 l(2)49Fa7 EMS Lasko l(2)38 l(2)49Fa8 EMS Lasko l(2)54 l(2)49Fa9 EMS Lasko l(2)55 l(2)49Fa10 EMS Lasko l(2)56 l(2)49Fb1 EMS Lasko l(2)3 l(2)49Fb2 EMS Lasko l(2)28 homozygous viable; lethal in combination with l(2)49Fb1 or a deficiency # l(2)49Fc phenotype: Embryonic lethal. alleles: Recovery of alleles described by Lasko and Pardue (1988, Genetics 120: 495-502). allele origin discoverer synonym __________________________________________ l(2)49Fc1 EMS Lasko l(2)5 l(2)49Fc2 EMS Lasko l(2)32 l(2)49Fc3 EMS Lasko l(2)40 l(2)49Fc4 EMS Lasko l(2)48 l(2)49Fc5 EMS Lasko l(2)57 l(2)49Fd1 EMS Lasko l(2)6 l(2)49Fd2 EMS Lasko l(2)7 l(2)49Fd3 EMS Lasko l(2)35 l(2)49Fd4 / ray Lasko l(2)R4 l(2)49Fd5 / ray Lasko l(2)R5 l(2)49Fd6 / ray Lasko l(2)R6 l(2)49Fd7 / ray Lasko l(2)R8 # l(2)49Ff phenotype: Embryonic lethal. alleles: Recovery of alleles described by Lasko and Pardue (1988, Genetics 120: 495-502). allele origin discoverer synonym comments ____________________________________________________________________ l(2)49Ff1 EMS Lasko l(2)11 l(2)49Ff2 EMS Lasko l(2)22 temperature-sensitive lethal l(2)49Ff3 EMS Lasko l(2)23 l(2)49Ff4 EMS Lasko l(2)37 l(2)49Ff5 EMS Lasko l(2)42 l(2)49Ff6 EMS Lasko l(2)43 l(2)49Ff7 EMS Lasko l(2)46 l(2)49Ff8 / ray Lasko l(2)R2 l(2)49Ff9 EMS J.Mohler l(2)IIIE94 l(2)49Fg1 EMS Lasko l(2)14 l(2)49Fh1 EMS Lasko l(2)24 embryonic lethal l(2)49Fh2 EMS Lasko l(2)47 embryonic lethal l(2)49Fi1 EMS Lasko l(2)53 l(2)49Fj1 EMS Lasko l(2)41 recessive semilethal l(2)49Fk1 EMS Lasko l(2)13 l(2)49Fk2 EMS Lasko l(2)50 l(2)49Fk3 EMS Lasko l(2)51 fails to complement all alleles of l(2)49Fm l(2)49Fl1 EMS Lasko l(2)29 l(2)49Fm1 EMS Lasko l(2)51 fails to complement all alleles of l(2)49Fm l(2)49Fm2 EMS Lasko l(2)52 l(2)49Fo1 EMS Lasko l(2)30 recessive semilethal l(2)49Fo2 EMS Lasko l(2)44 l(2)49Fo3 HD Lasko l(2)P1 # DEFICIENCY MAP OF REGION 49D-F side breakpoint variant ___________________________________ left 49D3-5 Df(2R)vg-B l(2)49Da l(2)49Db left 49D Df(2R)vg56 left Df(2R)vg136 vg l(2)49Dc left Df(2R)R9 right Df(2R)vg133 right 49D6-E1 Df(2R)vg135 right 49E7-F1 Df(2R)vg-C l(2)49Ea Psc Su(z)2 right 49E1-F2 Df(2R)vg62 right 49E2 Df(2R)vg79a right 49E2 Df(2R)vg79b3 right Df(2R)vg79d8 right Df(2R)vg81 right 49E7-F1 Df(2R)vg83f15 right Df(2R)vg107 right Df(2R)vg120 right Df(2R)vg124 right Df(2R)vg136 right 49E2-7 Df(2R)vg-D right Df(2R)vg-R7 right Df(2R)vg-R9 l(2)49Fa l(2)49Fb l(2)49Fc l(2)49Fd l(2)49Ff l(2)49Fg l(2)49Fh l(2)49Fi right 49F Df(2R)vg56 l(2)49Fj right Df(2R)vg106 l(2)49Fk 49F9-13 Mp20 right Df(2R)vg104 l(2)49Fl l(2)49Fm right Df(2R)P2 right 50A Df(2R)vg33 cos1 l(2)49Fo right 50A2-3 Df(2R)vg-B # l(2)52 Nine lethally mutable complementation groups identified in the region uncovered by Df(2R)WMG = Df(2R)52A2-B4;52D7-E1 and one in the region uncovered by Df(2R)KL32 = Df(2R)52C5-D1;- 52E2-5, but not by Df(2R)WMG. Two additional complementation groups inferred from the lethality of overlapping deficien- cies. Eight of the nine uncovered by Df(2R)WMG were also uncovered by Df(2R)XTE18 = Df(2R)51E3-4;52C9-D1, and were not further studied (Davis and MacIntyre, 1988, Genetics 120: 755-66). # l(2)52ACa-l(2)52ACh Eight complementation groups identified but not further characterized. # l(2)52Da location: 2-{75}. origin: Induced by ethyl methanesulfonate. synonym: Group 1. alleles: Nine. cytology: Placed in 52D3 based on its inclusion in Df(2R)KL9 = Df(2R)52D3;53D7-9 but not Df(2R)KL69 = Df(2R)52D2-3;52D9-E1. # l(2)52Db location: 2-{75}. alleles: None recovered. cytology: Inferred to be in 52D7-9 based on the inviability of the heterozygote between Df(2R)KL9 = Df(2R)52D3;53D7-9 and Df(2R)KL69 = Df(2R)52D3;52D9-E1 but not of that between Df(2R)KL9 and Df(2R)WMG = Df(2R)52A4-B2;53D7-E1. # l(2)52Dc location: 2-{75}. alleles: None recovered. cytology: Inferred to be in 52D6-E1 based on the inviability of the heterozygote between Df(2R)l30 = Df(2R)52D6-7;52E1 and Df(2R)KL69 = Df(2R)52D3;52D9-E1. # l(2)52Ea location: 2-{75}. origin: Induced by ethyl methanesulfonate. alleles: Two. cytology: Placed in 52D9-E5 based on its inclusion in Df(2R)KL32 = Df(2R)52C5-D1;52E2-5 but not Df(2R)KL69 = Df(2R)52D3;52D9-E1. # DEFICIENCY MAP OF REGION 52 side breakpoint variant _________________________________ left 50D Df(2R)L7 left 50F6-51A1 Df(2R)L48 left 51A2 Df(2R)L4 right 51A12-B1 Df(2R)L4 left 51B3-4 Df(2R)sf right 51B4-7 Df(2R)L48 right 51B5-C2 Df(2R)L7 right 51C7-E2 Df(2R)sf left 51E3-4 Df(2R)XTE11 left 52B2-C1 Df(2R)KL99 left 51E3-4 Df(2R)XTE18 left 52A4-B2 Df(2R)WMG right 52A6-10 Df(2R)XTE11 l(2)52ACa l(2)52ACb l(2)52ACc l(2)52ACd l(2)52ACe l(2)52ACf l(2)52ACg l(2)52ACh left 52C5-D1 Df(2R)KL32 right 52C9-D1 Df(2R)XTE18 ( Gpo left 52D3 Df(2R)KL9 l(2)52Da left 52D2-3 Df(2R)KL69 right 52D7-E1 Df(2R)WMG c l(2)52Db ( right 52D7-9 Df(2R)KL9 left 52D6-7 Df(2R)l30 l(2)52Dc ( right 52D9-E1 Df(2R)KL69 l(2)52Ea right 52E2-5 Df(2R)KL32 right 52E2-5 Df(2R)KL99 right 52E1 Df(2R)l30 ( Loci inferred from lethality of overlapping deficiencies. # l(2)54 location: 2-41 (not separated from J: 2-41.0). origin: Induced by ethyl methanesulfonate. discoverer: Sandler, 1976. references: 1977, Genetics 86: 567-82. phenotype: Recessive lethal. cytology: Located to 31B-F based on its inclusion in Df(2L)J- der-27 = Df(2L)31B-D;31F. other information: Not allelic to da or mfs(2)48. # l(2)55i location: 2-55.0 (probably to the left of the centromere). origin: Spontaneous. discoverer: Burdick, 55i. references: 1956, DIS 30: 69. Mukai and Burdick, 1959, Genetics 44: 211-32. 1960, Genetics 45: 1581-93. Schnick, Mukai, and Burdick, 1960, Genetics 45: 315-29. Mukai and Burdick, 1961, Japan J. Genetics 36: 97-104. phenotype: Larvae hatch but die before pupation. Females heterozygous for l(1)55i have higher fecundity than homozy- gous, wild-type females. The lethal is therefore not elim- inated from laboratory populations. RK3. # l(2)56a location: 2-90. origin: Spontaneous. discoverer: Burdick, 56a. references: 1956, DIS 30: 69. phenotype: Homozygous lethal; heterozygote shows normal viabil- ity. RK3. other information: Crossing over normal. # l(2)56F A series of mostly recessive lethals recovered based on their lethality in combination with Df(2R)173 (cytology nor- mal) and Df(2R)017 = Df(2R)56F5;56F15 [Shellenbarger and Dut- tagupta, 1978, Mutat. Res. 52: 395-407; Duttagupta and Shel- lenbarger, 1980, Development and Neurobiology of Drosophila (Siddiqi, Babu, Hall, and Hall, eds.). Plenum Press, New York and London, pp. 25-33]. Four complementation groups within Df(2R)017 but not Df(2R)173 (not further described) plus five sites uncovered by both deficiencies, which are separable by complementation analysis, but arbitrarily considered to represent three gene loci, two of which have complementing alleles, and the third of which interacts in trans with the other two. Except for the fact that l(2)56Fa maps to the left of M(2)56F and the inference that l(2)56Fb lies between them, nothing known of order of loci. genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(2)56Fa 2-92.3 56F5-15 Df(2R)173 l(2)56Fb 2-92.3 56F5-15 Df(2R)173 l(2)56Fc 2-92.3 56F5-15 Df(2R)173 M(2)56F l(2)56Fd 2-92.3 56F5-15 Df(2R)017 Df(2R)173 l(2)56Fe 2-92.3 56F5-15 Df(2R)017 Df(2R)173 l(2)56Ff 2-92.3 56F5-15 Df(2R)017 Df(2R)173 l(2)56Fg 2-92.3 56F5-15 Df(2R)017 Df(2R)173 # l(2)56Fa phenotype: Recessive lethal; no phenotype in heterozygote, except when heterozygous to l(2)56Fb in which case short thin bristles are observed. alleles: Nine alleles, two complementing and seven noncomple- menting. Shown to map to the left of M(2)56F by recombina- tion. allele origin synonym comments _____________________________________________ l(2)56Fa1 EMS l(2)36 noncomplementing l(2)56Fa2 EMS l(2)157 noncomplementing l(2)56Fa3 EMS l(2)775 noncomplementing l(2)56Fa4 EMS l(2)1991 noncomplementing l(2)56Fa5 EMS l(2)2735 complementing l(2)56Fa6 EMS l(2)D91 noncomplementing l(2)56Fa7 EMS l(2)D292 noncomplementing l(2)56Fa8 EMS l(2)D932 noncomplementing l(2)56Fa9 EMS l(2)D1368 complementing # l(2)56Fb location: Position between l(2)56Fa and M(2)56F provisional; based on interactions with mutants at both loci. synonym: l(2)12. phenotype: A single allele, which is lethal in homozygotes but produces an extreme Minute, semilethal phenotype in trans heterozygotes with Df(2R)017 and Df(2R)173. Complements all other l(2)56F mutants for viability; interacts with the the noncomplementing alleles of l(2)56Fa and M(2)56F to produce a Minute-like phenotype in the case of l(2)56Fa and an enhanced Minute phenotype in combination with M(2)56F. Trans heterozygotes of l(2)56Fb with the complementing alleles of the other two loci are wild type. #*l(2)57 origin: Spontaneous. discoverer: Paik. references: 1960, Evolution 14: 293-303. other information: A series of 11 lethals selected from Korean wild populations. # l(2)57 Two lethal-saturation studies carried out in the region; tests against Df(2R)D17 = Df(2R)57B5;58B1-2 or against smaller deficiencies including Pu and tud in 57C were carried out by O'Donnell, Boswell, Reynolds, and Mackay, (1989, Genetics 121: 273-80); they recovered 76 lethal mutations identifying sixteen complementation groups between 57B17 and 57F6; in addition, there were fourteen mutations outside this region, but still uncovered by Df(2R)D17. The second study by Schejter and Shilo (1989, Cell 56: 1093-1104) identified eight comple- mentation groups among sixteen lethal mutations uncovered by Df(2R)PK1 = Df(2R)57C5;57F6, the region containing Egfr. Few complementation crosses were carried out between mutations from the two screens. # l(2)57B genetic cytological locus location location included in excluded from ________________________________________________________ l(2)58Ba 2-{97} 57B16-20 Df(2R)PC18 Df(2R)PL3 l(2)58Bb 2-{97} 57B16-20 Df(2R)PC18 Df(2R)PL3 l(2)58Bc 2-{97} 57B16-20 Df(2R)PC18 Df(2R)PL3 l(2)58Bd 2-{97} 57B16-20 Df(2R)PC18 Df(2R)PL3 allele origin discoverer synonym ______________________________________ l(2)57Ba1 EMS O'Donnell l(2)JE7 l(2)57Bb1 EMS O'Donnell l(2)JE6 l(2)57Bc1 EMS Mackay l(2)WE188 l(2)57Bd1 ENU Boswell l(2)E14B l(2)57Bd2 EMS Boswell l(2)SHB1 genetic cytological locus location location included in excluded from synonym ________________________________________________________________ l(2)57Ca 2-{97} 57B18-C4 Df(2R)PL3 Df(2R)MP1 l(2)57Cb 2-{97} 57C3-4 Df(2R)MP1 Df(2R)K11 l(2)57Cc 2-{97} 57C5-7 Df(2R)PC18 Df(2R)PF1 l(2)57Cd 2-{97} 57C5-7 Df(2R)PC18 Df(2R)PF1 l(2)57Ce 2-{97} 57C6-D1 Df(2R)PF1 Df(2R)PC18 l(2)57Cf 2-97 57C4-6 Df(2R)Pl12 Pu Df(2R)CC2 # l(2)57C allele origin discoverer synonym _________________________________________ l(2)57Ca1 ENU Boswell l(2)E19A l(2)57Ca2 EMS Boswell l(2)SHL1 l(2)57Ca3 EMS Reynolds l(2)RE2 l(2)57Ca4 EMS Reynolds l(2)RE7 l(2)57Ca5 EMS Mackay l(2)WE7 l(2)57Cb1 EMS Mackay l(2)WE5A l(2)57Cb2 EMS Reynolds l(2)RE6 l(2)57Cc1 ENU Boswell l(2)E12A l(2)57Cc2 EMS Mackay l(2)WE12 l(2)57Cc3 EMS Mackay l(2)WE9 l(2)57Cc4 EMS Reynolds l(2)RE4 l(2)57Cc5 EMS Reynolds l(2)RE3 l(2)57Cc6 EMS Reynolds l(2)RE8 l(2)57Cc7 EMS Reynolds l(2)RE11 l(2)57Cc8 EMS Boswell l(2)K8-1 l(2)57Cc9 l(2)RE10 l(2)57Cd1 EMS Boswell l(2)K1b2 l(2)57Cd2 EMS Boswell l(2)FAMII-14 l(2)57Ce1 EMS Mackay l(2)WE8 l(2)57Ce2 EMS Mackay l(2)WE10 l(2)57Ce3 EMS Mackay l(2)WE5 l(2)57Ce4 EMS Mackay l(2)WE2 l(2)57Ce5 EMS Reynolds l(2)RE1 l(2)57Ce6 EMS Reynolds l(2)RE5 l(2)57Ce7 EMS Boswell l(2)FAMII-12 l(2)57Ce8 EMS Boswell l(2)K10b2 # l(2)57CD Three complementation groups were identified by Schejter and Shilo in 57C5-D9, the region of overlap between Df(2R)PK1 and Df(2R)PI12; O'Donnell et al. identified five complementation groups in the same region, and no complementation tests have been carried out. Until they are, these mutations are con- sidered independently of those of O'Donnell et al. genetic cytological locus location location included in ___________________________________________ l(2)57CDa 2-{97} 57C5-D9 Df(2R)PK1 Df(2R)PI12 l(2)57CDb 2-{97} 57C5-D9 Df(2R)PK1 Df(2R)PI12 l(2)57CDc 2-{97} 57C5-D9 Df(2R)PK1 Df(2R)PI12 allele discoverer synonym ________________________________ l(2)57CDa1 Schejter l(2)ES16 l(2)57CDa2 Schejter l(2)ES27 l(2)57CDa3 Schejter l(2)ES43 l(2)57CDa4 Schejter l(2)ES46 l(2)57CDb1 Schejter l(2)ES20 l(2)57CDc1 Schejter l(2)ES26 # l(2)57D Two sets of three complementation groups found in this region; they have not been cross checked for complementation; two of the three isolated by O'Donnell et al. are within Df(2R)PI12, whereas those isolated by Schejter et al. are not; the latter could be in 57E as well. Further complementation and deficiency analyses are required to determine the actual number of loci identified. genetic cytological locus location location included in excluded from ________________________________________________________ l(2)57Da 2-{98} 57D6-8 Df(2R)K11 Df(2R)MP1 l(2)57Db 2-{98} 57D7-9 Df(2R)PI12 Df(2R)K11 l(2)57Dc 2-{98} 57D8-12 Df(2R)AA21 Df(2R)PI12 l(2)57Dd 2-{99} 57D8-E Df(2R)PI12 Df(2R)BP7 l(2)57De 2-{99} 57D8-E Df(2R)PI12 Df(2R)BP7 l(2)57Df 2-{99} 57D8-E Df(2R)PI12 Df(2R)BP7 allele origin discoverer synonym ref ( comments _________________________________________________________ l(2)57Da1 EMS Mackay l(2)WE76 1 l(2)57Da2 EMS Reynolds l(2)RE12 1 l(2)57Db1 EMS Boswell l(2)SH1 1 l(2)57Db2 EMS Boswell l(2)SH10 1 l(2)57Db3 EMS Boswell l(2)SH12 1 l(2)57Db4 EMS O'Donnell l(2)JE4 1 l(2)57Db5 EMS O'Donnell l(2)JE9 1 l(2)57Db6 EMS Boswell l(2)SH6B 1 l(2)57Db7 l(2)WEC 1 l(2)57Dc1 EMS O'Donnell l(2)JE8 1, 2 l(2)57Ed of Schejter and Shilo l(2)57Dd1 Schejter l(2)ES1 2 l(2)57Dd2 Schejter l(2)ES4 2 l(2)57Dd3 Schejter l(2)ES38 2 l(2)57De1 Schejter l(2)ES2 2 l(2)57Df1 Schejter l(2)ES15 2 ( 1 = O'Donnell, Boswell, Reynolds, and Mackay, 1989, Genetics 121: 273-80; 2 = Schejter and Shilo, 1989, Cell 56: 1093- 1104. # l(2)57E Three complementation groups were localized between 57D11 and 57F6 by O'Donnell et al.; two of these, including Egfr, were further localized to 57E by Price et al.. Schejter et al. localized l(2)57Dc of O'Donnell to 57E-F, whereas O'Donnell placed it to the left of 57D11-12. genetic cytological locus location location included in excluded from synonym ___________________________________________________________________________ l(2)57Ea 2-100 57E4-F1 Df(2R)Egfr18 Egfr, l(2)57DEFa l(2)57Eb 2-{99} 57E1-11 Df(2R)Egfr3 Df(2R)Egfr18 l(2)57DEFb l(2)57Ec 2-{99} 57D11-F6 Df(2R)PK1 Df(2R)AA21 l(2)57DEFc l(2)57Ed 2-{99} 57E-F Df(2R)BP7 Df(2R)PK1 allele origin discoverer synonym ref ( comments ______________________________________________________________________ l(2)57Eb1 EMS Boswell l(2)SH7 1, 2, 3 l(2)57Eb2 Schejter l(2)ES37 3 l(2)57Ec1 EMS Boswell l(2)SH14 1 l(2)57Ed1 EMS O'Donnell l(2)JE8 1, 3 l(2)57Dc1 according to O'Donnell et al. ( 1 = O'Donnell, Boswell, Reynolds, and Mackay, 1989, Genetics 121: 273-80; 2 = Price, Clifford, and Schupbach, 1989, Cell 56: 1085-92; 3 = Schejter and Shilo, 1989, Cell 56: 1093- 1104. # DEFICIENCY MAP OF REGION 57 side breakpoint variant ( variant | variant / ______________________________________________________________ left 56F9-17 Df(2R)AA21 left 57B5 Df(2R)D17 Df(2R)D17 left 57B16-17 Df(2R)PC18 left 57B16-17 Df(2R)F36 l(2)57Ba l(2)57Bb l(2)57Bc l(2)57Bd left 57B18-20 Df(2R)PL3 Df(2R)PL3 l(2)57Ca left 57C3 Df(2R)CC2 left 57C3-4 Df(2R)MP1 l(2)57Cb left 57C3-4 Df(2R)K11 left 57C4 Df(2R)PI12 Df(2R)PI12 Df(2R)PI12 left Pu left 57C5 Df(2R)PK1 Df(2R)PK1 Df(2R)PK1 left 57C5 Df(2R)PF1 right Pu l(2)57Cc l(2)57Cd right 57C6 Df(2R)CC2 right 57C6-7 Df(2R)PC18 right 57C6-7 Df(2R)F36 l(2)57Ce tud l(2)57CDa l(2)57CDb l(2)57CDc right 57D1 Df(2R)PF1 left 57D2-8 Df(2R)Egfr5 right 57D6-7 Df(2R)MP1 l(2)57Da right 57D7-8 Df(2R)K11 l(2)57Db right 57D8-9 Df(2R)PL3 Df(2R)PL3 right 57D8-9 Df(2R)PI12 Df(2R)PI12 Df(2R)PI12 l(2)57Dc l(2)57Dd l(2)57De l(2)57Df right 57D11-12 Df(2R)AA21 left 57E Df(2R)BP7 left 57E1 Df(2R)Egfr3 57F T(Y;2)JL11 l(2)57Eb l(2)57Eb l(2)57Eb mat(2)N left 57E4-11 Df(2R)Egfr18 Egfr Egfr Egfr l(2)57Ec l(2)57Ed right 57F1 Df(2R)Egfr18 right 57F5-6 Df(2R)PK1 Df(2R)PK1 Df(2R)PK1 right 57F11 Df(2R)Egfr3 right 58A1 Df(2R)BP7 right 58B1-2 Df(2R)D17 Df(2R)D17 right 58D1 Df(2R)Egfr5 ( O'Donnell, Boswell, Reynolds, and Mackay, 1989, Genetics 121: 273-80. | Schejter and Shilo, 1989, Cell 56: 1093-1104. / Price, Clifford, and Schupbach, 1989, Cell 56: 1085-92. # l(2)64 location: 2-70. origin: X ray induced. references: Ytterborn, 1967, Hereditas 58: 165-90. phenotype: Homozygous lethal. Allele frequency maintained in experimental populations in higher-than-expected frequencies; this "overdominance" effect lost in later generations (Ytter- born, 1968, Hereditas 60: 33-71). cytology: Polytene configuration normal. # l(2)74i location: 2R. origin: Spontaneous. references: Wright, Hodgetts, and Sherald, 1976, Genetics 84: 267-85. # l(2)85 location: 2-54.8. origin: X ray induced. references: Ytterborn, 1967, Hereditas 58: 165-90. phenotype: Homozygous lethal; eliminated from experimental populations less rapidly than expected. cytology: No aberrations observed. #*l(2)1076 location: 2-15 (about 40 units from Bl). origin: Spontaneous. discoverer: Ives, 49h. references: 1951, DIS 25: 70. phenotype: Lethal homozygous and in combination with In(2L)Cy. RK3. #*l(2)1323 location: 2-55 (0/162 crossovers with Bl). origin: Spontaneous. discoverer: Ives, 51g. references: 1951, DIS 25: 70. phenotype: Lethal homozygous and in combination with In(2L)Cy + In(2R)Cy. RK3. # l(2)1542 location: 2-unmapped. origin: Induced by ethyl methanesulfonate. references: Gateff, 1978, Biol. Rev. 53: 123-68. 1978, Science, 200: 1448-59. phenotype: Causes malignant neuroblastoma of the adult neurob- lasts and ganglion mother cells; also displays intermediate imaginal disc neoplasm with compact mode of growth. # l(2)a location: 2-64.7. origin: Spontaneous. discoverer: Bridges, 16a15. references: Bridges and Morgan, 1919, Carnegie Inst. Washington Publ. No. 278: 286, 302. phenotype: Almost completely lethal; body color of rare sur- vivor pale. RK3. # l(2)ax location: 2-106.9. origin: Spontaneous. discoverer: Bridges, 19b28. references: 1937, Cytologia (Tokyo), Fujii Jub., Vol. 2: 745- 55. phenotype: Lethal in very early larval stage. RK3. cytology: Located in 60B on salivary chromosome by Bridges but not included in Df(2R)Px = Df(2R)60B8-10;60D1-2. # l(2)ay location: 2-8.3. origin: Spontaneous. discoverer: Bridges, 30d5. # l(2)B location: 2- [in 2L of In(2L)t]. discoverer: Bridges, 1930. # l(2)bl: lethal (2) bluter location: 2-43.8. origin: X ray induced. discoverer: Kafer, 50b. references: Benz, 1953, DIS 27: 55. 1957, Z. Indukt. Abstamm. Vererbungsl. 88: 78-114 (fig.). phenotype: Lethal at end of pupal stage. Homozygotes make emerging movements, but puparia have abnormally thick protein layer so that imaginal hypodermis is punctured in attempt to eclose. Hemolymph is lost, and flies die. Apparently-normal homozygotes may be obtained by artificially opening puparium. Occasionally, a fly spontaneously escapes puparium without serious injury. Differences in content of free amino acids and peptides between l(2)bl and wild type can be distinguished in third-instar larvae, prepupae, and early pupae. RK3. # l(2)Bld: see l(2)36Da # l(2)bw: lethal (2) with brown location: 2-104. origin: Spontaneous in bw2b mr chromosome. discoverer: Curry, 36i. cytology: Salivary chromosomes seem to show slight deficiency or disturbance in 59C and D (Bridges). # l(2)C: see l(2)49Dc # l(2)CA6 location: 2-distal to Df(2L)64j. synonym: l(1)br6. references: Woodruff and Ashburner, 1979, Genetics 92: 133-49. alleles: Three ethyl-methanesulfonate-induced alleles (SF3, SF24, SF27). # l(2)cg: lethal (2) with comb gap location: 2-15 (between dp and cl). origin: Spontaneous. discoverer: Nichols-Skoog, 33d19. references: Curry, 1939, DIS 12: 46. # l(2) cn bwco-3a: see l(2)S3a # l(2) cn bwco-7: see l(2)S7 # l(2)cos: see cos # l(2)crc: see crc # l(2)DTS origin: Induced with ethyl methanesulfonate; selected as dom- inant temperature-sensitive lethal. references: Suzuki and Procunier, l969, Proc. Nat. Acad. Sci. USA 62: 369-76. phenotype: Homozygotes lethal at all temperatures; l(2)DTS/+ flies lethal when raised at 29, but survive development at 25. l(2)DTS/+/+ heterozygotes survive development at 29. genetic locus location T.S.P. ( lethal phase synonym ________________________________________________________________________ l(2)DTS1 just to left of px 115-120 hr 115-144 hr DTS-L1, DTS-L15 l(2)DTS6 b-pr 144-192 hr 190-210 hr DTS-L6 l(2)DTS8 synthetic DTS-L8 l(2)DTS9 FS | DTS-L9 l(2)DTS18 FS DTS-L18 l(2)DTS19 pr-c 115-120hr >210 hr; DTS-L19 eclosion incomplete l(2)DTS20/ FS late pupal DTS-L20 stage ( T.S.P. = temperature sensitive period of heterozygote. | FS = dominant female sterile and therefore not genetically localizable. / Heterozygotes raised at 25 show abnormal chitin development on dorsal surface of abdomen. locus ( chromosome ref | ______________________________ l(2)DTS18 In(2LR)bwV1 1 l(2)DTS100 Cy0 1 l(2)DTS486 Cy0 1 l(2)DTS513 Cy0 1 ( Not tested for allelism with l(2)25Ca. | 1 = Falke and Wright, 1972, DIS 48: 89-91. other information: Many dominant temperature-sensitive lethal mutations on chromosome 2 are allelic and are described under l(2)25Ca. # l(2)ff10 location: 2R. origin: Induced by ethyl methanesulfonate. discoverer: Ransom. references: Campos-Ortega, 1980, Current Topics in Developmen- tal Biology, (R.K. Hunt, ed.). Academic Press, New York, Vol. 15, pp. 347-71. phenotype: Recessive lethal; in homozygous mutant clones in mosaic eyes, cone cells are absent; thus, lenses of eye facets do not form and their place is occupied by cuticle with bris- tles; other constituents of ommatidia are present, though abnormal. # l(2)G: lethal (2) of Golubovsky A group of mapped lethals isolated from natural populations in the vicinity of Unmanj, the Ukraine. references: Golubovsky, 1971, Genetika 7: 77. locus location ___________________ l(2)G78 2-9.4 l(2)G80 2-54.8 l(2)G84 2-73.4 l(2)G93 2-53.9 l(2)G94 2-53.9 l(2)G97 2-73.1 l(2)G99 2-9.3 l(2)G121 2-76.2 l(2)G129 2-0.0 l(2)G137 2-51.9 l(2)G145 2-51.8 l(2)G151 2-54.0 l(2)G156 2-78.6 l(2)G305 2-73.9 l(2)G341 2-103.5 l(2)G552 2-52.2 l(2)G559 2-32.8 l(2)G560 2-81.8 l(2)G562 2-24.2 l(2)G563 2-26.7 l(2)G566 2-54.3 l(2)G571 2-11.3 l(2)G572 2-18.8 l(2)G583 2-49.0 # l(2)gd1: lethal (2) giant discs location: 2-47.7. origin: Spontaneous. references: Bryant, 1969, DIS 44: 47. Bryant and Schubiger, 1971, Dev. Biol. 24: 233-63. phenotype: Pupariation delayed, up to nine days in crowded cul- tures; pupariation is but one day in uncrowded cultures. Discs continue to grow, becoming very large with long delays. Mutant discs transplanted into normal larval hosts metamor- phose; cuticular patterns normal but bristles and to a greater degree sensillae and bracts missing; unguis missing from tar- sal claws; tarsi two jointed. Mutant discs yield low incidence of trans-determination. cytology: Chromosomes normal (Ashburner). # l(2)gd2 location: 2-10.4 (Jurgens). origin: Induced by ethyl methanesulfonate. synonym: l(2)gd-l. references: Gateff, 1977, DIS 52: 4. phenotype: Lethal shortly after pupation; imaginal discs two to four times normal size. Usually display abnormal shapes and folding patterns; occasionally appear normal. Metamorphosed fragments in normal larval hosts exhibit hair patterns; occa- sional single bristles seen; often only naked cuticle forms. # l(2)gl: lethal (2) giant larvae location: 2-0.0. synonym: lgl. references: Hadorn, 1937, Proc. Soc. Exp. Biol. Med. 36: 632-34. 1937, Proc. Nat. Acad. Sci. USA 23: 478-84. 1938, Rev. Suisse Zool. 45: 425-29. Vogt, 1947, Z. Naturforsch 26: 292-94. Gateff and Schneiderman, 1974, Wilhelm Roux's Arch. Dev. Biol. 176: 23-65. Gateff, 1978, Biol. Rev. Cambridge Phil. Soc. 53: 123-68. Mechler, McGinnis, and Gehring, 1985, EMBO J. 4: 1551-57. phenotype: Homozygotes undergo embryogenesis and the first three larval instars; larvae reach normal maximum size; then for some alleles most homozygotes fail to pupate, becoming bloated and 1.5-2 times normal size, whereas for others the majority form prepupae but fail to progress into morpho- genesis. Ring gland small and appears immature in third- instar larvae (Scharrer and Hadorn, 1938, Proc. Nat. Acad. Sci. USA 24: 236-42); third-instar l(2)gl larvae implanted with a normal ring gland pupate but do not metamorphose; injection of ecdysone elicits the same result (Karlson and Hanser, 1952, Z. Naturforsch 76: 80-83); thus a deficiency of hormones from the ring gland is probably one, but not the only, result of l(2)gl. Homozygotes that die as prepupae have underdeveloped corpora allata and prothoracic glands, whereas larval lethals have underdeveloped prothoracic glands but nor- mal corpora allata (Korochkina and Nazarova, 1977, Chromosoma 62: 175-90). Prothoracic glands contain approximately 1% the normal quantity of smooth endoplasmic reticulum (Aggarwal and King, 1969, J. Morph. 129: 171-99). Alleles range from 98% larval and 2% pupal death to 18% larval and 82% pupal death (Gateff, Golubovsky, and Sokolova, 1977, DIS 52: 128-29). In the most extreme phenotypes (+++), the larval brain and optic lobes become enlarged and disorganized and the imaginal discs large and clumped; when discs of such larvae are transplanted into wild-type-female abdomens, they form large contained tumors, whereas transplanted optic primordia from larval brains form invasive neuroblastomas, which grow rapidly, kil- ling the host within 7-14 days; they can be serially cultured in adult abdomens (Gateff and Schneiderman, 1974). These observations have led to l(2)gl's being designated a Drosophila oncogene. Intermediate alleles (++) exhibit moderately enlarged brain and discs, which show enhanced growth when transplanted into wild-type females and death of host is delayed. In weak alleles (+) the brain and discs are small and rudimentary and grow slowly in transplants. One allele normal in disc morphology and behavior in transplants (-). The lethal phase is not well correlated with the pheno- typic expression. Most abundant transcription noted in early (0-6 h) embryos and late third-instar larvae, with the smaller transcript more abundant in embryos and the larger in larvae (Mechler, McGinnis, and Gehring). Immunocytochemistry shows localiza- tion of l(2)gl product at cell surfaces, specifically at the interfaces between proliferating cells (Klambt and Schmidt, 1986, EMBO J. 5: 2955-61; Klambt, Muller, Lutzelschwab, Rossa, Totzke, and Schmidt, 1989, Dev. Biol. 133: 425-36; Lutzelschwab, Klambt, Rossa, and Schmidt, 1987, EMBO J. 6: 1791-97). During later embryogenesis relatively high amounts of l(2)gl protein is detected in pole cells and cells of the lethal phase (%) phenotypic allele origin discoverer ref ( larvae pupae grade coordinates | ______________________________________________________________________________________ l(2)gl1 spont Bridges, 33e9 5, 8 98.0 2.0 +++ 19 l(2)gl2 UV Meyer, 51a 9 l(2)gl3 spont Meyer, 51a 9 l(2)gl4 spont Gateff 3, 8 89.1 10.9 +++ 22.4 l(2)gl6 EMS Gateff 8 11.1 l(2)gl25 spont 8 22.4 l(2)gl26 spont 4, 8 17.4 l(2)gl52 spont 4, 8 12.8 l(2)gl110 spont 2, 8 53.6 43.4 +++ 35.6 l(2)gl138 spont 2, 8 98.0 2.0 + 22.4 l(2)gl150 spont 8 17.4 l(2)gl258 spont 8 23.9 l(2)gl271 spont 2, 8 81.4 18.6 + 34.7 l(2)gl275 spont 2, 8 79.1 20.9 ++ 11.4 to 19.3 l(2)gl309 spont 2 54.0 46.0 ++ l(2)gl314 spont 2, 8 57.3 42.7 + 10.2 l(2)gl334 spont 2, 8 18.4 81.6 + l(2)gl351 spont 2 17.5 82.5 ++ l(2)gl353 spont 2, 8 19.5 80.5 + 27.2 l(2)gl432 spont 8 32.1 l(2)gl558 spont 2, 8 97.2 2.8 - 27.2 l(2)gl705 spont 2 89.7 10.3 ++ l(2)glB spont Burnet 1 l(2)glD150 spont 2 97.3 2.7 +++ l(2)glM119 spont 2 85.0 15.0 + l(2)glts1 EMS Hanratty 6, 7 l(2)glts2 EMS Hanratty 6, 7 ( 1 = Burnet, 1968, DIS 43: 61; 2 = Gateff, Golubovsky, and Sokolova, 1977, DIS 52: 128-29; 3 = Gateff and Schneider- man, 1974, Wilhelm Roux's Arch. Dev. Biol. 176: 23-65; 4 = Green and Shepherd, 1979, Genetics 92: 823-32; 5 = Hadorn, 1937, Proc. Nat. Acad. Sci. USA 23: 478-84; 6 = Hanratty, 1984, Dev. Biol. 193: 90-97; 7 = Hanratty, 1984, Dev. Biol. 193: 98-107; 8 = Mechler, McGinnis, and Gehring, 1985, EMBO J. 4: 1551-57; 9 = Meyer and Edmondson, 1951, DIS 25: 72. | DNA coordinates with respect to an arbitrarily chosen origin close to the tip of 2L; positive values to the right. Most tested alleles are molecular deficiencies with one break- point distal to the origin of the 40 kb walk and the other as indicated in the table. Only l(2)gl52, which has a 10 kb insertion, and l(2)gl275, in which 7.9 kb have been deleted and replaced by an insert of 6.5 kb, are exceptions. developing nervous system; specifically neurons in the peri- pheral nervous system undergoing axogenesis express the pro- tein. Monoclonal antibodies specifically stain junctions between mammalian cells in culture as though they are recog- nizing either membrane or intercellular-matrix proteins (Klambt et al., 1989). Ten-to-eleven-day-old larvae homozygous for larval-lethal alleles exhibit remarkably few puff sites, only 63BC and occa- sionally 88D and 89B; however, heat shock induced puffs develop normally (Ashburner, 1970, Chromosoma 31: 356-76). Homozygotes able to form prepupae exhibit more nearly normal puffing patterns; puffing in response to administration of ecdysone also appears normal (Richards, 1976, Wilhelm Roux's Arch. Dev. Biol. 179: 339-48). alleles: A high incidence of mutant alleles found in natural populations in the Soviet Union (Golubovsky and Sokolova, 1973, DIS 50: 124). More than fifty independent alleles recorded. cytology: Placed in 21A3-4 by in situ hybridization (Mechler, McGinnis, and Gehring). molecular biology: Region from tip of 2L cloned and a 40 kb walk and restriction mapping carried out. Coordinate 0 at the left end of the walk, with positive coordinate values extend- ing to the right toward the centromere. A transcribed region between coordinates 7.3 and 19.4 kb, which is interrupted or deleted by every l(2)gl allele tested, is able to rescue l(2)gl homozygotes by transformation (Opper, Schuler, and Mechler, 1987, Oncogene 1: 91-96); it produces transcripts of 4.3 and 5.5-6 kb in length, which originate from the same sequence through alternative splicing. The larger RNA encodes a polypeptide of 1114 amino acids and approximately 130 kd, whereas the smaller one contains only the 708 N-terminal resi- dues of the larger for a molecular weight of 780 kd. Com- parison of genomic and cDNA sequences show l(2)gl to contain ten exons and to comprise two major blocks of coding exons, the core segment, comprising predominantly exons IV and V, which encodes the majority of the smaller polypeptide and the N-terminal portion of the larger one, and the tail segment comprising exons VII and VIII, which encodes the C-terminal portion of the larger polypeptide. Alternative splicing takes place in and around exon VI (Jacob, Opper, Metzroth, Phanna- vong, and Mechler, 1987, Cell 50: 215-25). The conceptual sequence of the 130 kd protein shares many features with mam- malian cell adhesion proteins, specifically members of the vertebrate cadherin family of proteins, suggesting a function in cell to cell interaction (Lutzelschwab et al., 1987; Klambt et al., 1989). l(2)gl protein lacks the transmembrane domain found in cadherins, but it does have an internally located signal sequence near the N-terminus. It contains four kinds of sequences that show 30 to 40% homology, and half that level of identity with similar sequences in mammalian cadherins (e.g. L-CAM): sequence A of some 60 residues has three charac- teristically spaced N-glycosylation sites; sequence B is around 140 amino acids in length with two cysteine residues and all N-glycosylation sites conserved; sequence C is 70 residues in length and has a high concentration of negative charges; and sequence D contains 45 residues and is positively charged. The sequence of L-CAM can be represented as cyto- plasmic domain-transmembrane domain-B-A-C-D- and that of l(2)gl as AA-B-AD-CC-D-. other information: At least one allele of bhe (broad head) fails to complement l(2)gl alleles and is covered by duplica- tions for the 2L terminus (Kennison). # l(2)H: lethal (2) of Humphrey location: 2-50. origin: Spontaneous. discoverer: Humphrey, 32k. references: Dunn, 1934, DIS 1: 30. 1935, DIS 4: 9. phenotype: Usually dies as pupa; 10-15% of flies survive and look normal but are weak. Homozygote usually sterile when inbred but fertile in outcrosses. RK3. # l(2)hst: lethal (2) histolytic location: 2-56. origin: X ray induced. discoverer: Thompson, 59k. phenotype: Homozygote dies in early pupal stage. Heterozygous viability good. RK3. # l(2)K: lethals from Kofu-Katsunama, Japan origin: Repeatedly isolated from natural population in Kofu- Katsunama, Japan. references: Watanabe and Oshima, 1970, Genetics 64: 93-106. genetic locus location ___________________ l(2)K201 2-47.9 l(2)K202 2-33.7 l(2)K203 2-5.5 l(2)K204 2-32.1 l(2)K207 2-58.4 l(2)K208 2-16.7 l(2)K215 2-1.9 l(2)K224 2-46.2 l(2)K225 2-27.5 l(2)K234 2-57.9 l(2)K255 2-65.1 l(2)K300 2-56.6 l(2)K305 2-53.0 l(2)K326 2-37.7 l(2)K327 2-101.8 l(2)K333 2-65.4 l(2)K335 2-59.9 l(2)K483 2-53.7 l(2)K508 2-69.7 l(2)K513 2-57.8 l(2)K534 2-1.0 # l(2)M: lethal (2) from Mohr location: 2- (between dp and b). origin: Spontaneous. discoverer: Bridges, 33l18. # l(2)Mad51n-: see l(2)S # l(2)Mass38x-: see l(2)S # l(2)mat: lethal (2) maternal location: 2- (near pr). origin: Spontaneous. discoverer: Redfield, 23b. references: 1924, Am. Naturalist 58: 566-69. 1926, Genetics 11: 482-502. phenotype: Homozygous females produce 1 daughter to 5.5 sons. Abnormal sex ratio caused by inviability of females. l(2)mat does not seem to be allelic to da, which has a similar effect. RK3. # l(2)mbn: lethal (2) malignant blood neoplasm origin: Induced by ethyl methanesulfonate. references: Gateff, 1977, DIS 52: 4. 1978, Biol. Rev. Cambridge Philos. Soc. 53: 123-68. 1978, Nature 200: 1448-59. phenotype: Hyperplasia of cellular components of larval hemo- lymph; cell counts 30-40 times normal; cells resemble immature plasmatocytes. In premortal stages the larval tissues have mostly disintegrated and larvae appear to be sacks filled with blood cells. Cells do not proliferate when transplanted to normal larvae. # l(2)me: lethal (2) meander location: 2-72 (71-73). origin: Spontaneous. discoverer: Hadorn, 44g20. synonym: lme. references: 1947, Exptl. Biol. Symp., Vol. 2: 177-95, Cam- bridge Univ. Press. 1947, DIS 21: 68. Schmid, 1949, Z. Indukt. Abstamm. Vererbungsl. 83: 220-53 (fig.). Chen and Hadorn, 1954, Rev. Suisse Zool. 61: 437-51. 1955, Rev. Suisse Zool. 62: 338-47. phenotype: Larvae do not grow normally, die while small. Body length remains relatively shorter than tracheal stems, which become convoluted in a meandering manner. Salivary glands reach 30% normal size; pharyngeal development normal. Intes- tines lack proteolytic enzymes. RK3. Homozygotes show altered charged tRNAGlu isoacceptor pattern. Kubli (1978, Rev. Suisse Zool. 85: 790) suggests a deletion for tRNA-Glu and HexC. # l(2)mr2: lethal (2) with morula location: 2-70. origin: Spontaneous. discoverer: Bridges, 25k24. # l(2)MV: lethal (2) of Mglinetz and Vikulova location: 2-82 (not separated from wt). references: Mglinetz and Vikulova, 1977, Genetika 13: 1318-20. phenotype: Homozygotes die after head eversion at 29, but viable and fertile adults produced at 17 and 25. Transplanted mutant disks into wild-type hosts develop normally. #*l(2)NS: lethal (2) Nova Scotia location: 2-107.0 [to the right of l(2)ax and to the left of sp]. discoverer: Bridges, 23j31. references: 1937, Cytologia (Tokyo), Fujii Jub., Vol. 2: 745- 55. phenotype: Lethal when larvae are about 2 mm long. Development of tracheae and other chitinized parts abnormal. RK3A. cytology: Exists only as In(2R)NS, px 1(2)NS sp. Salivary chromosome locus in 60B10-12 on the basis of its inclusion in Df(2R)Px = Df(2R)60B8-10;60D1-2 but not in the 2RPXD element of T(1;2)Bld = T(1;2)1C3-4;60B12-13 (Bridges). # l(2)pm: lethal (2) polymorph location: 2-30.3. origin: X ray induced. discoverer: Kafer, 50b. references: Benz, 1953, DIS 27: 55. 1957, Z. Indukt. Abstamm. Vererbungsl. 88: 78-114 (fig.). phenotype: Flies die throughout larval and pupal stages. Lar- vae do not contract before pupation; hence, pupae are long and thin. Imagos often cryptocephalic. Chief characteristic is a severe muscular dystrophy. Protein metabolism extremely dis- turbed. In larval stage, free amino acids and one peptide are in abnormally high concentration. Prepupae only slightly dif- ferent from normal in this respect. Occasional survivors viable and fertile. RK3. #*l(2)pup: lethal (2) pupal location: 2-47. origin: Spontaneous. discoverer: Ives, 38j25. references: 1945, Genetics 30: 175. 1945, DIS 19: 46. phenotype: Dies during middle or late pupal stage. External anatomy appears normal except for heavy melanization of wings and legs. RK3. # l(2)R: lethal (2) of Redfield location: 2- [in 2L with In(2L)t]. discoverer: Redfield, 1933. # l(2)S: lethal (2) of Seto A series of late larval and pupal lethals recovered and examined developmentally by Seto. All are lost; more thorough phenotypic descriptions may be found in the references. references: 1954, J. Exp. Zool. 126: 17-32. 1954, Am. Nat. 88: 373-78. 1956, J. Hered. 47: 21-27 (fig.). 1957, DIS 31: 160-62. 1958, DIS 32: 157-58. 1961, DIS 35: 94-95. 1963, DIS 37: 128-229. genetic locus location origin ______________________________ *l(2)S1 spont *l(2)S1A Sp-b spont *l(2)S3 c-px X ray *l(2)S3a dp-Sp / ray *l(2)S4 near pr spont *l(2)S7 Sp-b / ray *l(2)S11 X ray *l(2)S13 spont *l(2)S32 dp-Sp spont *l(2)S42 Bl-L spont *l(2)S42A spont *l(2)S45 Sp-b spont *l(2)S50 spont *l(2)S51 near pr spont *l(2)S55 dp-Sp spont *l(2)S59 h spont *l(2)S61 near pr spont # l(2)Sp: lethal (2) of Spiess A series of recessive lethal mutations extracted from a long term (170 generations) laboratory population. references: Spiess, Helling, and Capenos, 1963, Genetics 48: 1377-86. genetic locus location synonym comments _________________________________________________________ *l(2)Sp1 2-35.0 *l(2)Sp2b 2-49 *l(2)Sp6b 2-50.0 l(2)Sp7 2-3.2 *l(2)Sp18 2-61.5 *l(2)Sp19a 2-1.9 l(2)Sp9b 2-49 *l(2)Sp9c 2-55.1 l(2)41Ae39 between rl and stw *l(2)Sp9d 2-55.1 to the right of stw *l(2)Sp10 2-37.5 l(2)Sp11 2-55.1 l(2)41Ae40 *l(2)Sp12 2-61.5 *l(2)Sp14 2-32.0 l(2)Sp15 2-55.1 l(2)41Ah33 *l(2)Sp18 2-65.3 # l(2)Su(H): lethal (2) from Suppressor of Hairless location: 2-99. origin: Spontaneous. discoverer: Bridges, 37l7. cytology: Located in salivary region 58Al through 58F8 on the basis of its inclusion in Df(2R)M-1 = Df(2R)57F11-58A1;58F8- 59A1. # l(2)Stn: lethal (2) of Steinmetz location: 2-50. origin: Naturally occurring. discoverer: Steinmetz. references: Liebenguth and Steinmetz, 1976, Biochem. Genet. 14: 299. phenotype: Late pupal lethal; pigmentation of eyes and cuticu- lar tissues retarded. cytology: Not included in Df(2L)64j, Df(2L)75c, or Df(2L)fn1 (Woodruff and Ashburner, 1979, Genetics 92: 117-32). #*l(2)T: lethal (2) of Thompson origin: Spontaneous in normal chromosome of SM1/+ heterozygote. discoverer: Thompson, 1956, 1957. synonym: l(2)56i24 through l(2)57h10. other information: A series of 13 independently-occurring and genetically-located lethals. # l(2)Wau55n-: see l(2)S # l(3)1: see l(3)a # l(3)26: see Ace1 # l(3)36d10 location: 3- (close to D, or rearrangement). origin: Spontaneous. discoverer: Bridges, 36d10. #*l(3)36d24 location: 3- (near centromere). origin: Spontaneous. discoverer: Bridges, 36d24. references: 1937, DIS 7: 13. Bridges and Bridges, 1938, Genetics 23: 111-14.